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Yaroslavl, Russia

Yaroslavl State Medical Academy has been founded in 1944. At present, YSMA is the big regional center of excellent quality medical education and bio-medical research. It is also the leader in medical training and post-graduation education, retraining of specialists of practical healthcare, medicine, pharmacy, and high-skilled academic staff for the central regions of Russia. Wikipedia.

Kratnov A.E.,Yaroslavl State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2011

Markers of infl ammation and intracellular metabolism of neutrophils were studied in 58 patients with acute coronary syndrome with different levels of troponin T. In patients with repeated coronary events within a year, more pronounced endothelial dysfunction associated with activation of oxygen-dependent metabolism of neutrophils and lipid peroxidation process was revealed at admission to the hospital. © 2011 Springer Science+Business Media, Inc. Source

Masliukov P.M.,Yaroslavl State Medical Academy
Brain Research Journal | Year: 2013

Sympathetic ganglia consist of neurochemically and functionally distinct populations of neurons, characterized by a specific projection pattern and a set of neutransmitters including classical neutransmitters (catecholamines and acetylcholine), neuropeptides and small molecules such as NO, H2S, CO. The majority of the principal ganglionic sympathetic neurons is noradrenergic and expresses tyrosine hydroxylase (TH), i.e., a key enzyme in catecholamine synthesis. In mammals, two third of catecholaminergic neurons also co-localizes NPY. A small number of postganglionic sympathetic neurons contains enzyme of acetylcholine synthesis (ChAT) and some neuropeptides, such as somatostatin (SOM), vasoactive intestinal (poly)peptide (VIP), calcitonin gene-related peptide (CGRP). Acetylcholine-containing sympathetic neurons in most cases colocalize VIP and/or CGRP. Phenotype of autonomicneurons is regulated by both target-independent and target-dependent mechanisms. The most of transmitters are expressed during embryogenesis. TH appears during embryonic development and the percentage of THpositive neurons remains virtually identical during ontogenesis. After birth, cholinergic neurons initially express catecholamine synthesising enzymes and exhibit a noradrenergicphenotype. Expression of different neuropeptides changes in pre- and postnatal development. Neurotransmitter expression in sympathetic neurons is influenced by soluble growth factor signaling via innervated target tissues. Multiple growth factors including bone morphogenetic proteins, neurotrophins, glialcellline-derived neurotrophic factor family ligands and neuropoietic cytokines play instructive role at different stages of neurotransmitter development. © Nova Science Publishers, Inc. Source

Pizova N.V.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objective. To study the efficacy and safety of cereton in the treatment of patients with chronic brain ischemia and moderate cognitive impairment. Material and methods. The study included 25 patients, 16 women and 9 men, mean age 53,8±1,3 years. Moderate cognitive impairment measured with MMSE and HADS was found in all patients. Quality of life was assessed with SF-36. Somatic and neurological studies as well as brain MRI were carried out. Inpatients received cereton in dose 1000 mg in 200 ml of physiological solution during 15 days, after the discharge from the hospital patients received 1 capsule three times a day during 3 months. Results and conclusion. Cereton had a significant positive effect on patient’s condition including cognitive function. Subjective effect was recorded after 5-6 days of treatment, more evident and stable effect was seen from the 15th day. In the end of treatment, clinicians recorded «moderate» effect in 11 patients and “marked” effect in 8 patients (according to patients’ reports, those effects were noted in 9 and 12 cases, respectively). The drug was well-tolerated and had a positive effect on quality of life of the patients © 2014, Media Sphera. All rights reserved. Source

Porseva V.V.,Yaroslavl State Medical Academy
Cell and Tissue Biology | Year: 2013

Morphological peculiarities of neurons that had TRPV1, SP, CGRP, and NF200 markers in thoracic spinal ganglia nerves were studied in 3-month-old rats subjected to chemical deafferentation produced by capsaicin. The obtained results have shown that from 6. 5 to 41. 3% of ganglion neurons in the control group of animals contain, as a rule, one of the above-mentioned markers. The heterogeneity of nociceptive neurons observed in a control group of rats was also preserved in the capsaicin-treated animals. In both groups, the spinal ganglion TRPV1 neurons were predominant, whereas populations of SP, CGRP, and NF200 neurons formed smaller groups. In each population, sensitivity to capsaicin was shown in the largest neurons, regardless of marker; this sensitivity was pronounced to the greatest degree in the group of TRPV1 neurons. © 2013 Pleiades Publishing, Ltd. Source

Kasatkin D.S.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

The article reviews the literature on the diagnosis and treatment of cognitive impairment in the aspect of activity of main functional systems involved in functioning of the higher mental functions, cortical/subcortical interactions, afferent activating pattern of the reticular system and the cerebral blood flow system. The role of the latter is considered in frames of the concept of the neurovascular unit. Main points of application of drugs used for treatment of cognitive functions, including those which exert an effect on the capillary blood flow, are defined. Source

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