Yawatahama City, Japan
Yawatahama City, Japan

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Takahashi T.,Yamaguchi Grand Medical Center | Maeda K.,Laboratory of Veterinary Microbiology | Suzuki T.,National Institute of Infectious Diseases | Ishido A.,Yamaguchi Grand Medical Center | And 46 more authors.
Journal of Infectious Diseases | Year: 2014

Background. Severe fever with thrombocytopenia syndrome (SFTS) is caused by SFTS virus (SFTSV), a novel bunyavirus reported to be endemic in central and northeastern China. This article describes the first identified patient with SFTS and a retrospective study on SFTS in Japan.Methods. Virologic and pathologic examinations were performed on the patient's samples. Laboratory diagnosis of SFTS was made by isolation/genome amplification and/or the detection of anti-SFTSV immunoglobulin G antibody in sera. Physicians were alerted to the initial diagnosis and asked whether they had previously treated patients with symptoms similar to those of SFTS.Results. A female patient who died in 2012 received a diagnosis of SFTS. Ten additional patients with SFTS were then retrospectively identified. All patients were aged ≥50 years and lived in western Japan. Six cases were fatal. The ratio of males to females was 8:3. SFTSV was isolated from 8 patients. Phylogenetic analyses indicated that all of the Japanese SFTSV isolates formed a genotype independent to those from China. Most patients showed symptoms due to hemorrhage, possibly because of disseminated intravascular coagulation and/or hemophagocytosis.Conclusions. SFTS has been endemic to Japan, and SFTSV has been circulating naturally within the country. © 2013 The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.


Oda S.,Ehime University | Yanagihara Y.,Ehime University | Sawada Y.,Ehime University | Azuma K.,Ehime University | And 9 more authors.
Nishinihon Journal of Urology | Year: 2011

We report an extensive case of small cell carcinoma of the urinary bladder in a patient who was treated with multimodal therapy and achieved complete remission. A 54-year-old women with the chief complaint of macrohematuria was admitted to our hospital. MRI showed a bladder tumor in the posterior wall of the urinary bladder and invasion into the perivesical fat. Abdominal CT showed liver and right intra-pelvic lymph node metastases. Transurethral resection of the bladder tumor (TUR-BT) was performed and histological diagnosis was pure small cell carcinoma of the urinary bladder. Three courses of combination chemotherapy with etoposide and carboplatin were administered under a preoperative diagnosis of T3bN2M1. After the chemotherapy, the sizes of lymph node metastases became reduced and the liver metastasis disappeared. Total cystectomy and pelvic lymphadenectomy with ileal conduit were performed. Microscopic examination did not show any viable tumor cells. Five months after the operation, multiple brain metastases were revealed. Cranial irradiation (total, 30Gy) and three cycles of combination chemotherapy with etoposide and carboplatin were administered. Subsequent brain CT showed complete remission. The patient was carefully followed up for 12 months after completion of the second course of chemotherapy, without any tumor recurrence.


Fujiwara Y.,Yawatahama City General Hospital | Nakajima M.,Yamaguchi University | Tomochika S.,Yawatahama City General Hospital | Matoba K.,Yawatahama City General Hospital
Japanese Journal of Cancer and Chemotherapy | Year: 2014

A 65-year-old woman was admitted to our hospital owing to difficulty walking and an abdominal tumor in the right lower abdomen. An irregular mass with calcification was detected in her cecum, and abdominal, intraabdominal, and retroperitoneal abscess was detected by computed tomography (CT). An irregular mass was diagnosed as Group 5 adenocarcinoma by biopsy. After the inflammation improved by abscess drainage, we conducted ileocecal resection and fenestrated the abscess. Pathological analysis showed well-differentiated tubular adenocarcinoma: dimensions 20×20 mm, pSS, stroma: med, INFa, ly1, v0, pPM0 (70mm), pDM0 (70mm), pRM0 (8mm), LN (-): #201: (0/9), fStage II. The patients can now walk, and she remains in good health and has been recurrence-free 8 months after surgery. To our knowledge, colon cancer with an abdominal abscess is comparatively rare, and we discuss this in light of the literature.


