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Ozgul M.A.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Cetinkaya E.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Gul S.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Dincer H.E.,University of Minnesota | And 3 more authors.
European Journal of Oncology | Year: 2016

Objective: Endobronchial benign tumors are rarely seen in lung cancers or in pulmonary benign tumors. In recent years, endoscopic treatment has increasingly been used to treat benign endobronchial lesions. Methods: Data from all adult patients diagnosed with a histologically proven endobronchial hamartoma and lipoma were collected between 2009 and 2014 at our clinic in the Yedikule Chest Diseases Education and Research Hospital. Results: 9 patients were included in the study; 6 patients were diagnosed with endobronchial hamartoma(66%) and 3 had endobronchial lipoma. Six patients were symptomatic. All patients underwent rigid bronchoscopy and biopsies taken during treatment were diagnostic in all cases. Lesions were mostly located at the lobar bronchus. Seven (77%) cases were successfully treated and there were no complications because of the procedure. Two patients was sent for lobectomy because of inadequate debulking. Recurrence was not seen in any patient. Conclusion: Interventional bronchoscopic techniques may be a safe and effective method for diagnosing and treating endobronchial benign tumors. © Mattioli 1885.

Boyac H.,Merzifon Karamustafa Pasa State Hospital | Cortuk M.,Karabük University | Gul S.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Tanrverdi E.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | And 3 more authors.
Medicinski Glasnik | Year: 2017

Aim Carcinoid tumors of the lung are the tumors originating from the neuroendocrine cells. Surgical excision remains the gold standard for the treatment. Treatment with interventional bronchoscopic excision has also been reported as an alternative option in typical carcinoid tumors of the lung. The aim of this study was to present results and outcomes in patients who were bronchoscopically treated and followed-up. Methods Data of 14 patients, who had undergone bronchoscopic excision due to typical carcinoid tumor of the lung between April 2008 and July 2015 were retrospectively evaluated. Bronchoscopic excision procedures were performed under general anesthesia, while control bronchoscopies were carried out with flexible bronchoscopy. Time between the first and last bronchoscopies was accepted as the follow-up duration. Results A total of 14 patients was evaluated with eight (57.1%) males. Mean age was 43.57±14.07 (23-68) years. The most common symptoms were shortness of breath and coughing. Mean of 5.69±3.35 (2-12) bronchoscopy procedures were performed in the patients during the diagnosis, treatment and follow-up. Mean follow-up duration was 32.0±19.22 months. At the long-term follow-up, two patients developed 50% stenosis and one patient developed granulation tissue in the endobronchial treatment site. None of the patients developed recurrence during the mean 32-month follow-up. Conclusion Endobronchial treatment is a safe and successful treatment method in well selected typical carcinoid tumor cases that are centrally located, having no radiological suspicion of local or distant metastasis, distally visible but not located on the bronchi with a wide base on bronchoscopy. © 2017, Medical Association of Zenica-Doboj Canton. All rights reserved.

Kocagoz T.,Acibadem University | Altin S.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Turkyilmaz T.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Tas T.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | And 8 more authors.
Diagnostic Microbiology and Infectious Disease | Year: 2012

We have evaluated the efficiency of the TK Rapid Mycobacterial Culture System in isolating mycobacteria from clinical samples and in susceptibility testing. The TK Medium indicates mycobacterial growth by changing its color from red to yellow. During a 1-year period, 16,303 clinical samples were inoculated to TK selective (TK SLC) and Löwenstein-Jensen media (LJ). Mycobacteria were isolated in 2150 (13.04%) samples in at least 1 type of medium. While LJ isolated mycobacteria from 1920 (11.69%) of all samples, TK SLC isolated 2070 (12.63%). Among all positives, the isolation rates for LJ and TK SLC were 89.30% and 96.27%, respectively. Contamination of cultures by other organisms was observed in 878 (5.33%) LJ tubes and in 90 (0.55%) TK SLC tubes. On average, time-to-growth detection was 15.57 days in TK SLC and 25.14 days in LJ. The modes of time-to-growth detection were 12 and 25 days for TK SLC and LJ, respectively. The reliability of antimycobacterial susceptibility testing was checked by 36 . Mycobacterium tuberculosis strains with known susceptibility patterns which were obtained from the World Health Organization collection and by participating in an external quality control program. All susceptibility results, except for a few borderline-resistant strains, were consistent with the expected susceptibility patterns. The TK Rapid Mycobacterial Culture System is a practical and reliable automated system that shortens the time required for both culture and susceptibility results. All types of TK Media are ready to use, saving time and effort as well as drastically reducing contamination during testing. © 2012 Elsevier Inc.

