Boris Yeltsin Federal University

Yekaterinburg, Russia

Boris Yeltsin Federal University

Yekaterinburg, Russia
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Savateev K.V.,Boris Yeltsin Federal University | Ulomsky E.N.,Boris Yeltsin Federal University | Fedotov V.V.,Boris Yeltsin Federal University | Rusinov V.L.,Boris Yeltsin Federal University | And 4 more authors.
Russian Journal of Bioorganic Chemistry | Year: 2017

Promising 6-nitro-1,2,4-triazolo[1,5-a]pyrimidine analogues, structural analogues of synthetic inhibitors of adenosine receptors, were sorted out on the basis of quantum-chemical calculations. The compounds were synthesized by nitration and chlorodeoxygenation reactions. The in vivo activity of 6-nitroheterocycles was studied and the affinity to adenosine receptor A2A was demonstrated in regard to septic conditions. © 2017, Pleiades Publishing, Ltd.

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