Yuvarajas College

Mysore, India

Yuvarajas College

Mysore, India
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Sharath Chandra S.P.,Yuvarajas College | Sharath Chandra S.P.,Government Science College | Raghava B.,University of Mysore | Sharada A.C.,Yuvarajas College
International Journal of Pharmaceutical Sciences Review and Research | Year: 2014

Our present study focuses on Synthesis, Characterisation, Molecular Property predictions and Structure-Toxicity studies to choose the molecule possessing Antipsychotic properties. A new series of benzisoxazole derivatives were synthesized, which are close structural analogs of resperidone, a known Second generation Antipsychotic Drug. The structures of the newly synthesized molecules were confirmed by 1) NMR, LC MS, FTIR and elemental analysis. In silico analysis of the parameters of Lipinski’s Rule of five, along with Polar surface area (PSA), absorption%(%ABS), drug likeness indicated that all the synthesized compounds may have prospective role as antipsychotic molecules. In silico structure-toxicity predictions and bioactive scores of synthesized molecules showed identical properties as that of known antipsychotic drugs Haloperidol and Resperidone. The antipsychotic behavioural studies also indicate the antagonistic property of synthesized molecules (S1-S4) to dopamine D2 and serotonin receptors and also lower propensity to caused extra pyramidal symptoms (EPS). These encouraging results of the synthesized molecules have led to further analysis for In vivo and In vitro Antipsychotic Properties. © 2014, Global Research Online. All rights reserved.


Chandra S.P.S.,Government Science College | Puneeth H.R.,Yuvarajas College | Mahadimane P.V.,Alvas Education Foundation | Sharada A.C.,Yuvarajas College
Advanced Science Letters | Year: 2017

The present investigation was carried out to evaluate the bioactive potential of Cordia dichotoma seeds. The seed extracts were examined for antioxidant, cytoprotective and antiulcer properties. Total polyphenol content in aqueous and methanolic extracts were found to be 5.62 and 3.32 tannic acid equivalents (TAE) mg/g respectively. The phenol contents were examined for radical scavenging activity by DPPH method. The antioxidant potential of these extracts was determined by reducing power assay and IC50 was calculated. The cytoprotective studies were carried out using RBC by biochemical methods. Finally, antiulcer activity was evaluated by using H+K+-ATPase inhibition assay. During antiulcer studies the aqueous extract exhibited almost equal potential with respect to pantoprazole (proton potassium ATPase inhibitor) drug. Whereas methanolic extract exhibited more potential than that of aqueous extract. The potentiality was based on IC50 values. © 2017 American Scientific Publishers. All rights reserved.


Gurunanjappa P.,Yuvarajas College | Kariyappa A.K.,Yuvarajas College
Asian Journal of Chemistry | Year: 2017

A series of six new 3-(1-hydroxynaphthalen-2-yl)-1-aryl-1 H-pyrazole-4-carbaldehyde derivatives were synthesized by Vilsmeier-Haack reaction of phenyl hydrazones. The new compounds were characterized by spectral studies and elemental analysis. Synthesized compounds were evaluated in vitro for their antimicrobial and antioxidant susceptibilities. The results suggest that the compounds with methyl and methoxy substitutions in the aromatic ring have good in vitro antimicrobial activities and those with methyl, methoxy and no substitutions possess promising DPPH and hydroxyl free radical scavenging abilities.


Fazal E.,Yuvarajas College | Kaur M.,University of Mysore | Sudha B.S.,Yuvarajas College | Nagarajan S.,Indian Central Food Technological Research Institute | Jasinski J.P.,Keene State College
Acta Crystallographica Section E: Structure Reports Online | Year: 2013

In the title compound, C16H10ClNO2, the dihedral angle between the quinoline ring system and the benzene ring is 14.7 (5)°. The carboxylate group is twisted from the mean planes of the quinoline ring system and the benzene ring by 17.7 (5) and 32.1 (4)°, respectively. In the crystal, inversion dimers are formed with the molecules linked by pairs of weak C-H⋯O interactions arising from an activated aromatic C atom adjacent to the C-Cl bond, generating R 22(14) loops.