Tezuka M.,Ehime Prefectural Central Hospital | Ohta M.,Ehime University | Ochi F.,Yawatahama City General Hospital | Chisaka T.,Ehime University | And 2 more authors.
Pediatrics International | Year: 2015

Infantile hemangioma (IH) is the most common tumor of infancy, and it sometimes associated with Kasabach-Meritt syndrome (KMS) characterized by anemia, intraperitoneal hemorrhage secondary to rupture, coagulopathy, jaundice, and vascular malformations involving the brain, skin, gut, and other organs. Here, we report two newborn patients having IH with KMS at birth. The first patient had a giant hemangioma in the liver, which was successfully treated with i.v. corticosteroid and coil embolization. The second patient had a large hemangioma of the right axillary region, which was also successfully treated with i.v. corticosteroid, beta-blocker, coil embolization and local irradiation. All symptoms were controlled without any side-effects in both patients. According to these findings, combination therapy including coil embolization and corticosteroid is effective for IH patients with KMS. The indications for and timing of coil embolization should be determined further cases have been accumulated. © 2015 Japan Pediatric Society.


Yanagihara Y.,Ehime University | Miura N.,Ehime University | Azuma K.,Ehime University | Sasaki T.,Ehime University | And 8 more authors.
Japanese Journal of Urology | Year: 2011

(PURPOSE) Efficacy and tolerability of docetaxel-based chemotherapy against hormone-refractory prostate cancer (HRPC) has been shown lately. The objective of this study was to evaluate retrospectively the efficacy and toxicity of low-dose docetaxel in combination with dexamethasone. (PATIENTS AND METHODS) Sixteen patients, with a median age of 69.5 years (range 54-85 years), diagnosed with HRPC were administered a treatment regimen consisting of docetaxel (60-80 mg/body or 50 mg/m2) once every 3 or 4 weeks and dexamethasone 1 mg daily at our institution between November, 2004 and March, 2010. (RESLTS) The patients received a median of 11.5 cycles of treatment (range, 2-35 cycles). Eleven of 16 patients (68.8%) had a ≥ 50% decrease in serum prostate-specific antigen. The median progression-free survival and overall survival times were 7.1 and 20.3 months, respectively. Grade 3 neutropenia occurred only in 2 patients. Infective endocarditis, gastrointestinal or cerebral hemorrhage, and compressive fracture were occurred in each patient. (CONCLUSINONS) The combination of low-dose docetaxel every 3-4 weeks and dexamethasone daily was effective and well tolerated in patients with HRPC. However, it is necessary to pay continuous attention to side effects due to the frequent presence of comorbid diseases particularly in the elderly. © 2011 Japanese Urological Association.


Fujiwara Y.,Yawatahama City General Hospital | Nakajima M.,Yawatahama City General Hospital | Tomochika S.,Yawatahama City General Hospital | Matoba K.,Yawatahama City General Hospital
Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2014

A 65-year-old woman was admitted to our hospital owing to difficulty walking and an abdominal tumor in the right lower abdomen. An irregular mass with calcification was detected in her cecum, and abdominal, intraabdominal, and retroperitoneal abscess was detected by computed tomography(CT). An irregular mass was diagnosed as Group 5 adenocarcinoma by biopsy. After the inflammation improved by abscess drainage, we conducted ileocecal resection and fenestrated the abscess. Pathological analysis showed well-differentiated tubular adenocarcinoma: dimensions 20 × 20 mm, pSS, stroma: med, INF a, ly1, v0, pPM0 (70 mm), pDM0 (70 mm), pRM0 (8mm), LN(-): #201: (0/9), fStageII. Thepatie nts can now walk, and she remains in good health and has been recurrence-free 8 months after surgery. To our knowledge, colon cancer with an abdominal abscess is comparatively rare, and we discuss this in light of the literature.


