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Kunming, China

Yunnan University is one of the largest and most prestigious universities in Yunnan province, China. Its main campuses are located in the provincial capital city of Kunming. It has been developed into the only "National Key University" in Yunnan province, having trained over 17,000 specialist professionals in various fields.Founded in December 1922, Yunnan University started to enroll in April 1923. It began as a privately run institution called the "University of the Eastern Land" and its name has changed six times since then. Currently, Yunnan University is one of the "Project 211" universities in China authorized by the central government to be specially developed. Yunnan University has also been included on the list of the key national universities for the "China Western Development" program.Yunnan University Science Park was established as an experimental site of University Science Park in 1999 and was awarded the status of national university science park in May 2001. The Park is supported by Yunnan University, Kunming University of Science & Technology and Yunnan Normal University. Wikipedia.

Zhou Y.,Ewha Womans University | Zhou Y.,Yunnan University | Zhang J.F.,Yunnan Normal University | Yoon J.,Ewha Womans University
Chemical Reviews | Year: 2014

Knowledge about the importance of fluoride ions in biological and medical processes has grown in recent years. It is now known that this anion plays a role in dental health and has potential use for the treatment of osteoporosis. Fluoride is easily absorbed by the body but is excreted slowly. Fluoride also plays an important role in a number of military applications. For example, the refinement of uranium in nuclear weapons manufacturing utilizes fluoride. GB, more commonly known as sarin (isopropyl methylphosphonofluoridate), is a nerve agent employed by the Aum Shinrikyu cult in terrorist attacks in Tokyo in 1995. Over the past two decades, a large number of optical sensors have been developed for detecting fluoride. For the most part, the methods employed in these sensors rely on strong interactions taking place between Lewis-acidic boron and fluoride, as well as hydrogen bonding and other types of interactions involving fluoride as a participant or a disrupter. In addition, reaction-based chemodosimeters have been devised for the selective detection of fluorides.

Du Z.,Northwest University, China | Shao Z.,Northwest University, China | Shao Z.,Yunnan University
Chemical Society Reviews | Year: 2013

The combination of transition metal catalysis and organocatalysis as a new and exciting research area has attracted increasing attention as it can enable the development of unprecedented transformations that is not possible by use of either of the catalytic systems alone, and can improve the reactivity, efficiency and stereocontrol of existing chemical transformations. In this review, we summarize recent remarkable progress in the field of combined transition metal catalysis and organocatalysis, further highlighting the potential of this new and exciting research area and the many challenges that still remain for the future. © 2013 The Royal Society of Chemistry.

The snub-nosed monkey genus Rhinopithecus includes five closely related species distributed across altitudinal gradients from 800 to 4,500 m. Rhinopithecus bieti, Rhinopithecus roxellana, and Rhinopithecus strykeri inhabit high-altitude habitats, whereas Rhinopithecus brelichi and Rhinopithecus avunculus inhabit lowland regions. We report the de novo whole-genome sequence of R. bieti and genomic sequences for the four other species. Eight shared substitutions were found in six genes related to lung function, DNA repair, and angiogenesis in the high-altitude snub-nosed monkeys. Functional assays showed that the high-altitude variant of CDT1 (Ala537Val) renders cells more resistant to UV irradiation, and the high-altitude variants of RNASE4 (Asn89Lys and Thr128Ile) confer enhanced ability to induce endothelial tube formation in vitro. Genomic scans in the R. bieti and R. roxellana populations identified signatures of selection between and within populations at genes involved in functions relevant to high-altitude adaptation. These results provide valuable insights into the adaptation to high altitude in the snub-nosed monkeys. © 2016 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

A sensitive amperometric acetylcholinesterase (AChE) biosensor based on NiO nanoparticles (NiO NPs), carboxylic graphene (CGR) and nafion (NF) modified glassy carbon electrode (GCE) has been developed. NiO NPs-CGR-NF nanocomposites with excellent conductivity, catalysis and biocompatibility offered an extremely hydrophilic surface for AChE adhesion. The AChE biosensor showed favorable affinity to acetylthiocholine chloride (ATCl) and could catalyze the hydrolysis of ATCl with an apparent Michaelis-Menten constant value of 135 μM. Under optimum conditions, the biosensor detected methyl parathion and chlorpyrifos in the linear range from 1.0 × 10(-13) to 1 × 10(-10)M and from 1.0 × 10(-10) to 1 × 10(-8)M with the detection limits 5 × 10(-14)M. The biosensor detected carbofuran in the linear range from 1.0 × 10(-12) to 1 × 10(-10)M and from 1.0 × 10(-10) to 1 × 10(-8)M with the detection limit of 5 × 10(-13)M. The developed biosensor exhibited good sensitivity, stability and reproducibility, thus providing a promising tool for analysis of enzyme inhibitors. Copyright © 2013 Elsevier B.V. All rights reserved.

Zhou Y.,Ewha Womans University | Zhou Y.,Yunnan University | Yoon J.,Ewha Womans University
Chemical Society Reviews | Year: 2012

Due to the biological importance of amino acids, the development of optical probes for these molecules has been an active research area in recent years. This tutorial review focuses on recent contributions since the year 2000 concerning the fluorescent or colorimetric sensors for amino acids, and is organized according to their structural classification and reaction types. For reaction based chemosensors, the works are classified according to the mechanisms between sensors and amino acids, including imine formation, Michael addition, thiazinane or thiazolidine formation, cleavage of a sulfonate ester, cleavage of disulfide, metal complexes-displace coordination and others.

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