Yangzhou, China
Yangzhou, China

Yangzhou University is a university in Jiangsu Province, China. It grew out of a merger in 1992 of six existing colleges. The school has around 2,000 faculty and 31,000 undergraduates. It offers 92 undergraduate programs covering 11 disciplines.The programs and research include humanity, science, business, engineering, architecture, computer, medicine, art, music, agriculture, animal husbandry, etc.Around 2,000 faculty members work on campus, including around 1000 professors and associate professors. 97 faculty members are entitled to State Fund for Specialists, 29 are entitled as Outstanding Contribution-making Young Experts by the government. At undergraduate level, the university has over 16,000 adult students in its continued education programs. Undergraduate programs are also available for students from Hong Kong, Macao and Taiwan. Students from foreign countries can be seen in this program as well.At the graduate level, around 3800 graduate students are studying in 21 doctoral and 122 master's programs, in which around 748 faculties are involved as doctoral and master's program supervisors.YZU has one national key laboratory, 14 ministerial and provincial key laboratories, and 37 teaching laboratory centers.YZU has seven libraries with 3.25 million volumes of books and journals. The libraries have a collection of rare Chinese classics. The university has its own Yangzhou University Journal , Jiangsu Agricultural Research, Jiangsu Clinical Medicine Journal and Yangzhou University Cuisine Journal.YZU closely combines industry, teaching and research. There are over 900 research projects underway at the university, including 65 national projects listed in 863 Hi-tech Projects, 973 High-tech Projects and National Priority Projects for the Ninth Five-Year Plan, and 144 provincial- or ministerial-level research projects. More than 260 research accomplishments have received awards at provincial or national level. The annual research fund amounts to over 120 Million RMB, ranking far above other universities of the same level.YZU has established ties with institutions of higher education in 10 countries. More than 100 foreign language teachers and experts and over 2500 foreign scholars have taught, delivered lectures or participated in academic exchange programs over the past few years.Over 700 faculty members have been sent abroad for academic visits, advanced studies, research cooperation or attendance at international academic conferences. Besides the exchanges at the faculty and researchers level, exchanges at the student level are developing. The number of international students in Yangzhou University is on the rise as is the number of Chinese students learning English. Wikipedia.


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Zhang X.,Yangzhou University | Xu W.,Yangzhou University | Dai J.,Yangzhou University | Liu Y.,Yangzhou University
Carbon | Year: 2017

The effect of transition metal atoms on the electronic and magnetic properties of defective bilayer graphene (TM@dBLGs, TM = Ti-Fe) have been systematically studied by first principles calculations. Mixed covalent and ionic bonding is demonstrated between transition metal atoms and on-site graphene layers. Except Ti and Fe, all the TM@dBLG systems anchored by V, Cr and Fe atoms are found to be robust ferromagnetic. Different from the metallic pristine BLG, a number of TM@dBLGs are transformed to be semiconductors, of which, the band gaps of GTiG_SV_H, GVG_SV_H and G(N)FeG_SV are about 361 meV, 219 meV and 147 meV, respectively. In comparison, the B/N doped TM@dBLGs exhibit distinct electronic and magnetic properties due to the charge redistribution. Our findings propose an effective route to manipulate the electronic and magnetic properties of graphene, which allows its potential application in modern spintronic and electronic devices. © 2017 Elsevier Ltd


Zhang B.,Tongji University | Le Y.,Tongji University | Xia B.,Queensland University of Technology | Skitmore M.,Yangzhou University
Journal of Professional Issues in Engineering Education and Practice | Year: 2017

Guanxi is the Chinese word for personal relationships or connections. Infrastructure project procurement in China is dominated by the government, and the entire tendering and bidding process is subject to administrative control in which business-to-government (B2G) guanxi is thought to have a significant impact. To date, however, little is known of its impact and perception in infrastructure procurement. This paper aims to bridge this research gap through a questionnaire survey of 149 contractors' and consultants' perceptions of B2G guanxi in terms of its importance, mode of establishment, and impact on infrastructure bidding in China's eastern coastal cities. The results indicate that over half of the respondents surveyed consider B2G guanxi to have important benefits for current practice whereas others hold different perceptions. Four groups of perspectives are identified by K-means cluster analysis, ranging from a low/moderate perception of B2G guanxi (48%) to passive-high/positive-high (52%). A chi-square test suggests the differences between groups is attributable to the types of organizations involved, with contractors and quantity surveying consultant organizations placing significantly more emphasis on the benefits and establishment of B2G guanxi. Finally, the current informal tendering and bidding processes in China are questioned as a contributing factor and suggestions are made for increased government and legislative intervention, leading to a greater emphasis by bidders on improving their technical and management capacity in order to develop their competitive advantage in the market. © 2017 American Society of Civil Engineers.


Li B.,Yangzhou University | Gu P.,Yangzhou University | Feng Y.,Yangzhou University | Zhang G.,Yangzhou University | And 3 more authors.
Advanced Functional Materials | Year: 2017

2D materials are ideal for constructing flexible electrochemical energy storage devices due to their great advantages of flexibility, thinness, and transparency. Here, a simple one-step hydrothermal process is proposed for the synthesis of nickel–cobalt phosphate 2D nanosheets, and the structural influence on the pseudocapacitive performance of the obtained nickel–cobalt phosphate is investigated via electrochemical measurement. It is found that the ultrathin nickel–cobalt phosphate 2D nanosheets with an Ni/Co ratio of 4:5 show the best electrochemical performance for energy storage, and the maximum specific capacitance up to 1132.5 F g−1. More importantly, an aqueous and solid-state flexible electrochemical energy storage device has been assembled. The aqueous device shows a high energy density of 32.5 Wh kg−1 at a power density of 0.6 kW kg−1, and the solid-state device shows a high energy density of 35.8 Wh kg−1 at a power density of 0.7 kW kg−1. These excellent performances confirm that the nickel–cobalt phosphate 2D nanosheets are promising materials for applications in electrochemical energy storage devices. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


Baker S.,University of Warwick | Kong D.,Yangzhou University | Kong D.,Leiden University
Nonlinearity | Year: 2017

To each we associate the Cantor set Γα:={∑i=1∞iαi:i∈{0,1}, i1}. In this paper we consider the intersection for any translation . We pay special attention to those t with a unique {-1, 0, 1} α-expansion, and study the set Dα:={dimH(Γα∩(Γα+t)):t has a unique {-1,0,1} α-expansion}. We prove that there exists a transcendental number αKL ≈ 0.39433 such that:Dα is finite for α ∈(αKL, 1/2)DαKL is infinitely countable, and Dα contains an interval for α ∈(1/3, α KL). We also prove that Dα equals [O,log2/-log α] if and only if α ∈(1/3, 3-√5/2] . As a consequence of our investigation we prove some results on the possible values of dimH(Γα∩ (Γ α+t ) when (Γα∩(Γα+t ) is a self-similar set. We also give examples of t with a continuum of {-1, 0, 1} α-expansions for which we can explicitly calculate dimH(Γα∩(Γα+ t))and for which Γα∩(Γα + t)is a self-similar set. We also construct α and t for which Γα∩(Γα + t)contains only transcendental numbers. Our approach makes use of digit frequency arguments and a lexicographic characterisation of those t with a unique {-1, 0, 1} α-expansion. © 2017 IOP Publishing Ltd & London Mathematical Society.


Lian Y.,Yangzhou University
Chemical Engineering Transactions | Year: 2016

In recent years, with the rapid development of road transport, the leakage accidents of hazardous chemicals caused by road transport are also increasing, which seriously threaten people's lives and property safety. The establishment of safety management mechanism is an urgent mission for the government departments, and accurately and reasonably evaluate the safety status of hazardous chemicals road transport system is an important basic work for ensuring smooth operation of safety management mechanism. The hazardous chemicals road transport safety is taken as a complete system. From the scientific research achievements at home and abroad, through the statistics and analysis of the road transportation accidents of hazardous chemicals in the domestic industry, this paper summarizes and establishes the safety evaluation system of hazardous chemicals road transport, makes use of combination weighting method of entropy value method and expert method to obtain the weights of each index in the index system, adopts comprehensive index method to establish the road transport of hazardous chemicals safety evaluation model, and applied to the road transportation safety evaluation of hazardous chemicals in Liaoning province. In the safety evaluation of road transportation of hazardous chemicals in Liaoning province, according to the existing problems, starting from the actual situation of Liaoning Province, this paper puts forward several suggestions for how to improve the safety level of road transport of hazardous chemicals. Copyright © 2016, AIDIC Servizi S.r.l.


Zhang C.,Nanjing Southeast University | Shen C.,Yangzhou University | Chen Y.,Nanjing Southeast University | Chen Y.,Yangzhou University
International Journal of Heat and Mass Transfer | Year: 2017

The condensation flow patterns of ethanol–water mixture in a wide range of ethanol mass concentration inside a hydrophobic microchannel is experimentally studied via a high speed imaging system. The effects of channel surface wettability and ethanol concentration on flow condensation are compared and discussed. The experimental results indicate that the surface hydrophobic modification and ethanol concentration play a significant role in the flow condensation of mixture in a microchannel. The droplet condensation appears almost the whole two-phase flow region when the water steam is the main component, in which the droplet flow, droplet-streak flow, droplet-annular flow, droplet-injection flow and droplet-slug/bubble flow occur sequentially in a hydrophobic microchannel. With increasing ethanol concentration, the droplet-slug/bubble flow after droplet-injection flow disappears and is replaced by the pure slug/bubble flow. When the ethanol vapor is the main component, the droplet condensation almost disappears, and the annular-streak flow, annular flow, injection flow and slug/bubble flow appear sequentially along the flow direction. Both an increase in vapor Reynolds number and a decrease in ethanol concentration cause the injection location move toward the channel outlet. In addition, the surface hydrophobic modification introduces the droplet condensation, which is beneficial for the flow condensation heat transfer. © 2016 Elsevier Ltd


Chi Y.,Yangzhou University | Guo S.-P.,Yangzhou University
Journal of Molecular Structure | Year: 2017

Five isostructural quaternary rare-earth sulfide MgRE6Si2S14 (RE = Y, Ce, Pr, Nd and Sm) have been successfully synthesized via high-temperature solid-state method. They crystallize in the hexagonal space group P63 and belong to the MnLa6Si2S14 structure type. Their 3-D structures are constructed by the connection between infinite 1-D [(RE6S6)6+]∞ tubular and (SiS4)4– tetrahedron, and Mg2+ ions occupy the octahedral interspaces in the [(RE6S6)6+]∞ tubular. The lanthanide contraction phenomenon among these compounds is also discussed. Electronic structure calculation indicates that MgY6Si2S14 has an indirect optical energy gap of 2.26 eV, and its optical absorption is mainly ascribed to the charge transition from S-3p to Y-4d states. © 2016 Elsevier B.V.


Chi Y.,Yangzhou University | Guo S.-P.,Yangzhou University | Xue H.-G.,Yangzhou University
RSC Advances | Year: 2017

Four isostructural europium chalcogenides, EuZnGeS4 (1), EuGa2S4 (2), EuIn2S4 (3) and EuIn2Se4 (4), have been synthesized using a high-temperature solid-state method. Single-crystal X-ray diffraction analysis indicates that they crystallize in the orthorhombic space group Fddd with Z = 32. Their structures feature an MQ4 (M = Zn, Ge, Ga and In; Q = S and Se) tetrahedrally constructed 3D network, and Eu2+ ions occupy the bicapped trigonal prismatic cavities. Compounds 1-3 have optical band gaps of 2.26, 2.32 and 2.37 eV, respectively. Theory calculations indicate that 2, with an indirect band gap, can be tuned to 1, with a direct band gap, via simple chemical substitution. © 2017 The Royal Society of Chemistry.


Yao G.,Yangzhou University | Yao Q.,Yangzhou University | Xia Z.,Yangzhou University | Li Z.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

Solubility of 3,5-dimethylpyrazole in nine organic solvents including ethanol, isopropanol, n-propanol, 1-butanol, methanol, ethyl acetate, toluene, acetone, acetonitrile was determined experimentally by using the isothermal saturation method over a temperature range from (283.15 to 313.15) K under 101.3 kPa. For the temperature range studied, the solubility of 3,5-dimethylpyrazole in the solvents increased with a rise of temperature. In general, they obeyed the following order from high to low in different solvents: 1-butanol > n-propanol > (ethanol, isopropanol, methanol, ethyl acetate, acetone) > toluene > acetonitrile. The acquired solubility data of 3,5-dimethylpyrazole in the studied solvents were correlated by using the modified Apelblat equation, λh equation, Wilson model and NRTL model. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 3.293 × 10−3 and 2.62%, respectively. The RAD values acquired with the modified Apelblat equation were smaller than those with the other three models for a certain solvent except for the system of n-propanol. Generally, the four thermodynamic models were all acceptable for the systems of 3,5-dimethylpyrazole in these solvents. Furthermore, the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration (γ1 ∞) and reduced excess enthalpy (H1 E,∞) were obtained. The solution process of 3,5-dimethylpyrazolewas spontaneous in the studied solvents. The obtained solubility and thermodynamic studies would be very helpful for optimizing the purification process of 3,5-dimethylpyrazole. © 2017 Elsevier Ltd


LaFeO3 was synthesized via a simple gel-combustion method at the calcination temperatures of 200-400°C. The X-ray diffraction characterization indicated that the products synthesized at 200-400°C were all pure perovskite phase LaFeO3. The scanning electron microscopy images revealed that the LaFeO3 synthesized at 200°C had a porous nanostructure, but became a solid nanostructure at 400°C. The nitrogen adsorption measurements suggested that the specific surface area of LaFeO3 increased with the lowering of the calcination temperature. The UV-vis diffuse reflection spectra showed that the LaFeO3 synthesized at 200°C exhibited the strongest absorption of visible-light. The photocatalytic experiments demonstrated that as the calcination temperature was lowered, the resultant LaFeO3 exhibited obviously enhanced photocatalytic activity in reduction of Cr(VI) in aqueous solution under visible-light (wavelength longer than 420nm) irradiation. This work can enrich our knowledge on the synthesis and photoabsorption properties of porous nanostructure LaFeO3, and contribute to the application of LaFeO3 nanomaterials in treating the wastewaters contaminated by highly toxic and intractable Cr(VI). © 2017 Elsevier B.V.


Gu S.,Yangzhou University | Chen L.,Yangzhou University
Communications in Computer and Information Science | Year: 2017

In complex networks, link prediction involves detecting both unknown links and links that may appear in the future. Recently, various approaches have been proposed to detect potential or future links in temporal social networks. To evaluate the performance of link prediction methods, precision are usually used to measure the accuracy of the predicting results. This paper proposes an algorithm based on the precision optimization. In the method, precision is treated as the objective function, and link prediction is transformed as an optimization problem. A group of topological features are defined for each ordered pair of nodes. Using those features as the attributes of the node pairs, link prediction can be treated as a binary classification where class label of each node pair is determined by whether there exists a directed link between the node pair. Then the binary classification problem can be solved by precision optimization. Empirical results show that our algorithm can achieve higher quality results of prediction than other algorithms. © Springer Nature Singapore Pte Ltd. 2017.


Yang H.M.,Yangzhou University | Wang Y.,Yangzhou University | Wang Z.Y.,Yangzhou University | Wang X.X.,Yangzhou University
Poultry Science | Year: 2017

This study aimed at the reproductive endocrine profile under a natural photoperiod in Yangzhou female geese. Geese in the breeding industry were exposed to a natural photoperiod and the results showed the breeding season of Yangzhou geese initiated in autumn, reached peak in February and March, and terminated in June. Fifteen female geese were randomly selected for blood collection samples monthly. The results showed serum luteinizing hormone (LH) concentrations in female geese were higher in the breeding season than in the non-breeding season. The concentrations of Prolactin (PRL) were also high in the breeding season. Follicle-stimulating hormone (FSH) concentrations were high from March to May and decreased to low levels in other periods. Furthermore, 6 female birds were selected randomly monthly, sacrificed, and the hypothalamus and pituitary isolated. The expressions of FSH were also high in the breeding season, while the expressions of the gonadotropin-releasing hormone (GnRH) fluctuated. These results indicated that the reproductive hormones and their transcript expressions were closely related to the reproductive activities in Yangzhou geese. © 2016 Poultry Science Association Inc.


