Yerevan Institute Plastpolymer

Yerevan, Armenia

Yerevan Institute Plastpolymer

Yerevan, Armenia
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Tavakalyan N.B.,Yerevan Institute Plastpolymer | Karapetyan A.G.,Scientific Center for Radiation Medicine and Burns | Pogosyan A.S.,Scientific Center for Radiation Medicine and Burns | Abrahamyan A.K.,Scientific Center for Radiation Medicine and Burns | And 3 more authors.
Journal of Materials Science: Materials in Medicine | Year: 2010

The aim of this study was to investigate hemocompatibility and cytotoxicity properties of synthetic polymer coatings containing various unsaturated carbonic acids with vinylacetate. Co-polymers of vinylacetate and crotonic acid (CA), maleic acid (MA), and itaconic acid (IA) were made. The materials were characterized in terms of their adhesion to metal supports (titanium and stainless steel) as well as hemocompatibility (% hemolysis, wettability, erythrocyte aggregation, hemoglobin content, thrombocyte count and lipid peroxidation levels) and cytotoxicity (human endothelial cell activity in vitro and chromosome aberrations, bone marrow proliferation and cell ploidy in rats). Co-polymers of unsaturated carbonic acids with vinylacetate exhibited good hemocompatibility properties, as opposed to vinylacetate homopolymer for which substantial levels of hemolysis were observed. By coating the metal supports with co-polymers the cytotoxic effects associated with the bare metal samples were markedly reduced. MA samples showed excellent hemocompatibility and no cytotoxicity, yet they lacked good adhesion properties to metal substrate, probably due to high water content. CA samples, having the highest density of carboxylic groups among the samples under investigation, showed increased bone marrow proliferation activity and cell ploidy in rats, as compared to controls. The most promising results in the present study were obtained for the samples with IA, which showed good adhesion to metal substrates, good hemocompatibility and low cytotoxicity. Thus, co-polymers of vinylacetate and IA rich in carboxylic groups are promising materials for the design of novel drug-eluting stents. © Springer Science+Business Media, LLC 2010.


Sargsyan V.,Yerevan Institute Plastpolymer | Hayriyan L.,Yerevan Institute Plastpolymer | Harutyunyan G.,Yerevan Institute Plastpolymer | Tavakalyan N.,Yerevan Institute Plastpolymer | Voskanyan P.,Yerevan Institute Plastpolymer
NATO Science for Peace and Security Series B: Physics and Biophysics | Year: 2013

The objective of this investigation is to study kinetics of anesthetic lidocaine release from polymeric gel and film in water and saline. We also investigated the mechanism of binding of non-radioactive compounds of cobalt and cesium from various solid surfaces with water soluble polymeric systems. The participation of the functional units of copolymer in the binding of cobalt and cesium is studied. The efficiency of aqueous polymeric compositions for the treatment of various solid surfaces from radioactive contamination was established. © 2013 Springer Science+Business Media Dordrecht.


PubMed | Yerevan Institute Plastpolymer
Type: Journal Article | Journal: Journal of materials science. Materials in medicine | Year: 2010

The aim of this study was to investigate hemocompatibility and cytotoxicity properties of synthetic polymer coatings containing various unsaturated carbonic acids with vinylacetate. Co-polymers of vinylacetate and crotonic acid (CA), maleic acid (MA), and itaconic acid (IA) were made. The materials were characterized in terms of their adhesion to metal supports (titanium and stainless steel) as well as hemocompatibility (% hemolysis, wettability, erythrocyte aggregation, hemoglobin content, thrombocyte count and lipid peroxidation levels) and cytotoxicity (human endothelial cell activity in vitro and chromosome aberrations, bone marrow proliferation and cell ploidy in rats). Co-polymers of unsaturated carbonic acids with vinylacetate exhibited good hemocompatibility properties, as opposed to vinylacetate homopolymer for which substantial levels of hemolysis were observed. By coating the metal supports with co-polymers the cytotoxic effects associated with the bare metal samples were markedly reduced. MA samples showed excellent hemocompatibility and no cytotoxicity, yet they lacked good adhesion properties to metal substrate, probably due to high water content. CA samples, having the highest density of carboxylic groups among the samples under investigation, showed increased bone marrow proliferation activity and cell ploidy in rats, as compared to controls. The most promising results in the present study were obtained for the samples with IA, which showed good adhesion to metal substrates, good hemocompatibility and low cytotoxicity. Thus, co-polymers of vinylacetate and IA rich in carboxylic groups are promising materials for the design of novel drug-eluting stents.

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