Ninomiya D.,Yawatahama City General Hospital | Hasebe S.,Yawatahama City General Hospital | Senba T.,Yawatahama City General Hospital | Sakai T.,Yawatahama City General Hospital | Uemura S.,Yawatahama City General Hospital
Journal of the Japan Diabetes Society | Year: 2012

A 77-year-old male with hypertension was admitted to the hospital because of hypoglycemia. He had a history of back pain, and Loxoprofen had been prescribed for 1 month. The level of immunoreactive insulin was 196.6 jJ.U/ml, anti-insulin antibody was positive, and HLA typing indicated the presence of the DRB1 04 : 06 allele. The patient had not taken any medications, except for Loxoprofen, amlodipine, candesartan and hydrochlorothiazide. Therefore, he was diagnosed to have insulin autoimmune syndrome (IAS). He was initially permitted to take small meals 5 times a day to avoid hypoglycemia; however, hypoglycemia was observed several times. Subsequently, the patient was treated with an a-glucosidase inhibitor to decrease the frequency of hypoglycemia. Continuous glucose monitoring (CGM) showed that the a-glucosidase inhibitor could prevent hypoglycemia due to IAS. In conclusion, an a-glucosidase inhibitor should be considered for the treatment of hypoglycemia due to IAS. Further, CGM is useful for monitoring hypoglycemia.


PubMed | Yawatahama City General Hospital, Ehime Prefectural Central Hospital and Ehime University
Type: Journal Article | Journal: Pediatrics international : official journal of the Japan Pediatric Society | Year: 2015

Infantile hemangioma (IH) is the most common tumor of infancy, and it sometimes associated with Kasabach-Meritt syndrome (KMS) characterized by anemia, intraperitoneal hemorrhage secondary to rupture, coagulopathy, jaundice, and vascular malformations involving the brain, skin, gut, and other organs. Here, we report two newborn patients having IH with KMS at birth. The first patient had a giant hemangioma in the liver, which was successfully treated with i.v. corticosteroid and coil embolization. The second patient had a large hemangioma of the right axillary region, which was also successfully treated with i.v. corticosteroid, beta-blocker, coil embolization and local irradiation. All symptoms were controlled without any side-effects in both patients. According to these findings, combination therapy including coil embolization and corticosteroid is effective for IH patients with KMS. The indications for and timing of coil embolization should be determined further cases have been accumulated.


PubMed | Yawatahama City General Hospital
Type: Journal Article | Journal: Journal of orthopaedics | Year: 2016

We report a case of an 84-year-old male with multiple levels of canal stenoses who are diagnosed as Charcot arthropathy of bilateral knees. Although he did not feel any pain, recurrence of joint fluid collection and severe instability prevented him from standing and walking. Deficit in superficial sensation and bathyesthesia below the level of Th10, and tendon reflexes of extremities were seen. Romberg test was positive. Laboratory data showed no abnormal findings. We performed bilateral TKA based on the diagnosis of Charcot arthropathy. At 3-year follow-up, there is no complaint about joint instability and collection of joint fluid.


PubMed | Yawatahama City General Hospital
Type: Case Reports | Journal: Gan to kagaku ryoho. Cancer & chemotherapy | Year: 2015

A 65-year-old woman was admitted to our hospital owing to difficulty walking and an abdominal tumor in the right lower abdomen. An irregular mass with calcification was detected in her cecum, and abdominal, intraabdominal, and retroperitoneal abscess was detected by computed tomography(CT). An irregular mass was diagnosed as Group 5 adenocarcinoma by biopsy. After the inflammation improved by abscess drainage, we conducted ileocecal resection and fenestrated the abscess. Pathological analysis showed well-differentiated tubular adenocarcinoma: dimensions 20 20 mm, pSS, stroma: med, INF a, ly1, v0, pPM0 (70 mm), pDM0 (70 mm), pRM0 (8mm), LN(-): #201: (0/9), fStageII. Thepatie nts can now walk, and she remains in good health and has been recurrence-free 8 months after surgery. To our knowledge, colon cancer with an abdominal abscess is comparatively rare, and we discuss this in light of the literature.

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