Youjiang Medical University for Nationalities

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Baise City, China
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Cheng J.,Hefei University of Technology | Cheng J.,Youjiang Medical University for Nationalities | Tang L.,Tsinghua University | Xu J.,Tongji University
Advanced Synthesis and Catalysis | Year: 2010

In this paper, an economical, green pathway involving the palladium nanoparticles (Pd NPs) catalyzed reductive Ullmann reaction of an aryl chloride to afford a biaryl with high conversion and selectivity in an ionic liquid (IL)/supercritical carbon dioxide (ScCO2) system was developed. The combination of IL and ScCO2 provides superior advantages in product separation, catalyst recycling and reuse of reaction media over traditional organic solvents. Further investigations showed that the Brønsted-acidic imidazolium IL {e.g., (1-butyl-3-(sulfobutyl)-imidazolium) hydrogen sulfate, [bmim(HSO3C4)][HSO4]}, can replace the traditional active hydrogen donor readily with much enhanced product separation efficiency, the use of IL also led to an obvious improved stability of the Pd NPs, which was very helpful for catalyst recycling. Carbon dioxide, a naturally abundant, non-flammable, relatively non-toxic, economical and recyclable "greenhouse" gas, was found to significantly promote the selectivity of the Pd NPs-catalyzed aluminium-induced reductive Ullmann reaction of aryl chlorides. Investigations showed that the Pd NPs catalyst and IL can be recycled for at least five runs, indicating the economic viability of this process. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Cheng J.,Yancheng Teachers University | Cheng J.,Youjiang Medical University for Nationalities | Zhang G.,Yancheng Teachers University | Du J.,Youjiang Medical University for Nationalities | And 3 more authors.
Journal of Materials Chemistry | Year: 2011

An economical and green pathway: graphene oxide (GO)-supported palladium nanoparticles (Pd NPs) catalyzed a reductive Ullmann reaction of aryl chloride towards biaryl with high conversion and selectivity in ionic liquid (IL)-supercritical carbon dioxide (ScCO2). The combination of IL and ScCO2 provides superior advantages in product separation, catalyst recycling and reuse of the reaction media over traditional organic solvents. Further investigations showed that GO, the novel catalyst support bearing abundant carboxylic, hydroxyl, epoxy and aldehyde groups, can replace the traditional active hydrogen donor readily with much enhanced product separation efficiency. The use of IL, e.g. [hmim][Tf2N], led to obvious improved stability of the Pd NPs, which was helpful for catalyst recycling. Carbon dioxide, a naturally abundant, nonflammable, relatively nontoxic, economical and recyclable "greenhouse" gas, was found to significantly promote the selectivity of the graphene oxide-based Pd NP-catalyzed reductive Ullmann reaction of aryl chloride. Investigations showed that the Pd NP catalyst and IL can be recycled for more than 5 runs without obvious loss of conversion, indicating the economical viability of this process. © 2011 The Royal Society of Chemistry.


Li R.,Guilin Medical University | Xu L.,Youjiang Medical University for Nationalities | Liang T.,Guangxi Medical University | Li Y.,Guilin Medical University | And 2 more authors.
Food and Chemical Toxicology | Year: 2013

This study was designed to evaluate the potential effects of puerarin (PR), an effective isoflavonoid compound purified from Pueraria lobata, in treating hepatic fibrosis (HF) rats induced by carbon tetrachloride (CCl4, 2mLkg-1d-1). Compared to model control, PR treatment effectively lowered the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), total protein (TP) in HF rats. Masson stained analysis showed that the condition of HF rats was mitigated. Meanwhile, the tumor necrosis factor alpha (TNF-α), nuclear factor-kappa B (NF-κB) expressions were significantly down-regulated at protein level by PR intervention. Additionally, the activity of superoxide dismutase (SOD) was elevated, while the content of malondialdehyde (MDA) was lessened in liver tissue. As revealed by immunohistochemistry assay, PR therapy resulted in reduced production of transforming growth factor-βl (TGF-βl). Moreover, it also was attributed to decreased mRNA level of inducible nitric oxide synthase (iNOS) using RT-PCR analysis. These findings demonstrate that puerarin successfully reverses hepatotoxicity in CCl4-induced HF rats via the underlying mechanisms of regulating serum enzymes and attenuating TNF-α/NF-κB pathway for anti-inflammation response, as well as improving metabolic function in liver tissue. © 2012 Elsevier Ltd.


