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Zhou Q.,Tianjin Medical University | Fan Y.,Tianjin Medical University | Wu N.,Peking Union Medical College | Huang Y.,The Third Affiliated Hospital of Kunming Medical College Yunnan Tumor Hospital | And 6 more authors.
Thoracic Cancer

Background: Lung cancer is the leading cause of cancer-related death and has become an enormous economic burden in China. Low-dose spiral computed tomography (LDCT) screening could reduce lung cancer mortality. The feasibility of conducting a population-based lung cancer screening with LDCT in China is uncertain. Methods: In 2010, a demonstration program of lung cancer screening was initiated in China. High-risk individuals were enrolled in a cluster sampling design in different centers. Participants received baseline and annual screening with spiral CT and follow-up information was collected. The objective of this program is to evaluate the feasibility of conducting population-based LDCT lung cancer screening in the Chinese context. The rates of detection, early diagnosis and treatment are defined as indicators of program performance. The optimal management strategies for nodules are explored in the Chinese context based on experiences in other studies overseas. Results: A demonstration program of ongoing prospective, multi-center, population-based lung cancer screening is being performed in China. Conclusions: This demonstration program will provide opportunities to explore the feasibility of LDCT lung cancer screening in the Chinese setting. © 2013 The Authors. Thoracic Cancer published by Tianjin Lung Cancer Institute and Wiley Publishing Asia Pty Ltd. Source

Zhou Q.-H.,University of Sichuan | Zhou Q.-H.,Tianjin Medical University | Fan Y.-G.,Tianjin Medical University | Bu H.,University of Sichuan | And 6 more authors.
Thoracic Cancer

Background: Lung cancer is the leading cause of cancer-related death in China. Results from a randomized controlled trial using annual low-dose computed tomography (LDCT) in specific high-risk groups demonstrated a 20% reduction in lung cancer mortality. Methods: A China national lung cancer screening guideline was developed by lung cancer early detection and treatment expert group appointed by the National Health and Family Planning Commission, based on results of the National Lung Screening Trial, systematic review of evidence related to LDCT screening, and protocol of lung cancer screening program conducted in rural China. Results: Annual lung cancer screening with LDCT is recommended for high risk individuals aged 50-74 years who have at least a 20 pack-year smoking history and who currently smoke or have quit within the past five years. Individualized decision making should be conducted before LDCT screening. LDCT screening also represents an opportunity to educate patients as to the health risks of smoking; thus, education should be integrated into the screening process in order to assist smoking cessation. Conclusions: A lung cancer screening guideline is provided for the high-risk population in China. © 2015 China Lung Oncology Group and Wiley Publishing Asia Pty Ltd. Source

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