Wang H.-M.,Yiyang Medical College |
Shi W.-M.,Liujiahu Hospital for Schistosomiasis Control of Yiyang City |
Qin Z.-Q.,National Institute of Parasitic Diseases
Chinese Journal of Schistosomiasis Control | Year: 2016
Objective: To investigate the effect of nursing with solution focused approach in advanced schistosomiasis patients. Methods: Fifty three patients with advanced schistosomiasis in the Liujiahu Hospital for Schistosomiasis Control of Yiyang City were randomized selected and separated into an intervention group and a control group. The patients of the intervention group received the conventional nursing plus solution focused approach, while the patients of the control group received only the conventional nursing. The effectiveness of nursing and treatment was evaluated in the two groups comparatively. Results: The knowledge of self-care skills, medical compliance behaviors and services satisfaction degree in the intervention group were higher than those in the control group (χ2= 3.78, 2.87, 4.09 respectively, all P < 0.05). The occurrence rate of upper gastrointestinal bleeding in the intervention group was significantly lower than that in the control group (χ2= 4.894, P < 0.05). The average hospitalization duration of the intervention group was shorter than that of the control group (t = 4.17, P < 0.05). Conclusions: The solution focused approach is a feasible and effective method in course of nursing of advanced schistosomiasis patients. It enhances the confidence of the patients and the trustiness of the patients to the health care providers. The complications and the hospitalization duration of the patients are reduced.
Xiao L.,University of South China |
Xiao L.,YiYang Medical College |
Li L.-F.,University of South China |
Chen L.-X.,University of South China
Progress in Biochemistry and Biophysics | Year: 2013
Autophagy which is a process that damaged organelles and cellular proteins are degraded by lysosomes plays a critical role in cellular homeostasis. Previous studies have demonstrated that autophagy influenced the vascular function, even involved in the pathophysiology of vascular diseases. In this review we focus on the effect of autophagy on the vascular function and vascular diseases such as atherosclerosis, abdominal aortic aneurysm, pulmonary hypertension and diabetes mellitus. Moreover, we try to provide a new way of vascular diseases treatment from the point of autophagy.
Bai J.,Red Cross |
Tan G.,Yiyang Medical College |
Chen L.,Red Cross |
Ning Y.,Guangzhou Medical College
Chinese-German Journal of Clinical Oncology | Year: 2013
Objective: The aim of the study was to investigate the effect of Casticin (CAS) combination with Cisplatin (DDP) in sub-toxic concentration on apoptosis of human ovarian cancer HO-8910 cells in vitro and unravel the associated mechanisms. Methods: Human ovarian cancer HO-8910 cells were cultured in vitro. The inhibitory effect of CAS combination with DDP in sub-toxic concentration on viability of human ovarian cancer HO-8910 cells was evaluated by the MTT assay. Morphological changes of cell apoptosis were detected by Hoechst 33258 staining assay. Cell apoptosis rate was analyzed by flow cytometry. The protein expression level was analyzed by Western blot. Results: CAS in sub-toxic concentration and DDP in sub-toxic concentration could slightly inhibit Human ovarian cancer HO-8910 cells, but CAS combination with DDP in sub-toxic concentration significantly inhibited the growth of HO-8910 cells, and growth inhibition rate was increased drastically compared with the control group (P<0.01), and the inhibiting effect showed synergistic action. Human ovarian cancer HO-8910 cells showed the typical morphological changes of apoptosis and apoptosis rate markedly increased when they were exposed to CAS combination with DDP in sub-toxic concentration for 48 h. Western blot showed that the expression of bcl-2 protein was down-regulated and protein level of caspase-3 was activated by CAS combination with DDP in sub-toxic concentration. Conclusion: CAS combination with DDP in sub-toxic concentration could inhibit the cells growth and lead to cell apoptosis in human ovarian cancer HO-8910 cells. And the down-regulation of bcl-2 protein expression and activation of caspase-3 protein might contribute to CAS combination with DDP in sub-toxic concentration in human cancer HO-8910 cells. © 2013 Springer-Verlag Berlin Heidelberg.