Liu J.,Yangzhou University | Meng C.-G.,Yangzhou University | Liu S.,Yangzhou University | Kan J.,Yangzhou University | Jin C.-H.,Yangzhou University
Food Hydrocolloids | Year: 2017

In this study, novel chitosan (CS) based active films were developed by grafting natural phenolic antioxidant of protocatechuic acid (PA) onto chitosan backbones. The physicochemical, mechanical and antioxidant properties of three PA grafted CS (PA-g-CS) films with different grafting ratios were characterized. The transparent PA-g-CS films exhibited yellowish color with thickness ranging from 44.1 to 48.6 μm. By contrast with CS film, PA-g-CS films with medium and high grafting ratios showed decreased moisture content, water vapor permeability; however, increased water solubility and tensile strength. The barrier to UV light of CS film could be improved by grafting with PA. An increase in the total color difference was observed for PA-g-CS films, indicating PA-g-CS films were more colored. Among four kinds of films tested, PA-g-CS film with medium grafting ratio exhibited the highest tensile strength (45.7 MPa) and elongation at break (5.05%). According to thermogravimetric analysis, the maximum rates of weight loss for PA-g-CS films appeared at 291.8–294.0 °C. Antioxidant activity assays showed that PA-g-CS films had both dose-dependent and time-dependent scavenging activity on DPPH radical. Our results suggest that PA-g-CS films are expected to serve as novel antioxidant food packaging materials. © 2016 Elsevier Ltd


Hu Y.,Yangzhou University | Zhang H.,Yangzhou University
Journal of Plant Nutrition | Year: 2017

Nitrogen (N) application plays an important role in rice production. Limited attention has already been paid to optimizing N fertilizer management strategy for higher grain yield and nitrogen use efficiency (NUE) of rice with crop residue incorporation. Field experiments were conducted with the objective to determine the response of several N application methods to rice production and to evaluate their NUE. Three N fertilizer application methods, i.e., local farmers' N fertilizer practice (FNP), modified farmers' N fertilizer practice (MNP), and increased the amount of N fertilizer practice (INP), were adopted with zero N application as control (CK). The results showed that, compared with that under FNP, grain yield was significantly higher under MFP, owing to signficantly enhanced total spikelets as a result of more panicles per unit area. Relative to FNP, MNP markedly increased nitrogen agronomic efficiency (AEN), nitrogen recovery efficiency (REN), nitrogen physiological efficiency (PEN) and nitrogen partial factor productivity (PFPN), but AEN, PEN and PFPN of INP were significantly lower. Further analysis showed that the number of tiller, leaf area index, aboveground biomass, SPAD value, plant N content and N uptake at the early vegetative stage were improved significantly under MNP compared to those under FNP, contributing to higher total aboveground biomass and total N uptake. © 2017 Taylor & Francis Group, LLC.


Jing X.,Yangzhou University | Yuan D.,Yangzhou University | Yu L.,Yangzhou University
Advanced Synthesis and Catalysis | Year: 2017

Organoselenium-catalyzed oxidative deoximations afforded ketones and aldehydes under mild conditions. The reactions employ hydrogen peroxide and air as clean oxidants and lead to a waste-free and metal-free deprotection protocol for carbonyl protection strategies as well as the green synthesis of ketones and aldehydes. The mechanisms of this interesting organoselenium-catalyzed reaction have been investigated by control experiments as well as the selenium 77 nuclear magnetic resonance (77Se NMR) tests. This novel reaction largely expands the application scope of organoselenium catalysis. (Figure presented.). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


Wang M.,Yangzhou University | Zhang W.,Yangzhou University | Zheng X.,Shanghai Institute of Technology | Zhu P.,Yangzhou University
RSC Advances | Year: 2017

Spherical biogenic silver nanoparticles (AgNPs) were synthesized using aqueous green coffee bean extract as a reducing agent. The green coffee bean extract was used for the time to reduce silver ions via a one-step, green, and rapid approach. The prepared AgNPs were characterized via transmission electron microscopy (TEM), atomic force microscopy (AFM), and UV-visible spectroscopy. Dynamic light scattering (DLS) was performed to measure the particle size. These AgNPs exhibit strong antibacterial activity against both Gram-negative and Gram-positive bacteria and the minimum inhibitory concentration (MIC) of AgNPs for Escherichia coli and Staphylococcus aureus are 0.05 μmol L−1 and 0.1 μmol L−1, respectively. Furthermore, AgNPs could serve as an effective catalyst for the reduction of 4-nitrophenol to 4-aminophenol in the presence of NaBH4. © The Royal Society of Chemistry.


Wang M.,Yangzhou University | Han J.,Yangzhou University | Hu Y.,Yangzhou University | Guo R.,Yangzhou University
RSC Advances | Year: 2017

Mesoporous C, N-codoped TiO2 (C/N-TiO2) hybrid shells incorporated with graphite carbon were synthesized using polystyrene spheres as templates, followed by polyaniline (PANI) and TiO2 coating, and then post-treatments of etching and calcination, where PANI functioned as both C and N doping sources and supplied the graphite carbon. Compared with pure TiO2 and C-doped TiO2 (C-TiO2) hybrid shells, C/N-TiO2 hybrid shells exhibited enhanced photocatalytic activity in the degradation of organic dyes and H2 production under visible light irradiation, which could be attributed to the enhanced visible light absorption and charge separation efficiency associated with the codoped-C and N and the presence of graphite carbon. It is believed that the strategy presented here will provide a promising route for the construction of other C/N-semiconductor hybrid shells for broader applications. © The Royal Society of Chemistry.


Ling X.-M.,Anhui Xinhua University | Xu L.-S.,Yangzhou University
Advances in Intelligent Systems and Computing | Year: 2017

This paper gives new properties of WBR0-algebras and commutative WBR0-algebras.Acomprehensive characterization for commutativeWBR0-algebras by various other logic algebras is obtained. Three characterizations with simpler types and fewer axioms of commutative WBR0-algebras are also given. © Springer International Publishing Switzerland 2017.


Wei W.,Yangzhou University | Huang Q.,Yangzhou University
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2017

Silver nanoparticles (Ag NPs) were fabricated on the fibers of the filter paper by the reaction between silver nitrate (AgNO3) and hydrazine hydrate (N2H4·H2O). By using the Ag NPs-coated paper, the limit of detection as low as 10− 11 M for Rhodamine B (RhB) and 10− 10 M for crystal violet (CV) was achieved. Moreover, the uniformity, reproducibility and stability of the Ag NPs-coated paper were also involved. Meanwhile, the detection of 10− 4–10− 6 M moxifloxacin in deionized water and tap water was also carried out successfully by using the paper-based substrates. The fabrication process is easy to handle, cost-efficient and the as-prepared paper-based SERS substrate is ideal for rapid and simple detection of low-abundance molecules. © 2017 Elsevier B.V.


Yang J.,Yangzhou University | Zhou Q.,Yangzhou University | Zhang J.,Chinese University of Hong Kong
Crop Journal | Year: 2017

To meet the major challenge of increasing rice production to feed a growing population under increasing water scarcity, many water-saving regimes have been introduced in irrigated rice, such as an aerobic rice system, non-flooded mulching cultivation, and alternate wetting and drying (AWD). These regimes could substantially enhance water use efficiency (WUE) by reducing irrigation water. However, such enhancements greatly compromise grain yield. Recent work has shown that moderate AWD, in which photosynthesis is not severely inhibited and plants can rehydrate overnight during the soil drying period, or plants are rewatered at a soil water potential of − 10 to − 15 kPa, or midday leaf potential is approximately − 0.60 to − 0.80 MPa, or the water table is maintained at 10 to 15 cm below the soil surface, could increase not only WUE but also grain yield. Increases in grain yield WUE under moderate AWD are due mainly to reduced redundant vegetative growth; improved canopy structure and root growth; elevated hormonal levels, in particular increases in abscisic acid levels during soil drying and cytokinin levels during rewatering; and enhanced carbon remobilization from vegetative tissues to grain. Moderate AWD could also improve rice quality, including reductions in grain arsenic accumulation, and reduce methane emissions from paddies. Adoption of moderate AWD with an appropriate nitrogen application rate may exert a synergistic effect on grain yield and result in higher WUE and nitrogen use efficiency. Further research is needed to understand root–soil interaction and evaluate the long-term effects of moderate AWD on sustainable agriculture. © 2016 Crop Science Society of China and Institute of Crop Science, CAAS


Xu Y.,Yangzhou University | Li P.,Yangzhou University | Yang Z.,Yangzhou University | Xu C.,Yangzhou University
Crop Journal | Year: 2017

Dissecting the genetic architecture of complex traits is an ongoing challenge for geneticists. Two complementary approaches for genetic mapping, linkage mapping and association mapping have led to successful dissection of complex traits in many crop species. Both of these methods detect quantitative trait loci (QTL) by identifying marker–trait associations, and the only fundamental difference between them is that between mapping populations, which directly determine mapping resolution and power. Based on this difference, we first summarize in this review the advances and limitations of family-based mapping and natural population-based mapping instead of linkage mapping and association mapping. We then describe statistical methods used for improving detection power and computational speed and outline emerging areas such as large-scale meta-analysis for genetic mapping in crops. In the era of next-generation sequencing, there has arisen an urgent need for proper population design, advanced statistical strategies, and precision phenotyping to fully exploit high-throughput genotyping. © 2016


Background: Avian pathogenic E. coli (APEC) can lead to a loss in millions of dollars in poultry annually because of mortality and produce contamination. Studies have verified that many immune-related genes undergo changes in alternative splicing (AS), along with nonsense mediated decay (NMD), to regulate the immune system under different conditions. Therefore, the splicing profiles of primary lymphoid tissues with systemic APEC infection need to be comprehensively examined. Results: Gene expression in RNAseq data were obtained for three different immune tissues (bone marrow, thymus, and bursa) from three phenotype birds (non-challenged, resistant, and susceptible birds) at two time points. Alternative 5' splice sites and exon skipping/inclusion were identified as the major alternative splicing events in avian primary immune organs under systemic APEC infection. In this study, we detected hundreds of differentially-expressed-transcript-containing genes (DETs) between different phenotype birds at 5 days post-infection (dpi). DETs, PSAP and STT3A, with NMD have important functions under systemic APEC infection. DETs, CDC45, CDK1, RAG2, POLR1B, PSAP, and DNASE1L3, from the same transcription start sites (TSS) indicate that cell death, cell cycle, cellular function, and maintenance were predominant in host under systemic APEC. Conclusions: With the use of RNAseq technology and bioinformatics tools, this study provides a portrait of the AS event and NMD in primary lymphoid tissues, which play critical roles in host homeostasis under systemic APEC infection. According to this study, AS plays a pivotal regulatory role in the immune response in chicken under systemic APEC infection via either NMD or alternative TSSs. This study elucidates the regulatory role of AS for the immune complex under systemic APEC infection. © 2017 The Author(s).


Liu Z.,Yangzhou University | Cheng Z.-L.,Yangzhou University | Liu Y.-Y.,Yangzhou University
Micro and Nano Letters | Year: 2017

Carbon nanorods (CNRs) have been attracting increasing interest because of their potential applications in high-performance nanoscale materials and electronic devices. Among the many preparation methods, the nanocasting method via inorganic template materials exhibited a controllable and facile feature. This work was to present a novel preparation of CNRs through the nanocasting method using halloysite nanotubes (HNTs) as the template and polyvinyl alcohol (PVA) as the nanocasting carbon source. For the sake of PVA nanocasted in the hollow structure of HNTs, we adopted the repeated soakage method. The forming process and structure of CNRs were revealed by XRD, FT-IR, SEM, TEM, SAED XPS, Raman and Brunner-Emmet-Teller (BET) characterisation techniques. The results showed that the as-obtained CNRs with the rod-like structure had a high specific surface area of ca. 284 m2/g and exhibited typical mesoporous features. © 2016 The Institution of Engineering and Technology.


Ahmed Bakheet A.A.,Yangzhou University | Ahmed Bakheet A.A.,University of Khartoum | Zhu X.S.,Yangzhou University
Journal of Fluorescence | Year: 2017

Fe3O4@Ionic liquids β-cyclodextrin polymer(Fe3O4@ mono-6- deoxy-6- (1-ethyl- imidazolium)-β-cyclodextrin iodide polymer, ILs-β-CDCP) was prepared. A novel method based on Fe3O4@ILs-β-CDCP solid phase extraction coupled with fluorescence spectrophotometry for Rhodamine B (RhB) determination, was investigated. Results were shown that RhB was adsorbed on Fe3O4@ILs-β-CDCP and eluted with sodium dodecyl sulfate (SDS) (1.0%) rapidly. Different parameters, such as pH, adsorption time and volume, eluent volume and time were studied. This method introduced linearity for RhB between 0.01–9.00 μg/mL−1 , the limit of detection was 5.2 ng/mL−1 , correlation coefficient (R) was >0.9987 and the relative standard deviation (RSD) was 3.1% (n = 3, c = 4.00 μg/mL). The mechanism of adsorption of RhB on Fe3O4@ILs-β-CDCP was studied through the FTIR analysis and the inclusion constant of Fe3O4@ILs-β-CDCP-RhB. This method was applied successfully for determination of RhB in real samples with satisfactory results. © 2017 Springer Science+Business Media New York


Wang Y.,Yangzhou University | Zhao J.,Yangzhou University | Lu W.,Yangzhou University | Deng D.,Yangzhou University
Plant Cell Reports | Year: 2017

Height relates to plant architecture, lodging resistance, and yield performance. Growth-promoting phytohormones gibberellins (GAs) play a pivotal role in plant height control. Mutations in GA biosynthesis, metabolism, and signaling cascades influence plant height. Moreover, GA interacts with other phytohormones in the modulation of plant height. Here, we first briefly describe the regulation of plant height by altered GA pathway. Then, we depict effects of the crosstalk between GA and other phytohormones on plant height. We also dissect the co-localization of GA pathway genes and established quantitative genetic loci for plant height. Finally, we suggest ways forward for the application of hormone GA knowledge in breeding of crops with plant height ideotypes. © 2017 Springer-Verlag Berlin Heidelberg


Liu Y.,Yangzhou University | Liu Y.,Rutgers University | Liu R.,Yangzhou University | Szostak M.,Rutgers University
Organic and Biomolecular Chemistry | Year: 2017

A novel synthesis of anhydrides from twisted amides is reported. Sc(OTf)3 catalysis in the presence of water is used to synthesize anhydrides in one step from amides without external nucleophiles. Mechanistic studies indicate that the coordination of the catalyst is critical to induce the challenging N-C activation step. This process further highlights the utility of twisted amides in organic synthesis. Notably, the reaction indicates that twisted amides based on the glutarimide scaffold are more reactive than carboxylic acid anhydrides under the developed conditions, which opens the door to controlled sequential catalysis through amide N-C bond cleavage. © The Royal Society of Chemistry.