Fazal E.,Yuvarajas College | Jasinski J.P.,Keene State College | Krauss S.T.,Keene State College | Sudha B.S.,Yuvarajas College | Yathirajan H.S.,University of Mysore
Acta Crystallographica Section E: Structure Reports Online | Year: 2012

In the title compound, C17H13NO2, two molecules crystallize in the asymmetric unit. The dihedral angle between the mean planes of the quinoline and benzene rings are 78.3(4) and 88.2(3)°. The carboxylate group is twisted slightly from the quinoline ring by 7.1(2) and 13.3(4)°, respectively. In the crystal, weak C-H⋯O interactions are observed. Further stabilization is provided by weak π-π stacking interactions, with centroid-centroid distances of 3.564(9)/3.689(2) and 3.830(1)/3.896(5)Å, respectively.


Fazal E.,Yuvarajas College | Jasinski J.P.,Keene State College | Anderson B.J.,Keene State College | Sudha B.S.,Yuvarajas College | Nagarajan S.,Indian Central Food Technological Research Institute
Acta Crystallographica Section E: Structure Reports Online | Year: 2014

In the title compound, C20H25NO2, the cyclohexyl ring adopts a slightly disordered chair conformation. The dihedral angle between the mean planes of the quinoline ring and the carboxylate group is 22.2(6)°. In the crystal, weak C-H⋯N interactions make chains along [010].


PubMed | Fatima Mata National College, Indian Central Food Technological Research Institute, Dr Hari Singh Gour University, Yuvarajas College and 2 more.
Type: | Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | Year: 2015

FT-IR and FT-Raman spectra of 4-chlorophenyl quinoline-2-carboxylate were recorded and analyzed. The vibrational wavenumbers were computed using DFT quantum chemical calculations. The data obtained from wavenumber calculations are used to assign vibrational bands obtained experimentally. Potential energy distribution was done using GAR2PED program. The geometrical parameters obtained theoretically are in agreement with the XRD data. NBO analysis, HOMO-LUMO, first hyperpolarizability and molecular electrostatic potential results are also reported. The calculated hyperpolarizability of the title compound is 77.53 times that of the standard NLO material urea and the title compound and its derivatives are attractive object for future studies of nonlinear optical properties. Molecular docking results suggest that the compound might exhibit inhibitory activity against GPb.


PubMed | Fatima Mata National College, Indian Central Food Technological Research Institute, Dr Hari Singh Gour University, Yuvarajas College and 2 more.
Type: | Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | Year: 2015

FT-IR and FT-Raman spectra of 4-Methylphenylquinoline-2-carboxylate were recorded and analyzed. The structure of the molecule has been optimized and structural characteristics have been determined by density functional theory. The geometrical parameters (DFT) are in agreement with the XRD results. HOMO and LUMO and other chemical properties are reported. Nonlinear optical properties are also reported. A detailed molecular picture of the title compound and its interactions were obtained from NBO analysis. The negative (red and yellow) regions of the MEP are related to electrophilic reactivity and the positive (blue) regions to nucleophilic reactivity, as shown in the MEP plot and the carbonyl group and the phenyl rings are observed as electrophilic. PASS analysis predicts that the 4-Methylphenylquinoline-2-carboxylate might exhibit anti-diabetic activity. Molecular docking results suggest that the compound might exhibit inhibitory activity against GPb.


Gurunanjappa P.,Yuvarajas College | Kariyappa A.K.,Yuvarajas College
Asian Journal of Chemistry | Year: 2017

An efficient and accessible procedure for the synthesis of 1,3,4-oxadiazines was developed. Reaction involves the cyclocondensation of phenylhydrazones catalyzed by a mild base triethylamine to produce 1,3,4-oxadiazines in good yields. The synthesized new compounds were characterized by spectral studies and elemental analyses and were screened to explore in vitro antimicrobial activity against bacteria and fungi species. The compounds displayed good to excellent potency against tested microorganisms, in particular, compound with chloro substitution showed good antimicrobial potential.


PubMed | Yuvarajas College, Manipal University India, R. L. Fine Chemicals Ltd. Yelahanka and Karnatak University
Type: | Journal: European journal of medicinal chemistry | Year: 2016

A series of 6-chloro-5-(2-substituted-ethyl)-1,3-dihydro-2H-indol-2-ones (3a-h) and 6-chloro-5-(2-chloroethyl)-3-(alkyl/aryl-2-ylidene)indolin-2-ones (5i-x) were synthesized. Compounds 3a-e, 5i-l and 5q-r were selected by NIH, USA for invitro anti-proliferative screening. Based on the impressive growth inhibitory (GI %) effect by the compounds 3a-b and 3e which showed growth inhibition in the range 1.22-76.30%, 2.85-76.03% and 10.98-82.05% respectively at 10(-5) concentration, these compounds were further analyzed for anti-proliferative activity at 5 dose concentration and genotoxicity.

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