Jiang L.,Yuhuangding Hospital and 20 Yuhuangding East Road |
Sui W.,Yuhuangding Hospital and 20 Yuhuangding East Road |
Chu J.,Yuhuangding Hospital and 20 Yuhuangding East Road |
Zhao W.,Yuhuangding Hospital and 20 Yuhuangding |
Wang P.,Yuhuangding Hospital and 20 Yuhuangding East Road
International Journal of Clinical and Experimental Medicine | Year: 2016
Recent advances in systems biology have revealed that variety in the frame structure and activity of gene network play an important role in burn injury progression. One biological data set E-GEOD-19743 was derived to construct differential co-expression networks (DCNs). There were 35 normal pediatric controls and 26 pediatric burn injury samples, 28 adult controls and 26 adult burn injury patients in total with different post-burn periods. The inference of multiple differential modules (iMDM) algorithm was applied to identify both unique and shared gene modules across multiple DCNs, termed M-DMs (multiple differential modules). One M-module in child group and one M-module in adult group were detected with significant dynamic scores. Dramatic differences are observed in genes and modules between post burn children and adults. As the burn injury progresses, multiple interactions in these modules are significantly changed, with P<0.01 between the two stages. Module analysis can lead to further insights and investigations of therapeutic options targeting specific age groups and disease stages. © 2016, E-Century Publishing Corporation. All rights reserved.