PubMed | Ankara University, Celal Bayar University, Pamukkale University, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital and 13 more.
Type: Journal Article | Journal: Cancer epidemiology | Year: 2015

The early diagnosis and treatment of lung cancer are important for the prognosis of patients with lung cancer. This study was undertaken to investigate patient and doctor delays in the diagnosis and treatment of NSCLC and the factors affecting these delays.A total of 1016 patients, including 926 (91.1%) males and 90 (8.9%) females with a mean age of 61.510.1 years, were enrolled prospectively in this study between May 2010 and May 2011 from 17 sites in various Turkish provinces.The patient delay was found to be 49.996.9 days, doctor delay was found to be 87.799.6 days, and total delay was found to be 131.3135.2 days. The referral delay was found to be 61.6127.2 days, diagnostic delay was found to be 20.444.5 days, and treatment delay was found to be 24.454.9 days. When the major factors responsible for these delays were examined, patient delay was found to be more frequent in workers, while referral delay was found to be more frequent in patients living in villages (p<0.05). We determined that referral delay, doctor delay, and total delay increased as the number of doctors who were consulted by patients increased (p<0.05). Additionally, we determined that diagnostic and treatment delays were more frequent at the early tumour stages in NSCLC patients (p<0.05).The extended length of patient delay underscores the necessity of educating people about lung cancer. To decrease doctor delay, education is a crucial first step. Additionally, to further reduce the diagnostic and treatment delays of chest specialists, multidisciplinary management and algorithms must be used regularly.

Aydin S.,Istanbul University | Aytac E.,Istanbul University | Uzun H.,Istanbul University | Altug T.,Istanbul Science University | And 4 more authors.
Asian Journal of Surgery | Year: 2010

OBJECTIVE: Obstructive jaundice develops after occlusion of the common bile duct. Direct hyperbilirubinaemia, which occurs secondary to the condition, causes various life-threatening pathologies. Cytoprotective effects of Ganoderma lucidum (GL) have previously been shown. In this study, the effects of GL on oxidative stress and oxidant DNA damage in experimental obstructive jaundice were evaluated. METHODS: Sixty Wistar albino adult female rats were randomly divided into six weight-matched equal groups: sham group, bile duct ligated group (BDL); after sham operation 250 mg/kg/d of GL administered group, after sham operation 500 mg/kg/d of GL administered group, after bile duct ligation 250 mg/kg/d of GL administered (GL1BDL) group, and after bile duct ligation 500 mg/kg/d of GL administered (GL2BDL) group. GL polysaccharide was orally administered to the rats via gavage tube once a day for 14 days after bile duct ligation. RESULTS: The plasma malondialdehyde levels of the GL1BDL and GL2BDL groups were significantly lower than those of the BDL group (p < 0.01). The plasma 8-hydroxy-2′-deoxyguanosine levels of the GL1BDL and GL2BDL groups were significantly lower than those of the BDL group (p < 0.001). The liver tissue Cu-Zn superoxide dismutase level of the GL2BDL group was significantly higher than that of the BDL group (p < 0.05). CONCLUSION: GL protected against DNA and liver tissue damage by reducing oxidative stress in obstructive jaundice. © 2010 Asian Surgical Association.

Okumus G.,Istanbul University | Musellim B.,Istanbul University | Cetinkaya E.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Turker H.,Sureyyapasa Training and Research Hospital for Chest Diseases and Thoracic Surgery | And 21 more authors.
Respirology | Year: 2011

Background and objective: Extrapulmonary sarcoidosis is common, and is almost always associated with concomitant thoracic involvement. Extrapulmonary manifestations vary on the basis of gender, age at presentation and ethnicity. The aim of this study was to investigate extrapulmonary involvement in patients with sarcoidosis in Turkey. Methods: This study was conducted by Turkish Thoracic Society Clinical Problems Study Group.New cases of sarcoidosis between 1 June 2004 and 31 May 2006 were recorded on electronic case record forms sent to all potential investigators and information about extrapulmonary involvement was collected. Results: One hundred and nineteen of 293 patients (83 female, 36 male, mean age = 45 ± 12 years) had extrapulmonary involvement in this study (40.6%).The median time to diagnosis was 6 months and this was longer than patients with just thoracic sarcoidosis (P = 0.001). Extrapulmonary symptoms were present in 181 (61.8%) patients,and skin lesions, arthralgia and back pain were the commonest (33.4%, 20.8% and 16.4%, respectively). Incidence of organ involvement was independent of age with the exception of ocular involvement, which was higher in those under the age of 40 years (P = 0.007). Conclusions: Skin and peripheral lymph node involvement were the most common sites of extrapulmonary involvement and ocular involvement was more common in those under the age of 40 years in patients with sarcoidosis in a Turkish population. © 2011 The Authors Respirology © 2011 Asian Pacific Society of Respirology.

