Peoples Hospital Of Yinzhou

Ningbo, China

Peoples Hospital Of Yinzhou

Ningbo, China
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Wang C.M.,Peoples Hospital Of Yinzhou | Ye H.D.,Zhejiang University | Li Y.R.,Zhejiang University | Hong Q.X.,Zhejiang University | And 4 more authors.
Genetics and Molecular Research | Year: 2015

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, including 777 CHD cases and 732 controls. We selected a total of five polymorphisms whose genotypes were determined using Sequenom iPLEX technology. Our results showed there were no significant associations between the five MMP gene polymorphisms and CHD risk at either genotype or allele levels (P > 0.05). Further subgroup analyses by sex were also unable to reveal any significant association (P > 0.05). In conclusion, no significant associations were found between the five MMP gene polymorphisms and the risk of CHD in Han Chinese. © FUNPEC-RP.


PubMed | Peoples Hospital of Yinzhou, Shanghai JiaoTong University and Zhejiang University
Type: Journal Article | Journal: Genetics and molecular research : GMR | Year: 2015

Coronary heart disease (CHD) has become a leading cause of human deaths worldwide. Recent studied showed that polymorphisms of the matrix metalloproteinase (MMP) genes played important roles in extracellular matrix remodeling and contribute to the pathogenesis of vascular diseases. Here, we investigated whether these MMP gene polymorphisms were associated with CHD in Han Chinese. Our case-control study was involved with 1509 unrelated individuals, including 777 CHD cases and 732 controls. We selected a total of five polymorphisms whose genotypes were determined using Sequenom iPLEX technology. Our results showed there were no significant associations between the five MMP gene polymorphisms and CHD risk at either genotype or allele levels (P > 0.05). Further subgroup analyses by sex were also unable to reveal any significant association (P > 0.05). In conclusion, no significant associations were found between the five MMP gene polymorphisms and the risk of CHD in Han Chinese.


Lu Y.,Peoples Hospital of Yinzhou | Yu M.,Zhejiang University | Mu Q.,Ningbo First Hospital | Pei R.,Peoples Hospital of Yinzhou | And 3 more authors.
Chinese Journal of Medical Genetics | Year: 2014

Objective To explore the expression and clinical significance of Musashi2 (MSI2) gene in de novo acute myeloid leukemia (AMD. Methods Real-time quantitative PCR (RQ-PCR) was used to measure the expression of MSI2 gene in 181 de novo AML patients. Correlation between the expression level and clinical features of such patients was explored. Results Transcript of the MSI2 gene was detected in 181 AML patients, with the median expression level being 2.341 (0.1124-58.8566). By contrast, CD34+ cells from 10 healthy controls had a much lower expression level (P = 0.012), and the expression level of MSI2 in 24 patients with complete remission was significant lower than denovo patients (P=0.021). Based on the median expression level, such patients were divided into low expression group and high expression group. Patients from the high expression group had significantly higher rate of high white blood cell count (78% vs. 63%, P=0.034). Compared with MSI2-low group, FLT3-ITD mutation were much more common in MSI2-high group (28% vs. 7%, P= 0.002). The expression level of MSI2 in aberrant karyotypes was much higher than that in favorable karyotypes (the median expression level was 2.7726 and 2.0733, P=0.035). Kaplan - Meier analysis showed that the overall survival in high expression group of MSI2 was lower than the low expression group, with the median survival time being 28 months and 12 months, respectively (P=0.045). Conclusion De novo AML patients have a higher level of MSI2 gene expression. And the latter is much more common in those with high white blood cell count and aberrant karyotypes, and has a positive correlation with FLT3-ITD mutation. High expression of MS/2 gene may be a predictor for poorer prognosis among AML patients.


