Yunnan Provincial Hospital of Traditional Chinese Medicine

Kunming, China

Yunnan Provincial Hospital of Traditional Chinese Medicine

Kunming, China
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Yan L.,East China Normal University | Li L.,East China Normal University | Han W.,Tongji University | Pan B.,Yunnan Provincial Hospital of Traditional Chinese Medicine | And 3 more authors.
Brain Research Bulletin | Year: 2013

Alzheimer's disease (AD) is the most common form of dementia and causes impairments of memory, cognition and behavior. Remarkably, most AD patients exhibit personality changes that often precede other early clinical manifestations. Conditional presenilin1 (PS1) and presenilin2 (PS2) double knockout (DKO) mice have age-related forebrain atrophy, tau hyperphosphorylation, synaptic dysfunction, cognitive deficits and increased inflammatory responses in both the periphery and the brain. Whether these mice have age-related emotional changes have not yet been investigated. In the present study, we used 2-, 6- and 11-month-old DKO and littermate control (CON) mice to examine their age-related emotional conditions. Our results indicate that DKO mice have observable age-related neuropsychiatric symptoms, such as anxiety, irritability, depression, apathy, aggressivity, anhedonia and aberrant motor behavior when compared with other AD-like mouse models. In summary, our results not only indicate that DKO mice may be a valuable model for probing age-related AD diagnoses but also suggest a new pathogenesis of neurodegenerative diseases that is worth further investigation. © 2013 Elsevier Inc.


Song N.-L.,Chinese Institute of Materia Medica | Wan C.-P.,Yunnan Provincial Hospital of Traditional Chinese Medicine | Que L.,Yunnan University of Traditional Chinese Medicine | Bao Z.-R.-G.-T.,Yunnan University of Traditional Chinese Medicine
Chinese Pharmacological Bulletin | Year: 2013

Aim: To investigate the effect of piperine (PIP) on glucose metabolism and blood pressure (BP) of model rats with insulin resistance syndrome (IRS). Methods: Rats were fed with high-fat, high-glucose and high-salt diet to establish IRS model rats. Fasting blood glucose (FBG) and BP were observed dynamically every 4 weeks. The model rats started the treatment from the 4 th week and were treated for 8 weeks continuously. FBG (method of GOD-POD) and fasting insulin(FINS, method of RIA) were measured and insulin sensitivity index (ISI) was calculated, oral glucose tolerance test(OGTT) was observed, no invasion blood pressure instrument was used to measure BP. Results: After 8 weeks treatment, the level of ISI in PIP group increased obviously, while the levels of FBG in serum and BP were reduced significantly, and abnormal oral glucose tolerance improved accordingly. Conclusions: PIP could reduce BP and significantly improve abnormal glucose metabolism of model rats with IRS.


Li J.,Chengdu University of Traditional Chinese Medicine | Zheng H.,Chengdu University of Traditional Chinese Medicine | Zhao L.,Chengdu University of Traditional Chinese Medicine | Li Y.,Chengdu University of Traditional Chinese Medicine | And 9 more authors.
Trials | Year: 2013

Background: Several studies using acupuncture to treat essential hypertension have been carried out. However, whether acupuncture is efficacious for hypertension is still controversial. Therefore, this trial aims to evaluate the efficacy and safety of acupuncture for patients with mild hypertension.Methods/Design: This is a large scale, open-label, multicenter, randomized controlled clinical trial with four parallel arms. We will recruit 428 hypertensive patients with systolic blood pressure (SBP) between 140 and 159 mmHg, diastolic blood pressure (DBP) between 90 and 99 mmHg. The participants will be randomly assigned to four different groups (three acupuncture groups and one waiting list group) (1). The affected meridian acupuncture group (n = 107) is treated with acupoints on the affected meridians (2). The non-affected meridian acupuncture group (n = 107) is treated with acupoints on the non-affected meridians (3). The invasive sham acupuncture group (n = 107) is provided with sham acupoints treatment (4). The waiting-list group (n = 107) is not offered any intervention until they complete the trial. Each patient allocated to acupuncture groups will receive 18 sessions of acupuncture treatment over 6 weeks. This trial will be conducted in 11 hospitals in China. The primary endpoint is the change in average 24-hSBP before and 6 weeks after randomization. The secondary endpoints are average SBP and average DBP during the daytime and night-time, and 36-Item Short Form Survey (SF-36), and so on.Discussion: This is the first large scale, multicenter, randomized, sham controlled trial of acupuncture for essential hypertension in China. It may clarify the efficacy of acupuncture as a treatment for mild hypertension. Trial registration: Clinicaltrials.gov Identifier: NCT01701726. © 2013 Li et al.; licensee BioMed Central Ltd.