Zhao J.,National Climate Center | Yang L.,Yangzhou University | Feng G.,National Climate Center | Feng G.,Yangzhou University
Theoretical and Applied Climatology | Year: 2017

In this study, the simultaneous atmospheric circulation system configuration characteristics of the four rainfall patterns (FRP) over the East China during the period 1951–2015 are analyzed in order to investigate their formation mechanisms. The results confirm that the FRP possess obvious differences in the upper-level, middle-level, and lower-level troposphere. In northern China rainfall pattern (NCP) years, the East Asian subtropical westerly jet stream (EAJS) shows a northward trend, with a higher intensity than normal; the blocking high (BH) in the mid-high latitudes is inactive; and the western Pacific subtropical high (WPSH) tends to be stronger, with a location to the north of its normal position. The East Asian summer monsoon (EASM) is stronger, which promotes vapor transport to northern China, and this leads to increased rainfall. In intermediate rainfall pattern (IRP) years, the EAJS position is close to that in normal years; the BH is inactive; the WPSH tends to be weaker, with a location to the east of its normal position; and the EASM is stronger, which is conducive to increased rainfall over the Huaihe River Basin. In Yangtze River rainfall pattern (YRP) years, the circulations are found to be almost opposite in their features to those in NCP years. In South China rainfall pattern (SCP) years, the circulations are found to be almost opposite in their features to those in IRP years. This leads to increased rainfall over South China. Therefore, the different circulation system configuration characteristics lead to the different rainfall patterns. © 2017 Springer-Verlag Wien


Cheng Z.-L.,Yangzhou University | Li Y.-X.,Yangzhou University | Liu Z.,Yangzhou University
Journal of Alloys and Compounds | Year: 2017

In this paper, we developed an adsorption composite materials based on the incorporation of zeolite and graphene oxide (GO), which could significantly hoist the adsorption capacity of zeolite and improve the separation trouble of GO with outstanding adsorption ability. The GO/Beta zeolite (GB) composite materials with different GO contents were hydrothermally prepared by grafting the GO onto acid-treated Beta zeolite. The structure and physical properties of the GB composite materials were determined by a series of characterizations such as XRD, SEM, FTIR, Raman, BET and XPS. It was concluded that the GB composite materials were of the hierarchical porous structure and GO nanosheets were bonded onto the active surface of Beta zeolite. The adsorption capacity of the GB composite materials was examined by the adsorption of RB dye molecular from aqueous solution. Moreover, the effect of adsorption conditions on the adsorption of RB onto the GB composite materials for rhodamine B (RB) was extensively investigated. Finally, the adsorption behaviors of the GB composite materials for RB were fitted by Langmuir isotherm and Freundlich isotherm equations, respectively. The result showed that the maximum adsorption capacity of the GB composite materials was up to 64.47 mg/g. © 2017 Elsevier B.V.


Guo S.-P.,Yangzhou University | Ma Z.,Yangzhou University | Li J.-C.,Yangzhou University | Xue H.-G.,Yangzhou University
Journal of Alloys and Compounds | Year: 2017

α-LiFeO2 and its nanocomposite with porous carbon (α-LiFeO2/PC) is prepared by a simple one-step solid-state method. They are characterized by powder X-ray diffraction, scanning electron microscope, transmission electron microscope, thermogravimetry, differential scanning calorimetry, X-ray photoelectron spectroscopy, Raman spectrum, and BET surface area analysis techniques. When composited with PC, α-LiFeO2 particles with smaller sizes locate on the surface or insert in the pores of PC. α-LiFeO2/PC can deliver the first discharge capacity of 1830 mAh/g, and 792 mAh/g can be maintained after 120 cycles at 0.1 C. Its capacity can reach to 570 mAh/g after 120 cycles even at 1C. The facile preparation method and nice electrochemical data, together with cheap and eco-friendly iron sources, make α-LiFeO2/PC a promising anode material for lithium-ion batteries. © 2017 Elsevier B.V.


Wang J.,Yangzhou University | Xue C.,Yangzhou University | Zhu P.,Yangzhou University
Materials Letters | Year: 2017

Flower-like silicon-doped hydroxyapatite (Si-HA) nanosheets assembly were synthesized via hydrothermal process using ethylene diamine tetraacetic acid (EDTA-Na2) and cetyltrimethyl ammonium bromide (CTAB) as templates. The effects of EDTA-Na2 concentration and hydrothermal temperature on the self-assembly formation of Si-HAs were analysed by scanning electron microscopy (SEM), transmission electron microscope (TEM), selected electron diffraction (SEAD), Fourier transform infrared spectrometry (FTIR), X-ray diffraction (XRD) and X-ray Photoelectron Spectroscopy (XPS). © 2017 Elsevier B.V.


Liu Y.,Yangzhou University | Yin S.-N.,Yangzhou University | Yang S.,Yangzhou University
Materials Letters | Year: 2017

In this work, we developed a facile methodology for synthesizing fluorescence tunable CdS nanocrystals with glutathione acting as both ligand and sulfur source. The structure and property characteristics of the as-prepared CdS nanocrystals have been thoroughly investigated by various characterization techniques. The results indicate that CdS nanocrystals can be well-controllably prepared by using glutathione under basic condition in an oil bath with a temperature of 95 °C. Also, the surface chemistry stability of CdS nanocrystals is in favor of their fluorescence lifetime, showing possibilities of CdS nanocrystals in the construction of fluorescent devices. © 2017 Elsevier B.V.


Cheng Z.-L.,Yangzhou University | Li W.,Yangzhou University | Liu Z.,Yangzhou University
Journal of Alloys and Compounds | Year: 2017

In this paper, a simple facile route for preparing zinc borate (ZB)/graphene oxide (GO) composites (ZB/GO) through a liquid phase-based ultrasonic-assisted stripping approach was demonstrated. As revealed by the FT-IR, XRD, Raman, UV–vis, TEM and SEM techniques, ZB hybrids were successfully composited with GO sheets. In order to highly disperse the composites into the base oil, the composites would be chemically modified in a reflux reaction with oleic diethanolamide (OD), i.e. OD-ZB/GO. The tribological properties of OD-ZB/GO as an additive in the base oil were tested by the four-ball wear machine. The results showed that the friction coefficient (COF) and the wear scar diameter (WSD) of the OD-ZB/GO-based oil (2.0 wt% of ZB/GO) were about 48.2% and 40.0% decline than those of the 500 SN base oil. Moreover, it could be found that the OD-ZB/GO-based oil showed a good carrying capacity at higher applied loads and an obviously reducing oil temperature performance in comparison of GO sheets and ZB hybrids. For proposing the wear mechanism, the as-prepared OD-ZB/GO in different viscosity base oil also was investigated intensively. The Raman spectra of wear surface revealed that the OD-ZB/GO materials entered the interfaces of motorial frictional pairs relied on base oil, thus displaying its antifriction and antiwear ability. © 2017 Elsevier B.V.


Cao X.,Yangzhou University
Mathematical Problems in Engineering | Year: 2017

We first give a Bäcklund transformation from the KdV equation to a new nonlinear evolution equation. We then derive two Bäcklund transformations with two pseudopotentials, one of which is from the KdV equation to the new equation and the other from the new equation to itself. As applications, by applying our Bäcklund transformations to known solutions, we construct some novel solutions to the new equation. © 2017 Xifang Cao.


Fei K.,Yangzhou University | Xu J.,Yangzhou University
Advances in Materials Science and Engineering | Year: 2017

Clay-aggregate mixtures are frequently used in engineering practice. To improve the understanding of the effects of coarse particles on the dynamic behavior of clay-aggregate mixtures, series of stress controlled cyclic triaxial tests were performed on clay specimens with various glass bead contents. The results show that the initial shear modulus of clay-aggregate mixtures increased with the increase of the coarse aggregate content and the confining stress. At the confining stress of 100, 200, and 400 kPa, the addition of 32% coarse particles caused an increase in the initial shear modulus of 117%, 110%, and 67%, respectively. Moreover, the normalized shear modulus decreased and damping ratio increased with the coarse aggregate content, and the influence of the confining stress on the strain-dependent dynamic properties was negligible. The specimen with a higher coarse aggregate content was observed to have larger cyclic shear strength and smaller excess pore water pressure, but the effects of the coarse aggregate content became less pronounced under large cyclic stresses. © 2017 Kang Fei and Jinxin Xu.


Qi X.,Yangzhou University
Zhonghua yi xue za zhi | Year: 2016

OBJECTIVE: To investigate the causes of missed diagnosis in transrectal ultrasound-guided transperineal prostate biopsy.METHODS: The biopsy results of total 278 patients who received transrectal ultrasound-guided transperineal prostate biopsy from January 2012 to December 2014 in Subei People's Hospital were retrospectively analyzed, using 11 systemic divisions.RESULTS: One hundred and twenty-nine patients were diagnosed with prostate cancer, and 149 patients were hyperplasia of prostate. Fifty-six patients with biopsy-negative and obvious symptoms of lower urinary tract obstruction were underwent transurethral resection of the prostate. Four of which were found to be prostate cancer.CONCLUSION: Early-stage prostate cancer, special prostate tumor location, inadequate biopsy tissue, special patients in limited position, and dissatisfied anesthesia may increase the risk of missed diagnosis. Targeted and individualized puncture may improve the effectiveness.


Xi X.,Yangzhou University | Zhang R.,Yangzhou University | Sun F.,Yangzhou University
Diamond and Related Materials | Year: 2017

In this account, Ni-P coated diamond (NPCD) with different phosphorus contents was prepared by electroless plating, and Ni-Co-Mn/NPCD composite coatings were formed through electrodeposition. The effect of phosphorus content on NPCD suspension and wear resistance of Ni-Co-Mn/NPCD composite coatings were examined and compared with unmodified diamond particles. The morphology and the chemical composition of the as-prepared materials were determined by environmental scanning electron microscopy (ESEM), and the hardness was tested by Vickers tester. The volume wear rates and friction coefficients of the coatings were respectively evaluated by ball-on-disk testing machine. The results demonstrated that lower phosphorus contents in NPCD yielded better suspensions, and contributed to higher volume fractions in the composite coatings. The wear resistance of Ni-Co-Mn/LP-NPCD composite coatings was found superior to other NPCD samples and untreated diamonds. However, the latter was weakened as the phosphorus content increased in NPCD. © 2017 Elsevier B.V.


Sun J.,Yangzhou University
Civil Engineering and Urban Planning IV - Proceedings of the 4th International Conference on Civil Engineering and Urban Planning, CEUP 2015 | Year: 2016

With the development of society, more and more families have their own private vehicles. Thus, the total number of vehicles has been greatly increased in recent years, which has a bad effect on the process of achieving each family’s convenient life aims due to traffic jams and traffic accidents. Especially, the traffic accidents that occurred around the intersections between drivers and pedestrians have already become serious society issues recently. Therefore, it is necessary to give useful measures to avoid these kinds of accidents. Therefore, according to the authors’ knowledge, there have been no related measures until now, and currently it is just based on the personal judgments of the drivers and pedestrians. Hence, this paper gives a feasible scheme for how to avoid the traffic accidents between drivers and pedestrians in signalized intersections. A Markov chain-based scheme was proposed for the calculation of the traffic accident probability in the signalized intersections. Simulations were conducted to verify the performances of the proposed scheme, and its superiority could be observed by comparing with the situation of without accident avoiding schemes in typical urban road network scenarios. © 2016 Taylor & Francis Group, London.


Gao M.,Yangzhou University | Chen L.,Yangzhou University | Chen L.,Nanjing University
Proceedings - 2016 International Conference on Information System and Artificial Intelligence, ISAI 2016 | Year: 2016

An algorithm for link prediction in bipartite network is presented. In the algorithm, we first map the bipartite network onto a unipartite one called projected graph. Based on the projected graph, we define the concept of candidate node pair (CNP). We perform the link prediction only within the CNPs so as to reduce the computation time. We also define the pattern covered by the CNPs and the weight of the patterns. By calculating the weights of the patterns a CNP covers, the connectivity of the CNP can be obtained, which can be used as the final score of link prediction. Experimental results show that our algorithm can get higher speed and superior quality link prediction results in bipartite networks than other methods. © 2016 IEEE.


Yao G.,Yangzhou University | Xia Z.,Yangzhou University | Li Z.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

The solubility of 2-amino-4-chloro-6-methoxypyrimidine in methanol, ethanol, chloroform, toluene, ethyl acetate, acetonitrile, n-propanol, acetone, N,N-dimethylformamide, isopropanol, 1,4-dioxane and ethyl benzene was obtained experimentally using the high-performance liquid chromatography analysis at temperatures ranging from (273.15 to 323.15) K under atmospheric pressure. The solubility of 2-amino-4-chloro-6-methoxypyrimidine in a fixed solvent increased with an increase in temperature. At a certain temperature, the mole fraction solubility in different solvents decreased according to the following order: N,N-dimethylformamide > dioxane > acetone > ethyl acetate > chloroform > (acetonitrile, n-propanol) > (ethanol, isopropanol) > methanol > toluene > ethyl benzene. Four models, modified Apelblat equation, λh equation, Wilson model and NRTL model were applied to correlate of the experimental solubility results. The largest values of relative average deviation and root-mean-square deviation acquired by the four models are 1.21% and 10.71 × 10−4, respectively. The modified Apelblat model is regarded as the best one for describing the experimental values. Furthermore, the mixing Gibbs energy, mixing enthalpy, and mixing entropy, activity coefficient and reduced excess enthalpy at infinitesimal concentration were obtained based on the mole fraction solubility. The mixing process of 2-amino-4-chloro-6-methoxypyrimidine in the selected solvents is discussed. © 2016 Elsevier Ltd


Yao G.,Yangzhou University | Yao Q.,Yangzhou University | Xia Z.,Yangzhou University | Li Z.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

In the present study, the solubility of o-phenylenediamine in four pure solvents (methanol, ethanol, acetonitrile and water) and three binary solvents (methanol + water), (ethanol + water) and (acetonitrile + water) was determined experimentally by using the isothermal dissolution equilibrium method within the temperature range from (283.15 to 318.15) K under atmospheric pressure. The solubility increased within creasing temperature in the four pure solvents and binary solvent mixtures at constant solvent composition. At constant temperature and solvent composition, the mole fraction solubility of o-phenylenediamine in four pure solvents decreased according to the following order: acetonitrile > methanol > ethanol > water; and in the three binary solvent mixtures ranked as (acetonitrile + water) > (methanol + water) > (ethanol + water). The dependence of o-phenylenediamine solubility in mole fraction on temperature and solvent composition in the binary solvent mixtures was correlated by employing the Jouyban-Acree model, van't Hoff-Jouyban-Acree model, modified Apelblat-Jouyban-Acree model, Ma model and Sun model. The largest value of relative average deviations (RAD) was 4.79 × 10−2; and of root-mean-square deviations (RMSD), 4.14 × 10−3. The five models were proven to give good representation of the experimental solubility results. Furthermore, the apparent enthalpy of the dissolution process was calculated. The dissolution process of o-phenylenediamine in the mixed solvents was endothermic. The experimental solubility and the models in this study could be helpful in purifying o-phenylenediamine. © 2016 Elsevier Ltd


Wang J.,Yangzhou University | Xu R.,Yangzhou University | Xu A.,Yangzhou University | Cong Y.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

Solubilities of 5-chloro-1-methyl-4-nitroimidazole in eleven organic solvents of methanol, ethanol, isopropanol, n-propanol, N-methyl-2-pyrrolidone, ethyl acetate, toluene, acetone, 2-butanone, trichloromethane and 1,4-dioxane were measured by using an isothermal saturation method at temperatures between 283.15 K and 318.15 K under 101.3 kPa. For the temperature range investigated, the solubilities of 5-chloro-1-methyl-4-nitroimidazole in these solvents increased with the increase in temperature. Overall, the mole fraction solubility obeyed the following order from high to low in different solvents: N-methyl-2-pyrrolidone > acetone > 2-butanone > trichloromethane > ethyl acetate > 1,4-dioxane > methanol > ethanol > toluene > n-propanol > isopropanol. The solubility values obtained for 5-chloro-1-methyl-4-nitroimidazole in the selected solvents were correlated via the λh equation, modified Apelblat equation, NRTL model and Wilson model. The largest value of root-mean-square deviation (RMSD) was 9.20 × 10−4, and the relative average deviation (RAD), 2.86%. The RAD values obtained with the modified Apelblat equation were smaller than those with the other three models except for the solvents of acetone and ethanol. Generally, the four thermodynamic models were all acceptable for describing the solubility of 5-chloro-1-methyl-4-nitroimidazole in the solvents. Moreover, the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration (γ1 ∞) and reduced excess enthalpy (H1 E,∞) were achieved. The solution process of 5-chloro-1-methyl-4-nitroimidazole was spontaneous and favourable in the solvents selected. The solubility values and thermodynamic studies would provide a fundamental basis for optimizing the purification process of 5-chloro-1-methyl-4-nitroimidazole. © 2016 Elsevier Ltd


Li X.,North China University of Water Conservancy and Electric Power | Du C.,Yangzhou University | Zhao H.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

The solubility of 3,5-dinitrobenzoic acid in acetone at the temperatures ranging from (283.15 to 318.15) K and the mutual solubility of the ternary m-nitrobenzoic acid + 3,5-dinitrobenzoic acid + acetone system at (283.15, 298.15 and 313.15) K were determined experimentally by using the isothermal saturation method under atmosphere pressure (101.2 kPa). Three isothermal ternary phase diagrams were constructed according to the measured mutual solubility data. In each ternary phase diagram, there was one co-saturated point, two boundary curves, and three crystalline regions. The modified Apelblat equation, λh equation, NRTL model and Wilson model were used to correlate the solubility of 3,5-dinitrobenzoic acid in acetone; and the NRTL and Wilson models, the mutual solubility for the ternary m-nitrobenzoic acid + 3,5-dinitrobenzoic acid + acetone system. The value of root-mean-square deviation (RMSD) was 8.53 × 10−4 for the binary system of 3,5-dinitrobenzoic acid + acetone; and the largest value of RMSD was 81.08 × 10−4 for the ternary system. © 2016 Elsevier Ltd


Zhang T.-P.,Yangzhou University | Wang N.-N.,Yangzhou University | Xia M.-Z.,Yangzhou University
Kongzhi yu Juece/Control and Decision | Year: 2017

An adaptive output feedback dynamic surface control scheme is proposed for a class of output feedback nonlinear systems with unmodeled dynamics and output constraint. The radial basis function neural networks are utilized to approximate unknown nonlinear continuous functions. The K-filters and dynamic signal are designed to estimate the unmeasured states and deal with the dynamic uncertainties, respectively. By introducing a barrier Lyapunov function(BLF) and designing the adaptive controller, the boundedness of the BLF and the output constraint can be guaranteed. By theoretical analysis, the closed-loop control system is shown to be semi-globally uniformly ultimately bounded, and satisfy the output constraint. Simulation results show the effectiveness of the proposed approach. © 2017, Editorial Office of Control and Decision. All right reserved.


