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Linyi Shandong, China

Zhang H.,Yishui Central Hospital of Linyi
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2013

To investigate the effectiveness of the penile ventral scrotum cohesion place wedge cutting and improved Brisson technique for congenital buried penis. Between March 2010 and June 2012, 68 boys with congenital buried penis were treated by the penile ventral scrotum cohesion place wedge cutting and improved Brisson technique, with a median age of 4 years and 10 months (range, 3 months-13 years). Of 68 cases, 14 were classified as phimosis type, 14 as rope belt type, 20 as moderate type, and 20 as severe type. The body of penis developed well and had no deformity. After operation, complications were observed, and the effectiveness was evaluated by the designed questionnaire. Early postoperative complications occurred in 11 cases, including obvious adhesion of the outside wrapping mouth in 4 cases, scrotal skin bloat in 5 cases, and distal foreskin necrosis in 2 cases; long-term complications occurred in 9 cases, including abdominal incision scar formation in 4 cases, wrapping mouth scar stricture in 3 cases, and short penis in 2 cases. Primary healing of incision was obtained in the other boys. Fifty-four cases were followed up 6-12 months (mean, 8 months). According to the designed questionnaire, satisfaction rate with the overall view in parents was 77.78% (42/54); the clinical improvement rate was 85.19% (46/54); exposure of the penis was satisfactory in parents of 50 cases; and the parents had no psychological burden of penis exposure in 46 cases, which were significantly improved when compared with preoperative ones (P < 0.05). The boys had no psychological burden of penis exposure in 29 cases (53.70%) after operation, showing no significant difference when compared with preoperative one (18 cases, 33.33%) (chi2 = 1.22, P = 0.31). Application of the penile ventral scrotum cohesion place wedge cutting and improved Brisson technique can effectively correct congenital buried penis. Source


Ma W.-H.,Guilin Medical University | Zhao N.,Guilin Medical University | Su Y.,Yishui Central Hospital of Linyi | Zhao K.,Guilin Medical University | And 2 more authors.
Chinese Traditional and Herbal Drugs | Year: 2015

Objective: To observe the effect of aqueous extract from roots of Arctium lappa (AERAL) on vascular remolding in hypertensive rats. Methods: The hypertensive rat model was induced by N-nitro-L-arginine from 50 female Wistar rats, and randomly divided into model control group, positive control group (15 mg/kg), low-, mid-, and high-dose AERAL (0.5, 1.0, and 2.0 g/kg), groups. After six weeks of continuous gavage administration, rat tail artery systolic pressure, angiotensin II (Ang-II), endothelin-1 (ET-1), tumor necrosis factor-α (TNF-α), left ventricular mass index (LVWI), and thickness of thoracic aortic tunica media (TTATM) were detected. Results: Compared with the normal control group, Ang-II, ET-1, TNF-α, LVWI, and TTATM were increased and rat tail artery systolic pressure was elevated in the model control group, with significant differences between the two groups (P < 0.05); Compared with the model control group, rat tail artery systolic pressure in each treatment groups declined, serum Ang-II, ET-1, TNF-α, LVWI, and TTATM were all lowered, showing significant differences among them (P < 0.05). Conclusion: AERAL can significantly improve vascular remolding in rats with hypertension. © 2015, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved. Source


Li W.,Soochow University of China | Ma D.-L.,Yishui Central Hospital of Linyi | Li Y.,First Peopleps Hospital of Wujiang | Zhou C.,Soochow University of China | And 5 more authors.
Chinese Journal of Cancer Prevention and Treatment | Year: 2015

OBJECTIVE: To investigate the application of circulating tumor cells (CTC) detection in chemotherapeutic efficacy evaluation in metastatic breast cancer(MBC). METHODS: 136 patients were enrolled in this study. The tumors were monitored by computed tomography every 3 chemotherapy cycles and evaluated according to Response Evaluation Criteria in Solid Tumors (RECIST). In the mean time, the levels of CTCs were monitored using cell filtration (isolation by size of epithelial tumor cells, ISET) together with laser scanning cytometry (LSC). RESULTS: Among the 341 samples collected from 136 patients, CTC could be found in 262 specimens (76.83%), and the mean number of CTC was (6.73±4.92)/7.5 mL blood. Among the 136 patients, 43 cases achieved complete or partial remission (31.62%). 39 cases remained stable (28.67%). And 54 cases were progressive (39.71%). Changes in CTC numbers were significantly associated with the disease progresses after chemotherapy (r=0.514 83, P<0.01). However, CTC baseline level did not predict response to treatment (χ2=3.62, P=0.08215). CONCLUSION: CTC detection could be used in the efficacy evaluation of chemotherapy in MBC. © 2015, Editorial Board of Chinese Journal of Cancer Prevention and Treatment. All right reserved. Source


Sun Q.,Yishui Central Hospital of Linyi | Lin P.,Yishui Central Hospital of Linyi | Zhang J.,Yishui Central Hospital of Linyi | Li X.,Yishui Central Hospital of Linyi | And 5 more authors.
Tohoku Journal of Experimental Medicine | Year: 2015

Fibroblast growth factor receptor 2 (FGFR2) has been proved to be a significant prognostic factor and a potential therapeutic target in several types of cancer, including gastric cancer. FGFR2 consists two isoforms: FGFR2-IIIb and FGFR2-IIIc, which can be stimulated by different ligands and trigger different downstream signaling pathways. As a specific ligand to FGFR2-IIIb, fibroblast growth factor 10 (FGF10) is expressed in the gastric mesenchyme cell and is involved in stomach development and morphogenesis, but its expression and clinical significance is not well elucidated in gastric cancer. We analyzed FGF10 expression by immunohistochemistry in 178 samples of gastric adenocarcinoma (134 male and 44 female patients, with the average age of 63.2 years old and the average follow-up of 21.6 months). Using the arbitrarily scoring method based on positive cell percentage and staining intensity, we sub-divided the patients into FGF10 high-expression group (58 patients) and low-expression group (120 patients). We thus found that FGF10 expression is significantly associated with lymph node invasion (P = 0.004) and distant metastasis (P = 0.032). Importantly, FGF10 expression is an independent unfavorable prognostic factor (P = 0.042). Moreover, FGF10 knockdown significantly decreased the migration of cultured gastric adenocarcinoma cells, suggesting that FGF10 could promote the invasion of gastric adenocarcinoma. In conclusion, FGF10 expression was identified as a poor prognostic biomarker in gastric adenocarcinoma, and FGF10 could promote the invasion of gastric cancer cells. We suggest that FGF10 could be a potential and promising drug target in gastric adenocarcinoma. © 2015 Tohoku University Medical Press. Source

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