Yi S.-M.,Yiyang Medical College |
Tan A.-Q.,Affiliated Hospital of Yiyang Medical College
Chinese Journal of Evidence-Based Medicine | Year: 2013
Objective To explore the rehabilitation effects of musicokinetic therapy on perimenopausal syndrome, so as to provide scientific basis for the treatment of perimenopausal syndrome. Methods Perimenopausal women living in Yiyang city were screened and then 100 cases aged 45 to 55 years with Kupperman score ≥ 15 and depression score (SDS) ≥ 0.5 were selected. They were then divided into two groups (experimental group: 50 cases treated by musicokinetic therapy; control group: 50 cases). Evaluation was taken using Kupperman scale and SDS scale 24 weeks after training. Results Compared to the control group, Kupperman scores and SDS scores in the musicokinetic therapy group were lower with a significant difference (P<0.01). There were significant differences in Kupperman scores and SDS scores (P<0.01) and in the single items of Kupperman scores in the musicokinetic therapy group before and after the experiment (P<0.05). Conclusion Musicokinetic therapy could significantly alleviate physical and psychological status of women with perimenopausal syndrome. © 2013 Editorial Board of Chin J Evid-based Med.
Bai J.,Red Cross |
Tan G.,Yiyang Medical College |
Chen L.,Red Cross |
Ning Y.,Guangzhou Medical College
Chinese-German Journal of Clinical Oncology | Year: 2013
Objective: The aim of the study was to investigate the effect of Casticin (CAS) combination with Cisplatin (DDP) in sub-toxic concentration on apoptosis of human ovarian cancer HO-8910 cells in vitro and unravel the associated mechanisms. Methods: Human ovarian cancer HO-8910 cells were cultured in vitro. The inhibitory effect of CAS combination with DDP in sub-toxic concentration on viability of human ovarian cancer HO-8910 cells was evaluated by the MTT assay. Morphological changes of cell apoptosis were detected by Hoechst 33258 staining assay. Cell apoptosis rate was analyzed by flow cytometry. The protein expression level was analyzed by Western blot. Results: CAS in sub-toxic concentration and DDP in sub-toxic concentration could slightly inhibit Human ovarian cancer HO-8910 cells, but CAS combination with DDP in sub-toxic concentration significantly inhibited the growth of HO-8910 cells, and growth inhibition rate was increased drastically compared with the control group (P<0.01), and the inhibiting effect showed synergistic action. Human ovarian cancer HO-8910 cells showed the typical morphological changes of apoptosis and apoptosis rate markedly increased when they were exposed to CAS combination with DDP in sub-toxic concentration for 48 h. Western blot showed that the expression of bcl-2 protein was down-regulated and protein level of caspase-3 was activated by CAS combination with DDP in sub-toxic concentration. Conclusion: CAS combination with DDP in sub-toxic concentration could inhibit the cells growth and lead to cell apoptosis in human ovarian cancer HO-8910 cells. And the down-regulation of bcl-2 protein expression and activation of caspase-3 protein might contribute to CAS combination with DDP in sub-toxic concentration in human cancer HO-8910 cells. © 2013 Springer-Verlag Berlin Heidelberg.
Qiang X.,Hunan City University |
Yu X.,Yiyang Medical College
Proceedings - 2013 5th Conference on Measuring Technology and Mechatronics Automation, ICMTMA 2013 | Year: 2013
Following the theory of linear piezoelectricity, we analyzed propagation of guided waves in layered piezoelectric structure. The pattern is a piezoelectric plate sandwiched between two piezoelectric half spaces. The waves propagate near intermediate plate. From this, we get precise dispersion relation which can be changed into to piezoelectric surface acoustic waves. The result will help us to know better about and improve acoustic wave devices. © 2013 IEEE.
Xiao L.,University of South China |
Xiao L.,Yiyang Medical College |
Li L.-F.,University of South China |
Chen L.-X.,University of South China
Progress in Biochemistry and Biophysics | Year: 2013
Autophagy which is a process that damaged organelles and cellular proteins are degraded by lysosomes plays a critical role in cellular homeostasis. Previous studies have demonstrated that autophagy influenced the vascular function, even involved in the pathophysiology of vascular diseases. In this review we focus on the effect of autophagy on the vascular function and vascular diseases such as atherosclerosis, abdominal aortic aneurysm, pulmonary hypertension and diabetes mellitus. Moreover, we try to provide a new way of vascular diseases treatment from the point of autophagy.
Mo Y.,Southern Medical University |
Mo Y.,Yiyang Medical College |
Tang L.,Southern Medical University |
Ma Y.,Zunyi Medical College |
Wu S.,Southern Medical University
Biochemical and Biophysical Research Communications | Year: 2016
This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significantly reduced the myocardial infarction size, decreased the CK and LDH activities at the serum level and enhanced autophagy. In the in vitro study, the pramipexole treatment significantly elevated the survival rate, decreased the LDH activity, reduced ROS generation and restored the ΔΨm in H9C2 cells during H/R. Additionally, its use could increase the autophagy flux level in H9c2 cells. The underlying mechanisms were determined by measuring the expression of the autophagic protein levels. These results further indicated that pramipexole treatment modulated H/R-induced autophagy via an AMPK-dependent pathway. All of these data indicate that pramipexole exerted protective effects against myocardial I/R injury and enhanced autophagy in part through the AMPK-mediated pathway. © 2016 Elsevier Inc. All rights reserved.