Yuan Y.-G.,Yangzhou University | Peng Q.-L.,Yichun University | Gurunathan S.,Konkuk University
International Journal of Molecular Sciences | Year: 2017

Recently, silver nanoparticles (AgNPs) have been widely used in various applications as antimicrobial agents, anticancer, diagnostics, biomarkers, cell labels, and drug delivery systems for the treatment of various diseases. Microorganisms generally acquire resistance to antibiotics through the course of antibacterial therapy. Multi-drug resistance (MDR) has become a growing problem in the treatment of infectious diseases, and the widespread use of broad-spectrum antibiotics has resulted in the development of antibiotic resistance by numerous human and animal bacterial pathogens. As a result, an increasing number of microorganisms are resistant to multiple antibiotics causing continuing economic losses in dairy farming. Therefore, there is an urgent need for the development of alternative, cost-effective, and efficient antimicrobial agents that overcome antimicrobial resistance. Here, AgNPs synthesized using the bio-molecule quercetin were characterized using various analytical techniques. The synthesized AgNPs were highly spherical in shape and had an average size of 11 nm. We evaluated the efficacy of synthesized AgNPs against two MDR pathogenic bacteria, namely, Pseudomonas aeruginosa and Staphylococcus aureus, which were isolated from milk samples produced by mastitis-infected goats. The minimum inhibitory concentrations (MICs) of AgNPs against P. aeruginosa and S. aureus were found to be 1 and 2 μg/mL, respectively. Our findings suggest that AgNPs exert antibacterial effects in a dose- and time-dependent manner. Results from the present study demonstrate that the antibacterial activity of AgNPs is due to the generation of reactive oxygen species (ROS), malondialdehyde (MDA), and leakage of proteins and sugars in bacterial cells. Results of the present study showed that AgNP-treated bacteria had significantly lower lactate dehydrogenase activity (LDH) and lower adenosine triphosphate (ATP) levels compared to the control. Furthermore, AgNP-treated bacteria showed downregulated expression of glutathione (GSH), upregulation of glutathione S-transferase (GST), and downregulation of both superoxide dismutase (SOD) and catalase (CAT). These physiological and biochemical measurements were consistently observed in AgNP-treated bacteria, thereby suggesting that AgNPs can induce bacterial cell death. Thus, the above results represent conclusive findings on the mechanism of action of AgNPs against different types of bacteria. This study also demonstrates the promising use of nanoparticles as antibacterial agents for use in the biotechnology and biomedical industry. Furthermore, this study is the first to propose the mode of action of AgNPs against MDR pathogens isolated from goats infected with subclinical mastitis. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.


Xia M.,Yangzhou University | Zhang T.,Yangzhou University | Yang Y.,Yangzhou University | Zhu J.,Yangzhou University
IET Control Theory and Applications | Year: 2017

An adaptive dynamic surface control (DSC) method is proposed for a class of stochastic non-linear systems with input and state unmodelled dynamics in this paper. A normalisation signal is introduced to restrict the input unmodelled dynamics. By introducing a non-linear transformation, modified DSC is extended and applied to a class of more general stochastic non-linear systems. By theoretical analysis, it is shown that all the signals in the closed-loop system are bounded in probability. Two simulation examples further demonstrate the effectiveness of the proposed control approach. © The Institution of Engineering and Technology 2017.


Dai C.,Yangzhou University | Chen L.,Yangzhou University | Chen L.,Nanjing University | Li B.,Yangzhou University | Li Y.,Yangzhou University
Information Sciences | Year: 2017

Many real-world networks contain multiple types of interactions and relations. Link prediction in such multi-relational networks has become an important area in network analysis. For link prediction in multi-relational networks, we should consider the similarity and influence between different types of relations. In this paper, we propose a link prediction algorithm in multi-relational networks based on relational similarity. In the algorithm, a belief propagation method is presented to calculate the belief of each node and to construct the belief vector for each type of link. We use the similarity between belief vectors to measure the influence between different types of relations. Based on the influence between different relations, we present a nonnegative matrix factorization -based method for link prediction in multi-relational networks. The convergence and correctness of the presented method are proved. Our experimental results show that our method can achieve higher-quality prediction results than other similar algorithms. © 2017 Elsevier Inc.


Zhang J.,Yangzhou University | Han J.,Yangzhou University | Wang M.,Yangzhou University | Guo R.,Yangzhou University
Journal of Materials Chemistry A | Year: 2017

Multifunctional magnetic adsorbents containing MnO2 and polyaniline (PANI) with optimized adsorption properties toward heavy metal ions have been developed. In particular, Fe3O4 spheres were chosen as the magnetic core, followed by PANI and MnO2 coating, realizing the formation of Fe3O4/PANI/MnO2 core-shell hybrids. The as-synthesized Fe3O4/PANI/MnO2 core-shell hybrids showed a hierarchical structure with a large surface area and high magnetic saturation value. In comparison with Fe3O4/PANI and Fe3O4/MnO2 core-shell hybrids, Fe3O4/PANI/MnO2 core-shell hybrids displayed the highest adsorption capacity toward heavy metal ions (including Cd(ii), Zn(ii), Pb(ii) and Cu(ii)), thanks to the integrated physical and chemical adsorption behaviors resulting from MnO2 inorganic oxide and the PANI polymer. The developed multifunctional Fe3O4/PANI/MnO2 adsorbents synthesized by a facile and economic route are believed to show high potential in environmental remediation for heavy metal removal. © The Royal Society of Chemistry.


Sun Y.,Yangzhou University | Fu W.,CAS Beijing National Laboratory for Molecular | Chen C.,Ningbo University | Wang J.,Industrial Research Ltd. | And 2 more authors.
Chemical Communications | Year: 2017

Well-defined nanostructures were constructed by self-assembling hexamethylenediamine-functionalized tetrachloroperylene bisimides (compound A) in water/acetone. These structures could further reversibly transform into fluorescent vesicles by adding and removing water-soluble pillar[5]arene. © 2017 The Royal Society of Chemistry.


Guo M.,Yangzhou University | Huang Z.,Yangzhou University | Yang J.,Yangzhou University
Biotechnology Advances | Year: 2017

Agrobacterium tumefaciens, a soil-born phytopathogenic bacterium, is well known as a nature's engineer due to its ability to genetically transform the host by transferring a DNA fragment (called T-DNA) from its Ti plasmid to host-cell genome. To combat the harsh soil environment and seek the appropriate host, A. tumefaciens can sense and be attracted by a large number of chemical compounds released by wounded host. As a member of α-proteobacterium, A. tumefaciens has a chemotaxis system different from that found in Escherichia coli, since many chemoattractants for A. tumefaciens chemotaxis are virulence (vir) inducers. However, advances in the study of the chemotaxis paradigm, E. coli chemotaxis system, have provided enough information to analyze the A. tumefaciens chemotaxis. At low concentration, chemoattractants elicit A. tumefaciens chemotaxis and attract the species to the wound sites of the host. At high concentration, chemoattractants induce the expression of virulence genes and trigger T-DNA transfer. Recent studies on the VirA and ChvE of the vir-induction system provide some evidences to support the crosstalk between chemotaxis and vir-induction. This review compares the core components of chemotaxis signaling system of A. tumefaciens with those observed in other species, discusses the connection between chemotaxis and vir-induction in A. tumefaciens, and proposes a model depicting the signaling crosstalk between chemotaxis and vir-induction. © 2017 Elsevier Inc.


Ge J.,Huaiyin Normal University | Ge J.,Yangzhou University | Lei C.,Hefei University of Technology | Lin Z.,Yangzhou University
Nonlinear Analysis: Real World Applications | Year: 2017

This paper deals with a simplified SIS model, which describes the transmission of infectious disease in time-periodic heterogeneous environment. To grasp the impact of spatial heterogeneity of environment, temporal periodicity and small advection intensity on the persistence and eradication of the disease, the left and right free boundaries are introduced to represent the expanding fronts. The basic reproduction numbers R0 D and R0 F(τ), which depend on spatial heterogeneity, temporal periodicity, spatial diffusion and advection, are introduced. A spreading–vanishing dichotomy is established and sufficient conditions for the spreading and vanishing of the disease are given. The asymptotic spreading speeds for the left and right fronts are also obtained, and numerical simulations are presented to illustrate the influences of the advection intensity, dispersal rate and expanding capability on the moving fronts. © 2016 Elsevier Ltd


Ding L.,Yangzhou University | Sun R.,Yangzhou University | Zhang X.,Yangzhou University | Zhang X.,Jiangsu Electric Power Company | Zhang X.,Jiangsu Key Laboratory of Zoonosis
Oncotarget | Year: 2017

Rap2b is a novel p53 target we have identified recently. Knockdown of Rap2b sensitizes HCT116 cells to adriamycin-induced apoptosis, indicating that Rap2b promotes adriamycin resistance in cancer cells. In the present study, we designed a nanostructure-based drug/gene delivery system to evaluate the potential of Rap2b siRNA as a therapeutic agent against human cancers. Specifically, after coincubated with HCT116 cells, adriamycin- and Rap2b siRNA-loaded gold nanoshells were internalized. Subsequent laser irradiation promoted release of adriamycin and Rap2b siRNA from the nanoparticles. The laser-induced release of Rap2b siRNA decreased cellular expression of Rap2b and significantly enhanced the anticancer therapeutic efficacy of adriamycin in vitro and in vivo. In addition, laser irradiation of the nanoparticles might exert an additional thermal killing effect on cancer cells and further improved the anticancer efficacy of adriamycin. In summary, Rap2b siRNA is a potential enhancing agent for adriamycin-based anticancer therapeutics and the gold nanoshell-based drug/gene delivery system carrying both adriamycin and Rap2b siRNA provides a promising anticancer therapeutic strategy.


Chen Z.,Yangzhou University | Du Y.,Yangzhou University
Annales de la Societe Entomologique de France | Year: 2017

The winter stonefly genus Isocapnia Banks, 1938​​​ is mainly distributed in western North America and eastern Asia, but has never been reported from China. In this paper, we report, describe and illustrate a new species of this genus, I. anguis n. sp. from Sichuan Province of China. This is the first record for the genus Isocapnia from China, extending the distribution of Isocapnia into the southwestern China. An identification key to all the Isocapnia species from Asia is provided.​​​ © 2017 Société entomologique de France


Tang Y.,East China University of Science and Technology | Wu X.,Nanjing Southeast University | Zhang W.,Yangzhou University
2016 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2016 - Conference Proceedings | Year: 2016

This paper is concerned with pth moment exponential stability of stochastic delayed neural networks. By using the Lyapunov function method, some stability criteria of impulsive stochastic delayed systems are obtained, and these results are applied to the study on the stability criteria of stochastic delayed neural networks. It is shown that if the continuous stochastic delayed neural network is stable and the impulsive effects are destabilizing, then the stochastic delayed neural network is exponentially stable with respect to a lower bound of the impulsive interval. Moreover, if the continuous stochastic delayed neural network is not stable, the impulsive effects can successfully stabilize the delayed neural network for a given upper bound of the impulsive interval. One example is presented to demonstrate the usefulness of the proposed results. © 2016 IEEE.


Zhang Q.,Beijing Normal University | Gu X.,Yangzhou University | Shi P.,Beijing Normal University | Singh V.P.,Texas A&M University
Global and Planetary Change | Year: 2017

Using flood peaks data from 62 hydrological stations covering a period of 1951–2014 and tropical cyclone (TC) tracks, floods due to TCs were differentiated and relations between occurrences of floods and TCs were investigated. Then, the impact of TCs on the flood magnitude and frequency was evaluated. Results indicated that there was more than one external influencing factor for flood occurrences, i.e. convective precipitation and TC-related heavy precipitation. In general, the landed TC events have a crucial influence on the occurrence of floods in eastern and western parts of Guangdong province. The mountainous topography limits the northward propagation of TC events and hence limits their impact on the occurrence of floods in the northern part. More than 60% of the largest 10 hazardous floods in the northern and eastern parts were attributed to TCs and hence they significantly modified the probability distributions of flood peaks, increasing the location and scale parameters of the generalized extreme value (GEV) probability distribution model. Therefore, development of measures for mitigation of coastal flooding would need to consider the occurrences of TCs. © 2017


Tsai C.-W.,National Ilan University | Lai C.-F.,National Chung Cheng University | Chao H.-C.,National Ilan University | Chao H.-C.,Yangzhou University | And 2 more authors.
Journal of Big Data | Year: 2015

The age of big data is now coming. But the traditional data analytics may not be able to handle such large quantities of data. The question that arises now is, how to develop a high performance platform to efficiently analyze big data and how to design an appropriate mining algorithm to find the useful things from big data. To deeply discuss this issue, this paper begins with a brief introduction to data analytics, followed by the discussions of big data analytics. Some important open issues and further research directions will also be presented for the next step of big data analytics. © 2015, Tsai et al.


Huang Y.,Yangzhou University | Zhang L.,Yangzhou University
Methods in Molecular Biology | Year: 2017

Site-directed mutagenesis is a powerful method to introduce mutation(s) into DNA sequences. A number of methods have been developed over the years with a main goal being to create a high number of mutant genes. The single-mutagenic primer method for site-directed mutagenesis is the most direct method that yields mutant genes in about 25–50% of transformants in a robust, low-cost reaction. The supercompetent XL10-Gold bacteria used in the Stratagene protocol carry a phage, which may be a problem for some applications; however, in our single-mutagenic primer method the supercompetent bacteria are not needed. A thermostable DNA polymerase with high fidelity and processivity, such as Phusion DNA polymerase, is required for our optimized procedure to avoid extra mutation(s) and enhance mutagenic efficiency. © Springer Science+Business Media New York 2017.


