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Wang X.,Harbin Institute of Technology | Wang L.,Harbin Institute of Technology | Han X.,Harbin Institute of Technology | Guo C.,Yuhuangding Hospital of Yantai
Nano | Year: 2013

This paper reviews recent progress in studies on the migration of charged species, including charged lipids, membrane-attached proteins and vesicles, and integrated membrane proteins, in lipid bilayer membranes under an external electric field. The migration of these charged substances is controlled by the interplay of electrophoresis and electroosmosis. This phenomenon can be employed to separate the charged lipids and membrane-attached proteins, and concentrate integrated membrane proteins. © 2013 World Scientific Publishing Company.

Jiang Z.,Nanjing Medical University | Zou Y.,Yuhuangding Hospital of Yantai | Ge Z.,Nanjing Medical University | Zuo Q.,Nanjing Medical University | And 2 more authors.
Biology of Reproduction | Year: 2015

Pre-eclampsia (PE) is a hypertensive disorder that occurs during pregnancy, and is a multifactorial disease. The antiangiogenic factor, soluble fms-like tyrosine kinase 1 (sFlt-1), has been reported to be important in the pathogenesis of PE, but the mechanism of its involvement remains unknown. To test the effects of sFlt-1 on pregnancy, we injected pregnant mice with exogenous mouse sFlt-1. After 18 days of gestation, higher blood pressure, proteinuria, and histological differences were observed compared with controls. Mitochondrial swelling inside the trophoblast cells in the placenta of sFlt-1-treated pregnant mice was observed by electron microscopy, which suggested a role of sFlt-1 in oxidative stress in trophoblasts in PE. Furthermore, apoptosis markers were upregulated in sFlt-1-treated mice. In conclusion, sFlt-1 appears to play a role in oxidative stress, which promotes apoptosis of trophoblasts. This may be an important mechanism in the development of PE. © 2015 by the Society for the Study of Reproduction, Inc.

Chu H.,Huazhong University of Science and Technology | Yang J.,Yuhuangding Hospital of Yantai | Mi S.,Yuhuangding Hospital of Yantai | Bhuyan S.S.,University of Nebraska Medical Center | And 5 more authors.
Journal of Cardiovascular Disease Research | Year: 2012

Objectives: The tumor necrosis factor-alpha (TNF-) gene may play an important role in coronary heart disease (CHD) and myocardial infarction (MI) risk. Recently, controversial results regarding the association of the G-308 A (rs1800629)polymorphism of the TNF- gene with CHD/MI have been reported. We herein examine a possible association between the G-308 A (rs1800629) polymorphism of the TNF- gene and CHD/MI in a sample of the Chinese Han population. Materials and Methods: We determined the genotypes of TNF-α G-308 A (rs1800629) in 535 unrelated Chinese patients with CHD, 420 patients with MI, and 1020 coronary artery disease-free controls. Additionally, a meta-analysis of all previous studies on the TNF-α G-308 A polymorphism and the risk of CHD and MI was performed. Results: AA genotypes in the G-308 A (rs1800629)polymorphism of the TNF-α gene did not occur more frequently in CHD/MI patients than in controls; odds ratios (95% confidence intervals) were 1.743 (0.325 to 1.423) for CHD and 1.731 (0.442 to 1.526) for MI, after adjusting for conventional risk factors. Further stratification for age, gender, and other cardiovascular risk factors did not alter the prior negative findings. Pooled meta-analysis of 23 studies also found no statistically significant associations between the TNF-α polymorphism and CHD/MI risk in the genetic additive, dominant, and recessive models. Subgroup analyses showed no association between the TNF-α polymorphism and CHD/MI in Asian and Caucasian populations. Conclusion: Our study showed no association between the G-308 A (rs1800629) polymorphism of the TNF-α gene (presence of A allele) and CHD/MI in the Chinese Han population. There was no evidence of a difference in risk effects of rs1800629 between Caucasians and Asians.

Xiu C.,Yuhuangding Hospital of Yantai | Qi W.,Capital Medical University | Wang Y.,Yuhuangding Hospital of Yantai | Zhang H.,Yuhuangding Hospital of Yantai | Chi N.,Yuhuangding Hospital of Yantai
Current Signal Transduction Therapy | Year: 2014

Pioneer works have identified some microRNAs (miRNAs) with oncogenic or tumor-suppressive properties in glioblastoma multiforme (GBM), an aggressive brain tumor with dismal prognosis. Differential expression of these noncoding small RNA in cancers positions them as attractive biomarkers for diagnosis, prognosis and therapeutic decision in GBMs. In addition, abnormal miRNAs provide new interesting therapeutic targets for clinical GBM treatments despite the hurdles associated with such an approach. This review firstly summarizes abnormal expressed genes and upstream miRNAs in GBMs. Next, our focus will be towards the signature of miRNAs in GBM, and discuss the importance of circulating miRNAs for cancer diagnosis. Finally, we summarize present miRNA target therapeutic strategies, and discuss the deficiencies and challenges. © 2014 Bentham Science Publishers.

Xiu C.,Yuhuangding Hospital of Yantai | He Q.,Yuhuangding Hospital of Yantai | Zou P.,Yuhuangding Hospital of Yantai | Zhang H.,Yuhuangding Hospital of Yantai
International Journal of Clinical and Experimental Medicine | Year: 2016

X-ray cross-complementing group 4 (XRCC4) is crucial for cells to maintain genetic stability thereby inflicting carcinogenesis. To date, epidemiologic findings have reached conflicting and ambiguous conclusions on the role of XRCC4 rs1805377 polymorphism in cancer risks. We made a comprehensive quantitative evaluation by performing a meta-analysis. Eligible publications assessing the association between XRCC4 rs1805377 polymorphism and cancer risks from PubMed, Embase and China national knowledge infrastructure (CNKI) databases were indentified. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess association strengths with the fixed-effect model or the random-effects model dependent on the heterogeneity. At the same time, subgroup analysis and sensitivity analysis were conducted. A total of 8 studies including 1911 cases and 2688 controls were included based on the search criteria. It was revealed by this meta-analysis that, in the Asian population, there was significant correlation between XRCC4 rs1805377 polymorphism and the risk of cancers (GG vs. AA: OR = 1.28, 95% CI = 1.05-1.57, Pheterogeneity = 0.392). In further stratified analyses, XRCC4 rs1805377 polymorphism was associated with increased glioma risk among Asians in homozygote comparison (GG vs. AA: OR = 1.59, 95% CI = 1.12-2.25, Pheterogeneity = 0.261). Significantly elevated cancers risk were also observed in population-based studies (GG versus AA: OR = 1.38, 95% CI = 1.11-1.72, Pheterogeneity = 0.571) and using other method studies (GG versus AA: OR = 1.63, 95% CI = 1.11-2.39, Pheterogeneity = 0.275). This meta-analysis indicated that XRCC4 rs1805377 polymorphism probably was associated with gliomas susceptibility in Asians. © 2016, E-Century Publishing Corporation. All rights reserved.

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