Yidu Central Hospital of Weifang

of Weifang, China

Yidu Central Hospital of Weifang

of Weifang, China

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Jia Y.,Yidu Central Hospital of Weifang | Xu B.,Yidu Central Hospital of Weifang | Xu J.,Yidu Central Hospital of Weifang
Pharmaceutical biology | Year: 2017

CONTEXT: Berberine is an active alkaloid isolated from Rhizoma coptidis [Coptis chinensis Franch. (Ranunculaceae)] that is widely used for the treatment of diabetes, hyperlipidemia and hypertension. However, the pharmacokinetics of berberine in normal rats and type 2 diabetes mellitus (T2DM) model rats are not clear.OBJECTIVE: This study compares the pharmacokinetics of berberine between normal and T2DM model rats.MATERIALS AND METHODS: The T2DM model rats were fed with high fat diet for 4 weeks, induced by low-dose (30 mg/kg) streptozotocin for 72 h and validated by determining the peripheral blood glucose level. Rats were orally treated with berberine at a dose of 20 mg/kg and then berberine concentration in rat plasma was determined by employing a sensitive and rapid LC-MS/MS method.RESULTS: The significantly different pharmacokinetic behaviour of berberine was observed between normal and T2DM model rats. When compared with the normal group, Cmax, t1/2 and AUC(0-t) of berberine were significantly increased in the model group (17.35 ± 3.24 vs 34.41 ± 4.25 μg/L; 3.95 ± 1.27 vs 9.29 ± 2.75 h; 151.21 ± 23.96 vs 283.81 ± 53.92 μg/h/L, respectively). In addition, oral clearance of berberine was significantly decreased in the model group (134.73 ± 32.15 vs 62.55 ± 16.34 L/h/kg).DISCUSSION AND CONCLUSION: In T2DM model rats, the pharmacokinetic behaviour of berberine was significantly altered, which indicated that berberine dosage should be modified in T2DM patients.


Zhou Q.-X.,Weifang Peoples Hospital | Wang Z.-Y.,Yidu Central Hospital of Weifang | Zhao H.-F.,Weifang Peoples Hospital | Wang S.,Peoples Hospital Of Shouguang City
Experimental and Therapeutic Medicine | Year: 2017

The aim of the study was to evaluate the clinical efficacy of glucagon-like peptide-1 (GLP-1) analogues in children of pre-diabetes to delay or reverse the development of pre-diabetes into the state of diabetes by early intervention. Prospective and randomized controlled clinical trials were performed in 42 cases of newly diagnosed pre-diabetes in children. The sample size was randomly divided into the two groups. The first group included 21 subjects comprising the lifestyle intervention group, i.e., control group, and the second group included 21 subjects comprising the lifestyle intervention+GLP-1 analogues liraglutide group, i.e., observation group. Interventions carried out lasted 3 months. A review of intervention was carried out at 1 month and after 3 months. Medical examinations were carried out at the the time following diagnosis with pre-diabetes and after the intervention of 3 months. The medical test examinations included the fasting blood glucose (FPG), 2-hour postprandial blood glucose (2hPG), detection of glycated hemoglobin A1c (HbA1C), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), body mass index (BMI), insulin resistance (IR) and the islet cell functions. After 1 month of intervention, the observation group exhibited a better control on FPG and 2hPG compared with the control group (P<0.05). After 3 months of the intervention, FPG and 2hPG levels of the observation group were significantly lower than those of the control group (P<0.01). The levels of HbA1C, TC, TG, LDL-C, HDL-C, and BMI of the observation group were statistically better controlled, when compared with the control group after the intervention of 3 months. The IR index of the observation group was significantly decreased compared to that of the control group (P<0.05) and the islet function index of theβ-cell of the observation group showed statistically higher values than that of the control group (P<0.05). In conclusion, GLP-1 analogues are a better regulator of blood sugar levels, effectively improve lipid profile, body mass, IR and isletβ-cell function. Furthermore, GLP-1 analogues opens up a new way to intervene pre-diabetes in children. © 2017, Spandidos Publications. All rights reserved.