Li X.,North China University of Water Conservancy and Electric Power | Du C.,Yangzhou University | Cong Y.,Yangzhou University | Zhao H.,Yangzhou University
Journal of Chemical Thermodynamics | Year: 2017

The solubility of 3-amino-1,2,4-triazole in ten organic solvents including ethanol, isopropanol, n-propanol, methanol, ethyl acetate, acetone, acetonitrile, 1,4-dioxane, N-methyl-2-pyrrolidone and 2-butanone was determined experimentally by the isothermal saturation method over a temperature range from T = 283.15 K to T = 318.15 K under 101.1 kPa. For the studied temperature range, the solubility of 3-amino-1,2,4-triazole in mole fraction in the solvents increased with a rise of temperature. On the whole, they obeyed the following order from high to low in different solvents: N-methyl-2-pyrrolidone > methanol > ethanol > n-propanol > (isopropanol, acetone) > 1,4-dioxane > 2-butanone > (ethyl acetate, acetonitrile). The determined solubility results of 3-amino-1,2,4-triazole in the solvents studied were correlated using the modified Apelblat equation, Buchowski–Ksiazaczak λh equation, Wilson model and NRTL model. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 9.45 × 10−4 and 2.16%, respectively. In general, the four thermodynamic models were all acceptable for describing the solubility behaviour of 3-amino-1,2,4-triazole in these solvents. Furthermore, the mixing properties including the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration (γ1 ∞) and reduced excess enthalpy (H1 E,∞) were acquired. The solution process of 3-amino-1,2,4-triazole was spontaneous and favourable in the selected solvents. The solubility values obtained and the thermodynamic studies would be very useful for optimizing the purification process of 3-amino-1,2,4-triazole. © 2016 Elsevier Ltd


Chen M.,Yangzhou University | Chen M.,Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province | Li W.,Yangzhou University | Li W.,Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province | And 4 more authors.
ACS Applied Materials and Interfaces | Year: 2014

In this work, a novel carbon-free core-shell α-iron oxide (α-Fe2O3)@ spinel lithium titanate (Li 4Ti5O12, LTO) composite has been synthesized via a facile hydrothermal process. Element mapping confirmed the core-shell structure of α-Fe2O3@LTO. The effects of various experimental parameters, including thickness of TiO2 coating, reaction temperature, and time on the morphologies of the resulted products, were systematically investigated. The electrochemical measurements demonstrate that uniform α-Fe2O3 ellipsoids are coated with LTO to avoid forming a solid electrolyte interface (SEI) layer, to reduce initial capacity loss, and to improve the reversibility of α-Fe2O 3 for Li ion storage. Compared with naked α-Fe 2O3 ellipsoids, the α-Fe2O 3@LTO composites exhibit lower initial capacity loss, higher reversible capacity, and better cycling performance for lithium storage. The electrochemical performance of α-Fe2O3@LTO composite heavily depends on the thickness and density of LTO coating shells. The carbon-free coating of LTO is highly effective in improving the electrochemical performance of α-Fe2O3, promising advanced batteries with high surface stability and excellent security. © 2014 American Chemical Society.


Pan J.,Yangzhou University
Wuli Xuebao/Acta Physica Sinica | Year: 2013

According to density functional theory of first-principles calculations theory, we systematically study the electronic structures, magnetisms and stabilities of transition metal (TM = V, Cr, Mn) doped MoS2 single-layers. The results show that V- and Mn- monodoped systems each have magnetism and the magnetic moment mainly concentrates on the transition metal dopant atom, but Cr-doped MoS2 does not display magnetism. Further study on the magnetic coupling of double atoms doped MoS2 shows that the stable ferromagnetic state at room temperature is observed in the Mn-doped MoS2. However, the system shows a non-spin polarization state due to doping with V. The calculated formation energy indicates that the Mn-doped MoS2 is the most stable system. Therefore, Mn-doped single-layer MoS2 maybe have potential applications in the spin electronic devices due to its good ferromagnetism and reliable stability. © 2013 Chinese Physical Society.


Chen M.,Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province | Wang J.,Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province | Zhang W.,Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province | Diao G.,Yangzhou University
Journal of Electroanalytical Chemistry | Year: 2013

A new water-solution inclusion complex of imidacloprid (IDP) with β-cyclodextrin polymer (β-CDP) was prepared by a facile strategy and characterized by FTIR, powder X-ray diffractometry, thermogravimetry, 1H NMR spectroscopy and UV-vis spectroscopy. The ratio of β-cyclodextrin (β-CD) unit in β-CDP to IDP is determined as 2:1. At 25 °C, the dissociated constant of IDP-β-CDP is measured as 1.79 ± 0.17 × 10-5 M2 by UV-vis spectroscopy. The well behaved electrochemical properties of IDP-β-CDP in water are observed. The diffusion coefficient of reduced state and the diffusion activation energy are calculated as 4.0 ± 0.5 × 10-7 cm2 s -1 and 9.8 ± 0.3 kJ mol-1, respectively. Compared with IDP, the solubility of IDP-β-cyclodextrin polymer (IDP-β-CDP) is greatly enhanced due to the water-soluble β-CDP host. © 2013 Elsevier Ltd. All rights reserved.


Jiang W.,Yangzhou University | Fahimi B.,University of Texas at Dallas
IEEE Transactions on Power Electronics | Year: 2011

The continuous effort to improve efficiency, reduce particle, and greenhouse gase emissions leads to the emergence of the concept more electric. This concept helps to boost the performance as well as the flexibility of the domestic and vehicular applications; however, on the other hand, it excessively burdens current power networks (including vehicle power systems). In order to remedy this problem, simultaneous usage of renewable sources and energy storages is encouraged. A multiconverter system is commonly adopted to process the renewable power in form of distributed generation. However, due to the discrete structure of such systems, power flow and load regulation are coordinated via communication channel, which inevitably reduces the reliability and dynamic response of the system. This paper presents the concept of multiport power electronic interface (MPEI) for renewable energy sources and storages. With a unified modular topology and highly integrated digital control system, controlled quasi-current source is achieved for each input port in both steady-state and transient power-sharing modes. MPEI analysis, modeling, design, and system operation are treated in a systematic manner in this paper. Both power stages and digital control system are implemented for a five-port MPEI. Experiments are conducted under meaningful operation scenarios. The results are presented to prove the feasibility of MPEI concept and system design methodology. © 2011 IEEE.


Zhu A.,Yangzhou University | Lu Y.,Yangzhou University | Si Y.,Yangzhou University | Dai S.,University of Adelaide
Applied Surface Science | Year: 2011

Rod-like hydroxyapatite (HAp) nanoparticles with various aspect ratios are synthesized by means of low-temperature hydrothermal method in the presence of a N-[(2-hydroxy-3-trimethylammonium) propyl]chitosan chloride (HTCC) template. The synthesized HAps were examined by X-ray diffraction (XRD), Fourier transform infrared spectrophotometer (FTIR) and transmission electron microscopy (TEM) techniques. The results reveal that HAps are rod-like monocrystals, where the size and morphology can be tailored by varying synthesis conditions, such as pH, hydrothermal synthesis temperature and the ratio of PO 4 3- to the quaternary ammonium in HTCC. The mechanism of HTCC template on HAp nanorod preparation is analyzed. © 2010 Elsevier B.V. All rights reserved.


Wang J.,Yangzhou University | Wang X.-M.,Yangzhou University | Chen Y.-F.,Nanjing Southeast University | Wang J.-S.,National University of Singapore
Journal of Physics Condensed Matter | Year: 2012

First-principles density-functional calculations are performed to investigate the thermal transport properties in graphene nanoribbons (GNRs). The dimensional crossover of thermal conductance from one to two dimensions (2D) is clearly demonstrated with increasing ribbon width. The thermal conductance of GNRs of a few nanometers width already exhibits an approximate low-temperature dependence of T 1.5, like that of 2D graphene sheets which is attributed to the quadratic nature of the dispersion relation for the out-of-plane acoustic phonon modes. Using a zone-folding method, we heuristically derive the dimensional crossover of thermal conductance with the increase of ribbon width. Combining our calculations with the experimental phonon mean-free path, some typical values of thermal conductivity at room temperature are estimated for GNRs and for 2D graphene sheet. Our findings clarify the issue of the low-temperature dependence of thermal transport in GNRs and suggest a calibration range of thermal conductivity for experimental measurements in graphene-based materials. © 2012 IOP Publishing Ltd.


Xu H.,Yangzhou University | Yang Z.,Yangzhou University | Yao G.,Yangzhou University | Zhao H.,Yangzhou University
Journal of Chemical and Engineering Data | Year: 2014

The solubility of 3,4-dichloronitrobenzene and 2,3-dichloronitrobenzene in ethyl acetate, tetrachloromethane, cyclohexane, hexane, heptane, 1-propanol, 2-propanol, and 1-butanol were measured experimentally under temperatures of (278.15 to 303.15) K by employing the gravimetric method. The solubility of 3,4-dichloronitrobenzene or 2,3-dichloronitrobenzene in all organic solvents studied increases with increasing in temperature. Four models, the modified Apelblat equation, λh equation, Wilson model, and nonrandom two-liquid (NRTL) model, were employed to correlate the measured solubility. Results indicated that the modified Apelblat equation was the better model than the other models. The solubility data would be very useful for optimizing the purification process of 3,4-dichloronitrobenzene and 2,3-dichloronitrobenzene on the industrial scale. © 2014 American Chemical Society.


Yu G.,Yangzhou University | Zheng Q.-S.,Shanghai University | Li G.-F.,Shanghai University
AAPS Journal | Year: 2014

Physiologically based pharmacokinetic (PBPK) modeling holds great promise for anticipating the quantitative changes of pharmacokinetics in pediatric populations relative to adults, which has served as a useful tool in regulatory reviews. Although the availability of specialized software for PBPK modeling has facilitated the widespread applications of this approach in regulatory submissions, challenges in the implementation and interpretation of pediatric PBPK models remain great, for which controversies and knowledge gaps remain regarding neonatal development of the gastrointestinal tract. The commentary highlights the similarities and differences in the gastrointestinal pH and transit time between neonates and adults from a PBPK modeling prospective. Understanding the similarities and differences in these physiological parameters governing oral absorption would promote good practice in the use of pediatric PBPK modeling to assess oral exposure and pharmacokinetics in neonates. © 2014 American Association of Pharmaceutical Scientists


Wang J.,Jiangsu University | Wang J.,Anhui University of Science and Technology | Wang J.,CAS Hefei Key Laboratory of Materials for Energy Conversion | Chen K.,Jiangsu University | And 3 more authors.
Nano Letters | Year: 2013

The catalytic mechanism offers an efficient tool to produce crystalline semiconductor nanowires, in which the choice, state, and structure of catalysts are active research issues of much interest. Here we report a novel solution-solid-solid (SSS) mechanism for nanowire growth catalyzed by solid-phase superionic conductor nanocrystals in low-temperature solution. The preparation of Ag2Se-catalyzed ZnSe nanowires at 100-210 C is exampled to elucidate the SSS model, which can be extendable to grow other II-VI semiconductor (e.g., CdSe, ZnS, and CdS) nanowires by the catalysis of nanoscale superionic-phase silver or copper(I) chalcogenides (Ag2Se, Ag2S, and Cu2S). The exceptional catalytic ability of these superionic conductors originates from their structure characteristics, known for high-density vacancies and fast mobility of silver or copper(I) cations in the rigid sublattice of Se2- or S2- ions. Insights into the SSS mechanism are provided based on the formation of solid solution and the solid-state ion diffusion/transport at solid-solid interface between catalyst and nanowire. © 2013 American Chemical Society.


Linquist B.A.,University of California at Davis | Liu L.,Yangzhou University | van Kessel C.,University of California at Davis | van Groenigen K.J.,Northern Arizona University | van Groenigen K.J.,Trinity College Dublin
Field Crops Research | Year: 2013

Nitrogen is deficient in most soils and is applied in the greatest quantities of all nutrients. Given its high potential for loss, efficient fertilizer N management has both economic and environmental consequences. Enhanced efficiency nitrogen fertilizers (EENF) have been developed to decrease N losses and improve N use efficiency. However, studies evaluating the effectiveness of EENF products in rice systems show mixed results. The objective of this meta-analysis was to quantify the benefits of EENF (i.e. nitrification and urease inhibitors, neem, and slow release fertilizers) in terms of yield and N uptake and to determine under what conditions EENF are most effective. The analysis included 32 field studies (178 observations) for the effects of EENF on crop yield and 14 studies (82 observations) on N uptake. Overall, the use of EENF led to a 5.7% (95% CI = 3.9-7.7%) increase in yield and an 8.0% (95% CI = 5.2-10.7%) increase in N uptake. Soil pH (pH of dry soil) had a significant impact on EENF effectiveness. In acidic soils (pH ≤ 6.0) the application of EENF did not significantly affect yield or N uptake; however the yield response to EENF increased to 10.2% (95% CI = 5.3-16.6%) in alkaline soils (pH ≥ 8.0). There was no difference among the classes of EENF when separated by their mode of action (i.e. urease inhibitors, nitrification inhibitors or slow release). When EENF products were analyzed separately, NBPT [N-(n-butyl) phosphoric triamide] and neem proved effective in increasing yield, while PPD (phenyl phosphorodiamidate) and DCD (dicyandiamide) were not effective. The EENF effectiveness was not dependent on N rate, method of first N application (incorporated, surface applied, or applied into water), timing of first N application in relation to a permanent flood being established, and how water was managed during the season (permanent flood vs. intermittent wet and dry). Overall, this meta-analysis suggests that certain EENF products can increase yield and N uptake but the average increase is modest. © 2013 Elsevier B.V.


Wang J.,University of California at Davis | Wang J.,Yangzhou University | Yang G.-X.,University of California at Davis | Tsuneyama K.,University of Toyama | And 3 more authors.
Seminars in Liver Disease | Year: 2014

Within the last decade, several mouse models that manifest characteristic features of primary biliary cirrhosis (PBC) with antimitochondrial antibodies (AMAs) and immune-mediated biliary duct pathology have been reported. Here, the authors discuss the current findings on two spontaneous (nonobese diabetic autoimmune biliary disease [NOD.ABD] and dominant negative transforming growth factor-β receptor II [dnTGFβRII]) and two induced (chemical xenobiotics and microbial immunization) models of PBC. These models exhibit the serological, immunological, and histopathological features of human PBC. From these animal models, it is evident that the etiology of PBC is multifactorial and requires both specific genetic predispositions and environmental insults (either xenobiotic chemicals or microbial), which lead to the breaking of tolerance and eventually liver pathology. Human PBC is likely orchestrated by multiple factors and hence no single model can fully mimic the immunopathophysiology of human PBC. Nevertheless, knowledge gained from these models has greatly advanced our understanding of the major immunological pathways as well as the etiology of PBC. Copyright © 2014 by Thieme Medical Publishers, Inc.


Wu Y.-P.,Yangzhou University | Shen Y.-P.,CAS Lanzhou Cold and Arid Regions Environmental and Engineering Research Institute | Larry Li B.,University of California at Riverside
Ecological Complexity | Year: 2012

Atmospheric water vapor transport (WVT) plays an important role in the Earth's climate system, especially in arid and semi-arid regions, but its physical mechanism has escaped wide attention. Here the distribution of WVT over Tarim River Basin and its relationships with local topography and precipitation are analyzed; the variation and trend of WVT and its correlation with westerly circulation index are also calculated; and the possible physical mechanism is discussed. All statistics and analysis are based on daily precipitation data of 25 weather stations in Tarim River Basin of China and NCEP/NCAR monthly mean reanalysis data (2.5° × 2.5°).It is shown that the western and the northwestern-based horizontal WVT is the main path for Tarim River Basin. But, the greatest contribution of the average annual water vapor net input (WVNI) is 3483.57×10 11kga -1 through eastern boundary. According to Bernoulli's equation, the reason is that the U-shaped terrain around Tarim River Basin causes the shift of WVT from west and northwest to north and northeast. Moreover, in lower troposphere, there is a significant positive correlation between the zonal and meridional WVNI due to the U-shaped terrain. Additionally, zonal WVNI in upper and middle troposphere grow up steadily as well as westerly circulation index; but WVNI in lower troposphere, meridional WVNI in middle troposphere and horizontal WVNI in whole troposphere all decrease significantly. This implies that there are other factors that reduce the WVNI, which counteracts the increase of WVNI caused by enhanced west winds. Last but not least, due to the pumping function of plant on local moisture recycling, precipitation in mountains increased rapidly, but decreased smoothly in plains between the late 1970s and the early 21st century.So we can conclude that climate in interior regions links closely to the local moisture recycling, which depends, to a large extend, on local forest-covered situation; and that the trend of the drying and desertification in Tarim River Basin is not likely to slow down because of the block of the U-shaped terrain, decreasing of WVNI in meridian and sparse vegetation. However, we still do not know how the climate of TRB will develop. There are some other factors such as NAO, runoff and the East Asia Monsoon that need to be further explored. It is also very necessary and urgent to study the mutual feedback relationship between water cycle and climate, and we should pay more attention to the influence of ecosystem. © 2011 Elsevier B.V.


