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Wang C.,Yunnan Provincial Hospital of Traditional Chinese Medicine
Journal of Acupuncture and Tuina Science | Year: 2011

Objective: To observe the effects of combined tuina and Calcitonin on pain and functional activities in primary osteoporosis. Methods: Eighty-eight cases of confirmed primary osteoporosis were randomized into two groups. The treatment group with 44 cases was treated by tuina and Calcitonin, while the control group with 44 cases was treated with Calcitonin alone. The severity of pain and functional activities were assessed respectively before treatment and after two courses of treatment. Results: There were significant differences in the clinical efficacy for pain and functional activities between the two groups, with better efficacy in the treatment group than that in the control group (P<0. 01). Conclusion: The combination of tuina and Calcitonin is quite effective to relieve pain and improve functional activities in primary osteoporosis. © 2011 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg. Source


Chen C.-L.,Yunnan University of Traditional Chinese Medicine | Tan W.-H.,Yunnan University of Traditional Chinese Medicine | Wang Y.,Yunnan University of Traditional Chinese Medicine | Xue Z.-G.,U.S. Food and Drug Administration | And 4 more authors.
Journal of Natural Medicines | Year: 2015

Aconitum vilmorinianum Komarov is a local medicinal plant used in many well-known clinical preparations to treat rheumatism and pains in Yunnan Province, China. Phytochemical examination of the roots of A. vilmorinianum led to the isolation of three novel imine-type norditerpenoid alkaloids named vilmorrianines E-G (1-3), and a new natural alkaloid N-desethyl-N-formyl-8-O-methyltalatisamine (4), together with 14 known alkaloids. Their structures were elucidated on the basis of spectroscopic evidence. Vilmorrianine E is the first known norditerpenoid alkaloid containing both an imine group and a three-membered ring formed by C8, C9, and C10. © 2015 The Japanese Society of Pharmacognosy and Springer Japan. Source


Li J.,Chengdu University of Traditional Chinese Medicine | Zheng H.,Chengdu University of Traditional Chinese Medicine | Zhao L.,Chengdu University of Traditional Chinese Medicine | Li Y.,Chengdu University of Traditional Chinese Medicine | And 9 more authors.
Trials | Year: 2013

Background: Several studies using acupuncture to treat essential hypertension have been carried out. However, whether acupuncture is efficacious for hypertension is still controversial. Therefore, this trial aims to evaluate the efficacy and safety of acupuncture for patients with mild hypertension.Methods/Design: This is a large scale, open-label, multicenter, randomized controlled clinical trial with four parallel arms. We will recruit 428 hypertensive patients with systolic blood pressure (SBP) between 140 and 159 mmHg, diastolic blood pressure (DBP) between 90 and 99 mmHg. The participants will be randomly assigned to four different groups (three acupuncture groups and one waiting list group) (1). The affected meridian acupuncture group (n = 107) is treated with acupoints on the affected meridians (2). The non-affected meridian acupuncture group (n = 107) is treated with acupoints on the non-affected meridians (3). The invasive sham acupuncture group (n = 107) is provided with sham acupoints treatment (4). The waiting-list group (n = 107) is not offered any intervention until they complete the trial. Each patient allocated to acupuncture groups will receive 18 sessions of acupuncture treatment over 6 weeks. This trial will be conducted in 11 hospitals in China. The primary endpoint is the change in average 24-hSBP before and 6 weeks after randomization. The secondary endpoints are average SBP and average DBP during the daytime and night-time, and 36-Item Short Form Survey (SF-36), and so on.Discussion: This is the first large scale, multicenter, randomized, sham controlled trial of acupuncture for essential hypertension in China. It may clarify the efficacy of acupuncture as a treatment for mild hypertension. Trial registration: Clinicaltrials.gov Identifier: NCT01701726. © 2013 Li et al.; licensee BioMed Central Ltd. Source


Li D.,Chengdu University of Traditional Chinese Medicine | Yang M.,Chengdu University of Traditional Chinese Medicine | Zhao L.,Chengdu University of Traditional Chinese Medicine | Zheng H.,Chengdu University of Traditional Chinese Medicine | And 8 more authors.
Trials | Year: 2014

Background: Chronic stable angina pectoris (CSAP) is a common cardiovascular condition that endangers a patient's life quality and longevity. As demonstrated in several clinical trials, acupuncture is attested to be effective for CSAP. Current trials are not adequate enough to provide high-quality evidence for clinical decision making, as a result of inadequate methodology design and small sample size. Notably, stark controversy toward acupoint specificity also exists in the clinical acupuncture trials for CSAP. Therefore, we designed the present study as a randomized controlled trial primarily to investigate the effectiveness of acupuncture in addition to routine care among patients with CSAP. Meanwhile, we examined whether acupoint on the disease-affected meridian (DAM) is superior to either acupoint on the non-affected meridian (NAM) or non-acupoint (NA), to further investigate the meridian-based characteristics of acupoint specificity.Methods/Design: This study was a multicenter, assessor and statistician blinded, randomized controlled trial in China. In this study, 404 participants in sum will be randomly assigned to four groups through central randomization in a 1:1:1:1 ratio. The whole study period is 20 weeks including a 4-week baseline period, a 4-week treatment period and a 12-week follow-up. Participants in the DAM group receive acupuncture stimulation at acupoints on the disease-affected meridian, and three different control groups will undergo acupuncture stimulation at the NAM, the non-acupoint and no intervention respectively, in addition to basic treatment. Participants in the acupuncture groups will receive 12 sessions of acupuncture treatment over 4 weeks, while the wait-listed (WL) group would receive free acupuncture treatment after the completion of the study. The outcome measures in this trial include the frequency of angina attack during 4 weeks as the primary outcome and eight other secondary outcomes.Discussion: This trial will provide new and relatively high-quality evidence in acupuncture treatment for CSAP. Moreover, this trial may further validate the meridian-based characteristics of acupoint specificity by comparing the strength of acupoints on the disease-affected meridian versus that of the non-affected meridian, to further inspire optimization of acupuncture therapy for CSAP.Trial registration: Clinical Trials.gov NCT01686230. © 2014 Li et al.; licensee BioMed Central Ltd. Source


Zheng Y.,Beijing University of Chinese Medicine | Liu B.,China Japan Friendship Hospital | Wang J.,Beijing University of Chinese Medicine | Chen J.,Beijing University of Chinese Medicine | And 3 more authors.
Pakistan Journal of Zoology | Year: 2014

This study was aimed at investigating the effects of Huangjingzanyu optimized formula on the energy metabolism of sperm and on the activities of mitochondrial marker enzymes. Polyglycoside of Tripterygium wilfordii (GTW) was used to establish rat asthenospermia models. We investigated the mechanism of the action of the Huangjingzanyu optimized formula on mitochondrial energy metabolism by measuring sperm adenosine triphosphate (ATP) content and changes in succinic dehydrogenase (SDH) and lactate dehydrogenase-C4 (LDH-C4) activities, Compared to the model group, the sperm ATP content was significantly increased in the high- and moderate dose Huangjingzanyu optimized formula. The SDH and LDH-C4 activities were also significantly increased after treatment with the high- and moderate dose. No significant difference was noted between the optimized formula small-dose group and the model group. The Huangjingzanyu optimized formula can increase sperm ATP content by improving the activities of SDH and LDH-C4 and other mitochondrial marker enzymes for energy metabolism, thereby improving sperm motility. © Copyright 2014 Zoological Society of Pakistan. Source

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