Xu B.,Yidu Central Hospital of Weifang | Zhang Y.,Weifang Medical University | Chen X.,Weifang Medical University | Zhang H.,Weifang Medical University
International Journal of Clinical and Experimental Medicine | Year: 2017

Renal transplantation is currently the most effective method for renal failure treatment. Renal transplant rejection is the main factor influencing the postoperative graft survival. Study showed that adenovirus mediated PD-L1 gene transfection can inhibit T cell proliferation and activation, while its role in renal transplantation has not been elucidated. Recipient rats were randomly divided into three groups, including control group, empty vector control, and transfection group. Real-time PCR and Western blot were applied to detect PD-L1 expression. The level between receptor survival and serum creatinine (Scr) were compared. ELISA was carried out to test the levels of IFN-γ, IL-2, IL-10, and IL-6. PD-L1 mRNA and protein expression increased significantly in transfection group than that of control group (P < 0.05). The rats in transfection group showed obvious longer survival time and better renal function index (P < 0.05). Cytokine IL-10 and IL-6 elevated, while IFN-γ and IL-2 declined in transfection group than that of control group (P < 0.05). Donar renal adenovirus mediated PD-L1 transfection can regulate the balance of Th1/ Th2 cytokines, improve receptor function, extend graft survival time, and inhibit renal transplant rejection through regulating immunosuppressive factor expression. © 2017, E-Century Publishing Corporation. All rights reserved.


Zhang Z.,Yidu Central Hospital of Weifang | Chen J.,Zhejiang Provincial Hospital of Traditional Chinese Medicine
Medicine (United States) | Year: 2016

Background: The study aimed to compare the effectiveness and safety of topical versus intravenous (IV) tranexamic acid (TXA) for reducing blood loss in primary total hip arthroplasty (THA). Methods: This systematic review and meta-analysis were performed according to the preferred reporting items for systematic reviews and meta-analyses statement criteria. PubMed, Embase, the Cochrane Library, Web of Science, Chinese Biomedicine Literature (CBM), Wanfang Database, China National Knowledge Infrastructure (CNKI), and Google Scholar were searched for randomized controlled trials (RCTs) and non-RCTs that compare topical versus IV-TXA administration for reducing blood loss during TKA from their inception to February, 2016. Meta-analysis was performed by Stata 12.0 software. Results: Seven studies comprising 2056 patients were included in this meta-analysis. No significant difference is found between topical TXA groups and IV-TXA groups regarding transfusion requirements (RR=1.37, 95% confidence interval [CI]: 0.96-1.97, P=0.083), total blood loss (MD 17.09, 95% CI: 33.74-67.91, P=0.510), and hemoglobin decline (MD 0.32, 95%CI: 0.04-0.69, P=0.122). Meanwhile, there is no significant difference in terms of the occurrence of deep venous thrombosis (RR= 1.09, 95% CI: 0.40-3.90, P=0.869). Conclusion: Topical TXA has a similar efficacy to IV-TXA in reducing both blood loss and transfusion rate without sacrificing safety in primary THA. Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. All.


Guo C.,University of Jinan | Yang X.,University of Jinan | Yang X.,Yidu Central Hospital of Weifang | Zhu W.,Yidu Central Hospital of Weifang | And 2 more authors.
Sensors and Actuators, B: Chemical | Year: 2014

The new polythiophene-based conjugated polymers Poly{3-[(4-{[2-(dimethylamino)ethyl]amino}cyclohexylidene)methyl]thiophene} (P1), Poly{3-[(4-{[3-(dimethylamino)propyl]amino}cyclohexylidene)methyl]thiophene} (P2) and Poly{3-{[4-(4-methylpiperazin-1-yl)cyclohexylidene]methyl}thiophene} (P3) have been synthesized by FeCl3 oxidative polymerization. Among the common metal ions tested, P1, P2 and P3 exhibited high selectivity and sensitivity toward Hg2+ in methanol aqueous solutions at pH 3 with a turn-off mode in which the detection limit of P3 for Hg2+ reached a level of 10-8 M. Additionally, the fluorescence of P1 in Tris-HCl buffer solution could be dramatically quenched in the presence of Cu2+ with a detection limit of 10-9 M. These sensing processes for Hg2+ and Cu2+ have been shown to be mediated by electrostatic effects and complexation. In addition, the P1-Cu2+ system was also employed as a turn-on fluorescence probe for the label-free detection of amino acids. © 2014 Elsevier B.V. All rights reserved.


