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Yantai, China

Yantai University is a public university founded in 1984 with the assistance of Peking University and Tsinghua University in Yantai, Shandong, China. Wikipedia.

The ABC phenomenon is described as a syndrome of accelerated clearance of polyethylene glycol (PEG)-modified liposomes from the bloodstream when repeatedly injected, with their increased accumulation in the liver and spleen. To clarify this immune response phenomenon, we evaluated a novel modified pH-sensitive liposome with a cleavable double smart PEG-lipid derivative (mPEG-Hz-CHEMS). The ABC phenomenon in mice was brought about by repeated injection of conventional PEG-PE liposomes and was accompanied by a greatly increased uptake in the liver. However, a slight ABC phenomenon was brought about by repeated injection of mPEG-CHEMS liposomes and was accompanied by only a slightly increased uptake in the liver, and repeated injection of mPEG-Hz-CHEMS liposomes did not induce the ABC phenomenon and there was no increase in liver accumulation. This finding indicates that the cleavable mPEG-Hz-CHEMS derivative could lessen or eliminate the ABC phenomenon induced by repeated injection of PEGylated liposomes. This research has shed some light on a solution to the ABC phenomenon using a cleavable PEG-Hz-CHEMS derivative encapsulated in nanoparticles. Source

Li Y.,Yantai University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014

Using the factorization approach, we investigate the B̄0→K̄ 0K+π- and B̄0→K0K-π+ decays individually including the resonant and nonresonant contributions. Under the flavor SU(3) symmetry, we obtain the total branching fraction BR[B̄0→(K̄0K+π-+K0K-π+)]=(7.17-0. 53-1.42-0.07+0.50+1.97+0.08)×10-6, which is in agreement with the recent measurements of BABAR and LHCb within errors. For the decay B̄0→ K̄0K+π-, the nonresonant background and a0+(1450) pole in the current-induced process provide a large contribution, the latter of which has not been included in previous studies. On the contrary, the decay B̄0→K0K-π+ is dominated by the nonresonant background and the off-shell ρ- pole. When the flavor SU(3) symmetry breaking and the final-state rescattering are considered under two different scenarios, the results can also accommodate the experimental data with large uncertainties. Moreover, the direct CP asymmetry of B̄0→K̄0K+π- is found to be sensitive to the matrix element of scalar density. These predictions could be further tested in the LHCb experiment or Super-b factory in the future. © 2014 American Physical Society. Source

Li Y.,Yantai University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2014

Within the perturbative QCD approach, we recalculate the branching ratio and polarization fractions of the pure annihilation decay B→ in both the standard model and the family nonuniversal Z′ model. We find that this decay is dominated by the longitudinal part, while the transverse parts are negligibly due to the absence of the (S-P)(S+P)-type operator. In the standard model, the branching ratio is predicted as (4.4-0.6-0.5+0.8+0.3)×10-8, which is larger than the previous predictions. With an additional Z′ boson, the branching ratio can be enhanced by a factor of 2 or reduced one-half in the allowed parameter space. These results will be tested by the ongoing LHCb experiment and forthcoming Super-B experiments. © 2014 American Physical Society. Source

Wang J.-P.,Yantai University
Physical Review B - Condensed Matter and Materials Physics | Year: 2010

Thermodynamic stability of composite vortex in a two-component superconductor is investigated by the Ginzburg-Landau theory. The predicted nature of these vortices has recently attracted much attention. Here we consider axially symmetric quantized vortex and show that the stability of vortex depends on three independent dimensionless parameters: κ1, κ2, and κξ, where κi (i=1,2) is the Ginzburg-Landau parameter of individual component, κξ = ξ1/ξ2 is the ratio of two coherence lengths. We also show that there exists thermodynamically stable vortex in a two-component superconductor over a range of these three parameters. © 2010 The American Physical Society. Source

Yantai University | Date: 2015-05-22

The present invention relates to a benzothiazole derivative of formula 1 or a pharmaceutically acceptable salt thereof and a process for preparation thereof. The present invention also relates to a pharmaceutical composition comprising the compounds and the use of the compounds in the preparation of an anti-tumor medicament.

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