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Aurangābād, India

Kalyankar T.M.,Swami Ramanand Teerth Marathwada University | Kulkarni P.D.,Swami Ramanand Teerth Marathwada University | Panchakshari P.P.,Swami Ramanand Teerth Marathwada University | Narute A.S.,Yash Institute of Pharmacy
Research Journal of Pharmacy and Technology

A simple reversed-phase high-performance liquid chromatographic method has been developed and validated for simultaneous estimation of Cinnarizine and Domperidone in tablets. The compounds were separated on a ‘Hypersil C18’ analytical column. The mobile phase used for separation was methanol: 0.05M phosphate buffer in the ratio (80:20 v/v). The pH was adjusted to 3.8 with ortho phosphoric acid. The flow rate was maintained to 1 ml/min. UV detection was performed at 275 nm. The method was validated for accuracy, precision, specificity, linearity, and sensitivity. Total chromatographic analysis time per sample was 10 min. The retention time for Cinnarizine and Domperidone was found to be 7.33 and 3.14 min respectively. Validation studies revealed that the method is specific, rapid, reliable, and reproducible. Calibration plots were linear over the concentration ranges of 10-35 μg/mL and 5-30 μg/mL for Cinnarizine and Domperidone respectively. The limit of detection and quantitation was 0.067 μg/ml and 0.221 μg/ml for Cinnarizine and 0.051 μg/ml and 0.169 μg/ml for Domperidone respectively. The high recovery and low relative standard deviation confirm the suitability of the method for determination of Cinnarizine and Domperidone in tablets. © RJPT All right reserved. Source

Devdhe S.,Yash Institute of Pharmacy
International Journal of Pharmaceutical Sciences Review and Research

Natural carbohydrates have been popularly used as a material for centuries in all kinds of pharmaceutical applications. It is the world's most abundant renewable and biodegradable polymer. Isabgol has been popularly used as therapeutic agent for the treatment of constipation, diarrhea, irritable syndrome, inflammatory bowel disease, ulcerative colitis, colon cancer, diabetes, and hypercholesterolemia The uniqueness of the chemical structures and macromolecular configurations of mucilage obtain from the Isabgol (plantago ovata forskal) has attracted Carbohydrate chemists in last decade, as the hydrogel produced by it is rigid, difficult to brake, to dissolve. Ironically solubility, flexibility is very important criteria for materials to be used in pharmacy. To meet these criteria chemical modifications of isabgol husk mucilage is indispensable so that it can be transformed into carrier for new drug delivery system, as a low cost non-conventional source for the using pharmaceutical formulations as an "Excipient", which can improve its procesability and performance for specific application in the broad field of pharmacy. Exploitation of Isabgol husk mucilage as an "Excipient" and its innovative, non-conventional applications, chemical derivatization, use of its derivative in modern fashion of drug designing has become a room for inventions for research scholar. Gums and Mucilage are naturally occurring biopolymers, finding increasing applications in pharmaceutical and biotechnology industry. It has been used successfully for many years in the food and pharmaceutical industry as a thickening agent, as a gelling agent, and as a colloidal stabilizer. Mucilage also has several unique properties that have enabled it to be used as a matrix for entrapment and/or delivery of variety of drugs, proteins, and cells. Being a naturally occurring polysaccharide, in recent year it has gained increased importance in industrial applications. The benefits of natural carbohydrates are also more and more appreciated by the scientists and consumers from various industries due to its inertness, biocompatibility, and biodegradability. Source

Shelke S.D.,Yash Institute of Pharmacy
Journal of Applied Pharmaceutical Science

The body normally hosts a variety of microorganisms, including bacteria and fungi. Some of these are useful to the body and others may cause infections. Fungi can live on the dead tissues of the hairs, nails. Continuous exposal of nail to warm, moist environments usually develops nail infection. Nail plate is main route for penetration of drug. Varity of conventional formulation like gel, cream and also oral antifungal are available for treatment of nail infection. The nail lacquer is a new drug delivery system in treatment of nail infections. The major hurdle associated with developing nail lacquers treatment for nail disorders is to deliver the active (antifungal) therapeutically effective concentrations to the site of infection, which is often under nail. However possible means to enhance nail penetration must be explored in greater depth before effective local treatments for fungal nail infections are developed. Lack of proper in vitro methods to measure the extent of drug permeation across the nail plate is the major difficulty in the development of transungual delivery. Penetration of topical antifungal through the nail plate requires a vehicle that is specifically formulated for transungual delivery. Recent focus is emphasizing on development of a promising antifungal treatment in form of nail lacquer owing to its beneficial advantages. Source

Tayade P.M.,Yash Institute of Pharmacy | Borde S.N.,Dr. BAMU | Joshi A.S.,Yash Institute of Pharmacy | Angadi S.S.,Yash Institute of Pharmacy | Devdhe S.J.,Yash Institute of Pharmacy
Oriental Pharmacy and Experimental Medicine

Psoralea corylifolia Linn were used traditionally in Ayurveda for the treatment of male sexual dysfunction. The extract was administered (100 and 200 mg/kg, p. o.) to different groups of male rats. The female rats involved in mating were made receptive by hormonal treatment. The orientational activity, body weight, haematoogical parameters were studied and compared with the standard reference drug Yohimbine. Psoralea corylifolia produced significant aphrodisiac activity when compared to Diabetic Control and Normal Control. Psoralea corylifolia Linn showed a significant increase in number of licking, number of anogenital sniffing towards female and number of genital grooming towards self. Whereas significant decrease in number of climbing and nongenital grooming towards self was observed during all time observation in animals treated for 14 days and observation on one day, seven day and fourteen days treatment. © 2013 Institute of Oriental Medicine, Kyung Hee University. Source

Narute A.S.,Yash Institute of Pharmacy
International Journal of Pharma and Bio Sciences

Anti-inflammatory agents have attracted much attention in recent yearsin the design of non-steroidal anti-inflammatory agents (NSAIDs), which aredevoid of the common side effects of classical NSAIDs. QSAR studies have been performed on a series of 3-substituted indole derivatives with a hope to design compounds with better antiinflammatory activity and lesser side effects. Various physicochemical parameters were calculated and good predictive QSAR models were generated for anti-inflammatory activity using stepwisemultiple regression analysis. Statistically significant models were obtained that gave r-value (correlation coefficient) as <0.80 which depicts a goodcorrelation between anti-inflammatory activity with physicochemical properties, connectivity and conformation of molecule. The indicator variables like presence of aromatic ring and lipophilic groups play an important role inanti-inflammatory activity. Cross validation was performed using the leave one-out method. The results obtained along with validated models bring important structural insight in designing novel 3-substituted indole derivatives as anti-inflammatory agents. Source

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