Yaroslavl State Medical Academy

Yaroslavl, Russia

Yaroslavl State Medical Academy has been founded in 1944. At present, YSMA is the big regional center of excellent quality medical education and bio-medical research. It is also the leader in medical training and post-graduation education, retraining of specialists of practical healthcare, medicine, pharmacy, and high-skilled academic staff for the central regions of Russia. Wikipedia.

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Malakhov M.V.,Yaroslavl State Medical Academy | Melnikov A.A.,Yaroslavl State Pedagogical University
Human Physiology | Year: 2017

The present work investigated the effect of different breathing strategies performed with and without body immobilization on postural performance. Sway amplitude and mean velocity of center of pressure displacement in the anteroposterior and mediolateral planes were assessed by the force platform in 48 healthy volunteers. Balance was estimated during quiet breath, inspiratory, expiratory breath holding and hyperventilation with and without immobilization of the neck, trunk, hip, and knee joints. In general, restriction of body mobility caused a reduction of the postural stability in anteroposterior plane, while mediolateral body sway decreased. Our results imply that body immobilization reduced the ability to compensate respiratory disturbances in the anteroposterior direction and, on the contrary, facilitated mamtaining balance in the mediolateral plane. © 2017, Pleiades Publishing, Inc.

Smirnova E.M.,Yaroslavl State Medical Academy
History of Medicine | Year: 2014

The creation of zemstvo county medicine led to the emergence of new categories of health workers – zemstvo council paramedics and midwives. This article discusses the formation of this professional group, their social standing, educational level, employment status, working conditions and material support for these medical workers. © Elena M. Smirnova.

Porseva V.V.,Yaroslavl State Medical Academy
Neuroscience and Behavioral Physiology | Year: 2015

The aim of the present work was to study the topography and structure of 28-kDa calbindin (CB)-containing interneurons in the ventral horn and intermediate zone of the gray matter at levels TII and LIV of the spinal cord (SC). Experiments were performed in adult female Wistar rats (n = 4) using immunohistochemical and morphometric methods. Cryostat transverse sections of the SC of thickness 14 μm were studied. The intermediate zone of the SC was found to contain two subpopulations of CB-immunoreactive (IR) interneurons in lamina VII in both segments: sympathetic preganglionic neurons and “partition” cells. The ventral horn also contained two subpopulations of CB-IR interneurons: Renshaw cells in lamina IX in TII and lamina VII in LIV and large interneurons in lamina VIII in TII and lamina VII in LIV. The only differences between segments were in the larger numbers of Renshaw cells and partition cells in LIV. The mean cross-sectional areas of CB-IR Renshaw cells and autonomic preganglionic neurons were greater in TII, while large interneurons of the ventral horn and partition cells were larger in LIV. © 2015, Springer Science+Business Media New York.

Pizova N.V.,Yaroslavl State Medical Academy
Neuroscience and Behavioral Physiology | Year: 2014

The therapeutic efficacy and tolerance of Valdoxan (agomelatine) in the treatment of mild and moderate depression in cerebrovascular diseases (CVD) in routine neurological practice were evaluated. A total of eight Russian centers took part in the study. The study included 88 patients with CVD (18 men, 70 women) aged 40-65 (mean 55.4 ± 6.5) years. Treatment for six weeks eliminated depressive symptomatology in 81.20% of patients. Patients showed regression of fatigue, improvements in working efficiency, achievement of normal values for the coefficient of mental stability, and improvements in sleep. © 2014 Springer Science+Business Media New York.

Porseva V.V.,Yaroslavl State Medical Academy
Neuroscience and Behavioral Physiology | Year: 2014

Experiments were performed on 80 white male Wistar rats aged 3, 10, 20, 30, 60, 180, and 360 days to address the influences of capsaicin deafferentation on the topography of neurons containing 200-kDal neurofilament protein (NF200+) in the gray matter of the second thoracic segment of the spinal cord. Deafferentation was modeled by s.c. administration of single doses of 150 mg/kg capsaicin to rat pups on day 2 of life. Controls were intact animals (n = 40). NF200+ neurons were detected by labeling cells with anti-NF200 antibodies. The proportion of immunoreactive neurons was calculated by labeling the whole neuron population with NeuroTrace Green Fluorescent Nissl Stain. The results obtained from these experiments show that NF200+ neurons were detected in the ventral horn, the intermediate zone, and the dorsal horn of the spinal cord and were discriminated by their morphometric characteristics. Administration of capsaicin led to identical decreases in the numbers and mean cross sectional areas of medially and laterally located NF200+ motoneurons in the spinal cord (plate IX). In the intermediate zone (plate VII) and dorsal horn (plates III–IV), there were no changes in the numbers of NF200+ neurons, though the mean cross sectional area was greater than that in controls. © 2014, Springer Science+Business Media New York.