PubMed | Hunan University, Central South University and Yiyang Medical College
Type: Journal Article | Journal: Neural regeneration research | Year: 2015
The main active components extracted from Panax notoginseng are total saponins. They have been shown to inhibit platelet aggregation, increase cerebral blood flow, improve neurological behavior, decrease infarct volume and promote proliferation and differentiation of neural stem cells in the hippocampus and lateral ventricles. However, there is a lack of studies on whether total saponins of Panax notoginseng have potential benefits on immature neuroblasts in the olfactory bulb following ischemia and reperfusion. This study established a rat model of global cerebral ischemia and reperfusion using four-vessel occlusion. Rats were administered total saponins of Panax notoginseng at 75 mg/kg intraperitoneally 30 minutes after ischemia then once a day, for either 7 or 14 days. Total saponins of Panax notoginseng enhanced the number of doublecortin (DCX)(+) neural progenitor cells and increased co-localization of DCX with neuronal nuclei and phosphorylated cAMP response element-binding/DCX(+) neural progenitor cells in the olfactory bulb at 7 and 14 days post ischemia. These findings indicate that following global brain ischemia/reperfusion, total saponins of Panax notoginseng promote differentiation of DCX(+) cells expressing immature neuroblasts in the olfactory bulb and the underlying mechanism is related to the activation of the signaling pathway of cyclic adenosine monophosphate response element binding protein.
Yi S.-M.,Yiyang Medical College |
Tan A.-Q.,Affiliated Hospital of Yiyang Medical College
Chinese Journal of Evidence-Based Medicine | Year: 2013
Objective To explore the rehabilitation effects of musicokinetic therapy on perimenopausal syndrome, so as to provide scientific basis for the treatment of perimenopausal syndrome. Methods Perimenopausal women living in Yiyang city were screened and then 100 cases aged 45 to 55 years with Kupperman score ≥ 15 and depression score (SDS) ≥ 0.5 were selected. They were then divided into two groups (experimental group: 50 cases treated by musicokinetic therapy; control group: 50 cases). Evaluation was taken using Kupperman scale and SDS scale 24 weeks after training. Results Compared to the control group, Kupperman scores and SDS scores in the musicokinetic therapy group were lower with a significant difference (P<0.01). There were significant differences in Kupperman scores and SDS scores (P<0.01) and in the single items of Kupperman scores in the musicokinetic therapy group before and after the experiment (P<0.05). Conclusion Musicokinetic therapy could significantly alleviate physical and psychological status of women with perimenopausal syndrome. © 2013 Editorial Board of Chin J Evid-based Med.
Huang F.,Central South University |
Yang Z.,Yiyang Medical College |
Liu X.,Yiyang Medical College |
Li C.-Q.,Central South University
BMC Neuroscience | Year: 2014
Background: Previous studies have shown that melatonin is involved in the processes that contribute to learning and memory. At present study, we tested the effects of exogenous melatonin (2.5 mg/kg) on the acquisition, expression and extinction of cued fear in rats.Results: Results showed that a single afternoon administration 30 min before conditioning has no effect on the acquisition of cued fear. Compared to rats injected with vehicle, rats injected with melatonin 30 min before extinction training presented a significant lower freezing during both extinction training and extinction test phases, however, freezing response did not differ for the initial four trials during extinction training. Melatonin injected immediately after extinction training was ineffective on extinction learning.Conclusions: These results suggest that melatonin, at the dose applied in this study, facilitates the extinction of conditional cued fear without affecting its acquisition or expression, and melatonin facilitates cued fear extinction only when it is present during extinction training. These findings extend previous research on the melatonin effects on learning and memory and suggest that melatonin may serve as an agent for the treatment of anxiety disorders such as posttraumatic stress disorder (PTSD). © 2014 Huang et al.; licensee BioMed Central Ltd.