Guo C.,Guangxi Medical University | Xu L.,Youjiang Medical University for Nationalities | He Q.,Guangxi Medical University | Liang T.,Guangxi Medical University | And 2 more authors.
Food and Chemical Toxicology | Year: 2013

Hepatic fibrosis (HF) is a chronic disease, which primarily leads to liver unregulated metabolism. In this study, we aimed to investigate the therapeutic effects of puerarin (PR), an active ingredient from kudzu root, on CCl4-induced HF rats. PR effectively ameliorated the liver metabolic function, resulting in reduced serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total-bilirubin (T-bilirubin), extracellular matrix (ECM) contents and increased levels of albumin, total-protein (T-protein) in HF rats. Similarly, pathological examination showed that the CCl4-lesioned liver was mitigated by PR treatments. Meanwhile, we also detected significantly reduced levels of hydroxyproline (Hyp), type III precollagen (PCIII) and collagen I (Col I) in the liver tissue of HF rats, whereas the peroxisome proliferator-activated receptor-gamma (PPAR-γ) expression was effectively increased. Moreover, the expression of tissue inhibitor of metal protease-1 (TIMP-1) was decreased, while the expression of matrix metalloproteinase-2 (MMP-2) was increased. In addition, the expression of p-PI3K and p-Akt was significantly down-regulated by PR treatments. Taken together, PR could attenuate the CCl4-induced toxicity in the hepatocytes of HF rats. It played a protective role in the liver tissue probably through regulating the PPAR-γ expression and blocking the PI3K/Akt pathway to inhibit the excessive deposition of collagen. © 2013.


Li R.,Guilin Medical University | Liang T.,Guangxi Medical University | Xu L.,Youjiang Medical University for Nationalities | Zheng N.,Guangxi Medical University | And 2 more authors.
Brain Research | Year: 2013

An increasing number of studies suggest that oxidative stress is associated with the Parkinsonian process. This study evaluated the potential neuroprotective role of puerarin (PR) on lesioned substantia nigra (SN) induced by 6-hydroxydopamine (6-OHDA). Data from a rotational test showed that PR treatment significantly decreased apomorphine-induced rotations. Both the dopamine (DA) content in the SN and the endogenous expression of brain-derived neurotrophic factor (BDNF) were also elevated by the treatment. Pathological examination showed that dopaminergic neuronal degeneration in the SN was attenuated by PR treatment. Meanwhile, the contents of γ-glutamylcysteine synthetase (γ-GCS), glutathione (GSH) and catalase (CAT) in SN tissue were gradually elevated. Additionally, cytochrome c oxidase (COX) mRNA expression in the SN was markedly up-regulated. At the same time, nuclear factor E2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keapl) levels were progressively increased by the PR treatment. Our findings indicated that puerarin effectively protects against 6-OHDA-mediated oxidative stress injury in SN neurons, in which the underlying mechanisms are involved in modulating BDNF expression and activating the Nrf2/ARE signaling pathway. © 2013 Elsevier B.V.


Guo C.,Guangxi Medical University | Li R.,Guilin Medical University | Zheng N.,Guangxi Medical University | Xu L.,Youjiang Medical University for Nationalities | And 2 more authors.
International Immunopharmacology | Year: 2013

Diabetes mellitus is a clinically complex disease characterized by the dysfunctions of pancreas. In this study, we investigated the therapeutic effects of ramulus mori polysaccharides (RMP) on diabetic mice induced by streptozotocin. Our results showed that body weight and insulin level were notably increased after metformin and RMP treatments, while the blood glucose was lowered. HE-staining assay showed that the treatments mitigated the pathological lesions in pancreas tissue. In addition, the expression levels of tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-6 (IL-6) and cyclo-oxygenase-2 (COX-2) were effectively reduced in pancreas tissue by the treatments, respectively. We also found that upon these treatments, the activities of manganese superoxide dismutase (MnSOD) and glutathione reductase (GSH-Rd) were increased; the content of malonaldehyde (MDA) was decreased in pancreas tissue; and the mRNA expression of heme oxygenase-1 (HO-1) was markedly increased in pancreas tissue. Taken together, these results suggest that RMP plays the blood glucose-lowering and metabolism-normalizing roles, and it may improve the function of pancreas through inhibiting the inflammatory response and attenuating the oxidative stress in pancreas tissue. © 2013 Elsevier B.V. All rights reserved.