Masliukov P.M.,Yaroslavl State Medical Academy | Korobkin A.A.,Yaroslavl State Medical Academy | Nozdrachev A.D.,RAS Pavlov Institute of Physiology | Timmermans J.-P.,University of Antwerp
Autonomic Neuroscience: Basic and Clinical | Year: 2012

Expression of CB in the sympathetic ganglia was investigated by immunohistochemistry. The distribution of CB immunoreactivity was studied in the superior cervical ganglion (SCG), stellate ganglion (SG) and celiac ganglion (CG) from rats and cats of different ages (newborn, 10-day-old, 20-day-old, 30-day-old, two-month-old, six-month-old).We observed that the percentage of CB-immunoreactive (IR) neurons decreased during early postnatal development in rats and cats. In all studied ganglia of both species, the percentage of CB-IR neurons was high in newborn and 10-day-old animals and significantly decreased up to 30. days of life. In rats of all ages, the largest percentage of CB-IR neurons was observed in the SG compared to the SCG and CG.In the cat sympathetic ganglia, the number of CB-IR neurons decreased more rapidly during the first two months of life, and only scattered CB-IR neurons were found in the sympathetic ganglia of two-month-old and six-month-old cats. In cats, the highest percentage of CB-IR neurons was observed in the SG, while the lowest percentage was found in the CG. The difference in size between CB. + and CB. - neurons equally changed during development. Finally, the changes in the size and percentages of CB-IR neurons were complete in rats at the first month of life, and in cats at the end of the second month. © 2011 Elsevier B.V.

Kratnov A.E.,Yaroslavl State Medical Academy
Bulletin of Experimental Biology and Medicine | Year: 2011

Markers of infl ammation and intracellular metabolism of neutrophils were studied in 58 patients with acute coronary syndrome with different levels of troponin T. In patients with repeated coronary events within a year, more pronounced endothelial dysfunction associated with activation of oxygen-dependent metabolism of neutrophils and lipid peroxidation process was revealed at admission to the hospital. © 2011 Springer Science+Business Media, Inc.

Porseva V.V.,Yaroslavl State Medical Academy
Cell and Tissue Biology | Year: 2013

Morphological peculiarities of neurons that had TRPV1, SP, CGRP, and NF200 markers in thoracic spinal ganglia nerves were studied in 3-month-old rats subjected to chemical deafferentation produced by capsaicin. The obtained results have shown that from 6. 5 to 41. 3% of ganglion neurons in the control group of animals contain, as a rule, one of the above-mentioned markers. The heterogeneity of nociceptive neurons observed in a control group of rats was also preserved in the capsaicin-treated animals. In both groups, the spinal ganglion TRPV1 neurons were predominant, whereas populations of SP, CGRP, and NF200 neurons formed smaller groups. In each population, sensitivity to capsaicin was shown in the largest neurons, regardless of marker; this sensitivity was pronounced to the greatest degree in the group of TRPV1 neurons. © 2013 Pleiades Publishing, Ltd.

Pizova N.V.,Yaroslavl State Medical Academy
Zhurnal Nevrologii i Psihiatrii imeni S.S. Korsakova | Year: 2014

Systemic rheumatic disorders affect multiple organ systems. Seizures are among the most common neurological manifestation and occasionally can be the presenting symptom. This article reviews the literature on the mechanisms underlying seizures in systemic rheumatic disorders and predisposing factors, including vascular disease (e.g., prothrombotic state, anticardiolipin antibody, emboli, vasculitis), antineuronal antibodies, immune complexes, cytokines, metabolic disorders, infection, and therapy. Diagnostic and therapeutic strategies must be individualized for both the disorder and the patient.

Shilkina N.P.,Yaroslavl State Medical Academy
Terapevticheskii Arkhiv | Year: 2015

A new nomenclature of systemic vasculitides (SV) and current approaches to their treatment have necessitated the discussion of some debatable questions on this condition. The paper gives the data of examining 325 patients with different forms of SV, followed up in the Interregional Consulting Center for SV patients, and the results of testing the American College of Rheumatology classification criteria for SV and the authors' criteria, by taking into account the International Chapel Hill Consensus Conference, USA (1994 and 2011) guidelines for CV nomenclature. It discusses the etiological factors and pathogenetic components of SV, morphological aspects, and relationships between the local and systemic forms of SV. The findings were compared with the data available in the literature. It is concluded that differentially diagnostic criteria for CV should be elaborated to specify the stage of the disease, the activity and use of adapted therapy regimens.

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