Yangzhou University is a university in Jiangsu Province, China. It grew out of a merger in 1992 of six existing colleges. The school has around 2,000 faculty and 31,000 undergraduates. It offers 92 undergraduate programs covering 11 disciplines.The programs and research include humanity, science, business, engineering, architecture, computer, medicine, art, music, agriculture, animal husbandry, etc.Around 2,000 faculty members work on campus, including around 1000 professors and associate professors. 97 faculty members are entitled to State Fund for Specialists, 29 are entitled as Outstanding Contribution-making Young Experts by the government. At undergraduate level, the university has over 16,000 adult students in its continued education programs. Undergraduate programs are also available for students from Hong Kong, Macao and Taiwan. Students from foreign countries can be seen in this program as well.At the graduate level, around 3800 graduate students are studying in 21 doctoral and 122 master's programs, in which around 748 faculties are involved as doctoral and master's program supervisors.YZU has one national key laboratory, 14 ministerial and provincial key laboratories, and 37 teaching laboratory centers.YZU has seven libraries with 3.25 million volumes of books and journals. The libraries have a collection of rare Chinese classics. The university has its own Yangzhou University Journal , Jiangsu Agricultural Research, Jiangsu Clinical Medicine Journal and Yangzhou University Cuisine Journal.YZU closely combines industry, teaching and research. There are over 900 research projects underway at the university, including 65 national projects listed in 863 Hi-tech Projects, 973 High-tech Projects and National Priority Projects for the Ninth Five-Year Plan, and 144 provincial- or ministerial-level research projects. More than 260 research accomplishments have received awards at provincial or national level. The annual research fund amounts to over 120 Million RMB, ranking far above other universities of the same level.YZU has established ties with institutions of higher education in 10 countries. More than 100 foreign language teachers and experts and over 2500 foreign scholars have taught, delivered lectures or participated in academic exchange programs over the past few years.Over 700 faculty members have been sent abroad for academic visits, advanced studies, research cooperation or attendance at international academic conferences. Besides the exchanges at the faculty and researchers level, exchanges at the student level are developing. The number of international students in Yangzhou University is on the rise as is the number of Chinese students learning English. Wikipedia.
Guo X.,University of North Carolina at Chapel Hill |
Guo X.,Yangzhou University |
Huang L.,University of North Carolina at Chapel Hill
Accounts of Chemical Research | Year: 2012
Gene therapy has long been regarded a promising treatment for many diseases, whether acquired (such as AIDS or cancer) or inherited through a genetic disorder. A drug based on a nucleic acid, however, must be delivered to the interior of the target cell while surviving an array of biological defenses honed by evolution. Successful gene therapy is thus dependent on the development of an efficient delivery vector.Researchers have pursued two major vehicles for gene delivery: viral and nonviral (synthetic) vectors. Although viral vectors currently offer greater efficiency, nonviral vectors, which are typically based on cationic lipids or polymers, are preferred because of safety concerns with viral vectors. So far, nonviral vectors can readily transfect cells in culture, but efficient nanomedicines remain far removed from the clinic. Overcoming the obstacles associated with nonviral vectors to improve the delivery efficiency and therapeutic effect of nucleic acids is thus an active area of current research. The difficulties are manifold, including the strong interaction of cationic delivery vehicles with blood components, uptake by the reticuloendothelial system (RES), toxicity, and managing the targeting ability of the carriers with respect to the cells of interest.Modifying the surface with poly(ethylene glycol), that is, PEGylation, is the predominant method used to reduce the binding of plasma proteins to nonviral vectors and minimize clearance by the RES after intravenous administration. Nanoparticles that are not rapidly cleared from the circulation accumulate in the tumors because of the enhanced permeability and retention effect, and the targeting ligands attached to the distal end of the PEGylated components allow binding to the receptors on the target cell surface. Neutral and anionic liposomes have been also developed for systemic delivery of nucleic acids in experimental animal models. Other approaches include (i) designing and synthesizing novel cationic lipids and polymers, (ii) chemically coupling the nucleic acid to peptides, targeting ligands, polymers, or environmentally sensitive moieties, and (iii) utilizing inorganic nanoparticles in nucleic acid delivery.Recently, the different classes of nonviral vectors appear to be converging, and the ability to combine features of different classes of nonviral vectors in a single strategy has emerged. With the strengths of several approaches working in concert, more hurdles associated with efficient nucleic acid delivery might therefore be overcome.In this Account, we focus on these novel nonviral vectors, which are classified as multifunctional hybrid nucleic acid vectors, novel membrane/core nanoparticles for nucleic acid delivery, and ultrasound-responsive nucleic acid vectors. We highlight systemic delivery studies and consider the future prospects for nucleic acid delivery. A better understanding of the fate of the nanoparticles inside the cell and of the interactions between the parts of hybrid particles should lead to a delivery system suitable for clinical use. We also underscore the value of sustained release of a nucleic acid in this endeavor; making vectors targeted to cells with sustained release in vivo should provide an interesting research challenge. © 2011 American Chemical Society.
