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PubMed | Research Center for Cancer Prevention and Screening, Mizushima Kyodo Hospital, Kawasaki Medical School, Shikoku Cancer Center and 5 more.
Type: Journal Article | Journal: Japanese journal of clinical oncology | Year: 2015

The primary purpose of this large cohort study is to investigate the effects on breast cancer outcomes of modifiable lifestyle factors after breast cancer diagnosis. These factors include physical activity, smoking, alcohol consumption, obesity and weight gain after diagnosis, alternative medicine and dietary factors. Women diagnosed with Stage 0 to III breast cancer are eligible for participation to this study. Lifestyle, use of alternative medicine, psychosocial factors, reproductive factors and health-related quality of life will be assessed using a questionnaire at the time of breast cancer diagnosis (baseline), and 1, 2, 3 and 5 years after diagnosis. Clinical information and breast cancer outcomes will be obtained from a breast cancer database. The primary endpoint will be disease-free survival. Secondary endpoints are overall survival, health-related quality of life, breast cancer-related symptoms and adverse events. Patient recruitment commenced in February 2013. Enrollment of 2000 breast cancer patients is planned during the 5-year recruitment period. The concept of the study is described in this article.


Iwabu A.,Yashima General Hospital | Konishi K.,Yashima General Hospital | Tokutake H.,Yashima General Hospital | Yamane S.,Yashima General Hospital | And 3 more authors.
Clinical and Experimental Hypertension | Year: 2010

We examined the relationships between home blood pressure (BP) and atmospheric temperature in 20 treated-hypertensive patients. A significant correlation between morning and evening BP and atmospheric temperature was found. For morning systolic blood pressure (SBP), the maximal seasonal difference was 13.2 mmHg with 25.5°C temperature difference. Morning SBP increased by approximately 0.41 mmHg with a 1°C decrease in atmospheric temperature. A similar but weaker correlation with temperature was observed for morning diastolic, evening systolic and diastolic blood pressure (DBP). The present study provides important information in respect to BP changes with atmospheric temperature that should be taken into account in the analysis and treatment of hypertension. © Informa UK, Ltd.


Kitamura Y.,Tokushima University | Mizuguchi H.,Tokushima University | Ogishi H.,Tokushima University | Kuroda W.,Yashima General Hospital | And 3 more authors.
Acta Oto-Laryngologica | Year: 2012

Conclusions: These findings suggest that the down-regulation of interleukin (IL)-5 gene expression in collaboration with the suppression of histamine H1 receptor (H1R) gene expression in the nasal mucosa provides the basis for better therapeutic effects of preseasonal prophylactic treatment with antihistamines in patients with seasonal allergic rhinitis caused by Japanese cedar pollen. Objectives: The effects of prophylactic administration of antihistamines on the expression of IL-5 and IL-33 mRNA in the nasal mucosa of the patients with pollinosis were investigated. Methods: Eight patients had already visited the hospital before the peak pollen period and started preseasonal prophylactic treatment with antihistamines. Seventeen patients who first visited the hospital during the peak pollen period were designated as the no treatment group. After local anesthesia, nasal mucosa was obtained by scraping the inferior concha with a small spatula during the peak pollen period. Results: During the peak pollen period, the expression of IL-5 mRNA, but not that of IL-33 mRNA, in the nasal mucosa of patients receiving preseasonal prophylactic treatment with antihistamines was significantly lower in comparison with that of patients without treatment. Moreover, there was a significant correlation between the expression of IL-5 mRNA and the nasal symptoms or the expression of H1R mRNA. © Informa Healthcare.


Kitamura H.,Yashima General Hospital
Japanese Journal of Clinical Radiology | Year: 2016

Eosinophilic esophagitis (EE), which is characterized by dense infiltration of eosinophilis in esophageal intestinal epithelium, is rare disease, but recently show a tendency to increase. The patient suffer from gastroesophageal reflux symptom, such as dysphagia, food impaction, and heart-burn, but often there are no finding in the endoscopy, so in that case, diagnosis of EE is difficult. This time, we encountered two patients of EE, so we focused on computed tomography findings of EE and report.


Kitamura H.,Yashima General Hospital | Harada M.,Yashima General Hospital
Japanese Journal of Clinical Radiology | Year: 2012

What department will patients visit if they suffers from acute cervical pain? Because of the anatomical intricacy in the neck area, acute cervical pain is caused by some underlying diseases. If patients is inappropriately diagnosed in an early stage, they are at risk of receiving wrong treatment in the inadequate department. In addition to the clinical course, the radiological imaging test is useful for diagnosis of acute cervical pain. Radiologists have a responsibility to guide patients to the best department by the proper diagnostic imaging.