Shen Q.,Yangzhou University | Shi P.,University of Adelaide | Zhang T.,Yangzhou University | Lim C.-C.,Yangzhou University
IEEE Transactions on Neural Networks and Learning Systems | Year: 2014

This paper is concerned with the problem of adaptive neural tracking control for a class of uncertain pure-feedback nonlinear systems. Using the implicit function theorem and backstepping technique, a practical robust adaptive neural control scheme is proposed to guarantee that the tracking error converges to an adjusted neighborhood of the origin by choosing appropriate design parameters. In contrast to conventional Lyapunov-based design techniques, an alternative Lyapunov function is constructed for the development of control law and learning algorithms. Differing from the existing results in the literature, the control scheme does not need to compute the derivatives of virtual control signals at each step in backstepping design procedures. Furthermore, the scheme requires the desired trajectory and its first derivative rather than its first n derivatives. In addition, the useful property of the basis function of the radial basis function, which will be used in control design, is explored. Simulation results illustrate the effectiveness of the proposed techniques. © 2013 IEEE.


Zhang S.,Yangzhou University | Zhu A.,Yangzhou University | Dai S.,University of Adelaide
Journal of Applied Polymer Science | Year: 2011

In this study, various polypropylene (PP) nanocomposites were prepared by melt blending method. The effects of different spherical nanofillers, such as 50 nm CaCO 3 and 20 nm SiO 2, on the linear viscoelastic property, crystallization behavior, morphology and mechanical property of the resulting PP nanocomposites were examined. Rheological study indicated that coincorporation of nano-SiO 2 and nano-CaCO 3 favored the uniform dispersion of nanoparticles in the PP matrix. Differential scanning calorimeter (DSC) and polarizing optical microscopy (POM) studies revealed that the coincorporation of SiO 2 and CaCO 3 nanoparticles could effectively improve PP crystallizability, which gave rise to a lower supercooling temperature (ΔT), a shorter crystallization half-life (t 1/2) and a smaller spherulite size in comparison with those nanocomposites incorporating only one type of CaCO 3 or SiO 2 nanoparticles. The mechanical analysis results also showed that addition of two types of nanoparticles into PP matrix gave rise to enhanced performance than the nanocomposites containing CaCO 3 or SiO 2 individually. © 2011 Wiley Periodicals, Inc.


Zhang G.,University of Cincinnati | Zhang Y.C.,Yangzhou University | Nadagouda M.,National Risk Management Research Laboratory | Han C.,University of Cincinnati | And 4 more authors.
Applied Catalysis B: Environmental | Year: 2013

Motivated from the increasing environmental concerns associated with the formation of cyanotoxins released by cyanobacteria in waters, this study focused on the synthesis and evaluation of visible light-sensitized S, N and C co-doped polymorphic titanium dioxide (CDPM-TiO2) nanoparticles for photocatalytic destruction of microcystin-LR, one of the most common and toxic cyanotoxins. The CDPM-TiO2, containing anatase, brookite and rutile phase, was synthesized using a modified sol-gel method followed by calcination at 300600°C. Thiourea was utilized as a precursor for the dopants. This work took the initiative to have detailed characterization on the co-doped polymorphic TiO2 by several techniques and utilize the CDPM-TiO2 on cyanotoxin treatment. The results showed that the physicochemical properties of CDPM-TiO2 samples were highly dependent on the calcination temperature. The CDPM-TiO2 sample calcined at 300°C (CDPM300) exhibited better physicochemical characters including higher surface area and stronger photo-absorption in the visible light region. The sulfur dopant was attributed to S6+ species; nitrogen was ascribed to interstitial N; carbon was assigned to the TiOC bond. Moreover, CDPM300 showed highest photocatalytic activity for microcystin-LR destruction under visible light irradiation among all CDPM-TiO2 nanoparticles, which can be considered as a promising demonstration of such visible light-sensitized photocatalysts in the treatment of an important cyanotoxin in water. © 2013 Elsevier B.V.


Shen Q.,Nanjing University of Aeronautics and Astronautics | Shen Q.,Yangzhou University | Jiang B.,Nanjing University of Aeronautics and Astronautics | Shi P.,Victoria University of Melbourne | Shi P.,University of Adelaide
IEEE Transactions on Fuzzy Systems | Year: 2014

It is well known that there always exist some level of time delay between fault occurrence and fault accommodation, which is called as the time delay due to fault diagnosis (TDDTFD) in this paper. TDDTFD may cause severe loss of system performance and stability. This paper investigates the TDDTFD's adverse effect on the system performance. First, a fault diagnosis (FD) model is constructed to diagnose sensor faults which integrate time-varying gain and bias faults, where a novel FD algorithm is proposed, which removes the classical assumption that the time derivative of the output error should be known. Meanwhile, the time spent at each step in FD and its analytical expression are derived strictly. Further, the analysis of the system performance degraded by TDDTFD is developed, and the conditions under which the magnitudes of sensor faults should be satisfied such that the state of the faulty system controlled by the normal controller remains bounded during TDDTFD are derived. In addition, the corresponding solutions are proposed to minimize the adverse effect of the time delay. Finally, simulation results of near-space vehicle attitude dynamics are presented to demonstrate the efficiency of the proposed approach. © 1993-2012 IEEE.


Shen Q.,Nanjing University of Aeronautics and Astronautics | Shen Q.,Yangzhou University | Jiang B.,Nanjing University of Aeronautics and Astronautics | Shi P.,University of Adelaide | And 2 more authors.
IEEE Transactions on Fuzzy Systems | Year: 2014

In this paper, the cooperative adaptive fault tolerant fuzzy tracking control (CAFTFTC) problem of networked high-order multiagent with time-varying actuator faults is studied, and a novel CAFTFTC scheme is proposed to guarantee that all follower nodes asymptotically synchronize a leader node with tracking errors converging to a small adjustable neighborhood of the origin in spite of actuator faults. The leader node is modeled as a higher order nonautonomous nonlinear system. It acts as a command generator giving commands only to a small portion of the networked group. Each follower is assumed to have nonidentical unknown nonlinear dynamics, and the communication network is also assumed to be a weighted directed graph with a fixed topology. A distributed robust adaptive fuzzy controller is designed for each follower node such that the tracking errors are cooperative uniform ultimate boundedness (CUUB). Moreover, these controllers are distributed in the sense that the controller designed for each follower node only requires relative state information between itself and its neighbors. The adaptive compensation term of the optimal approximation errors and external disturbances is adopted to reduce the effects of the errors and disturbances, which removes the assumption that the upper bounds of unknown function approximation errors and disturbances should be known. Analysis of stability and parameter convergence of the proposed algorithm are conducted that are based on algebraic graph theory and Lyapunov theory. Comparing with results in the literature, the CAFTFTC scheme can minimize the time delay between fault occurrence and accommodation and reduce its adverse effect on system performance. In addition, the FTC scheme requires no additional fault isolation model, which is necessary in the traditional active FTC scheme. Finally, an example is provided to validate the theoretical results. © 2014 IEEE.


Tang X.,CAS Shanghai Institutes for Biological Sciences | Tang X.,Yangzhou University | Zhang Z.-Y.,CAS Shanghai Institutes for Biological Sciences | Zhang W.-J.,Shanghai University | And 5 more authors.
Plant Physiology | Year: 2010

Pollen mother cells (PMCs) represent a critical early stage in plant sexual reproduction in which the stage is set for male gamete formation. Understanding the global molecular genetics of this early meiotic stage has so far been limited to whole stamen or floret transcriptome studies, but since PMCs are a discrete population of cells in developmental synchrony, they provide the potential for precise transcriptome analysis and for enhancing our understanding of the transition to meiosis. As a step toward identifying the premeiotic transcriptome, we performed microarray analysis on a homogenous population of rice (Oryza sativa) PMCs isolated by laser microdissection and compared them with those of tricellular pollen and seedling. Known meiotic genes, including OsSPO11-1, PAIR1, PAIR2, PAIR3, OsDMC1, OsMEL1, OsRAD21-4, OsSDS, and ZEP1, all showed preferential expression in PMCs. The Kyoto Encyclopedia of Genes and Genomes pathways significantly enriched in PMC-preferential genes are DNA replication and repair pathways. Our genome-wide survey showed that, in the buildup to meiosis, PMCs accumulate the molecular machinery for meiosis at the mRNA level. We identified 1,158 PMC-preferential genes and suggested candidate genes and pathways involved in meiotic recombination and meiotic cell cycle control. Regarding the developmental context for meiosis, the DEF-like, AGL2-like, and AGL6-like subclades of MADS box transcription factors are PMC-preferentially expressed, the trans-zeatin type of cytokinin might be preferentially synthesized, and the gibberellin signaling pathway is likely active in PMCs. The ubiquitin-mediated proteolysis pathway is enriched in the 127 genes that are expressed in PMCs but not in tricellular pollen or seedling. © 2010 American Society of Plant Biologists.


Yang J.,CAS Shanghai Institute of Applied Physics | Yang J.,University of Chinese Academy of Sciences | Shi G.,CAS Shanghai Institute of Applied Physics | Tu Y.,Yangzhou University | And 2 more authors.
Angewandte Chemie - International Edition | Year: 2014

Recent experiments have shown the coexistence of both large unoxidized and oxidized regions on graphene oxide (GO), but the underlying mechanism for the formation of the GO atomic structure remains unknown. Now, using density functional calculations, 52 oxidation pathways for local pyrene structures on GO were identified, and a kinetic profile for graphene oxidation with a high correlation between oxidation loci was proposed, which is different from the conventional view, which entails a random distribution of oxidation loci. The high correlation is an essential nature of graphene oxidation processes and can be attributed to three crucial effects: 1) breaking of delocalized π bonds, 2) steric hindrance, and 3) hydrogen-bond formation. This high correlation leads to the coexistence of both large unoxidized and oxidized regions on GO. Interestingly, even in oxidized regions on GO, some small areas of sp2-hybridized domains, similar to "islands", can persist because of steric effects. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Sha O.,Yangzhou University | Sha O.,Huaihai Institute of Technology | Zhu X.,Yangzhou University | Feng Y.,Huaihai Institute of Technology | Ma W.,Huaihai Institute of Technology
Food Chemistry | Year: 2014

A rapid and effective method of aqueous two-phase systems based on ionic liquid microextraction for the simultaneous determination of five synthetic food colourants (tartrazine, sunset yellow, amaranth, ponceau 4R and brilliant blue) in food samples was established. High-performance liquid chromatography coupled with an ultraviolet detector of variable wavelength was used for the determinations. 1-alkyl-3-methylimidazolium bromide was selected as the extraction reagent. The extraction efficiency of the five colourants in the proposed system is influenced by the types of salts, concentrations of salt and [CnMIM]Br, as well as the extracting time. Under the optimal conditions, the extraction efficiencies for these five colourants were above 95%. The phase behaviours of aqueous two-phase system and extraction mechanism were investigated by UV-vis spectroscopy. This method was applied to the analysis of the five colourants in real food samples with the detection limit of 0.051-0.074 ng/mL. Good spiked recoveries from 93.2% to 98.9% were obtained. © 2014 Elsevier Ltd. All rights reserved.


Wang J.,Yangzhou University | Li L.,Yangzhou University | Wang J.-S.,National University of Singapore
Applied Physics Letters | Year: 2011

Using the atomistic nonequilibrium Green's function, we find that thermal conductance of carbon nanotubes with presence of topological lattice imperfects is remarkably reduced, due to the strong Rayleigh scattering of high-frequency phonons. Phonon transmission across multiple defects behaves as a cascade scattering based with the random phase approximation. We elucidate that phonon scattering by structural defects is related to the spatial fluctuations of local vibrational density of states (LVDOS). An effective method of tuning thermal transport in low-dimensional systems through the modulation of LVDOS has been proposed. Our findings provide insights into experimentally controlling thermal transport in nanoscale devices. © 2011 American Institute of Physics.


Chen L.,Shanghai University | Hu X.,Yangzhou University
Journal of Computational Information Systems | Year: 2010

Orthogonal Frequency Division Multiplexing (OFDM) has been focused on in high-data-rate wireless communication research. But the high Peak-to-Average Power Ratio (PAPR) is one of the main obstacles to limit wide applications of OFDM. In this paper, based on the thorough research of selective mapping (SLM), two modified SLM schemes with the standard arrays and the Riemann matrix are proposed. In the proposed schemes, it is not needed to exchange side information between transmitter and receiver. And it is shown that better PAPR reduction performance is achieved as compared to the basic SLM by Monte Carlo simulations. © 2010 Binary Information Press.


Zhang Y.-Z.,Nanjing University of Posts and Telecommunications | Wang Y.,Nanjing University of Posts and Telecommunications | Cheng T.,Nanjing University of Posts and Telecommunications | Lai W.-Y.,Nanjing University of Posts and Telecommunications | And 4 more authors.
Chemical Society Reviews | Year: 2015

Paper-based supercapacitors (SCs), a novel and interesting group of flexible energy storage devices, are attracting more and more attention from both industry and academia. Cellulose papers with a unique porous bulk structure and rough and absorptive surface properties enable the construction of paper-based SCs with a reasonably good performance at a low price. The inexpensive and environmentally friendly nature of paper as well as simple fabrication techniques make paper-based SCs promising candidates for the future 'green' and 'once-use-and-throw-away' electronics. This review introduces the design, fabrication and applications of paper-based SCs, giving a comprehensive coverage of this interesting field. Challenges and future perspectives are also discussed. This journal is © The Royal Society of Chemistry.


Chen L.,Shanghai University | Hu X.,Yangzhou University
Journal of Computational Information Systems | Year: 2010

Orthogonal Frequency Division Multiplexing (OFDM) has been focused on in high-data-rate wireless communication research. But the high Peak-to-Average Power Ratio (PAPR) is one of the main obstacles to limit wide applications of OFDM. In this paper, based on the definition of the PAPR in OFDM systems, these techniques on PAPR reduction are presented, including signal distortion, signal scrambling, and block coding. The related optimization problems as well as the advantages and disadvantages of these techniques are discussed in detail and some performances are achieved by Monte Carlo simulations. © 2010 Binary Information Press.


Ruan J.,Yangzhou University | Ruan J.,Shanghai JiaoTong University | Qian Y.,Yangzhou University | Xu Z.,Shanghai JiaoTong University
Resources, Conservation and Recycling | Year: 2014

The current generation pattern of e-waste consisted of dead electronic and electrical equipments poses one of the world's greatest pollution problem due to the lack of appropriate recovery technology. Crude recovery methods of resource materials (aluminum, zinc, copper, lead, gold) from e-waste caused serious pollution in China in the past years. Thus, environment-friendly technologies have been the pressing demand in e-waste recovering. Eddy current separation (ECS) was advised as the preferable technology for recovering nonferrous metals from e-waste. However, just a few reports focused on the application of ECS in e-waste recovering. This paper introduced the information about ECS including the models of eddy current force and movement behavior of nonferrous metallic particle in the separation process. Meanwhile, the developing process of eddy current separator was summarized. New industrial applications of ECS in e-waste (waste toner cartridges and refrigerator cabinets) recovering were also presented. Finally, for improving separation rate of ECS in industrial application of e-waste recovering, some suggestions were proposed related to crushing process, separator design, and separator operation. The aim of this paper is to demonstrate the effectiveness of ECS technology as practical and available tool for recovering non-ferrous metals from e-waste which is now being ignored. © 2014 Elsevier B.V.


