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Lin H.,Central Hospital of Yishui | Dong Y.,Central Hospital of Yishui | Fei Z.-Y.,Central Hospital of Yishui | Chen X.-T.,Central Hospital of Yishui | And 3 more authors.
World Chinese Journal of Digestology | Year: 2013

AIM: To investigate the correlation between changes in platelets and coagulation and disease severity in patients with ulcerative colitis (UC) and to investigate the therapeutic effect of salvianolate against UC. METHODS: One hundred and ten patients with UC and 84 healthy controls were included in the study. Platelet count (PLT), mean platelet volume (MPV), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were compared between UC patients and healthy controls. UC patients were randomly divided into a control group and a treatment group. The control group received only routine treatment, while the treatment group received both salvianolate and routine treatment. PLT, MPV, ESR, and CRP were compared between the two groups. Stool characters and colonoscopy performance were also observed to evaluate the treatment effect. RESULTS: PLT in UC patients was superior to that in normal controls (292.0 ± 104.8 vs 217.2 ± 45.6), while MPV in UC patients was inferior to that in normal controls (9.1 ± 0.8 vs 10.5 ± 1.1, P < 0.05). PLT was higher in patients with severe disease than in those with mild disease (292.0 ± 104.8 vs 244.2 ± 74.8, P < 0.05). There was no significant difference in PLT between patients with mild and those with moderate disease (244.2 ± 74.8 vs 255.0 ± 52.3, P > 0.05), or between those with moderate and severe disease (255.0 ± 52.3 vs 292.0 ± 104.8, P > 0.05). There were significant differences in MPV (9.5 ± 0.6 vs 9.2 ± 0.6 vs 8.5 ± 1.0), ESR (6.1 ± 4.5 vs 17.1 ± 9.0 vs 30.0 ± 19.7), CRP (9.3 ± 4.3 vs 14.7 ± 9.8 vs 31.2 ± 21.0) between patients with mild, moderate and severe disease (all P < 0.05). PLT (218.0 ± 34.8 vs 245.0 ± 45.3), ESR (7.3 ± 5.1 vs 14.7 ± 4.7) and CRP (8.3 ± 3.7 vs 11.6 ± 6.4) were lower, but the effective rate (93.8% vs 75.0%) and MPV(10.1 ±1.0 vs 9.7±0.8) were higher in the treatment group than in the control group after therapy (all P < 0.05). CONCLUSION: PLT and MPV can be used as markers for assessing the severity of UC. Treatment with salvianolate can improve the treatment effect of UC by reducing PLT number and activation and activating blood circulation. © 2013 Baishideng. All rights reserved. Source

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