Wang C.,Yunnan Provincial Hospital of Traditional Chinese Medicine
Journal of Acupuncture and Tuina Science | Year: 2011

Objective: To observe the effects of combined tuina and Calcitonin on pain and functional activities in primary osteoporosis. Methods: Eighty-eight cases of confirmed primary osteoporosis were randomized into two groups. The treatment group with 44 cases was treated by tuina and Calcitonin, while the control group with 44 cases was treated with Calcitonin alone. The severity of pain and functional activities were assessed respectively before treatment and after two courses of treatment. Results: There were significant differences in the clinical efficacy for pain and functional activities between the two groups, with better efficacy in the treatment group than that in the control group (P<0. 01). Conclusion: The combination of tuina and Calcitonin is quite effective to relieve pain and improve functional activities in primary osteoporosis. © 2011 Shanghai Research Institute of Acupuncture and Meridian and Springer-Verlag Berlin Heidelberg.


Li D.,Chengdu University of Traditional Chinese Medicine | Yang M.,Chengdu University of Traditional Chinese Medicine | Zhao L.,Chengdu University of Traditional Chinese Medicine | Zheng H.,Chengdu University of Traditional Chinese Medicine | And 8 more authors.
Trials | Year: 2014

Background: Chronic stable angina pectoris (CSAP) is a common cardiovascular condition that endangers a patient's life quality and longevity. As demonstrated in several clinical trials, acupuncture is attested to be effective for CSAP. Current trials are not adequate enough to provide high-quality evidence for clinical decision making, as a result of inadequate methodology design and small sample size. Notably, stark controversy toward acupoint specificity also exists in the clinical acupuncture trials for CSAP. Therefore, we designed the present study as a randomized controlled trial primarily to investigate the effectiveness of acupuncture in addition to routine care among patients with CSAP. Meanwhile, we examined whether acupoint on the disease-affected meridian (DAM) is superior to either acupoint on the non-affected meridian (NAM) or non-acupoint (NA), to further investigate the meridian-based characteristics of acupoint specificity.Methods/Design: This study was a multicenter, assessor and statistician blinded, randomized controlled trial in China. In this study, 404 participants in sum will be randomly assigned to four groups through central randomization in a 1:1:1:1 ratio. The whole study period is 20 weeks including a 4-week baseline period, a 4-week treatment period and a 12-week follow-up. Participants in the DAM group receive acupuncture stimulation at acupoints on the disease-affected meridian, and three different control groups will undergo acupuncture stimulation at the NAM, the non-acupoint and no intervention respectively, in addition to basic treatment. Participants in the acupuncture groups will receive 12 sessions of acupuncture treatment over 4 weeks, while the wait-listed (WL) group would receive free acupuncture treatment after the completion of the study. The outcome measures in this trial include the frequency of angina attack during 4 weeks as the primary outcome and eight other secondary outcomes.Discussion: This trial will provide new and relatively high-quality evidence in acupuncture treatment for CSAP. Moreover, this trial may further validate the meridian-based characteristics of acupoint specificity by comparing the strength of acupoints on the disease-affected meridian versus that of the non-affected meridian, to further inspire optimization of acupuncture therapy for CSAP.Trial registration: Clinical Trials.gov NCT01686230. © 2014 Li et al.; licensee BioMed Central Ltd.


