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Liu X.,Shihezi University | Chen W.-G.,Shihezi University | Li R.,Shihezi University | Liu F.,Shihezi University | And 5 more authors.
World Chinese Journal of Digestology | Year: 2013

Aim: To determine the relationship between methylation of the Smad4 promoter and the incidence of gastric cancer (GC) in Kazakh Chinese in Xinjiang Uygur Autonomous Region of China. Methods: Thirty patients with gastric cancer and 30 normal individuals were recruited from Kazak Autonomous Prefecture, an area with a high prevalence of gastric cancer. MassARRAY was used to detect Smad4 promoter methylation in samples taken from both GC patients and healthy controls. Results: The mean CpG methylation rate in GC was higher than that in normal gastric tissue (26.5% vs 21.7%). The mean methylation rates in CpG 3-4 and CpG 10-11 in GC were significantly higher than those in normal controls (19.1% vs 10.9%; 20.3% vs 11.5%, both P < 0.05). Conclusion: The Smad4 promoter methylation status is correlated with the presence of GC in Kazakh Chinese. Changes in the methylation of CpG 3-4 and/or CpG 10-11 of the Smad4 gene may lead to the development of GC. © 2013 Baishideng. All rights reserved. Source

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