Entity

Time filter

Source Type

Higashimurayama-shi, Japan

Noma H.,Tokyo Womens Medical University | Noma H.,Hiroshima University | Funatsu H.,Tokyo Womens Medical University | Mimura T.,University of Tokyo | And 3 more authors.
Acta Ophthalmologica | Year: 2010

Purpose: This study aimed to investigate whether vascular endothelial growth factor (VEGF) or interleukin-6 (IL-6) influence macular oedema in patients with central retinal vein occlusion (CRVO). Methods: Sixteen consecutive patients with unilateral CRVO and macular oedema were studied, along with eight age- and sex-matched patients without ischaemic ocular disease. Retinal ischaemia was evaluated from capillary non-perfusion on fluorescein angiography. Macular oedema was examined by optical coherence tomography. Aqueous humour (AH) samples were obtained during combined pars plana vitrectomy and cataract surgery, and were examined by enzyme-linked immunosorbent assay. Results: Aqueous levels of VEGF and IL-6 were significantly elevated in patients compared with controls (p = 0.0142 and p < 0.0001, respectively). Aqueous levels of both molecules were significantly higher in patients with ischaemia than in those without ischaemia (p = 0.0026 and p = 0.0487, respectively). Furthermore, AH levels of VEGF and IL-6 were correlated with the severity of macular oedema (→ = 0.7265, p = 0.0049, → = 0.5324, and p = 0.0392, respectively). Conclusions: Both VEGF and IL-6 were elevated in the AH of patients with macular oedema and ischaemic CRVO, suggesting that these molecules may be related to the increase in vascular permeability in such patients. © 2009 Acta Ophthalmol. Source


Noma H.,Tokyo Womens Medical University | Noma H.,Hiroshima University | Funatsu H.,Tokyo Womens Medical University | Mimura T.,University of Tokyo | And 2 more authors.
European Journal of Ophthalmology | Year: 2010

PURPOSE. Aqueous levels of vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) are associated with the severity of macular edema in patients with central retinal vein occlusion (CRVO). We investigated whether aqueous and vitreous levels of these molecules were correlated in CRVO patients. METHODS. Aqueous and vitreous samples were obtained during cataract surgery and vitreous surgery from 17 patients (17 eyes) with CRVO and macular edema. The levels of VEGF and IL-6 in aqueous humor, vitreous fluid, and plasma were determined by enzyme-linked immunosorbent assay. RESULTS. The aqueous levels of VEGF and IL-6 were significantly correlated with the vitreous levels of these molecules (ρ=0.8799, p=0.0004 and ρ=0.8088, p=0.0012, respectively). Vitreous levels of VEGF and IL-6 were significantly higher in CRVO patients with retinal ischemia than in those without ischemia (p=0.0013 and p=0.0009, respectively), as were the aqueous levels of VEGF and IL-6 (p=0.0026, p=0.0120, respectively). Furthermore, both the aqueous and vitreous levels of VEGF and IL-6 were significantly correlated with the severity of macular edema (ρ=0.7181, p=0.0041; ρ=0.8260, p=0.0010; ρ=0.5564, p=0.0260; and ρ=0.6599, p=0.0039, respectively). CONCLUSIONS. Our results suggest that aqueous levels of VEGF and IL-6 may reflect the vitreous levels of these molecules. Measurement of VEGF and IL-6 in the aqueous humor may be clinically useful to assess the severity of macular edema in patients with CRVO. © 2010 Wichtig Editore. Source


Noma H.,Chiba University | Funatsu H.,Chiba University | Mimura T.,University of Tokyo | Harino S.,Yodogawa Christian Hospital | Shimada K.,Tokyo Womens Medical University
Retina | Year: 2011

PURPOSE:: To investigate the relations among best-corrected visual acuity, retinal sensitivity, retinal thickness, and retinal volume in patients with branch retinal vein occlusion, and macular edema. METHODS:: In 49 consecutive patients with branch retinal vein occlusion (mean age, 68.2 ± 9.9 years; 25 women and 24 men), macular function was documented by microperimetry and best-corrected visual acuity was determined on the logarithm of the minimum angle of resolution scale. Retinal thickness and retinal volume were measured by optical coherence tomography, and mean retinal sensitivity was calculated for each of nine macular subfields on the retinal map obtained by optical coherence tomography. Pearson correlation coefficients were calculated and multiple linear regression analysis was performed with 7 variables (age, gender, hypertension, hyperlipidemia, duration of branch retinal vein occlusion, nonperfused retinal area, and serous retinal detachment). RESULTS:: On multivariate analysis, best-corrected visual acuity was significantly correlated with both retinal thickness and volume in 4 of 9 retinal subfields (fovea, superior inner, inferior outer, and nasal inner). In contrast, retinal sensitivity was correlated with both retinal thickness and volume in all 9 retinal subfields. CONCLUSION:: Retinal thickness and retinal volume are more closely associated with retinal sensitivity than with best-corrected visual acuity. Measurement of retinal sensitivity may be useful for assessing branch retinal vein occlusion patients with macular edema. © The Ophthalmic Communications Society, Inc. Source


Okano T.,Osaka City University | Hidaka N.,Yodogawa Christian Hospital | Nakamura H.,Osaka City University
Journal of Plastic Surgery and Hand Surgery | Year: 2011

We present two cases of trigger finger caused by partial laceration of a flexor tendon. Both patients had preceding skin injury and required operative treatment with resection of the lacerated portion of the tendon and incision of the A1 pulley. We describe keys to the diagnosis of this type of lesion. © 2011 Informa Healthcare. Source


Noma H.,Tokyo Womens Medical University | Funatsu H.,Tokyo Womens Medical University | Mimura T.,University of Tokyo | Harino S.,Yodogawa Christian Hospital | And 2 more authors.
Graefe's Archive for Clinical and Experimental Ophthalmology | Year: 2010

Background: We investigated whether pigment epithelium-derived factor (PEDF) or vascular endothelial growth factor (VEGF) influence macular edema in patients with branch retinal vein occlusion (BRVO). This investigation aimed to clarify the influence of PEDF in the vitreous fluid on retinal vascular permeability in patients with macular edema secondary to BRVO. The findings were expected to be useful for the treatment of macular edema in BRVO patients. Methods: This was a retrospective cross-sectional comparative case series. Thirty-three BRVO patients with macular edema and 24 control patients with nonischemic ocular diseases were enrolled. Retinal ischemia was evaluated by measuring the area of capillary nonperfusion on fluorescein angiography with Scion Image software. Macular edema was examined by optical coherence tomography. Vitreous fluid samples were obtained via pars plana vitrectomy, and the VEGF and PEDF levels were determined by enzyme-linked immunosorbent assay. Results: The vitreous level of VEGF was significantly higher in BRVO patients than controls (P<0.001). The vitreous PEDF level was significantly lower in BRVO patients than controls (P=0.026). In BRVO patients, vitreous levels of PEDF and VEGF showed a significant negative correlation with each other (P<0.001). Additionally, the vitreous VEGF level had a significant positive correlation (P<0.001) and the vitreous PEDF level had a significant negative correlation (P<0.001) with the nonperfused retinal area in BRVO patients. Furthermore, vitreous levels of VEGF and PEDF showed significant positive (P=0.001) and negative (P=0.014) correlations, respectively, with macular edema in BRVO patients. Conclusions: VEGF and PEDF may inversely influence retinal vascular permeability in patients with ischemic BRVO and macular edema. However, prospective validation will be needed to confirm these observations. © 2010 Springer-Verlag. Source

Discover hidden collaborations