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PubMed | Yuzuncu Yil University and Dskapi Yildirim Beyazit Training and Research Hospital
Type: | Journal: Medical science monitor : international medical journal of experimental and clinical research | Year: 2014

Adenosine deaminase (ADA) activity has been discovered in several inflammatory conditions; however, there are no data associated with cutaneous anthrax. The aim of this study was to investigate serum ADA activity in patients with cutaneous anthrax.Sixteen patients with cutaneous anthrax and 17 healthy controls were enrolled. We measured ADA activity; peripheral blood leukocyte, lymphocyte, neutrophil, and monocyte counts; erythrocyte sedimentation rate; and C reactive protein levels.Serum ADA activity was signicantly higher in patients with cutaneous anthrax than in the controls (p<0.001). A positive correlation was observed between ADA activity and lymphocyte counts (r=0.589, p=0.021) in the patient group.This study suggests that serum ADA could be used as a biochemical marker in cutaneous anthrax.


Calskan S.,Dskapi Yildirim Beyazit Training and Research Hospital | Acar M.,Dskapi Yildirim Beyazit Training and Research Hospital | Gurdal C.,Dskapi Yildirim Beyazit Training and Research Hospital
Current Eye Research | Year: 2016

Purpose: The purpose of the study is to compare choroidal thickness (CT) in patients with active and inactive Graves’ ophthalmopathy (GO) and that in healthy subjects by using spectral domain optical coherence tomography (SD-OCT). Methods: We conducted an observational, cross-sectional study of 28, 48, and 74 eyes of 14 patients with active GO (group 1), 24 patients with inactive GO (group 2), and 37 age-matched healthy subjects (group 3), respectively. Activity of GO was assessed by using initial clinical activity score (CAS). CT was measured by using SD-OCT. The differences in CT among the groups were compared, and the factors affecting subfoveal CT were analyzed. Results: The mean subfoveal CT was significantly greater in group 1 (395.84 ± 9.68 µm) than that in group 2 and group 3 (319.76 ± 7.07 µm and 314.22 ± 5.74 µm, respectively; p < 0.001) after adjusting for age, axial length, and intraocular pressure (IOP). Subfoveal CT was positively correlated with CAS (p < 0.001; r = 0.567). In multivariate analysis, thicker subfoveal CT was associated with younger age (p < 0.001; correlation coefficient B, −1.67; 95% CI, −2.57 to −0.78); disease activity (p < 0.001; correlation coefficient B, 95.28; 95% CI, 73.14–117.43); and lower IOP ((p < 0.001; correlation coefficient B, −4.09; 95% CI, −8.03 to −0.15). Conclusions: To our knowledge, this is the first study showing that the mean subfoveal CT increases in patients with active GO. Subfoveal CT may be a useful parameter to monitor disease activity. © 2016 Taylor & Francis


PubMed | Dskapi Yildirim Beyazit Training and Research Hospital
Type: | Journal: Retinal cases & brief reports | Year: 2016

Ectodermal dysplasia (ED) results from abnormal development of the ectodermal layer. Although coexistence of ED and retinal pathology has been described, concomitance with retinal venous tortuosity has not been reported in the literature.Case report.We report the case of a 23-year-old man with ED with bilateral retinal venous tortuosity, trichomegaly, meibomian gland dysfunction, and dry eye. Although the coexistence of ED with trichomegaly and meibomian gland dysfunction has been previously reported, to the best of our knowledge, this is the first reported case of retinal venous tortuosity associated with ED.Coexistence of retinal venous tortuosity and ED may be the consequence of a genetic mutation affecting cellular signaling pathways during retinal angiogenesis.


PubMed | Dskapi Yildirim Beyazit Training and Research Hospital
Type: | Journal: Current eye research | Year: 2016

The purpose of the study is to compare choroidal thickness (CT) in patients with active and inactive Graves ophthalmopathy (GO) and that in healthy subjects by using spectral domain optical coherence tomography (SD-OCT).We conducted an observational, cross-sectional study of 28, 48, and 74 eyes of 14 patients with active GO (group 1), 24 patients with inactive GO (group 2), and 37 age-matched healthy subjects (group 3), respectively. Activity of GO was assessed by using initial clinical activity score (CAS). CT was measured by using SD-OCT. The differences in CT among the groups were compared, and the factors affecting subfoveal CT were analyzed.The mean subfoveal CT was significantly greater in group 1 (395.84 9.68 m) than that in group 2 and group 3 (319.76 7.07 m and 314.22 5.74 m, respectively; p < 0.001) after adjusting for age, axial length, and intraocular pressure (IOP). Subfoveal CT was positively correlated with CAS (p < 0.001; r = 0.567). In multivariate analysis, thicker subfoveal CT was associated with younger age (p < 0.001; correlation coefficient B, -1.67; 95% CI, -2.57 to -0.78); disease activity (p < 0.001; correlation coefficient B, 95.28; 95% CI, 73.14-117.43); and lower IOP ((p < 0.001; correlation coefficient B, -4.09; 95% CI, -8.03 to -0.15).To our knowledge, this is the first study showing that the mean subfoveal CT increases in patients with active GO. Subfoveal CT may be a useful parameter to monitor disease activity.