Wu C.,Yangzhou University
Applied Surface Science | Year: 2014
N-doped ZnO micropolyhedrons were fabricated by calcining the mixture of commercial ZnO (analyticalgrade) and NH4NO3at 600C for 1.5 h, in which NH4NO3was utilized as the nitrogen source. The structure,composition, BET specific surface area and optical properties of N-doped ZnO sample were characterizedby X-ray diffraction, X-ray photoelectron spectroscopy, wavelength dispersive X-ray fluorescence spec-troscopy, field emission scanning electron microscopy, high resolution transmission electron microscopy,N2adsorption-desorption isotherms, and UV-vis diffuse reflectance spectroscopy. The photocatalyticresults demonstrated that the as-synthesized N-doped ZnO microcrystals possessed much higher pho-tocatalytic activity than N-doped TiO2(which was synthesized by calcining the mixture of P25 TiO2and NH4NO3at 600C for 1.5 h) and commercial pure ZnO in the decomposition of formaldehyde undervisible-light (λ > 420 nm) irradiation. The present work suggests that NH4NO3is a promising nitrogensource for one-step calcination synthesis of microcrystalline N-doped ZnO, which can be applied as avisible-light-activated photocatalyst in efficient utilization of solar energy for treating formaldehydewastewater. © 2014 Elsevier B.V. All rights reserved.
Wu C.,Yangzhou University
Materials Letters | Year: 2015
N-doped CeO2 microspheres were fabricated by a one-step low temperature (180 °C) solvothermal route from Ce(NO3)3·6H2O, HNO3, and ethanol, utilizing HNO3 as the nitrogen source. The structure, composition, BET specific surface area and optical properties of N-doped CeO2 sample were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, wavelength dispersive X-ray fluorescence, field emission scanning electron microscopy, N2 adsorption-desorption isotherms, and UV-vis diffuse reflectance spectroscopy. The photocatalytic results demonstrated that as-synthesized N-doped CeO2 microspheres possessed much higher photocatalytic activity than that of pure CeO2 in the photocatalytic activity of aqueous rhodamine 6G under visible light (λ>420 nm) irradiation. Moreover, the photocatalytic results indicated that the as-synthesized N-doped CeO2 was a kind of promising photocatalyst in remediation of water polluted by some chemically stable azo dyes under visible light irradiation. © 2014 Elsevier B.V. All rights reserved.
Wang Y.,Yangzhou University
Talanta | Year: 2013
A sensitive and simple method using magnetic multi-walled carbon nanotubes, as an adsorbent, has been successfully developed for extraction and preconcentration trace amounts of Se(IV) with detection by hydride generation atomic fluorescence spectrometry. The prepared nanoparticles were confirmed by Fourier transform infrared spectra, X-ray diffraction spectrometry, vibrating sample magnetometry, and transmission electron microscopy. These magnetic nanocomposites can be easily dispersed in aqueous samples and retrieved by the application of external magnetic field via a piece of permanent magnet. The main factors affecting the signal intensity such as sample pH value, adsorbent amount, eluent concentration and volume, sample volume, and coexisting ions have been investigated and established. The absorbent could be repeatedly used at least 100 times. The enhancement factor of the proposed method for Se(IV) was 100. The method had a linear calibration plot in the range from 0.05 to 10.0 μg L(-1) with a standard deviation of 2.3% at 0.5 μg L(-1) (n=11). The limit of detection was as low as 0.013 μg L(-1). Accuracy of the method was evaluated by the analysis of water samples and certified reference materials. Copyright © 2013 Elsevier B.V. All rights reserved.
Zhao D.,Yangzhou University
Molecular biology reports | Year: 2012
Herbaceous peony (Paeonia lactiflora Pall.) is an important ornamental plant which contains different flower colors. In this paper, eight genes encoding phenylalanine ammonialyase (PAL), chalcone synthase (CHS), chalcone isomerase (CHI), flavanone 3-hydroxylase (F3H), flavonoid 3'-hydroxylase (F3'H), dihydroflavonol 4-reductase (DFR), anthocyanidin synthase (ANS), UDP-glucose: flavonoid 3-o-glucosyltransferase (UF3GT) were isolated. Moreover, the expression patterns of these eight genes and UF5GT in the flowers were investigated in three cultivars, that is, 'Hongyanzhenghui', 'Yulouhongxing' and 'Huangjinlun' with purplish-red, white and yellow flower respectively. Furthermore, flavonoid accumulation in the flowers was also analyzed. The results showed that in different organs, most of genes expressed higher in flowers than in other organs. During the development of flowers, all genes could be divided into four groups. The first group (PlPAL) was highly expressed in S1 and S4. The second group (PlCHS and PlCHI) was at a high expression level throughout the whole developmental stages. The third group (PlF3H, PlF3'H, PlDFR, PlANS and PlUF5GT) gradually decreased with the development of flowers. The fourth group (PlUF3GT) gradually increased during the flower development. In addition, anthoxanthins and anthocyanins were detected in 'Hongyanzhenghui' and 'Yulouhongxing', chalcones and anthoxanthins were found in 'Huangjinlun'. When different color flowers were concerned, low expression level of PlCHI induced most of the substrate accumulation in the form of chalcones and displaying yellow, changing a small part of substrates to anthoxanthins, and there was no anthocyanin synthesis in 'Huangjinlun' because of low expression level of DFR. In 'Yulouhongxing', massive expressions of upstream genes and low expression of DFR caused synthesis of a great deal of anthoxanthins and a small amount of colorless anthocyanins. In 'Hongyanzhenghui', a large number of colored anthocyanins were changed from anthoxanthins because of PlDFR, PlANS and PlUF3GT high expressions. These results would provide us a theoretical basis to understand the formation of P. lactiflora flower colors.