Lang B.,China Three Gorges University |
Tang L.,China Three Gorges University |
Liu Y.,China Three Gorges University |
Ma J.,Yichang Peoples Central Hospital |
And 2 more authors.
Medical Journal of Wuhan University | Year: 2015
Objective: To investigate the differential value between the expression Cyclin D1, CD10 and Bcl-2in trichoblastoma (TB) and basal cell carcinoma (BCC). Methods: Cyclin D1, CD10 and Bcl-2were detected by immunochemical staining in mesenchymal cells of 19 TB and 50 BCC, Chi-square test was used for statistical analysis. Results: The negative rate of Cyclin D1 in TB was 100% and 10% in BCC, with significant difference (χ2=49.162 5, P<0.01). The positive rate of CD10 in TB and BCC were 89.5% and 36% respectively, the differences were statistically significant (χ2=15.750 9, P<0.01). The positive rate of Bcl-2in TB was 84.2% and the expression rate of Bcl-2was 18% in BCC, with statistical difference (χ2=26.123 7, P<0.01). In the single marker of the differential diagnosis, negative expression of Cyclin D1 showed high sensitivity and specificity. The positive expression of CD10 showed high sensitivity and the positive expression of Bcl-2showed high specificity. The specificity of the co-expression of Cyclin D1, CD10 and Bcl-2reached to 94%. Conclusion: The expression of Cyclin D1, CD10 and Bcl-2in mesenchymal cells of BCC and TB were remarkable different, which was valuable in the differential diagnosis. The specificity of the co-expression of Cyclin D1, CD10 and Bcl-2are higher than that of single marker. ©, 2015, Editorial Board of Medical Journal of Wuhan University. All right reserved.