Yokohama-shi, Japan
Yokohama-shi, Japan

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Taniguchi L.,Chigasaki Municipal Hospital | Higurashi T.,Yokohama City University | Uchiyama T.,Chigasaki Municipal Hospital | Kondo Y.,Chigasaki Municipal Hospital | And 11 more authors.
BMC Gastroenterology | Year: 2015

Background: Metabolic factors have been reported to increase the prevalence of colorectal adenomas, however, whether metabolic factors might also accelerate the recurrence after removal of adenomas has not yet been discussed. In this retrospective multicenter study, we clarified the risk factors for adenoma recurrence focusing on metabolic factors. Methods: We analyzed the medical records of 43,195 patients who had undergone colonoscopy between January 2005 and December 2011 at 5 hospitals in Japan. Of these, the data of 1111 patients who had undergone removal of adenomas at the first screening colonoscopy, and then been followed up by colonoscopy 1 year and 2 years later were analyzed. Results: The following 8 factors were demonstrated with a multivariate analysis as being associated with colorectal adenomas recurrence: for adenoma-related factors, 5 factors (villous features, grade of dysplasia, location and size of the largest removed adenoma, and number of the removed adenomas) were identified; for metabolic factors and other factors, 3 factors (age, body mass index (BMI), and fasting blood glucose (FBG)) were identified. A risk score (0-10 points) was developed based on these 8 factors. The risk of adenoma recurrence increased as the risk score increased. When the risk score was ≥3 (3-10) points, the odds ratio relative to <3 (0-2) points was 7.07 (95% CIs 5.30-9.43). Conclusions: In addition to adenoma-related factors (villous features, grade of dysplasia, location, size and number), 3 factors (age, BMI and FBG) were demonstrated to influence the recurrence rate of colorectal adenoma. When the risk score was ≥3, the risk of recurrence was significantly elevated. © 2014 Taniguchi et al.; licensee BioMed Central Ltd.


Fujibuchi T.,Kyushu University | Yonai S.,Japan National Institute of Radiological Sciences | Yoshida M.,Nuclear Safety Technology Center | Sakae T.,University of Tsukuba | And 3 more authors.
Health Physics | Year: 2014

Photonuclear reactions generate neutrons in the head of the linear accelerator. Therefore, some parts of the linear accelerator can become activated. Such activated materials must be handled as radioactive waste. The authors attempted to investigate the distribution of induced radioactivity using photostimulable phosphor imaging plates. Autoradiographs were produced from some parts of the linear accelerator (the target, upper jaw, multileaf collimator and shielding). The levels of induced radioactivity were confirmed to be non-uniform within each part from the autoradiographs. The method was a simple and highly sensitive approach to evaluating the relative degree of activation of the linear accelerators, so that appropriate materials management procedures can be carried out. © 2014 Health Physics Society.


Fujibuchi T.,Ibaraki Prefectural University of Health Sciences | Fujibuchi T.,University of Tsukuba | Obara S.,Ibaraki Prefectural University of Health Sciences | Yamaguchi I.,Japan National Institute of Public Health | And 4 more authors.
Radiation Protection Dosimetry | Year: 2012

The radioactivation of linear accelerator components for radiation therapy is interest for radiation protection in general, and particularly, when decommissioning these structures. The energy spectra of gamma rays emitted from the heads of two accelerator models, EXL-15SP and Clinac iX, after 10-MeV X-ray irradiation, were measured using a high-purity germanium semiconductor survey meter. After spectrum analyses, activities of 24Na, 28Al, 54Mn, 56Mn, 57Ni, 58Co, 60Co, 64Cu, 65Zn, 122Sb, 124Sb, 181W, 187W, 196Au, and 198Au were detected. One centimetre deep dose-equivalent rate of the heads of the linear accelerator was measured using the survey meter. The dose rate decreased to ~10 % of its initial rate after 1 week. Long-term activations were few, the radioactivity level was low, and a cooling time of several days was effective for reducing dose rate to an acceptable level for decommissioning. © The Author 2011. Published by Oxford University Press. All rights reserved.


Fujibuchi T.,Ibaraki Prefectural University of Health Sciences | Horitsugi G.,MI Clinic | Yamguchi I.,Japan National Institute of Public Health | Eto A.,MI Clinic | And 6 more authors.
Radiological Physics and Technology | Year: 2012

Some medical compact cyclotrons have selfshielding to reduce neutron fluxes. Thermal neutron fluxes in an 18-MeV unshielded cyclotron room and in a 16.5- MeV self-shielded cyclotron room were evaluated. In addition, the radioactivities in concrete and metals due to thermal neutrons in the cyclotron rooms for 30 years were calculated of operation such that the sum of the ratio of the nuclide concentration to the nuclide clearance level was equal to 1. The thermal neutron flux from the unshielded cyclotron was approximately 10 2 cm-2 s-1, whereas that from the self-shielded cyclotron was approximately 102 cm-2 s-1. The thermal neutron fluxes for concrete, stainless steel, vessel steel, and aluminum that reached their clearance levels were 9.80 × 104, 2.17 × 103, 1.87 × 104, and 2.41 × 10 5 cm-2 s-1, respectively. The specific activities in the cyclotron room were found to be sufficiently below the clearance level when the self-shield was employed. © Japanese Society of Radiological Technology and Japan Society of Medical Physics 2012.


