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Seo D.-H.,Yonsei University | Kim H.-S.,Yonsei University | Ko C.-Y.,Fraunhofer Institute for Non-Destructive Testing | Ko C.-Y.,Yonsei Fraunhofer Medical Device Laboratory | And 4 more authors.
Animal Cells and Systems | Year: 2012

We have examined the effect of circadian disturbances induced by night shifts (NSs) on the phenotypes of the tibiae and abdominal adipose tissues (ADTs) in a mouse model by using in vivo micro-computed tomography (micro-CT). We found that the volumes of total and visceral ADTs in the night-shifted group of mice were significantly larger (69 and 92%, respectively) than those in the control. The mean polar moment of inertia, cross-sectional thickness, and bone mineral density of the cortical bone in the night-shifted group of mice were less (13, 5, and 3%, respectively) than those in the control. Moreover, the volume and the thickness of growth plates (GPs) of the tibiae in the night-shifted mice were significantly smaller (22 and 20%, respectively) than those in the control. Taken together, our results indicate that disturbances in the mouse circadian rhythms induced by NSs affect the morphological characteristics of cortical bone, the volume and the thickness of GPs, and the volume of ADTs. © 2012 Copyright Korean Society for Integrative Biology. Source


Cho Y.K.,Yonsei University | Cho Y.K.,Yonsei Fraunhofer Medical Device Laboratory | Myeong S.-S.,Ahtti | Cho S.,Yonsei Fraunhofer Medical Device Laboratory | And 2 more authors.
Biomedical Engineering Letters | Year: 2015

Purpose: The excessive accumulation of work burden is one of the main factors underlying musculoskeletal disorders in the farming population. The present study was carried out to determine the joint torques and muscle contractions of the lower body in relation to slumped postures with or without a stool during push-and-pull weeding motions. Methods: Using data from a 3D motion analysis system, a 3D virtual human body model was created consisting of 19 segments and 59 muscles. Among these, the lower body joints (ankle, knee, hip, and lumbar) and muscles (tibialis anterior, gastrocnemius, biceps femoris, and erector spinae) were analyzed for four cases of slumped postures: without a stool and with stools of various heights (10, 15, and 20 cm). Results: The flexion of the lumbar joint was presented during push-and-pull weeding motions without a stool. However, the extension of the lumbar joint was presented during pushand-pull weeding motions with a stool. The ranges of the joint torques did not change in a meaningful way between the results for the cases without a stool and with a stool. In addition, the results according to the stool height did not present meaningful outcomes associated with the angle change in the joints. Conclusions: Irrespective of the height, a stool may provide support for slumped postures involving the lumbar joint and erector spinae. © 2015, Korean Society of Medical and Biological Engineering and Springer. Source


Cho S.,Yonsei University | Cho S.,Yonsei Fraunhofer Medical Device Laboratory | Eom S.,Yonsei University | Seo D.-H.,Yonsei University | And 6 more authors.
Biomedical Engineering Letters | Year: 2015

Objectives: This study is to investigate the synchronous phenomena between bone quality and longitudinal length in a same subject affected by landing exercise. Physical exercise on the ground induces external loading to human body due to resistance from ground which can activate bone generation or remodeling. Especially, when the impact stimulation is applied to bone, it may improve bone quality and lengthening. Methods: 6-week-old male Wistar rats were randomly allocated to one of two conditions: free fall from 40 cm-height (I40; n = 7), and control (IC; n = 7). The impact stimulations were administered to the free fall groups, 10 times/day, and 5 days/week for 8 weeks. Structural parameters and longitudinal length of tibia were measured to quantitatively evaluate the variation in morphological characteristics and bone length with maturing. Results: The landing impact seems to be commonly effective on the enhancement of bone quality as well as longitudinal growth. However, the extent of enhancement may be more dominant in bone quality than longitudinal growth. On the other hand, the ratio of longitudinal growth seems to be dependent on the duration of stimuli whereas the enhancement of bone quality does not. Conclusions: This study verified that free-falls exercise can be effective on the enhancement of bone qualities and promotion of vertical growth in long bones. We expect that it might be possible for the moderate impact stimulation to be proposed as an aid for prevention of bone loss and promotion of bone lengthening. © 2015, Korean Society of Medical and Biological Engineering and Springer. Source

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