Yang X.,Yunnan Provincial Hospital of Traditional Chinese Medicine | Chongsuvivatwong V.,Prince of Songkla University | Lerkiatbundit S.,Prince of Songkla University | Ye J.,Yunnan Provincial Hospital of Traditional Chinese Medicine | And 3 more authors.
Chinese Medicine (United Kingdom) | Year: 2014

Background: There are approximately five Zhengs reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the Zhengs in psoriatic patients based on the application of a checklist of traditional Chinese medicine (TCM) symptoms and signs followed by latent class analysis (LCA).Methods: A cross-sectional study of 507 psoriatic patients aged above 10 years was performed in Yunnan Provincial Hospital of TCM and the First Affiliated Hospital of Kunming Medicine University from October 2010 to September 2011 using a TCM symptoms and signs checklist obtained from 16 TCM experts by the Delphi technique. LCA was applied to obtain the best fitted model for clustering of symptoms and signs that can be interpreted as underlying Zhengs of psoriasis.Results: The LCA identified three Zhengs: dampness-heat Zheng (35.1%); blood heat Zheng (34.7%); and yin deficiency and blood dryness Zheng (30.2%). The first Zheng was associated with winter, the second with male sex, old age, smoking, and drinking alcohol, and the third with outpatient status, which reflected a mild disease course.Conclusions: In this study, 507 psoriasis patients were clustered into three Zhengs, which had different associated factors. © 2014 Yang et al.; licensee BioMed Central Ltd.


Shang X.,Kunming Medical University | Liabsuetrakul T.,Prince of Songkla University | Sangsupawanich P.,Prince of Songkla University | Xia X.,Kunming Medical University | And 2 more authors.
Journal of Alternative and Complementary Medicine | Year: 2015

Objectives: To evaluate the satisfaction, concerns, and preference for Traditional Chinese Medicine (TCM) drugs among guardians of children with acute bronchiolitis, assess the agreement between satisfaction and preference, and explore the factors associated with satisfaction. Design: A cross-sectional study was conducted in three main tertiary hospitals in Kunming, China, from September 2012 to July 2013 by structured questionnaire interviews. The characteristics of children and their guardians and guardians' satisfaction with and preference for TCM drugs were collected and analyzed by using chi-square or Fisher exact test. The agreement of satisfaction and preference was assessed by κ and prevalence-adjusted κ coefficients. Multiple logistic regression was used to identify factors associated with satisfaction. Results: A total of 286 guardians were enrolled in the study. Most children (97.6%) were younger than age 2 years. In total, the rates of satisfaction and preference for TCM drugs were 75.5% and 73.1%, respectively, and preference and satisfaction levels did not significantly differ between TCM and non-TCM hospitals. Guardians with higher socioeconomic status were more satisfied with TCM drugs, and the most common reason for preference for TCM drugs was that they had less toxicity or fewer adverse effects. Guardians were concerned most about safety and least concerned about cost. The agreement between satisfaction and preference was moderate in general (prevalence-adjusted κ=0.42). Conclusions: Three fourths of the Chinese guardians of children with acute bronchiolitis were satisfied with and preferred the TCM drugs. Moderate agreement between satisfaction and preference was shown. © Mary Ann Liebert, Inc. 2015.


PubMed | Yunnan Provincial Hospital of Traditional Chinese Medicine, Yanan Hospital of Kunming City, Kunming Medical University and Prince of Songkla University
Type: Journal Article | Journal: Journal of alternative and complementary medicine (New York, N.Y.) | Year: 2015

