Yaroslavl State Medical Academy

Yaroslavl, Russia

Yaroslavl State Medical Academy has been founded in 1944. At present, YSMA is the big regional center of excellent quality medical education and bio-medical research. It is also the leader in medical training and post-graduation education, retraining of specialists of practical healthcare, medicine, pharmacy, and high-skilled academic staff for the central regions of Russia. Wikipedia.

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Malakhov M.V.,Yaroslavl State Medical Academy | Melnikov A.A.,Yaroslavl State Pedagogical University
Human Physiology | Year: 2017

The present work investigated the effect of different breathing strategies performed with and without body immobilization on postural performance. Sway amplitude and mean velocity of center of pressure displacement in the anteroposterior and mediolateral planes were assessed by the force platform in 48 healthy volunteers. Balance was estimated during quiet breath, inspiratory, expiratory breath holding and hyperventilation with and without immobilization of the neck, trunk, hip, and knee joints. In general, restriction of body mobility caused a reduction of the postural stability in anteroposterior plane, while mediolateral body sway decreased. Our results imply that body immobilization reduced the ability to compensate respiratory disturbances in the anteroposterior direction and, on the contrary, facilitated mamtaining balance in the mediolateral plane. © 2017, Pleiades Publishing, Inc.

Smirnova E.M.,Yaroslavl State Medical Academy
History of Medicine | Year: 2014

The creation of zemstvo county medicine led to the emergence of new categories of health workers – zemstvo council paramedics and midwives. This article discusses the formation of this professional group, their social standing, educational level, employment status, working conditions and material support for these medical workers. © Elena M. Smirnova.

Masliukov P.M.,Yaroslavl State Medical Academy | Korobkin A.A.,Yaroslavl State Medical Academy | Nozdrachev A.D.,RAS Pavlov Institute of Physiology | Timmermans J.-P.,University of Antwerp
Autonomic Neuroscience: Basic and Clinical | Year: 2012

Expression of CB in the sympathetic ganglia was investigated by immunohistochemistry. The distribution of CB immunoreactivity was studied in the superior cervical ganglion (SCG), stellate ganglion (SG) and celiac ganglion (CG) from rats and cats of different ages (newborn, 10-day-old, 20-day-old, 30-day-old, two-month-old, six-month-old).We observed that the percentage of CB-immunoreactive (IR) neurons decreased during early postnatal development in rats and cats. In all studied ganglia of both species, the percentage of CB-IR neurons was high in newborn and 10-day-old animals and significantly decreased up to 30. days of life. In rats of all ages, the largest percentage of CB-IR neurons was observed in the SG compared to the SCG and CG.In the cat sympathetic ganglia, the number of CB-IR neurons decreased more rapidly during the first two months of life, and only scattered CB-IR neurons were found in the sympathetic ganglia of two-month-old and six-month-old cats. In cats, the highest percentage of CB-IR neurons was observed in the SG, while the lowest percentage was found in the CG. The difference in size between CB. + and CB. - neurons equally changed during development. Finally, the changes in the size and percentages of CB-IR neurons were complete in rats at the first month of life, and in cats at the end of the second month. © 2011 Elsevier B.V.

Kratnov A.E.,Yaroslavl State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2011

Markers of infl ammation and intracellular metabolism of neutrophils were studied in 58 patients with acute coronary syndrome with different levels of troponin T. In patients with repeated coronary events within a year, more pronounced endothelial dysfunction associated with activation of oxygen-dependent metabolism of neutrophils and lipid peroxidation process was revealed at admission to the hospital. © 2011 Springer Science+Business Media, Inc.

Pizova N.V.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Objective. To study the efficacy and safety of cereton in the treatment of patients with chronic brain ischemia and moderate cognitive impairment. Material and methods. The study included 25 patients, 16 women and 9 men, mean age 53,8±1,3 years. Moderate cognitive impairment measured with MMSE and HADS was found in all patients. Quality of life was assessed with SF-36. Somatic and neurological studies as well as brain MRI were carried out. Inpatients received cereton in dose 1000 mg in 200 ml of physiological solution during 15 days, after the discharge from the hospital patients received 1 capsule three times a day during 3 months. Results and conclusion. Cereton had a significant positive effect on patient’s condition including cognitive function. Subjective effect was recorded after 5-6 days of treatment, more evident and stable effect was seen from the 15th day. In the end of treatment, clinicians recorded «moderate» effect in 11 patients and “marked” effect in 8 patients (according to patients’ reports, those effects were noted in 9 and 12 cases, respectively). The drug was well-tolerated and had a positive effect on quality of life of the patients © 2014, Media Sphera. All rights reserved.

