Ganesan M.,CSIR - Central Electrochemical Research Institute |
Nizamuddin S.,CSIR - Central Electrochemical Research Institute |
Katkam S.K.,CSIR - Central Electrochemical Research Institute |
Kumaraswami K.,Nizam's Institute of Medical Sciences |
And 4 more authors.
PLoS ONE | Year: 2016
Background: Coronary artery disease (CAD) is one of the leading causes of mortality worldwide. It is a multi-factorial disease and several studies have demonstrated that the genetic factors play a major role in CAD. Although variations in cholesteryl ester transfer protein (CETP) gene are reported to be associated with CAD, this gene has not been studied in South Indian populations. Hence we evaluated the CETP gene variations in CAD patients of South Indian origin. Methods: We sequenced all the exons, exon-intron boundaries and UTRs of CETP in 323 CAD patients along with 300 ethnically and age matched controls. Variations observed in CETP were subjected to various statistical analyses. Results and Discussion: Our analysis revealed a total of 13 variations. Of these, one3'UTR variant rs1801706 (c. ∗84G>A) was significantly associated with CAD (genotype association test: OR = 2.16, 95% CI: 1.50-3.10, p = 1.88x10-5 and allelic association test: OR = 1.92, 95% CI: 1.40-2.63, p = 2.57x10-5). Mutant allele "A" was observed to influence the higher concentration of mRNA (p = 7.09×10-3, R2 = 0.029 and β = 0.2163). Since expression of CETP has been shown to be positively correlated with the risk of CAD, higher frequency of "A" allele (patients: 22.69% vs.controls: 13%) reveals that c.∗84G>A is a risk factor for CAD in South Indians. Conclusions: This is the first report of the CETP gene among South Indians CAD patients. Our results suggest that rs1801706 (c.∗84G>A) is a risk factor for CAD in South Indian population. © 2016 Ganesan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Shirodkar C.G.,Yashoda Super Specialty Hospital |
Venkategowda P.M.,Yashoda Super Specialty Hospital |
Amte R.,Yashoda Super Specialty Hospital |
Rao S.M.,Yashoda Super Specialty Hospital
Annals of Tropical Medicine and Public Health | Year: 2015
Dengue viral infection is one of the differential diagnoses in patients having fever with thrombocytopenia. Early diagnosis and timely supportive treatment form the basis for the successful management of these patients. Dengue infection associated with cyanotic congenital cardiac disease makes management more difficult and is associated with a fatal outcome. We report a case in which the patient presented with fever and thrombocytopenia diagnosed to be a case of dengue infection (NS-1 antigen-positive) and associated cyanotic congenital heart disease (double inlet left ventricle/univentricular heart). The patient was successfully managed with fluids and platelet transfusion. This case report mainly emphasizes the difficulties faced in hemodynamic monitoring and supportive management during the acute course of the disease.
Subramanian S.,Yashoda Super Specialty Hospital |
Srinivas C.,Yashoda Super Specialty Hospital |
Ramalingam K.,Yashoda Super Specialty Hospital |
Babaiah M.,Yashoda Super Specialty Hospital |
And 12 more authors.
International Journal of Radiation Oncology Biology Physics | Year: 2012
Purpose: To evaluate, with a dosimetric and clinical feasibility study, RapidArc (a volumetric modulated arc technique) for hypofractionated stereotactic radiotherapy treatment of large arteriovenous malformations (AVMs). Methods and Materials: Nine patients were subject to multimodality imaging (magnetic resonance, computed tomography, and digital subtraction angiography) to determine nidus and target volumes, as well as involved organs at risk (optical structures, inner ear, brain stem). Plans for multiple intensity-modulated arcs with a single isocenter were optimized for a fractionation of 25 Gy in 5 fractions. All plans were optimized for 6-MV photon beams. Dose-volume histograms were analyzed to assess plan quality. Delivery parameters were reported to appraise technical features of RapidArc, and pretreatment quality assurance measurements were carried out to report on quality of delivery. Results: Average size of AVM nidus was 26.2 cm 3, and RapidArc plans provided complete target coverage with minimal overdosage (V 100% = 100% and V 110% < 1%) and excellent homogeneity (<6%). Organs at risk were highly spared. The D 1% to chiasm, eyes, lenses, optic nerves, and brainstem (mean ± SD) was 6.4 ± 8.3, 1.9 ± 3.8, 2.3 ± 2.2, 0.7 ± 0.9, 4.4 ± 7.2, 12.2 ± 9.6 Gy, respectively. Conformity index (CI 95%) was 2.2 ± 0.1. The number of monitor units per gray was 277 ± 45, total beam-on time was 2.5 ± 0.3 min. Planning vs. delivery γ pass rate was 98.3% ± 0.9%. None of the patients developed acute toxicity. With a median follow-up of 9 months, 3 patients presented with deterioration of symptoms and were found to have postradiation changes but responded symptomatically to steroids. These patients continue to do well on follow-up. One patient developed headache and seizures, which was attributed to intracranial bleed, confirmed on imaging. Conclusion: Hypofractionated stereotactic radiotherapy can be successfully delivered using the RapidArc form of volumetric arc technology for intracranial AVMs. The quality of delivery and calculated parameters are in agreement with each other and are in line with published reports for other sites. © 2012 Elsevier Inc.
PubMed | Yashoda Super Specialty Hospital
Type: Journal Article | Journal: Indian journal of psychological medicine | Year: 2016
India is experiencing increasing suicides that have much economic impact.To calculate the short-term costs of suicide in India.All the official data of suicides in India in 2014 formed the base of computation. Both direct and indirect costs were computed basing on market rates and official estimates. Perceived gains were deducted to arrive at the total cost.The contribution of middle age group in the loss was high. Each suicide costs 2.65 L and the total cost of suicide in 2014 amounts to 348842.65 L in the first year.Much suffering and burden on individuals, family, and society can be reduced if adequate treatment facilities for psychiatry patients are made available at affordable rates everywhere. This should be complemented by much needed public education.