Xu L.,Youjiang Medical University for Nationalities | Yang F.,Youjiang Medical University for Nationalities | Wang J.,Youjiang Medical University for Nationalities | Huang H.,Youjiang Medical University for Nationalities | Huang Y.,Youjiang Medical University for Nationalities
Carbohydrate polymers | Year: 2015

Diabetes mellitus is a complicated metabolic disease, whose pathogenesis is related to apoptosis within pancreatic tissue. In this study, the potential therapeutic benefits of Ramulus mori polysaccharides (RMP) on streptozotocin (STZ)-induced diabetic mice were evaluated. Our experiments indicated that RMP lowered hyperglycemia and increased insulin levels in diabetic mice. Histopathological examination revealed that RMP contributed to the reduction of STZ-lesioned pancreatic cells. In addition, the serum level of HbA1c was decreased. RMP treatment also showed increased Bcl-2 expression and reduced Bax protein level in pancreatic tissue. Furthermore, intrapancreatic expressions of p-JNK, p-p38 and cleaved-caspase-3 were down-regulated by RMP treatment. Collectively, the findings demonstrate that RMP exerts the pronounced hypoglycemic effect via regulation of the intrapancreatic JNK/p38 pathway to protect against STZ-induced apoptosis in pancreatic tissue, eventually ameliorating metabolic function in the pancreas. Copyright © 2014 Elsevier Ltd. All rights reserved.


Li P.,Youjiang Medical University for Nationalities
Lecture Notes in Electrical Engineering | Year: 2013

Objective: The present study aimed to evaluate the effectiveness of Multimedia Approach in improving the English language procificency of college students in Youjiang Medical University for Nationalities in China. Methods: A descriptive method that involved comparative analyses of the scores obtained by students who was exposed to the Multimedia Approach and the traditional College English teaching method was used in the study. Results: The English language proficiency of the students was high after Multimedia approach was used in College English classes. Conclusions: The experimental teaching showed that the adoption and application of Multimedia approach in College English classes are very effective in enhancing the language proficiency of the students. © 2013 Springer Science+Business Media.


Huang Z.-Q.,Youjiang Medical University for Nationalities | Wang J.-L.,Youjiang Medical University for Nationalities | Pan G.-G.,Youjiang Medical University for Nationalities | Wei Y.-S.,Youjiang Medical University for Nationalities
Clinical Biochemistry | Year: 2012

Objectives: Interleukin-12 (IL-12) plays an important role in antitumor immunity. Interleukin-27 (IL-27) is a novel IL-12 family member. The present studies demonstrate that IL-27 mediates potent antitumor activity. However, No studies have examined the association of these polymorphism with colorectal cancer (CRC). Therefore, we investigated the relationship of IL-12 and IL-27 gene polymorphisms and CRC. Design and methods: We analyzed polymorphisms of IL-12 gene 16974 A/C and IL-27 gene - 964 A/G, 2905 T/G, 4730 T/C in 410 patients with CRC and 450 controls, using PCR-RFLP method. Results: There were no significant differences in the genotype and allele frequencies of IL-12 and IL-27 gene polymorphisms between the group of patients with CRC and the controls. Furthermore, no association was found between IL-12 family gene polymorphisms and different clinical stages in patients with CRC. Conclusion: These findings suggest that IL-12 and IL-27 gene polymorphisms may not be involved in susceptibility to CRC. © 2011.


Lan Y.,Youjiang Medical University for Nationalities | Luo B.,Youjiang Medical University for Nationalities | Wang J.-L.,Youjiang Medical University for Nationalities | Jiang Y.-W.,Youjiang Medical University for Nationalities | Wei Y.-S.,Youjiang Medical University for Nationalities
Gene | Year: 2014

Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B cell activation, plasma cell differentiation, and immunoglobulin production. Previous studies have identified that IL-21 was associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis and SLE. Variations in the DNA sequence in the IL-21 gene may lead to altered IL-21 production and/or activity, and thus this can modulate an individual's susceptibility to SLE. To test this hypothesis, we investigated the association of the IL-21 polymorphisms and its serum levels with the risk of SLE in a Chinese population. We analyzed three single nucleotide polymorphisms of IL-21 gene rs907715 C/T, rs2221903 T/C and rs2055979 C/A in 175 patients with SLE and 190 age- and sex-matched controls, using Snapshot SNP genotyping assays and DNA sequencing method. Soluble IL-21 (sIL-21) levels were measured by ELISA. There were significant differences in the genotype and allele frequencies of IL-21 gene rs2055979 C/A polymorphism between the group of patients with SLE and the control group (P<. 0.05). sIL-21 levels were increased in patients with SLE compared with controls (P<. 0.01). Moreover, genotypes carrying the IL-21 rs2055979 A variant allele were associated with increased IL-21 levels compared to the homozygous wild-type genotype in patients with SLE. The rs2055979 C/A polymorphism of IL-21 and its sIL-21 levels were associated with SLE in the Chinese population. Our data suggests that IL-21 gene may play a role in the development of SLE. © 2014.

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