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Kunming, China

Yunnan University of Traditional Chinese Medicine , established in 1960 in Kunming, Yunnan, China, was among the second group of TCM universities set up nationwide. With more than 45 years of history, the university is now able to award master degrees and has set up two campuses in sequence, the Bai Ta campus and Guan Shang campus. Presently the university is constructing a third campus which is located in Cheng Gong near Kunming, which will cover an area of over 546,940 square meters and the total construction area is 270,000 square meters, which will be finished in the autumn of 2008. The university has produced ten thousands doctorates of various levels and specialties. The university has more than 10,000 students, and 1,200 staff members.The university focuses on the education of undergraduate and post-graduates whilst enrolling pre-undergraduates and students of higher vocational education. Currently, the university grants medical degrees in two programs together with Guangzhou University of Traditional Chinese Medicine. It also grants first-rank discipline master degrees in three programs, and secondary discipline master degrees in 16 programs including 40 research fields. The university also has 14 undergraduate specialties and research fields ranging from medicine, science, technology and management, 9 pre-undergraduate and higher vocational education programs. Wikipedia.

Li J.B.,Yunnan University of Traditional Chinese Medicine
Zhongguo zhen jiu = Chinese acupuncture & moxibustion | Year: 2013

By taking "lumbar disc herniation", Chinese medicine", "acupuncture and moxibustion" as key words Chinese articles about acupuncture for lumbar disc herniation in recent 10 years were searched in three major Chinese databases of Wan fang database, VIP database and CNKI. Totally 546 relative articles were retrieved. After the elimination of invalid articles, 173 were included as valid articles with 49 main acupoints. The hierarchical clustering statistical method was used to analyze the possible rules among the former 20 acupoints. It turned out that there were 10 most common used acupoints on Bladder Meridian [Geshu (BL 17), Xiaochangshu (BL 27), Shenshu (BL 23), Dachangshu (BL 25), Pangguangshu (BL 28), Guanyuanshu (BL 26), Weizbong (BL 40), Zhibian (BL 54), Chengshan (BL 57), Kunlun (BL 60)], 2 on Gallbladder Meridian [Huantiao (GB 30), Yanglingquan (GB 34)], 2 on Governor Vessel [Yaoyangguan (GV 3), Shuigou (GV 26)], 2 on Stomach Meridian [Zusanli (ST 36), Juliao (ST 3)], 2 on Spleen Meridian [Sanyinjiao (SP 6), Xuehai (SP 10)], and the rest were extra points (Huatuo Jiaji) and Ashi points, so a conclusion could be drawn that the most common used acupoints were Bladder Meridian acupoints and supplemented by Gallbladder Meridian, Governor Vessel, Stomach Meridian, Spleen Meridian, extra points and Ashi points. The selected acupoints were most located on the lumbosacral region, leg and fewer located on the face, back and local part.

Dai Y.,Third Affiliated Hospital of Kunming Medical College | Cui J.,Second Affiliated Hospital of Kunming Medical College | Cun Y.,Third Affiliated Hospital of Kunming Medical College | Shi A.,Yunnan University of Traditional Chinese Medicine
Journal of Surgical Research | Year: 2012

Background: In the liver, eNOS appears to have a central role in protecting against ischemia/reperfusion (I/R) injury. We hypothesized that tetrahydrobiopterin (BH4) would protect livers subjected to I/R injury by coupling with eNOS. Methods: Chinese Kun Ming (KM) mice were subjected to 60 min of 70% hepatic ischemia 30 min after the administration of BH4 or saline. After reperfusion, survival was evaluated. The histologic appearance and ALT, BH4, nitrite/nitrate, 8-isoprostane, and eNOS protein expression levels were measured. Results: The 1-wk survival rate was 66.67% in the BH4 group and 33.33% in the saline group. The serum ALT values in the BH4 group 1, 3, 6, 12, and 24 h after reperfusion were significantly lower than those of the saline group. A histologic examination of the liver revealed only a small necrotic area in the BH4 group as opposed to massive necrosis in the saline group. The percentage values of the hepatic necrotic area 24 h after reperfusion were significantly less for the BH4 group than for the saline group. The nitrite/nitrate levels in the liver tissue were significantly increased by ∼2-fold in the BH4 group compared with the saline group. The free radical indicator 8-isoprostane was reduced approximately 50% in the BH4 group compared with the saline group. Western blotting showed that the level of eNOS protein between the groups was not significantly different. Conclusions: BH4 significantly improved the survival rate by reducing liver failure. This was supported by the histologic findings, and the mechanism was explored. According to the results, we suggest that BH4 prevents liver damage from I/R injury by attenuating reactive oxygen species and increasing NO synthesis, and might provide a novel and promising therapeutic option for preventing I/R injury. © 2012 Elsevier Inc. All rights reserved.