Hu M.-Y.,Zhejiang University | Hu M.-Y.,Peoples Hospital of Yinzhou | Xu L.-M.,Zhejiang University | Wang C.-M.,Peoples Hospital of Yinzhou | And 4 more authors.
Academic Journal of Second Military Medical University | Year: 2014

Objective: To explore the association between variant rs4299376 of ABCG5/ABCG8 gene with the risk of coronary heart disease (CHD) in Han Chinese and the association of related lipid levels with CHD. Methods: We collected blood samples from 290 CHD cases, 198 non-CHD controls and 331 healthy controls. The genomic DNA was acquired by the nucleic acid extraction automatic analyzer and the rs4299376 genotypes were analyzed by the Mass-ARRAY İPLEXR platform. Results: There were no significant differences in distribution of variant rs4299376 of ABCG5/ABCG8 gene among Han Chinese with CHD, non-CHD controls and healthy controls. There was no association between lipid levels and CHD in either total or male groups. While in female group, the triglyceride (TG) and total cholesterol (TC) were higher in CHD patients than in non-CHD controls (TG: 2. 23 ± 1. 05vs 1. 84 ± 1. 03, P = 0. 01; TC: 4. 7 9 ± 1. 17 vs 4. 36 ±1. 03, P = 0. 01). It was also found that, for those 60 years old and above, the CHD cases had a significantly lower high density lipoprotein (HDL) levll compared with non-CHD group (1. 09±0. 23 vs 1. 16±0. 25, P = 0. 03). Conclusion: There is no noticeable association between ABCG5/ ABCG8 rs4299376 polymorphism and the risk of CHD in Han Chinese. Female CHD patients have higher levels of TG and TC and when over 60 year old, CHD patients have a lower HDL level than non-CHD controls.


Lu M.,Peoples Hospital of Yinzhou | Chen Y.,Peoples Hospital of Yinzhou | Chen W.,Peoples Hospital of Yinzhou
Zhongguo gu shang = China journal of orthopaedics and traumatology | Year: 2014

OBJECTIVE: To retrospectively compare the occurrence of cubitus varus deformity after humeral supracondylar fractures treated with manipulative reduction and plaster fixation in pronated or supinated position in children, and to guide clinical treatment.METHODS: From June 2009 to December 2011, the medical data of 64 children with humeral supracondylar fractures treated by manipulative reduction and plaster fixation were reviewed. All the patients were divided into two groups: group A and group B. The 30 patients in group A were treated with manipulative reduction and plaster fixation in pronation, including 18 males and 12 females, with a mean age of (7.5 ± 3.5) years old. The 34 patients in group B were treated with manipulative reduction and plaster fixation in supination, including 23 males and 11 females, with a mean age of (7.0 ± 2.6) years old. The occurrence rates of cubitus varus and decreases of carrying angle were compared between two groups before and after treatment.RESULTS: There were 13 patients in group A and 16 patients in group B having cubitus varus,which had no statistical difference (χ2 = 0.089, P = 0.765). The decrease of carrying angle were (8 ± 4) degrees in group A and (9 ± 5) degrees in group B, which had no statistical difference (t = 0.584, P = 0.564). Within group A, the occurrence rate of cubitus varus and the decrease of carrying angle between the radial deviation and the ulnar deviation had statistically significant difference (χ2 = 6.160, P = 0.013; t = - 2.409, P = 0.035). Within group B, the occurrence rate of cubitus varus and the decrease of carrying angle between the radial deviation and the ulnar deviation had statistically significant difference (χ2 = 5.120, P = 0.024; t = -2.250, P = 0.041). The elbow function Flynn evaluation score had no significant difference between two groups (P = -0.822).CONCLUSION: The occurrence rate of cybutys varys and the decrease of carrying angle have no obvious difference in children with humeral supracondylar fractures treated with fixation in pronated or supinated position. However, when treating with pediatrics humerus supracondylar fractures with ulnar deviation, the fixation in pronation is more helpful for reducing the occurrence rate of elbow varus and decrease of carrying angle. When treating with the pediatrics humerus supracondylar fractures with radial deviation, fixation in supination is helpful for reducing the occurrence rate of elbow varus and decrease of carrying angle.

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