PubMed | University of Minnesota, Istanbul University, Karabük University, Yedikule Chest Diseases and Chest Surgery Education and Research Hospital and Merzifon Kara Mustafa Pasa State Hospital
Type: | Journal: Case reports in medicine | Year: 2016

Fungal infections of the lung are uncommon and mainly affect people with immune deficiency. There are crucial problems in the diagnosis and treatment of this condition. Invasive pulmonary aspergillosis and candidiasis are the most common opportunistic fungal infections. Aspergillus species (spp.) are saprophytes molds that exist in nature as spores and rarely cause disease in immunocompetent individuals. In patients with immune deficiency or chronic lung disease, such as cavitary lung disease or bronchiectasis, Aspergillus may cause a variety of aspergillosis infections. Here we present a case of a 57-year-old patient without immunodeficiency or chronic lung disease who was diagnosed with endotracheal fungus ball and chronic fungal infection, possibly due to Aspergillus. Bronchoscopic examination showed a paralyzed right vocal cord and vegetating mass that was yellow in color, at the posterior wall of tracheal lumen. After 3 months, both the parenchymal and tracheal lesions were completely resolved.

Onur S.T.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Gunluoglu Z.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Dalar L.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | Sokucu S.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | And 2 more authors.
Journal of the Pakistan Medical Association | Year: 2013

Angiosarcoma is a rare soft tissue tumour and constitutes less than 1% of all soft tissue cancers. Pleural angiosarcomas are extremely rare and have an aggressive course. We report the case of a 79-year-old female patient who presented with complaints of increasing dyspnoea on exertion and homogeneous opacification of the left hemithorax on chest radiograph. Epithelioid angiosarcoma was determined on pleural tissue obtained by video-assisted thoracoscopic surgery (VATS).

Kiran B.,Istanbul University | Cagatay T.,Istanbul University | Clark P.,Yeditepe University | Kosar F.,Yedikule Chest Diseases and Chest Surgery Education and Research Hospital | And 4 more authors.
Archives of Medical Science | Year: 2010

Introduction: Despite the development and wide implementation of Directly Observed Therapy Strategies (DOTS), multidrug-resistant tuberculosis (MDR-TB) remains a serious global health threat. In this study, the role of host immune response in patients with MDR-TB is investigated and compared with that of patients with smear-positive drug-sensitive tuberculosis (SP-TB). Material and methods: 27 patients with SP-TB, 20 patients with MDR-TB, and 20 healthy controls were included in the study. Immune parameters were determined by flow cytometry using monoclonal antibodies in order to compare the percentage values of these markers in the two study groups and the control group. Results: The levels of lymphocyte subgroups in the gate of CD45(+)/CD14(-) lymphocyte: CD45(+), CD3(+), CD4(+), NK, CD3/HLA-DR, CD 95(+) cells were significantly lower; by contrast CD23(+), CD25(+), CD19(+), CD4(+)/CD8(+), HLA-DR cells were found to be lower, but not significantly so in patients with MDR-TB, compared to levels in patients in the SP-TB and control groups. Besides these findings, the levels of NKT cells and γδ TCR(+) cells were significantly higher in the MDR-TB than in the healthy control and SP-TB group. Conclusions: The lower levels of CD3/HLA-DR, CD4 (+), Fas (+), and NK, and the higher level of NKT together with γδ T cells in patients with MDR-TB compared to those in SP-TB may indicate a profound immune suppression in MDR-TB patients and thereby may denote an accumulation in the bacterial load. Our findings may shed light on the pathogenesis and prognosis of MDR tuberculosis, and may point towards the use of flow cytometry findings as an aid to early diagnosis in MDR-TB patients. Copyright © 2010 Termedia & Banach.

PubMed | Yedikule Chest Diseases and Chest Surgery Education and Research Hospital
Type: Journal Article | Journal: Journal of bronchology & interventional pulmonology | Year: 2012

Endobronchial metastasis of urinary bladder cancer is rare. A 71-year-old man presented with shortness of breath and cough. He was diagnosed with prostate adenocarcinoma and transitional cell carcinoma of the urinary bladder in the past. Bronchoscopy identified grape-like endotracheal lesions clustering over the distal tracheal wall obstructing 50% of the tracheal lumen and causing an almost complete obstruction of the left main bronchus. There was also extrinsic compression of the left main bronchus along with patchy nodular tumoral lesions involving the right main and the intermediate bronchial walls. Histologic examination of the lesions showed endobronchial metastasis from the bladder cancer. Bronchoscopy is a highly valuable method for evaluating the uncommon endobronchial metastases. Therapeutic bronchoscopy in such cases can contribute to improving quality of life and may impact the survival of the patient. Our patient survived for 5 months after a therapeutic bronchoscopy.

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