PubMed | Central South University and Yiyang Medical College
Type: Journal Article | Journal: Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences | Year: 2016
To explore the effect of ROCK inhibitor Y-27632 on the matrix metalloproteinase 2 and 9 (MMP2 and MMP9) gene expression and activity in tumor necrosis factor (TNF-)-treated human umbilical vein endothelial cell (HUVEC).HHUVEC was divided into 3 groups, a control group, a TNF- group, and a TNF- plus Y-27632 group. The expressions of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), MMP2 and MMP9 were examined by real-time PCR. The MMP2/9 activity was measured by gelatin zymography.Compared to the control group, the mRNA expressions of ICAM-1, VCAM-1, MMP2 and MMP9 were increased TNF--treated cells, which were suppressed by ROCK inhibitor (P<0.01). The MMP2/9 activity was elevated in TNF--treated cells, which was reversed by ROCK inhibitor (P<0.05).ROCK inhibitor can suppress TNF--induced inflammation in endothelial cells through down-regulation of MMP2/9.
PubMed | Central South University and Yiyang Medical College
Type: | Journal: Vitamins and hormones | Year: 2017
Resistance to extinction of certain conditioned responses forms the basis of anxieties, phobias, and compulsions. There has been an available effective means of extinction-based exposure psychotherapy for the treatment of anxiety disorders, such as posttraumatic stress disorder (PTSD) that has been hypothesized to result from impaired extinction of fear memory. PTSD is considered as a memory disorder within a Pavlovian fear conditioning and extinction framework. Therefore, the aim of this review was to report the preclinical profile of melatonin, a pineal gland hormone, as a potential pharmacological option in the treatment of anxiety disorders such as PTSD, tested with the Pavlovian fear conditioning paradigm.We performed a literature review regarding studies that evaluated the effects of melatonin on fear conditioning and fear extinction.Results showed that a single administration 30min before conditioning has no effect on the acquisition of cued fear, but impaired contextual fear conditioning. Compared to rats injected with vehicle, rats injected with melatonin 30min before extinction training presented a significant lower freezing during both extinction training and extinction test phases. However, melatonin injected immediately after extinction training was ineffective on extinction learning.Melatonin impaired contextual fear conditioning, a hippocampus-dependent task. On the contrary, melatonin facilitates the extinction of conditional cued fear without affecting its acquisition or expression, and melatonin facilitates cued fear extinction only when it is present during extinction training. Although further studies are necessary, the research undertaken until now shows that melatonin modulates fear conditioning and fear extinction and consequently melatonin may serve as an agent for the treatment of PTSD.
Qiang X.,Hunan City University |
Yu X.,Yiyang Medical College
Proceedings - 2013 5th Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2013 | Year: 2013
Following the theory of linear piezoelectricity, we analyzed propagation of guided waves in layered piezoelectric structure. The pattern is a piezoelectric plate sandwiched between two piezoelectric half spaces. The waves propagate near intermediate plate. From this, we get precise dispersion relation which can be changed into to piezoelectric surface acoustic waves. The result will help us to know better about and improve acoustic wave devices. © 2013 IEEE.
Wang Q.,Yiyang Medical College |
Xu F.-H.,Yiyang Medical College
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials | Year: 2013
OBJECTIVE: To study the constituents of EtOAc extract from Aeschynanthus bracteatus.METHODS: The constituents were isolated and purified by chromatography on silica gel and the structures of the compounds were determined by MS and NMR spectral analysis.RESULTS: On the basis of spectroscopic analysis and comparison with the reported data, compounds were identified as koaburaside (1), coniferaldehyde (2), syringaldehyde (3), sinapinaldehyde (4), 2,4'-dihydroxyacetophenone (5), piceol (6), beta-daucosterol (7), beta-sitosterol (8).CONCLUSION: Compounds 1 and 2 are obtained from this genus for the first time.