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Tokman H.B.,Istanbul University | Aslan M.,Istanbul University | Ortakoylu G.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital | Algingil R.C.,Istanbul University | And 7 more authors.
Clinical Laboratory | Year: 2014

Background: Numerous molecular-based tests were applied for the laboratory-based diagnosis of viruses. In this cross-sectional case control study, in addition to bacteria, we aimed to determine respiratory viruses using, for the first time in our country, the Reverse Transcription PCR DNA Microarray method, and we also aimed to evaluate its diagnostic performance. Methods: Respiratory viruses were investigated from nasopharyngeal swabs of 76 patients diagnosed with atypical pneumonia and 64 healthy controls using the CLART® Pneumovir (Genomica, Spain) kit and from 10 mL blood samples of the same subjects. M. pneumoniae IgM was detected by ELISA and L. pneumophila IgM and C. pneumoniae IgM by indirect immunofluorescence. Person's chi-square test was used for statistical analysis. Results: Our results showed that the specificity (100%) and the positive predictive value (100%) of the CLART® Pneumovir kit were high, but its sensitivity (53%), its negative predictive value (64%), and its kappa value (50%) were low. Parainfluenza Virus type 3 and M. pneumoniae were found alone or together as the most common microorganisms while no cases of human bocavirus, adenovirus, rhinovirus, or coronavirus were detected. Conclusions: Our results demonstrated that, during the study period, most of our patients had atypical pneumonia due to Parainfluenza Virus type 3 and M. pneumoniae co-infection. Source


Kocatas A.,Tevfik Saglam Cad. No 11 | Dural A.,Tevfik Saglam Cad. No 11 | Sever N.,Bakirkoy Dr Sadi Konuk Training And Research Hospital | Kankaya B.,Tevfik Saglam Cad. No 11 | And 6 more authors.
Journal of Minimal Access Surgery | Year: 2014

Granular cell tumour (GCT), which is a rare benign soft tissue neoplasm, is mostly found in the skin and soft tissue but may develop anywhere in the body. There are less than 10 reported cases of mediastinal GCTs in the current literature. Furthermore, colonic GCTs have recently gained attention due to the increased public awareness on the importance of colonoscopy screening. We report a case of a 52-year-old woman diagnosed incidentally with synchronous GCTs of the mediastinum and the hepatic flexure on her routine screening for post-operative follow-up for status-post right modified radical mastectomy due to a T 2 N 1 M 0 , Stage 2B breast cancer. Source


Yasar Z.,Abant Izzet Baysal University | Cetinkaya E.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital
Tuberkuloz ve Toraks | Year: 2015

Idiopathic pulmonary fibrosis (IPF) is a progressive, irreversible and eventually fatal chronic interstitial pneumonia limited to the lung and associated with the histological and/or radiological pattern of usual interstitial pneumonia.The mean age of the disease is 65 and it is more frequent in men than women. The disease washistorically considered as an inflammatory disease, but currently this has shifted towards a prominent role of impaired wound healing process. The diagnosis of disease requires exclusion of other known causes of interstitial lung disease, the presence of a usual interstitial pneumonia pattern on high -resolution computed tomography (HRCT) in patients or specific combinations of HRCT and surgical lung biopsy patterns. The patients are considered as mild, moderate and severe according to the symptoms, radiological and pulmonary function tests. It is difficult to predict the course of the disease; clinical exacerbation can be seen after a long stable period. Average median survival is approximately 3 years. Advanced age, smoking, low body mass index, widespread radiological involvement, comorbidities and complications (pulmonary hypertension, emphysema, and bronchogenic cancer) are considered as poor prognostic factors. The treatment approach is the basis on the severity of the disease and patient preference. The recent positive result of the pirfenidone and nintedanib phase II and III clinical trials based on the prevailing mechanism of İPF pathogenesis particularly targeted fibroblast activation and myofibroblast differentiation have currently been reported. Initiating therapy with pirfenidone and nintedanib is recommended for the patients with mild and moderate İPF who do not have underlying liver disease and who live in area where these drugs are available. Nausea and rashes are more common in treatment with pirfenidone while diarrhea and deterioration in liver function tests are seen more frequently in nintedanib. The information regarding participation in randomized trials should be given to all patients and also early referral for transplantation should be considered. © 2015, Ankara University. All rights reserved. Source


Yasar Z.,Abant Izzet Baysal University | Cetinkaya E.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital
Tuberkuloz ve Toraks | Year: 2014

Bronchial thermoplasty is a non-drug treatment modality for moderate-to-severe asthma that involves the delivery of radio frequency energy to the airway wall in a precisely controlled manner to reduce excessive airway smooth muscle. Bronchial thermoplasty is performed under conscious sedation and completed in three bronchoscopy sessions, each lasting less than one hour, and each spaced apart by about three weeks. Bronchial thermoplasty has been demonstrated to reduce severe exacerbations, emergency rooms visits for respiratory symptoms, and time lost from work, school and other daily activities and improve asthma control and quality of life in patients with moderate-to-severe asthma. Adequate patient management is important for patient comfort and safety. In this review, we aim to discuss clinical studies, the evidence for the efficacy of bronchial thermoplasty, the importance of careful patient selection, patient preparation, patient management, procedure. © 2014 Ankara University. All rights reserved. Source


Kocaturk C.I.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital | Seyhan E.C.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital | Gunluoglu M.Z.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital | Urer N.,Yedikule Chest Diseases and Chest Surgery Training and Research Hospital | And 3 more authors.
Tuberkuloz ve Toraks | Year: 2012

Introduction: Primary pulmonary non-Hodgkin's lymphoma (PPNHL) of the lung occurs very rarely. To clarify clinical features, treatment alternatives and outcomes, we evaluated our surgically diagnosed PPNHL cases. Materials and Methods: A retrospective review of PPNHL cases from January 2004 to December 2009 was performed. Demographic and clinical data are presented as means or medians. Overall survival was estimated using the Kaplan-Meier method. Survival rates were compared using the log-rank test. A p value < 0.05 was considered significant. Results: Patients were eight males and two females with a median age of 50 years (range, 29-76 years). In 40% of the patients, antigenic stimulation, immune-suppression or auto-immune disease could not been found. All patients were symptomatic at presentation. Surgical procedures were needed to obtain a diagnosis (nine wedge resections and one pneumonectomy). Eight patients had an extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), and two had diffuse large B-cell lymphomas. The patients were treated with observation (pneumonectomy case), chemotherapy (n= 7), and chemotherapy and radiotherapy (n= 1). Five-year survival was 76%. Difference in survival rates of patients with bilateral vs. unilateral disease were not statistically different. Conclusions: On contrary of the literature, PPNHL can occur with absence of antigenic stimulation, and patients generally have some symptoms. Chemotherapy or surgery can be used to treat PPNHL. Patient survival is good. Source

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