Sato G.,Yashima General Hospital | Sekine K.,Tokushima University | Matsuda K.,Tokushima University | Takeda N.,Tokushima University
Acta Oto-Laryngologica | Year: 2012

Conclusion: The findings suggest that it is easy for otoconial debris dislodged from the utricle to fall into the posterior semicircular canal (PSCC) or the horizontal semicircular canal (HSCC) of the undermost ear during sleep, but not to exit from the uppermost ear in patients with benign paroxysmal positional vertigo (BPPV). Objective: The aims of the present study were two-fold. (1) To examine the association between the preferred side of head-lying during sleep and the side of the affected ear in patients with both posterior canal BPPV (P-BPPV) and horizontal canal BPPV (H-BPPV). (2) To see whether that position affects the time course in remission of their positional vertigo. Methods: One hundred and sixteen patients with P-BPPV and 40 patients with H-BPPV who showed a habitual preference for right or left side sleeping position were included in this study. Results: The side of the affected ear was significantly associated with the head-lying side during sleep in patients with P-BPPV and was closely but not significantly associated with it in patients with H-BPPV. However, the head-lying side during sleep did not affect the remission rate of their positional vertigo. © 2012 Informa Healthcare.


Mizuguchi H.,Tokushima University | Kitamura Y.,Tokushima University | Kondo Y.,Tokushima University | Kuroda W.,Yashima General Hospital | And 5 more authors.
Methods and Findings in Experimental and Clinical Pharmacology | Year: 2010

Administration of antihistamines 2-4 weeks before the pollen season showed a greater inhibitory effect on nasal allergy symptoms in patients with seasonal allergic rhinitis. However, the mechanism of slow-onset effects of preseasonal treatment with antihistamines remains unclear. Here, we investigated the effect of preseasonal prophylactic treatment with antihistamines on nasal symptoms and the expression of histamine H1 receptor (H1R) mRNA of the nasal mucosa in patients with cedar pollen pollinosis. During the peak pollen period, the expression of H1R mRNA in the nasal mucosa and the scores of sneezing and watery rhinorrhea in patients receiving preseasonal prophylactic treatment with antihistamines were significantly suppressed in comparison with those in the patients with-out treatment. Moreover, there was a significant correlation between the nasal symptoms and the expression of H1R mRNA in both patients with or without preseasonal prophylactic treatment. These findings suggest that preseasonal prophylactic treatment with antihistamines is more effective than on-seasonal administration to patients with pollinosis in reducing nasal symptoms during the peak pollen period by suppressing H1R gene expression in the nasal mucosa. © 2010 Prous Science, S.A.U. or its licensors.


PubMed | Yashima General Hospital
Type: Comparative Study | Journal: Acta oto-laryngologica | Year: 2012

The findings suggest that it is easy for otoconial debris dislodged from the utricle to fall into the posterior semicircular canal (PSCC) or the horizontal semicircular canal (HSCC) of the undermost ear during sleep, but not to exit from the uppermost ear in patients with benign paroxysmal positional vertigo (BPPV).The aims of the present study were two-fold. (1) To examine the association between the preferred side of head-lying during sleep and the side of the affected ear in patients with both posterior canal BPPV (P-BPPV) and horizontal canal BPPV (H-BPPV). (2) To see whether that position affects the time course in remission of their positional vertigo.One hundred and sixteen patients with P-BPPV and 40 patients with H-BPPV who showed a habitual preference for right or left side sleeping position were included in this study.The side of the affected ear was significantly associated with the head-lying side during sleep in patients with P-BPPV and was closely but not significantly associated with it in patients with H-BPPV. However, the head-lying side during sleep did not affect the remission rate of their positional vertigo.


PubMed | Yashima General Hospital
Type: Journal Article | Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society | Year: 2010

An 84-year-old woman was referred to our hospital with fever and dyspnea. Her arterial oxygen partial pressure was 48.3 Torr. Chest computed tomography (CT) showed a foreign body incarcerated in the right truncus intermedius. Bronchoscopy revealed the incarceration of a dark red foreign body with an elliptical shape in the right truncus intermedius, and bronchoscopic removal was performed. The foreign body was an iron pill. Steroids were administered to prevent local inflammation and granulation of the bronchial mucosa. She recovered and was discharged on day 15. A patient with severe bronchial mucosal injury caused by iron pill aspiration was successfully treated by bronchoscopic removal.


Harada T.,Yashima General Hospital | Kitamura H.,Yashima General Hospital | Ueda K.,Yashima General Hospital | Saito M.,Yashima General Hospital
Japanese Journal of Clinical Radiology | Year: 2016

The patient was a 71-year-old man with abdominal pain and vomiting. He has experienced left inguinal swelling several times. When seen, no inguinal hernia was found. Abdominal computed tomography (CT) suggested a dilated small intenstine and "closed loop" sign in the left lower abdominal cavity. The lower median abdominal section was selected. We found the intestines incarcerated in a hernial sac in the peritoneal space in what is termed a false reduction. False reduction of an inguinal hernia is extremely rare, therefore we report this case with a brief review of the literature. © 2016, Kanehara Shuppan Co. Ltd. All rights reserved.

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