PubMed | Dskapi Yildirim Beyazit Training and Research Hospital
Type: | Journal: Journal of ophthalmology | Year: 2015

Objective. To determine the effect of hemodialysis (HD) on choroidal thickness (CT). Methods. The right eyes of 41 patients with end-stage renal disease (ESRD) undergoing HD were included. All patients underwent an ophthalmic examination, including CT measurement via optical coherence tomography, intraocular pressure (IOP), blood pressure, and body weight measurement immediately before and after a HD session. Results. Mean subfoveal choroidal thickness (SFCT) after HD decreased significantly from 254.59 84.66m to 229.34 77.79m (p < 0.001). CT at the temporal and nasal regions also decreased significantly after HD (both p < 0.001). IOP changes after HD were insignificant (p = 0.958). CT difference was insignificant in patients with diabetes mellitus (DM) and without DM before and after HD, respectively (p = 0.285 and p = 0.707). Stepwise multivariate linear regression analysis showed that diastolic blood pressure was the best fitted factor to explain the changes in CT (r = 0.327 and p = 0.040).Conclusion. CT was decreased in the patients with ESRD following a HD session. This study suggested that the changes in CT may be related to the changes in systemic blood pressure.


PubMed | Dskapi Yildirim Beyazit Training and Research Hospital
Type: Journal Article | Journal: Cornea | Year: 2016

We aimed to investigate the association between atherosclerotic changes in the common carotid artery (CA) and conjunctival and corneal calcification (CCC) in maintenance hemodialysis (MHD) patients.Fifty eyes of MHD patients with the highest CCC scores were enrolled. CCCs were scored according to the method described by Tokuyama et al. The eyes with the highest CCC scores were selected for further analysis. According to their CCC scores, the patients were classified into 3 groups: mild (0-2 score), moderate (3-5), and severe (6-10 score). Atherosclerosis of the common CA was evaluated by determination of intima-media thickness (IMT), peak systolic (PSV) and end diastolic (EDV) flow velocities, pulsatility index, and resistive index values by using Doppler ultrasonography.The mean IMT of the CA was 0.61 0.09 mm in the mild group, 0.82 0.16 mm in the moderate group, and 1.21 0.32 mm in the severe group (P < 0.001). The PSV and EDV were significantly higher in the severe group than in the mild and moderate groups (all, P < 0.001). The CCC score was positively correlated with the duration of hemodialysis, ocular surface disease index score, IMT, PSV, EDV, lymphocyte, calcium, and sedimentation rate. In multiple stepwise linear regression analysis, IMT was the best predictive factor for the CCC score (R = 0.812, = 9.526 1.05, and P < 0.001).Our results suggest that chronic ocular ischemia due to atherosclerotic changes may have a role in the formation or progression of CCC in MHD patients.


PubMed | Dskapi Yildirim Beyazit Training and Research Hospital
Type: Journal Article | Journal: Renal failure | Year: 2016

To evaluate changes in ocular biometric parameters after hemodialysis (HD) in patients with end-stage renal disease (ESRD).Forty eyes of 40 patients undergoing HD were included in this cross-sectional study. Keratometry (K) readings, white-to-white (WTW) distance, central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter, lens thickness (LT), axial length (AL), and intraocular lens (IOL) power calculation were measured with Lenstar LS 900 (Haag Streit AG, Koeniz, Switzerland) before and after hemodialysis. Intraocular pressure (IOP) was measured with a non-contact tonometer (Tonopachy NT-530P, Nidek Co., LTD, Tokyo, Japan). Main outcomes were changes in biometric parameters after HD. Reliability of the measurements (intraclass correlation coefficients (ICCs)) and the effect size (Cohens d) were also calculated.Mean difference in AL before and after HD was -0.0410.022mm with ICCs>0.90 (p<0.001 and Cohens d=0.06). Pupil diameter was also significantly different before (4.280.81mm) and after (4.440.79mm) HD with ICCs>0.90 (p=0.041 and Cohens d=0.20). Hemodialysis had no significant effect on K readings, WTW distance, CCT, ACD, LT, or IOP.Axial length and pupil diameter increase after HD with small effect size, while HD does not significantly affect IOL power calculations.

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