Xu Q.,Yangzhou University | Gu S.-X.,Yangzhou University | Gu S.-X.,Yancheng Institute of Technology | Jin L.,Yangzhou University | And 4 more authors.
Sensors and Actuators, B: Chemical | Year: 2014

A novel glucose biosensor was developed based on the direct electrochemistry of glucose oxidase (GOD) adsorbed in graphene/polyaniline/gold nanoparticles (AuNPs) nanocomposite modified glassy carbon electrode (GCE). Compared with graphene, polyanilline (PANI) or graphene/PANI, the graphene/PANI/AuNPs nanocomposite was more biocompatible and it offered a favorable microenvironment for facilitating the direct electron transfer between GOD and electrode. The adsorbed GOD displayed a pair of well-defined quasi-reversible redox peaks with a formal potential of -0.477 V (vs. SCE) and an apparent electron transfer rate constant (ks) of 4.8 s -1 in 0.1 M pH 7.0 PBS solution. The apparent Michaelis-Menten constant of the adsorbed GOD was 0.60 mM, implying a fabulous catalytic activity and a remarkable affinity of the adsorbed GOD for glucose. The amperometric response of GOD-graphene/PANI/AuNPs modified electrode was linearly proportional to the concentration of glucose in the range of 4.0 μM to 1.12 mM with a low detection limit of 0.6 μM at signal-to-noise of 3. The combination of the direct electron transfer character of GOD and the promising feature of graphene/PANI/AuNPs nanocomposite favors the selective and sensitive determination of glucose with improved analytical capabilities. © 2013 Elsevier B.V.


Rao S.,Yangzhou University | Sun J.,Jiangnan University | Liu Y.,Jiangnan University | Zeng H.,Angel Yeast Co. | And 2 more authors.
Food Chemistry | Year: 2012

Lysozyme from hen egg white is a well-known antimicrobial protein with high ratio of hydrophobic and positively charged amino acid residues. In order to explore functional bioactivities of enzymatic hydrolysates of lysozyme, the protein was subjected to a simulated gastrointestinal digestion and the resulting hydrolysate (LPH2) showed a strong competitive angiotensin I-converting enzyme (ACE) inhibitory activity (IC50 = 12.6 μg/ml) and a remarkable antioxidant activity. The LPH2 was fractionated using a 3 kDa cut-off membrane and the obtained permeate LPH2-3 kDa was analysed by MALDI-TOF-TOF MS. Using this technology, 38 different peptides were identified and some of these peptides were well fit with structure requirements of ACE inhibitory peptides and/or antioxidant peptides. The findings from this study suggest that the protein containing high proportion of hydrophobic and positively charged residues have the potential to generate multifunctional peptides, and these peptides would be beneficial ingredient to be used in functional foods. © 2012 Elsevier Ltd. All rights reserved.


Yu J.-J.,Shanghai JiaoTong University | Wu Y.-X.,Yangzhou University | Zhao F.-J.,Shanghai JiaoTong University | Xia S.-J.,Shanghai JiaoTong University
Medical Oncology | Year: 2014

The present study aimed to investigate the biological functions of miR-96 in the processes of proliferation and clonogenicity in the prostate cancer cells. miR-96 was identified to be markedly up-regulated in prostate cancer cell and cancer tissues compared with normal prostate cell and normal prostate tissues by microarray method and RT-PCR analysis. Down-regulation of miR-96 expression reduced the proliferation and colony formation ability of PC3 prostate cancer cells, while over-expression of miR-96 induced proliferation and colony formation ability of LNCaP prostate cancer cells. Forkhead box protein O1 (FOXO1) is key tumor suppressors and has been shown to play key roles in the regulation of diverse cellular processes, including cell proliferation, differentiation, cell cycle progression and apoptosis. The expression level of FOXO1 was strikingly up-regulated in PC3 cells after transfected with miR-96 inhibitor, and FOXO1 expression was down-regulated in LNCaP cells after transfected with miR-96 mimics. miR-96 may play a vital role in promoting cell proliferation in human prostate cancer cells. Inhibition of miR-96 caused expression increase of tumor suppressor gene FOXO1, thus manipulating miR-96 expression may be a promising approach in treatment of prostate cancer. © 2014 Springer Science+Business Media New York.


Li H.,Yangzhou University | Li H.,Yancheng Institute of Technology | Li J.,Yancheng Institute of Technology | Yang Z.,Yangzhou University | And 4 more authors.
Journal of Hazardous Materials | Year: 2011

An ultrasensitive electrochemical method for simultaneous determination of lead and cadmium was first developed using the novel bismuth-Nafion-medical stone doped disposable electrode (an improved wax-impregnated graphite electrode). Through the synergistic sensitization effect of the resulting composite material, the disposable electrode showed remarkable electrochemical responses to lead and cadmium. The oxidation of the two metals produced two well-defined and separated square wave peaks at about -0.62V for Pb2+ and -0.85V for Cd2+, respectively. The effects of the amount of medical stone, concentration of Nafion, thickness of bismuth, pH of buffer solution, deposition potential, accumulation time, voltammetric measurement and possible interferences were investigated in detail. Under the optimal conditions, the fabricated electrode exhibited linear ranges from 2.0 to 12.0μgL-1 with detection limit of 0.07μgL-1 for lead and 2.0-12.0μgL-1 with detection limit of 0.47μgL-1 for cadmium. The assay results of heavy metals in wastewater with the proposed method were in acceptable agreement with the atomic absorption spectroscopy method. © 2011 Elsevier B.V.


Jin Z.,Shanghai JiaoTong University | Jin Z.,Yangzhou University | Cui Z.,Shanghai JiaoTong University
Journal of Materials Science and Technology | Year: 2010

A modified cellular automata (CA) model of dynamic recrystallization (DRX) and a flow stress-based nucleation parameter identification method have been developed. In the method, the modified CA model, which takes the role of deformation degree on nucleation behavior into consideration, is coupled with an adaptive response surface model (ARSM) to search for the optimum nucleation parameter. The DRX behavior of an oxygen free high conductivity (OFHC) copper with different initial grain sizes has been taken as an example to validate the model. Good agreement is found between the simulated and the experimental results, which demonstrates that the new method can effectively improve the simulation accuracy. © 2010 The Chinese Society for Metals.


Jin Z.,Yangzhou University | Cui Z.,Shanghai JiaoTong University
Computational Materials Science | Year: 2012

To predict and to control the microstructural evolution during dynamic recrystallization (DRX), a modified cellular automaton (CA) model based on mathematical statistics theory and physical metallurgical principles is developed. Initial microstructure and thermo-mechanical parameters are used as input data to the CA model. Dislocation density is used as a crucial internal state variable to link microstructural evolution with macroscopic flow stress. The latter two are output data, which can be compared with experimental one. In order to exhibit the effect of deformation stored energy on DRX, both the nucleation rate and the growth velocity of each recrystallizing grain (R-grain) are calculated from the dislocation density. The growth kinetics of R-grain is calculated from the metallurgical principles, and the nucleation kinetics is evaluated from a statistically based dislocation-related nucleation model. Model parameters are identified by a flow stress-based inverse analysis method, and then their variations with thermo-mechanical parameters (strain rate and temperature) are estimated and integrated into the CA model. The good agreement between the simulations and the experiments demonstrates the availability and predictability of the modified CA model. © 2012 Elsevier B.V. All rights reserved.


Zhang Y.C.,Yangzhou University | Du Z.N.,Yangzhou University | Li K.W.,China National Institute of Standardization | Zhang M.,Yangzhou University | Dionysiou D.D.,University of Cincinnati
ACS Applied Materials and Interfaces | Year: 2011

SnS2/SnO2 nanocomposites with tunable SnO2 contents were prepared via in situ hydrothermal oxidation of SnS2 nanoparticles in 0.375-4.5 mass% H2O2 aqueous solutions at 180 °C for 0-12 h. The structure, composition and optical properties of the as-prepared SnS2/SnO2 nanocomposites were characterized by X-ray diffraction, transmission electron microscopy, high-resolution transmission electron microscopy, Brunauer-Emmett-Teller (BET) surface area analysis, energy-dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and UV-vis diffuse reflectance spectra. Furthermore, their photocatalytic properties were tested for the degradation of methyl orange in water under visible light (λ > 420 nm) irradiation. It was found that the as-prepared SnS2/SnO2 nanocomposites with suitable SnO2 content not only demonstrated superior photocatalytic activity to both SnS2 nanoparticles and physically mixed SnS 2/SnO2 composite nanoparticles, but also had remarkable photocatalytic stability. The tight attachment of SnO2 nanoparticles to SnS2 nanoparticles, which can facilitate interfacial electron transfer and reduce the self-agglomeration of two components, was considered to play an important role in achieving the high photocatalytic performances exhibited by the as-prepared SnS2/SnO2 nanocomposites. © 2011 American Chemical Society.


Kong F.-Y.,Yancheng Institute of Technology | Gu S.-X.,Yancheng Institute of Technology | Gu S.-X.,Yangzhou University | Li W.-W.,Yancheng Institute of Technology | And 3 more authors.
Biosensors and Bioelectronics | Year: 2014

In this work, a convenient, fast, low cost, small sample volume and in situ detection of glucose in human whole blood has been developed by using a disposable screen-printed carbon electrode (SPCE) coupled with a paper disk. To perform the assay, the SPCE was modified with graphene/polyaniline/Au nanoparticles/glucose oxidase (Gr/PANI/AuNPs/GOD) biocomposite and then covered by a paper disk impregnated with the sample. After introducing PBS on the paper disk, the electrochemical measurement was carried out. The assay was based on measuring the current decrease of flavin adenine dinucleotide (FAD) in GOD provoked by the enzyme-substrate reaction using differential pulse voltammetry (DPV). The analytical performance was comparable to conventional methods, and covered the full range of clinically relevant concentrations of glucose in whole blood. This new paper-based electrochemical glucose sensor shows promise in applying point-of-care (POC) device in whole blood tests, and particularly being appropriate for use in the developing world and in resource-limited settings. © 2014 Elsevier B.V.


Xu Q.,Yangzhou University | Wei H.P.,Yangzhou University | Du S.,Yangzhou University | Li H.B.,Yangzhou University | And 3 more authors.
Journal of Agricultural and Food Chemistry | Year: 2013

Based on the synergetic effect of the electrochemical accumulation process and the signal amplification of enzymes, a new sensitive method has been developed for the detection of subnanomolar melamine. There are two steps involved in the sensor construction process: (1) accumulation of melamine on an electrode by cyclic voltammetric method and (2) chemical coupling of horseradish peroxidase (HRP) with the accumulated melamine through the linkage of glutaraldehyde. The coupled HRP catalyzes the oxidation of guaiacol to generate an amber-colored product. Quantitative analysis of melamine is performed by measuring the absorption intensities of the colored product. Under the optimal conditions, the method showed a wide linearity in the concentration range from 1.0 × 10-11 to 1.0 × 10-8 M for melamine detection. Moreover, it has been successfully applied to detect melamine in different infant formula powders and fish feed samples. © 2013 American Chemical Society.


Jin Z.,Shanghai JiaoTong University | Jin Z.,Yangzhou University | Cui Z.,Shanghai JiaoTong University
Materials Science and Engineering A | Year: 2010

Since it is difficult to accurately describe the nucleation behavior through analytical calculation or experimental observation, an inverse analysis method is used to evaluate the reasonability of two different nucleation models, i.e., a conventional constant nucleation model where the nucleation rate is assumed to be independent of strain and a dislocation-related nucleation model where it is strain dependent. In order to accurately estimate the parameters in the above two models, a flow stress-based inverse analysis method is developed. This method is implemented by coupling a cellular automata (CA) model with an adaptive response surface method (ARSM). Then the reasonability of each nucleation model is evaluated by comparing the level of agreement between the simulations and the experiments. Taking a low carbon steel deformed at 1173K and 0.1s-1 as an example, it is shown that the flow stress-based inverse analysis method is able to estimate the nucleation parameters accurately and the introduction of the dislocation-related nucleation model makes the simulation even closer to the actual physical process. © 2010 Elsevier B.V.


Wang J.,Nanjing University of Information Science and Technology | Zhang Z.,Nanjing University of Information Science and Technology | Li B.,Yangzhou University | Lee S.,Kyung Hee University | Sherratt R.,University of Reading
IEEE Transactions on Consumer Electronics | Year: 2014

Various fall-detection solutions have been previously proposed to create a reliable surveillance system for elderly people with high requirements on accuracy, sensitivity and specificity. In this paper, an enhanced fall detection system is proposed for elderly person monitoring that is based on smart sensors worn on the body and operating through consumer home networks. With treble thresholds, accidental falls can be detected in the home healthcare environment. By utilizing information gathered from an accelerometer, cardiotachometer and smart sensors, the impacts of falls can be logged and distinguished from normal daily activities. The proposed system has been deployed in a prototype system as detailed in this paper. From a test group of 30 healthy participants, it was found that the proposed fall detection system can achieve a high detection accuracy of 97.5%, while the sensitivity and specificity are 96.8% and 98.1% respectively. Therefore, this system can reliably be developed and deployed into a consumer product for use as an elderly person monitoring device with high accuracy and a low false positive rate. © 1975-2011 IEEE.


Liu Z.,Nanjing Southeast University | Chen H.,Nanjing Southeast University | Liu W.,Nanjing University of Information Science and Technology | Xu J.,Nanjing Southeast University | And 2 more authors.
Quantum Information Processing | Year: 2013

From the perspective of quantum circuit, a construction framework and a measurement framework of a general kind of four-qubit states are sketched, respectively. By utilizing the properties of this kind of states, a quantum secure direct communication (QSDC) protocol is put forward, which adopts the idea of optimal quantum superdense coding to achieve a maximal efficiency and high resources capacity. The security of the proposed protocol is discussed in detail and it is proved to be secure theoretically. Moreover, the sufficient and necessary condition of which multipartite states are suitable for optimal quantum superdense coding in quantum secure direct communication is figured out. © 2012 Springer Science+Business Media, LLC.


Tian C.,Yancheng Institute of Technology | Zhang L.,Technical University of Denmark | Lin Z.,Yangzhou University
Journal of the Franklin Institute | Year: 2011

In this paper, we develop a theoretical framework for investigating spatial patterns on plankton allelopathy with cross-diffusion. We show that under some conditions the cross-diffusion is able to induce the Turing instability, which is further confirmed by the numerical simulations. Moreover, applying the LeraySchauder degree theory, we demonstrate that the cross-diffusion leads to an inhomogeneous stationary pattern provided with even stronger conditions. Finally, the wavenumber and the type of pattern selection are computed numerically. Our theoretical results of the spatial pattern are coincident with the experimental observations. © 2010 The Franklin Institute. Published by Elsevier Ltd. All rights reserved.


Zhang Y.C.,Yangzhou University | Du Z.N.,Yangzhou University | Li K.W.,China National Institute of Standardization | Zhang M.,Yangzhou University
Separation and Purification Technology | Year: 2011

A simple hydrothermal method was developed for the size-controlled synthesis of SnS2 nanoparticles, using common and inexpensive SnCl4·5H2O and thioacetamide as the reactants and 5 vol.% acetic acid aqueous solution as the solvent. The structure, composition and optical property of the obtained products were characterized by X-ray diffraction, transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, Brumauer-Emmett-Teller (BET) surface area analysis and UV-vis diffuse reflectance spectra, and their possible formation mechanism was proposed. Besides, their photocatalytic properties were tested by degrading methyl orange in distilled water (20 mg/l) under visible light (λ > 420 nm) irradiation. It was found that SnS2 nanoparticles synthesized under the appropriate hydrothermal conditions not only exhibited high visible light-driven photocatalytic activity, but also had good photocatalytic stability. © 2011 Elsevier B.V. All rights reserved.


Chen L.,Yangzhou University | Chen L.,Nanjing University | Zou L.-J.,Yangzhou University | Tu L.,Jiangyin Polytechnic Institute
Information Sciences | Year: 2012

We propose a new algorithm to cluster multiple and parallel data streams using spectral component similarity analysis, a new similarity metric. This new algorithm can effectively cluster data streams that show similar behaviour to each other but with unknown time delays. The algorithm performs auto-regressive modelling to measure the lag correlation between the data streams and uses it as the distance metric for clustering. The algorithm uses a sliding window model to continuously report the most recent clustering results and to dynamically adjust the number of clusters. Our experimental results on real and synthetic datasets show that our algorithm has better clustering quality, efficiency, and stability than other existing methods. © 2011 Elsevier Inc. All rights reserved.


