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Sun P.,Yueyang Vocational Technical College
Advanced Materials Research | Year: 2013

Toget complicated curved surface parts in wire cut electronic discharge machining, a rotary CNC processingtable was designed.Through establishing the mathematical equations of the general motion form, the several major processed forms are obtained. Then the processing system and its experimental device were established. Through machining experiment and error analysis, it shows that the system has high machining quality and low cost and has practical applicability, to produce a novel research direction for solving the difficult problems of machining spatial curved surface parts. © (2013) Trans Tech Publications, Switzerland.


Huang Q.H.,Yueyang Vocational Technical College
Applied Mechanics and Materials | Year: 2014

Corner machining accuracy has always been one of the important properties of WEDM. In this paper, the reasons for the corner error of the WEDM were discussed. Then the mathematical deflection model of the electrode wire was established. By experimental measurements, the kerf width and the deflection of the electrode wire were obtained. Then the corner control strategy of the WEDM was proposed. Through experiment of the Comparison of corner error between control strategy with corner control and the one without corner control, it shows that the processing accuracy was improved effectively. © (2014) Trans Tech Publications, Switzerland.


Zhang X.,Yueyang Vocational Technical College
Tezhong Zhuzao Ji Youse Hejin/Special Casting and Nonferrous Alloys | Year: 2012

Through analyzing the cooling characteristics of the silica shell, based on hydrodynamic equations, it is derived that the liquid steel during filling process and the heat exchange time between ingate wall is proportional to the liquid steel in ingate, which affects the over-heat of flow channel near the ingate, resulting in occurrence of shrinkage porosity. The mass flow density is adopted to check area and number of ingate. It is acceptable for mass flow density less than 0.4 × 10 4 kg/m 2. Application of the mass flow density in the heat riser, ladder, bottom-pouring, multi-ingate, and composite gating system as well as balance pouring, hot flow channel was presented to effectively eliminate the shrinkage porosity in ingate and flow channel. Due to having considered parts weight in application of mass flow density in ingate, the parts on the assemble tree are not fall out as a result of large weight of parts with small hot spot size and small total ingate area.


Zhou S.,Yueyang Vocational Technical College
Combinatorial Chemistry and High Throughput Screening | Year: 2014

Farnesyltransferase (FTase) and geranylgeranyltransferase type-I (GGTase-I) are two members of protein prenyltransferases, which play critical roles in lipid post-translational modifications. Potent inhibitors of FTase and GGTase-I have been confirmed to show favorable influence on the therapies of various diseases, such as cancers, malaria and Toxoplasmosis. However, designing highly specific inhibitors toward FTase or GGTase-I without influencing their binding affinity remains a big challenge. In this work, molecular docking, molecular dynamics (MD) simulations and MM/GBSA free energy calculations were employed to study the bindings of two highly selective inhibitors (lonafarnib and GGTI-2133) towards FTase or GGTase-I. The specificities of the studied inhibitors derived from the predicted binding free energies are consistent with the experimental data. The analysis of the energetic components illustrates that both the non-polar and polar interactions play critical roles in determining the specificity between FTase and GGTase-I. Moreover, the protein-inhibitor interaction spectra for the studied inhibitors were determined through the decomposition of the binding free energies, and the important residues for binding and specificity were highlighted. Our study provides useful information for the rational design of selective FTase or GGTase-I inhibitors. © 2014 Bentham Science Publishers.


Huang Q.H.,Yueyang Vocational Technical College
Advanced Materials Research | Year: 2014

Tool nose radius compensation function is widely used in the numerical control turning, it is the key and difficult point for the numerical control turning. Correct and flexible use of tool nose radius compensation function is very important for the machining precision control of conical surface, circular surface and curved surface and improving the service life of the cutting tool. © (2014) Trans Tech Publications, Switzerland.

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