Yang L.-J.,Yunnan University of Traditional Chinese Medicine | Dai Z.-C.,Kunming University
Wuli Xuebao/Acta Physica Sinica | Year: 2012

The effects of correlated time between noises on the stability of unstable state in the Logistic system are investigated. Using the steepest-descent approximation, the analytic expression for the mean first-passage time from unstable state to stable state is derived. The numerically calculated results indicate that the additive noise, the multiplicative noise and the correlated time between the additive and the multiplicative noises weaken the stability of unstable state, but the correlation between the additive and the multiplicative noises enhances the stability of unstable state. © 2012 Chinese Physical Society.

Yang J.,National University of Singapore | Chen J.,Yunnan University of Traditional Chinese Medicine | Li Z.,Innovis
Australian Journal of Chemistry | Year: 2016

The discrimination of Pt-GG adducts by mismatch repair proteins, DNA damage-recognition proteins, and translation DNA polymerases was thought to be vital in determining the toxicity, efficacy, and mutagenicity of platinum anti-tumour drugs. Studies on cis-diammine-Pt-GG (from cisplatin and carboplatin) and trans-R,R-diaminocyclohexane (DACH)-Pt-GG indicated that these proteins recognized the differences in conformation and conformational dynamics of Pt-DNA complexes. However, the structural basis of enantiomeric DACH-Pt-GG forms is unclear. Molecular dynamics simulations results presented here reveal that the conformational dynamics between trans-R,R-DACH-Pt-GG, trans-S,S-DACH-Pt-GG, cis-DACH-Pt-GG and undamaged DNA are distinct and depend on the chirality of DACH though their major conformations are similar. Trans-DACH-Pt was found to be energetically favoured over cis-DACH-Pt to form DNA adducts. Moreover, oxaliplatin and its cis-DACH analogues were found to preferentially form hydrogen bonds on the 3′ side of the Pt-GG adduct, whereas the S,S-DACH-Pt preferred the 5′ side. A three-centre hydrogen bond formed between cis1-DACH-Pt and DNA was observed, and the differences in hydrogen bond formation are highly correlated with differences in DNA conformational dynamics. Based on these results, it is suggested that the different bioactivities of oxaliplatin and its enantiomeric analogues were controlled by the difference in hydrogen bonds formation dynamics between DNA and the Pt moiety. Our molecular dynamics approach was demonstrated to be applicable to the study of stereoisomer conformations of platinum-DNA model, thereby suggesting its potential application as a tool for the study and design of new effective platinum-based drugs. © 2016 CSIRO.

Zhao S.-D.,CAS Kunming Institute of Botany | Zhao S.-D.,Yunnan University of Traditional Chinese Medicine | Shen L.,CAS Kunming Institute of Botany | Shen L.,Chinese Academy of Sciences | And 2 more authors.
Current Organic Chemistry | Year: 2011

With the development of separation materials, more and more complex natural products with poly-stereogenic centers are obtained. However, due to small quantity of the isolated compounds, or no crystal formed, or complex 2D NMR correlation signals, absolute configuration identification for these compounds becomes difficult. Now, computational methods provide researchers many benefits in structural determinations for chiral natural products. Computational methods include (1) optical rotation (OR) and its dispersion (ORD) computations; (2) electronic circular dichroism (ECD or CD) calculations; (3) computations of determinant of matrix for stereogenic centers. In methods (1) to (2), the mostly used quantum theory contained density functional theory (DFT) with different basis sets, e.g. B3LYP/aug-cc-pVDZ//B3LYP/6-31G(d). Effects from solvents on OR value can be investigated using different corresponding software. In the cases, optimizations performed in the corresponding solution are helpful to obtain the correct predictions although it is not usual at present time. Matrix model as one of the mathematic methods is different from quantum methods, which is of easily being understood and effective in absolute configuration assignment for acyclic chiral compounds. In this review, necessary theory basis for the three methods are simply introduced for modern readers, the focus of which is the application of these methods in natural product chemistry by various examples reported in different journals from 1998 to the end of April of 2010 except for matrix method to the May of 2010 based on an experimental chemist's viewpoints. © 2011 Bentham Science Publishers Ltd.

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