PubMed | Red Cross, Oami Municipal Hospital, Funabashi Central Hospital, Yokohama Rousai Hospital and 6 more.
Type: | Journal: Clinica chimica acta; international journal of clinical chemistry | Year: 2016

LR11 (also called SorLA or SORL1) is a type I membrane protein, originally identified as a biomarker for atherosclerosis and Alzheimers disease. We recently found that LR11 was specifically expressed in Diffuse Large B-cell lymphoma (DLBCL) cells, and high serum sLR11 concentrations in retrospective cohort indicated inferior survival. In this study, we prospectively validated the clinical impact of serum sLR11 in 97 patients with newly-diagnosed, untreated DLBCL.Serum sLR11 concentrations were increased in DLBCL patients compared to normal controls (meanSD: 21.227.6 vs. 8.81.8ng/ml, P<0.0001), and significantly reduced at remission (meanSD: 17.416.4 vs. 10.94.5ng/ml, P=0.02). Increased serum sLR11 concentrations were affected by tumor burden and bone marrow invasion. The 2-y OS and PFS were significantly lower in patients with high sLR11 concentrations (18.1ng/ml vs. >18.1ng/ml; 2-y OS: 89.0% vs. 56.4%, P<0.0001; 2-y PFS: 85.8% vs. 56.9%, P<0.0001).Serum sLR11 is a tumor-derived biomarker for predicting the survival of newly diagnosed patients with DLBCL.


Hirata G.,Yokohama Rousai Hospital
Clinical calcium | Year: 2011

Measurement of the bone mineral density have shown that lactating women had 1 to 3% decrease in bone mineral density. Post pregnancy osteoporosis is rare condition that causes fragile fracture mostly in vertebrae. The bone loss in lactating women is caused by calcium loss, decrease in estrogen level, and increase in PTHrP (parathyroid hormone related protein) level. Some data have shown that extended lactation and amenorrhea had an association with the degree of bone loss. Mostly, the bone loss of the lactating women recovers to the baseline level, soon after the weaning, and there is no long term effect. Post pregnancy osteoporosis should be concerned, when we see a lactating woman with fragile fracture of the vertebrae.


Toyama Y.,Yokohama Rousai Hospital
Japanese Journal of Clinical Radiology | Year: 2015

We report four cases of pathologically diagnosed hypophysitis. We could diagnosed correctly in only one case of four hypophysitis with preoparative MRI, which followed a typical course of lymphocytic hypophysitis (in young woman during pregnancy). In two cases of four, enhancing enlarged pituitary gland with thickened stalk were demonstrated in MRI, so hypophysitis must have been counted among differential diagnosis. In the other case, preoperative imaging showed an intra- and suprasellar cystic mass, it might be hard to diagnose as hypopyhsitis.


Yamamoto S.,Yokohama Rousai Hospital | Chishima T.,Yokohama Rousai Hospital | Adachi S.,Yokohama Rousai Hospital | Harada F.,Yokohama Rousai Hospital | And 4 more authors.
Cancer Biomarkers | Year: 2014

BACKGROUND: The significance of the measurement of anti-p53 antibodies in serum remains undisclosed. The aim of this study was to assess anti-p53 antibodies in the serum of patients with breast cancer, and correlate these results with various clinicopathologic parameters. METHODS: We analyzed serum anti-p53 antibody levels in 124 patients with breast cancers and 7 patients with benign disease between April 2012 and March 2013, as well as levels of serum carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3. RESULTS: Twenty-two of 124 patients with breast cancer had an increased concentration of anti-p53 antibodies. By distribution of clinical stage, in stage 0-II the positive ratio of anti-p53 antibodies was significantly higher than that of CEA (p=0.03) and CA15-3 (p=0.01). There was a significant correlation between anti-p53 antibodies and family history (p=0.03). Triple-negative cancer also showed a significant correlation with anti-p53 antibodies (p=0.007). In patients with multiple and/or bilateral breast cancer, the level of anti-p53 was significantly higher than in unilateral breast cancer (62.5% vs 14.7%, p=0.004). CONCLUSION: Measurement of anti-p53 antibodies is useful for the prevention of oversight in the evaluation of multiple and/or bilateral breast cancer. © 2014 - IOS Press and the authors. All rights reserved.


PubMed | Yokohama Rousai Hospital
Type: Journal Article | Journal: Cancer biomarkers : section A of Disease markers | Year: 2014

The significance of the measurement of anti-p53 antibodies in serum remains undisclosed. The aim of this study was to assess anti-p53 antibodies in the serum of patients with breast cancer, and correlate these results with various clinicopathologic parameters.We analyzed serum anti-p53 antibody levels in 124 patients with breast cancers and 7 patients with benign disease between April 2012 and March 2013, as well as levels of serum carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3.Twenty-two of 124 patients with breast cancer had an increased concentration of anti-p53 antibodies. By distribution of clinical stage, in stage 0-II the positive ratio of anti-p53 antibodies was significantly higher than that of CEA (p=0.03) and CA15-3 (p=0.01). There was a significant correlation between anti-p53 antibodies and family history (p=0.03). Triple-negative cancer also showed a significant correlation with anti-p53 antibodies (p=0.007). In patients with multiple and/or bilateral breast cancer, the level of anti-p53 was significantly higher than in unilateral breast cancer (62.5% vs 14.7%, p=0.004).Measurement of anti-p53 antibodies is useful for the prevention of oversight in the evaluation of multiple and/or bilateral breast cancer.


PubMed | Yokohama Rousai Hospital
Type: Journal Article | Journal: Clinical calcium | Year: 2011

Measurement of the bone mineral density have shown that lactating women had 1 to 3% decrease in bone mineral density. Post pregnancy osteoporosis is rare condition that causes fragile fracture mostly in vertebrae. The bone loss in lactating women is caused by calcium loss, decrease in estrogen level, and increase in PTHrP (parathyroid hormone related protein) level. Some data have shown that extended lactation and amenorrhea had an association with the degree of bone loss. Mostly, the bone loss of the lactating women recovers to the baseline level, soon after the weaning, and there is no long term effect. Post pregnancy osteoporosis should be concerned, when we see a lactating woman with fragile fracture of the vertebrae.

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