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Bayraktar A.,Karadeniz Technical University | Altunlslk A.C.,Karadeniz Technical University | Muvaflk M.,Yuzuncu Yll University
Journal of Performance of Constructed Facilities | Year: 2016

This paper addresses field investigations of the performance of masonry buildings during the October 23 (Ercis) and November 9 (Edremit), 2011, Van earthquakes in Turkey. Ercis and Edremit are villages respectively located 90 km and 18 km from the city of Van in Turkey. Ground accelerations and response spectra for these earthquakes are discussed. A total of 28,000 buildings were damaged or collapsed in the city center and surrounding villages after the Ercis earthquake. This number increased to 35,000 after the Edremit earthquake. Almost all masonry buildings were affected in the region. Most of them in the area were constructed of random or coursed stone walls with no reinforcement to support heavy clay tile roofing over wooden logs. A large number of such buildings were heavily damaged or collapsed. Cracking and failure patterns are examined and interpreted according to current provisions for earthquake resistance of masonry structures. From the field investigations, it is shown that damages had several causes, among them site effect, location and length of the fault, and poor construction quality. In addition, the two earthquakes hit the masonry buildings within 17 days, causing progressive damage. A large number of nonengineered masonry buildings completely collapsed or were heavily damaged. Most of those in the affected area were not designed and constructed in accordance with the Turkish Earthquake Resistant Design Code. © 2014 American Society of Civil Engineers.

Balkan F.,Aksaray State Hospital | Usluogullar A.,Dr. Ersin Arslan State Hospital | Ucler R.,Yuzuncu Yll University
Turkish Journal of Endocrinology and Metabolism | Year: 2015

Purpose: Our objective in this study was to investigate the prevalence of metabolic syndrome in two different group of patients who had a thyroid-stimulating hormone (TSH) level within normal limits. Material and Method: Three hundred and ffty patients, who presented to Aksaray Public Hospital, Endocrinology and Metabolism Diseases Outpatient clinic and who had no thyroid disease, were included in the study. The patients were divided into two groups according to TSH levels. Group 1 had a TSH level of <2.5 mIU/L and group 2 had a TSH level of >2.5 mIU/L. The prevalence of metabolic syndrome, insulin resistance and lipid parameters were investigated in both groups. Results: A total of 350 patients were included in the study. Group 1 included 229 (65.5%) patients and group 2 included 121 (34.5%) patients. The prevalence of metabolic syndrome was found to be 112/229 (48%) in group 1 and 55/121 (45%) in group 2. There was no statistically signifcant difference between the two groups (p>0.05). FT3 level was found to be positively correlated with hip circumference (r=0.10, p=0.04), weight (r=0.12; p=0.016) and waist circumference (r=0.13; p=0.014). FT4 level was found to be positively correlated with height (r=0.12, p=0.02). Discussion: TSH level was not found to be correlated with the prevalence of metabolic syndrome (p>0.05). The prevalence of metabolic syndrome was found to be similar in both groups. © 2015 Galenos Yayincilik, All rights reserved.

Uner S.,Yuzuncu Yll University | Ozsayin E.,Hacettepe University | Kutluay A.,Hacettepe University | Dirik K.,Hacettepe University
Geologica Carpathica | Year: 2015

The Aksu Basin, within the Isparta Angle, is located to the north of the intersection of the Aegean and Cyprus arcs and has been evolving since the Middle Miocene. Correlation of: (1) kinematic analysis of fault planes that cut the basin fill, (2) the reactivation/inversion of fault planes and (3) sedimentological data indicate that the Aksu Basin has evolved by four alternating compressional and extensional tectonic phases since its formation. The first phase was NW-SE oriented compression caused by the emplacement of the Lycian Nappe units which ended in Langhian. This compressional phase that induced the formation and the initial deformation of the basin was followed by a NW-SE extensional phase. This tectonic phase prevailed between the Langhian and Messinian and was terminated by a NE-SW compressional regime known as the Aksu Phase. The neotectonic period is characterized by NE-SW extension and began in the Late Pliocene. Correlation with the existing tectonic literature shows that the order of deformational phases proposed in this study might also be valid for the entire Isparta Angle area. © 2015 Geologica Carpathica.

Kanberoglu G.S.,Yuzuncu Yll University | Coldur F.,Erzincan University | Topcu C.,Erzincan University | Cubuk O.,Erzincan University
IEEE Sensors Journal | Year: 2015

Novel tamoxifen-selective potentiometric electrodes based on various ion associations of tamoxifen were developed. The most suitable membrane composition, which has the best potentiometric characteristics, was examined under steady-state conditions. The membrane composed of (w/w) 3% tamoxifen-phosphomolibdate ion pair, 32% poly(vinylchloride), and 65% 2-nitrophenyloctylether was determined as the membrane with the best analytical properties. On the condition of pH=2-6, the fabricated electrode exhibited linear responses over the concentration range of 9.1 × 10-6- 1 × 10-3 M tamoxifen solutions (R2 =0.9989) with a sensitivity of 42.9 ± 0.3 mV/decade, detection limit of 7.3 ± 0.4 × 10-6 M and short response time of ≈25 s. The influences of some alkaline, alkaline earth metals, biologically significant molecules, and some pharmaceutical species over electrode responses were studied. The proposed electrode was applied for the determination of tamoxifen contents of some pharmaceutical formulations by using standard addition method. The potentiometric analysis results obtained for the pharmaceutical formulations were in good harmony with the results obtained by high performance liquid chromatography at 95% confidence level. © 2001-2012 IEEE.

Pirincci N.,Yuzuncu Yil University | Kaba M.,Van Training and Research Hospital | Gecit I.,Yuzuncu Yil University | Gunes M.,Yuzuncu Yil University | And 4 more authors.
Toxicology and Industrial Health | Year: 2016

Objectives: Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. Materials and Methods: A total of 37 male patients with renal cell cancer and with a mean age of 56.28 ± 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 ± 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at °'20°C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower (p < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer. © The Author(s) 2013.

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