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Merchant R.H.,Nanavati Hospital | Ahmed J.,Nanavati Hospital | Ahmad N.,Drdy Patil Medical College
Indian Journal of Pediatrics

Mendelian Susceptibility to Mycobacterial Disease (MSMD) is a relatively new term that describes a spectrum of inherited defects in the IL-12/23 and IFN- γ pathways that result in a selective predisposition to disease caused by poorly pathogenic mycobacteria. In contrast to previous reports of patients infected with environmental mycobacteria and BCG, this manuscript elucidates the clinical course and diagnosis of MSMD in a child harboring extensively drug resistant (XDR) Mycobacterium tuberculosis. © 2012 Dr. K C Chaudhuri Foundation. Source

Chandanwale S.S.,Drdy Patil Medical College | Buch A.C.,Drdy Patil Medical College | Vimal S.S.,Drdy Patil Medical College | Sachdeva P.,Drdy Patil Medical College
Indian Journal of Tuberculosis

Tuberculosis of thyroid gland is extremely rare. It spreads to thyroid by lymphogenous or heamatogenous route or from adjacent focus, either from larynx or cervical and mediastinal adenitis. We report an unusual case of a 33-year-old male with thyroid swelling. Fine needle aspiration (FNA) smears showed epithelioid cells without necrosis and acid fast bacilli (AFB). Subsequent investigation revealed mediastinal tuberculous lymphadenitis on Computerized Tomography (CT) scan. FNA confirmed the diagnosis of mediastinal tuberculous lymphadenitis. We conclude, when epithelioid cells are seen on FNA thyroid, tuberculosis must be ruled out especially in regions where there is high prevalence of tuberculosis. Source

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