Kasatkin D.S.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

The article reviews the literature on the diagnosis and treatment of cognitive impairment in the aspect of activity of main functional systems involved in functioning of the higher mental functions, cortical/subcortical interactions, afferent activating pattern of the reticular system and the cerebral blood flow system. The role of the latter is considered in frames of the concept of the neurovascular unit. Main points of application of drugs used for treatment of cognitive functions, including those which exert an effect on the capillary blood flow, are defined.

Porseva V.V.,Yaroslavl State Medical Academy
Cell and Tissue Biology | Year: 2013

Morphological peculiarities of neurons that had TRPV1, SP, CGRP, and NF200 markers in thoracic spinal ganglia nerves were studied in 3-month-old rats subjected to chemical deafferentation produced by capsaicin. The obtained results have shown that from 6. 5 to 41. 3% of ganglion neurons in the control group of animals contain, as a rule, one of the above-mentioned markers. The heterogeneity of nociceptive neurons observed in a control group of rats was also preserved in the capsaicin-treated animals. In both groups, the spinal ganglion TRPV1 neurons were predominant, whereas populations of SP, CGRP, and NF200 neurons formed smaller groups. In each population, sensitivity to capsaicin was shown in the largest neurons, regardless of marker; this sensitivity was pronounced to the greatest degree in the group of TRPV1 neurons. © 2013 Pleiades Publishing, Ltd.

Sidorov A.V.,Yaroslavl State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2013

Plasma LDL content increased in rats with mild chronic heart failure, but decreased in animals with severe pathology. The lipid profi le of β-adrenoceptor antagonists depended on their selectivity. The most selective antagonists of β-adrenoceptors had little effect on the lipid composition. Nonselective β-adrenoceptor antagonists increased the index of plasma atherogenicity, which did not depend on the severity of a pathological process. In mild chronic heart failure, these changes were associated with a decrease in HDL concentration, while in severe chronic heart failure; they were related to a tendency towards a decrease in HDL content and an increase in LDL concentration. The increase in survival rate was associated with true antagonism of the agent to β-adrenoceptors (the absence of intrinsic sympathomimetic activity) and, to a lesser extent, with nonselective blockade of β-adrenoceptors. © 2013 Springer Science+Business Media New York.

Pizova N.V.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Systemic rheumatic disorders affect multiple organ systems. Seizures are among the most common neurological manifestation and occasionally can be the presenting symptom. This article reviews the literature on the mechanisms underlying seizures in systemic rheumatic disorders and predisposing factors, including vascular disease (e.g., prothrombotic state, anticardiolipin antibody, emboli, vasculitis), antineuronal antibodies, immune complexes, cytokines, metabolic disorders, infection, and therapy. Diagnostic and therapeutic strategies must be individualized for both the disorder and the patient.

Shilkina N.P.,Yaroslavl State Medical Academy
Terapevticheskii Arkhiv | Year: 2015

A new nomenclature of systemic vasculitides (SV) and current approaches to their treatment have necessitated the discussion of some debatable questions on this condition. The paper gives the data of examining 325 patients with different forms of SV, followed up in the Interregional Consulting Center for SV patients, and the results of testing the American College of Rheumatology classification criteria for SV and the authors' criteria, by taking into account the International Chapel Hill Consensus Conference, USA (1994 and 2011) guidelines for CV nomenclature. It discusses the etiological factors and pathogenetic components of SV, morphological aspects, and relationships between the local and systemic forms of SV. The findings were compared with the data available in the literature. It is concluded that differentially diagnostic criteria for CV should be elaborated to specify the stage of the disease, the activity and use of adapted therapy regimens.

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