To evaluate the satisfaction, concerns, and preference for Traditional Chinese Medicine (TCM) drugs among guardians of children with acute bronchiolitis, assess the agreement between satisfaction and preference, and explore the factors associated with satisfaction.A cross-sectional study was conducted in three main tertiary hospitals in Kunming, China, from September 2012 to July 2013 by structured questionnaire interviews. The characteristics of children and their guardians and guardians satisfaction with and preference for TCM drugs were collected and analyzed by using chi-square or Fisher exact test. The agreement of satisfaction and preference was assessed by and prevalence-adjusted coefficients. Multiple logistic regression was used to identify factors associated with satisfaction.A total of 286 guardians were enrolled in the study. Most children (97.6%) were younger than age 2 years. In total, the rates of satisfaction and preference for TCM drugs were 75.5% and 73.1%, respectively, and preference and satisfaction levels did not significantly differ between TCM and non-TCM hospitals. Guardians with higher socioeconomic status were more satisfied with TCM drugs, and the most common reason for preference for TCM drugs was that they had less toxicity or fewer adverse effects. Guardians were concerned most about safety and least concerned about cost. The agreement between satisfaction and preference was moderate in general (prevalence-adjusted =0.42).Three fourths of the Chinese guardians of children with acute bronchiolitis were satisfied with and preferred the TCM drugs. Moderate agreement between satisfaction and preference was shown.


Yang X.,Yunnan Provincial Hospital of Traditional Chinese Medicine | Chongsuvivatwong V.,Prince of Songkla University | McNeil E.,Prince of Songkla University | Ye J.,Yunnan Provincial Hospital of Traditional Chinese Medicine | And 3 more authors.
Chinese Medicine (United Kingdom) | Year: 2013

Background: Psoriasis is a chronic inflammatory skin disease with a genetic basis. Its ill-defined causes make it difficult to diagnose. This study aims to develop a diagnostic checklist for psoriasis classification in the context of traditional Chinese medicine.Methods: A Delphi study was conducted with three rounds by a panel of 16 dermatology experts to develop a checklist for traditional Chinese medicine symptoms and signs of psoriasis. Dermatology experts in psoriasis research, nine in Yunnan and seven in Beijing, were selected as the expert panel. The initial list of symptoms and signs in psoriasis was developed by reviewing the literature retrieved from Chinese and English journals. Experts rated each item of the list on a 5-point Likert scale. The list was revised and re-evaluated in the same manner for a total of 3 rounds before it was finalized.Results: One hundred and thirty items were extracted from the literature review. After three rounds of expert ratings, 96 items were retained with eight domains: color, type and shape of skin lesion, physical expression, tongue and coating, pulse, associated factors, and living environment. Intraclass correlation coefficient and Kappa statistics indicated an inter-rater agreement in the final checklist.Conclusion: A checklist containing 96 items in 8 domains was developed for psoriasis diagnosis using traditional Chinese medicine symptoms and signs. © 2013 Yang et al.; licensee BioMed Central Ltd.


PubMed | Yunnan Provincial Hospital of Traditional Chinese Medicine, Yanan Hospital of Kunming City, Kunming Medical University and Prince of Songkla University
Type: | Journal: The clinical respiratory journal | Year: 2015

Laggera pterodonta, a traditional Chinese medicine, has been commonly used in respiratory tract infections for more than hundreds of years without any randomized controlled trials to evaluate its efficacy and safety.To evaluate the efficacy and safety of Laggera pterodonta in hospitalized children aged 3-24 months with acute bronchiolitis.A double-blind, randomized-controlled trial was conducted in three tertiary hospitals of Kunming, China. A total of 133 acute bronchiolitis children with an initial episode of wheezing were randomly assigned to a control mixture or Laggera pterodonta mixture. All recruited patients were given three doses of the mixture every 24 h for 5 days. Clinical symptoms and responses including adverse events in both groups were assessed and laboratory tests were done at enrolment and then after 120 h. Analysis was performed based on an intention-to-treat principle.Significantly more hospitalized children fulfilled the discharge criteria at 96 h and 120 h in the Laggera pterodonta mixture group compared to the control group (97% vs 75.8% P<0.001 and 98.5% vs 89.4% P=0.03), respectively. Better responses on clinical severity score, respiratory rate, oxygen saturation, wheezing and heart rate were also detected in the Laggera pterodonta mixture group along with lower white blood cell count, platelet count and aspartate aminotransferase. Vomiting and diarrhea were more common in the control group.Laggera pterodonta mixture is effective and safe to be prescribed in hospitalized children with acute bronchiolitis.

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