PubMed | Qingdao University and Yidu Central Hospital of Weifang
Type: Journal Article | Journal: Oncology letters | Year: 2017

The purpose of this study was to analyze the safety and effectiveness of percutaneous radiofrequency ablation (RFA) in early stage renal cell carcinoma. A total of 76 patients suffering from early stage renal cell carcinoma were selected and randomly assigned into the observation group (41 cases) or the control group (35 cases). Percutaneous RFA was used in the observation group, while retroperitoneoscopic radical operation of renal cell carcinoma was used in the control group, and the operative effects were compared. In the observation group, operation time, blood loss during operation, length of stay and incidence rate of complications were lower than those in control group (P<0.05). For both groups, serum C-reactive protein, interleukin-6 and T lymphocyte counts at 1, 2 and 3 days after operation were all increased; however, the control group had significantly greater increase for all the time points (P<0.05). For total effective rates, tumour-free survival times and survival rates, there were no statistically significant differences between the two groups (P>0.05). Percutaneous RFA has a reduced size of operation wound and a quick postoperative recovery time in the treatment of early stage renal cell carcinoma. It results in less inflammation and immunity-based injuries in the body and achieves the same clinical outcomes as retroperitoneoscopic radical operation of renal cell carcinoma.


Dou H.,Yidu Central Hospital of Weifang | Tang S.,Jinan University
Turkish Neurosurgery | Year: 2014

AIm: To determine whether nucleotomy may aggravate lumbar degeneration at the operated level. Mat erIal and Methods: A normal healthy finite element model, two degeneration models and corresponding nucleotomy models of the L4-5 segment were created. Combined with 800 N preloading, 10 Nm moment was applied on the L4 superior endplate to simulate extension, flexion, left axial rotation and lateral bending, respectively. The shear stress of annulus fibrosus, posterior annulus bulge along with the contact force of facet joint at L4-5 were investigated. Result s: In all loading directions, the shear stress and contact force of the facet joint in two nucleotomy models were higher than those in mildly or moderately degenerative models, while the posterior annulus bulge was lower than those in mildly or moderately degenerative models. ConclusIon: Nucleotomy may adversely aggravate lumbar degeneration at the operated level.


Wang S.,Yidu Central Hospital of Weifang
Journal of Craniofacial Surgery | Year: 2016

ABSTRACT: Dumbbell-shaped epidural cavernous hemangiomas (CHs) are extremely rare, and they are easily misdiagnosed as spinal schwannomas. Herein, the authors report 1 rare case of dumbbell-shaped epidural CH in the thoracic spine. To the best of our knowledge, only a few cases of dumbbell-shaped epidural CHs in thoracic spine have been reported. Furthermore, the clinical characteristics and treatments for spinal epidural CHs were investigated and reviewed. © 2016 by Mutaz B. Habal, MD.


Gao S.,Yidu Central Hospital of Weifang
Journal of Craniofacial Surgery | Year: 2016

ABSTRACT: Cerebellar glioblastoma multiforme (cGBM) is rare in adults, accounting for <1% of all patients with glioblastoma multiforme (GBM). The accurate diagnosis of cGBM is important for establishing a suitable therapeutic schedule. However, the diagnosis of cerebellar GBM is not usually suspected preoperatively because of its rarity. Generally, patients with cGBMs typically presented with symptoms of raised intracranial pressure, and infrequently cerebellar symptoms such as gait ataxia and disequilibrium. Nevertheless, the authors reported a cGMB patient, with his clinical presentations and imaging characteristics mimicking a vestibular schwannoma. To the best of our knowledge, this is the first reported patient with cGBM mimicking a vestibular schwannoma. Furthermore, the diagnosis, treatment, and prognosis for cGBM were broadly investigated. © 2016 by Mutaz B. Habal, MD.


Liu K.,Yidu Central Hospital of Weifang
Journal of Craniofacial Surgery | Year: 2016

ABSTRACT: Brain abscess is a rare but potentially lethal infection of brain parenchyma, requiring prompt surgical intervention and high-dose antibiotic therapy. Brain abscess is a known complication of surgically treated intracerebral hemorrhage (ICH), but it is exceptionally rare that it occurs at the same site of a nonoperated ICH. Such cases may result from hematogenous spread from distant foci (pneumonia, infectious endocarditis) or contiguous sites. Herein, the authors report a case of 75-year-old woman presenting with a brain abscess 6 weeks after a nonoperated ICH. As the patient suffered from pneumonia during the course of ICH, the authors suspected that the brain abscess might originate from the pneumonia via hematogenous spread. The awareness of brain abscess formation at the site of ICH is of great importance for early diagnosis and prompt treatment. © 2016 by Mutaz B. Habal, MD.

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