Li X.Q.,Yangzhou University | Zhu P.,No 401 Hospital | Myatt L.,University of Texas Health Science Center at San Antonio | Sun K.,Shanghai JiaoTong University | Sun K.,University of Texas Health Science Center at San Antonio
Placenta | Year: 2014

The pivotal role of glucocorticoids in the initiation of parturition has been very well documented in several domestic mammalian animal species. However the role of glucocorticoids in human parturition remains controversial mainly because of the absence of effect of synthetic glucocorticoids, given to promote fetal organ maturation in pregnant women with threatened preterm delivery, on the length of gestation. This article will review studies of glucocorticoids in human parturition and provide evidence for an important role of glucocorticoids in human parturition as well but a simultaneous high concentration of estrogen within the intrauterine tissues may be necessary for GCs to initiate parturition. The synthetic GCs dexamethasone and betamethasone pass through the placenta intact resulting in potent negative feedback on the fetal HPA axis and diminished production of DHEA from fetal adrenal glands for estrogen synthesis by the placenta. This may negate the effect of systemic administration of GCs on the induction of labor, especially in cases where the myometrium is not yet fully primed by estrogen. Endogenous glucocorticoids are inactivated by the placental 11β-HSD2 thus limiting the negative feedback of maternal cortisol on the fetal HPA axis and allowing the simultaneous rise of cortisol and estrogen levels towards the end of gestation. Therefore, endogenous glucocorticoids, particularly glucocorticoids produced locally in the intrauterine tissues may play an important role in parturition in humans by enhancing prostaglandin production in the fetal membranes and stimulating estrogen and CRH production in the placenta. © 2014 Elsevier Ltd. All rights reserved.


Zhang C.-Y.,Shanghai JiaoTong University | Zhang S.-J.,Zhejiang University of Technology | Zou D.-C.,Yangzhou University | Wang B.,Shanghai JiaoTong University
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2016

We study the charged scalar collapse in de Sitter spacetimes. With the electric charge, there is one more competitor to join the competition of dynamics in the gravitational collapse. We find that two factors can influence the electric charge. If we just adjust the charge conjugation, the electric charge effect is always perturbative at the black hole threshold. The electric charge can also be influenced by the initial conditions of perturbations. These initial parameters can be tuned to control the competition in dynamics and present us new and rich physics in the process of gravitational collapse. We give physical explanations of these phenomena found in dynamics. Furthermore we show that the properties of the gravitational collapse we observed do not depend on spacetime dimensions. © 2016 American Physical Society.


Li H.,Yangzhou University | Li H.,Yancheng Institute of Technology | Li J.,Yancheng Institute of Technology | Xu Q.,Yangzhou University | Hu X.,Yangzhou University
Analytical Chemistry | Year: 2011

A dramatic visible light photoelectrochemical sensing platform for the detection of pesticide molecules at zero potential (versus saturated calomel electrode) was first constructed using poly(3-hexylthiophene)-functionalized TiO 2 nanoparticles. Poly(3-hexylthiophene) (P3HT) was synthesized via chemical oxidative polymerization with anhydrous FeCl 3 as the oxidant, 3-hexylthiophene as the monomer, and chloroform as the solvent, and the functional TiO 2 nanoparticles were facilely prepared by blending TiO 2 nanoparticles and P3HT in chloroform solution. The resulting photoelectrocatalysts were characterized by scanning electron microscopy, Raman spectroscopy, and X-ray diffractometry. Under visible light irradiation, P3HT generated the transition from the valence band to the conduction band, delivering the excited electrons into the conduction band of TiO 2 and then to the glassy carbon electrode. Simultaneously, a positive charged hole (h +) of TiO 2 may form and migrate to the valence band of P3HT, which can react with H 2O to generate •OH, and then it converted chlopyrifos into chlopyrifos • that promoted the amplifying photocurrent response. On the basis of the proposed photoelectrochemical mechanism, a methodology for sensitive photoelectrochemical sensing for chlopyrifos at zero potential was thus developed. Under optimal conditions, the proposed photoelectrochemical method could detect chlopyrifos ranging from 0.2 to 16 μmol L -1 with a detection limit of 0.01 μmol L -1 at a signal-to-noise ratio of 3. The photoelectrochemical sensor had an excellent specificity against the other pesticides and could be successfully applied to the detection of reduced chlopyrifos in green vegetables, showing a promising application in photoelectrochemical sensing. © 2011 American Chemical Society.


Li H.,Yangzhou University | Li H.,Yancheng Institute of Technology | Li J.,Yancheng Institute of Technology | Yang Z.,Yangzhou University | And 2 more authors.
Analytical Chemistry | Year: 2011

A novel photoelectrochemical sensor for detection of the organophosphorus pesticide (OP) dichlofenthion using nanometer-sized titania coupled with a screen-printed electrode is presented. Nonelectroactive dichlofenthion can be indirectly determined through the photocatalytical degradation of dichlofenthion with nanometer-sized titania. The electrochemical characterization and anodic stripping voltammetric performance of dichlofenthion were evaluated using cyclic voltammetric (CV) and differential pulse anode stripping voltammetric (DPASV) analysis, respectively. DPASV analysis was used to monitor the amount of dichlofenthion and provide a simple, fast, and facile quantitative method for dichlofenthion. Operational parameters, including the photocatalysis time, pH of buffer solution, deposition potential, and accumulation time have been optimized. The stripping voltammetric response is linear over the 0.02-0.1 and 0.2-1.0 μmol/L ranges with a detection limit of 2.0 nmol/L. The assay result of dichlofenthion in green vegetable with the proposed method was in acceptable agreement with that of the gas chromatograph-mass spectrometer (GC-MS) method. The promising sensor opens a new opportunity for fast, portable, and sensitive analysis of OPs in environmental samples. © 2011 American Chemical Society.


Tian C.,Yancheng Institute of Technology | Ling Z.,Yangzhou University | Lin Z.,Yangzhou University
Nonlinear Analysis: Real World Applications | Year: 2011

In this paper, we develop a theoretical framework about spatial patterns in a three-species predatorpreymutualist system with cross-diffusion. We concentrate on three aspects of Turing pattern formation: (1) what conditions enable the occurrence of Turing patterns? (2) what are the underlying mechanisms? (3) what are the corresponding configurations? For the first two questions, by use of the stability analysis for the positive uniform solution and the LeraySchauder degree theory, we prove that under some conditions, the system admits at least a nonhomogeneous stationary solution. For the third question, we carry out numerical simulations for a Turing pattern, and we show that the configurations of Turing pattern are stable spotted patterns, which resemble a real ecosystem. © 2011 Elsevier Ltd. All rights reserved.


Zhang W.,Yangzhou University | Tang Y.,Humboldt University of Berlin | Tang Y.,Potsdam Institute for Climate Impact Research | Miao Q.,Shanghai JiaoTong University | Du W.,Hong Kong Polytechnic University
IEEE Transactions on Neural Networks and Learning Systems | Year: 2013

This paper investigates the synchronization problem of coupled switched neural networks (SNNs) with mode-dependent impulsive effects and time delays. The main feature of mode-dependent impulsive effects is that impulsive effects can exist not only at the instants coinciding with mode switching but also at the instants when there is no system switching. The impulses considered here include those that suppress synchronization or enhance synchronization. Based on switching analysis techniques and the comparison principle, the exponential synchronization criteria are derived for coupled delayed SNNs with mode-dependent impulsive effects. Finally, simulations are provided to illustrate the effectiveness of the results. © 2012 IEEE.


Tian C.,Yancheng Institute of Technology | Tian C.,Yangzhou University | Lin Z.,Yangzhou University
Nonlinear Analysis: Real World Applications | Year: 2010

This paper is concerned with the existence and asymptotic behavior of periodic solutions for a periodic reaction diffusion system of a planktonic competition model under Dirichlet boundary conditions. The approach to the problem is by the method of upper and lower solutions and the bootstrap argument of Ahmad and Lazer. It is shown under certain conditions that this system has positive or semi-positive periodic solutions. A sufficient condition is obtained to ensure the stability and global attractivity of positive periodic solutions. © 2009 Elsevier Ltd. All rights reserved.


Lin Z.,Yangzhou University | Ruiz-Baier R.,Ecole Polytechnique Federale de Lausanne | Tian C.,Yancheng Institute of Technology
Journal of Computational Physics | Year: 2014

This paper is concerned with the study of pattern formation for an inhomogeneous Brusselator model with cross-diffusion, modeling an autocatalytic chemical reaction taking place in a three-dimensional domain. For the spatial discretization of the problem we develop a novel finite volume element (FVE) method associated to a piecewise linear finite element approximation of the cross-diffusion system. We study the main properties of the unique equilibrium of the related dynamical system. A rigorous linear stability analysis around the spatially homogeneous steady state is provided and we address in detail the formation of Turing patterns driven by the cross-diffusion effect. In addition we focus on the spatial accuracy of the FVE method, and a series of numerical simulations confirm the expected behavior of the solutions. In particular we show that, depending on the spatial dimension, the magnitude of the cross-diffusion influences the selection of spatial patterns. © 2013 Elsevier Inc.


Liu C.,Yangzhou University | Liu P.,Brookhaven National Laboratory
ACS Catalysis | Year: 2015

We report the methanol synthesis from CO2 and H2 on metal (M = K, Ti, Co, Rh, Ni, and Cu)-modified model Mo6S8 catalyst using density functional theory (DFT). The results show that the catalytic behavior of a Mo6S8 cluster is changed significantly due to the modifiers, via the electron transfer from M to Mo6S8 and therefore the reduction of the Mo cation (ligand effect) and the direct participation of M in the reaction (ensemble effect) to promote some elementary steps. With the most positively charged modifier, the ligand effect in the case of K-Mo6S8 is the most obvious among the systems studied; however, it cannot compete with the ensemble effect, which plays a dominate role in determining activity via the electrostatic attraction in particular to stabilize the CHxOy species adsorbed at the Mo sites of Mo6S8. In comparison, the ligand effect is weaker and the ensemble effect is more important when the other modifiers are used. In addition, the modifiers also vary the optimal reaction pathway for methanol synthesis on Mo6S8, ranging from the reverse water-gas shift (RWGS) + CO hydrogenation as that of Mo6S8 to the formate pathway. Finally, K is able to accelerate the methanol synthesis on Mo6S8 the most, whereas the promotion by Rh is relatively small. Using the modifiers like Ti, Co, Ni, and Cu, the activity of Mo6S8 is decreased instead. The relative stability between ∗HCOO and ∗HOCO is identified as a descriptor to capture the variation in mechanism and scales well with the estimated activity. Our study not only provides better understanding of the reaction mechanism and actives on the modified Mo6S8 but also predicts some possible candidates, which can be used as a promoter to facilitate the CH3OH synthesis on Mo sulfides. © 2014 American Chemical Society.


Qu Q.,Yangzhou University | Peng S.,Yangzhou University | Mangelings D.,Vrije Universiteit Brussel | Hu X.,Yangzhou University | Yan C.,Shanghai JiaoTong University
Electrophoresis | Year: 2010

Nonporous monodispersed silica spheres of 1.3 μm were coated with gold nanoparticles (AuNPs) and subsequently coated with n-octadecanethiol. By transmission electron microscopy analysis, the average diameter of the AuNPs on the silica spheres was determined to be 12 nm. The chromatographic and electrochromatographic properties of self-assembled n-octadecanethiol AuNP-coated silica microspheres (C18-AuNPs-SiO 2) were investigated using a group of nonpolar PAHs. The stationary phase appears to display a characteristic reversed-phase behavior. Higher separation efficiency and shorter separation times were obtained using pressurized CEC (pCEC) compared with capillary LC (CLC). A maximum column efficiency of about 2.5 x 10 5 plates per meter and less than 18 min separation time for benzene were obtained in pCEC while only 66 507 plates per meter and an analysis time of nearly 100 min were observed in CLC mode. A chemical stability test of the C18-AuNPs-SiO 2 stationary phase under extremely high and low pH conditions demonstrated that it is stable at pH 12 and 1 for at least 60 h. The results confirm that C18-AuNPs-SiO 2 possesses a high rigidity to withstand high packing pressures and can be used as a good stationary phase for CLC and pCEC. & 2010 WILEY-VCH Verlag GmbH & Co. KGaA.


Qin X.,Yangzhou University | Liu X.,Yangzhou University | Hong-Bo L.,Yangzhou University | Hong-Bo L.,Yancheng Institute of Technology | And 2 more authors.
Biosensors and Bioelectronics | Year: 2013

The azocalix[4]arene film modified glassy carbon electrode was established for the convenient and sensitive detection of four DNA bases (guanine, adenine, thymine and cytosine). Field emission scanning electron microscopy, attenuated total reflectance-FTIR and X-ray photoelectron spectroscopy were used to characterize the film. The azocalix[4]arene film exhibited excellent electrocatalytic activity toward the oxidation of all bases. Well-separated voltammetric peaks were obtained among guanine, adenine, thymine and cytosine, which lead to the feasibility for the simultaneous determination of all of them in a mixture without separation or pretreatment. Linear calibration curves were obtained from 0.125 to 200.0. μM for adenine, 0.125 to 175.0. μM for guanine, 2.50 to 650.0. μM for thymine, and 2.50 to 650.0. μM for cytosine. This sensor also exhibits good stability, reproducibility and long lifetime. © 2012 Elsevier B.V.


Ma M.-Z.,Shanghai JiaoTong University | Ma M.-Z.,Yangzhou University | Li C.-X.,Shanghai JiaoTong University | Zhang Y.,Wannan Medical College | And 5 more authors.
Molecular Cancer | Year: 2014

Background: Protein coding genes account for only about 2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs including long non-coding RNAs. A growing volume of literature has proposed that lncRNAs are important players in cancer. HOTAIR was previously shown to be an oncogene and negative prognostic factor in a variety of cancers. However, the factors that contribute to its upregulation and the interaction between HOTAIR and miRNAs are largely unknown.Methods: A computational screen of HOTAIR promoter was conducted to search for transcription-factor-binding sites. HOTAIR promoter activities were examined by luciferase reporter assay. The function of the c-Myc binding site in the HOTAIR promoter region was tested by a promoter assay with nucleotide substitutions in the putative E-box. The association of c-Myc with the HOTAIR promoter in vivo was confirmed by chromatin immunoprecipitation assay and Electrophoretic mobility shift assay. A search for miRNAs with complementary base paring with HOTAIR was performed utilizing online software program. Gain and loss of function approaches were employed to investigate the expression changes of HOTAIR or miRNA-130a. The expression levels of HOTAIR, c-Myc and miRNA-130a were examined in 65 matched pairs of gallbladder cancer tissues. The effects of HOTAIR and miRNA-130a on gallbladder cancer cell invasion and proliferation was tested using in vitro cell invasion and flow cytometric assays.Results: We demonstrate that HOTAIR is a direct target of c-Myc through interaction with putative c-Myc target response element (RE) in the upstream region of HOTAIR in gallbladder cancer cells. A positive correlation between c-Myc and HOTAIR mRNA levels was observed in gallbladder cancer tissues. We predicted that HOTAIR harbors a miRNA-130a binding site. Our data showed that this binding site is vital for the regulation of miRNA-130a by HOTAIR. Moreover, a negative correlation between HOTAIR and miRNA-130a was observed in gallbladder cancer tissues. Finally, we demonstrate that the oncogenic activity of HOTAIR is in part through its negative regulation of miRNA-130a.Conclusion: Together, these results suggest that HOTAIR is a c-Myc-activated driver of malignancy, which acts in part through repression of miRNA-130a. © 2014 Ma et al.; licensee BioMed Central Ltd.


Li H.,Yangzhou University | Li H.,Yancheng Institute of Technology | Li J.,Yancheng Institute of Technology | Xu Q.,Yangzhou University | And 2 more authors.
Analytica Chimica Acta | Year: 2013

A novel visible light sensitized photoelectrochemical sensing platform was constructed based on the perylene-3,4,9,10-tetracarboxylic acid/titanium dioxide (PTCA/TiO2) heterojunction as the photoelectric beacon. PTCA was synthesized via facile steps of hydrolysis and neutralization reaction, and then the PTCA/TiO2 heterojunction was easily prepared by coating PTCA on nano-TiO2 surface. The resulting photoelectric beacon was characterized by transmission electron microscope, scanning electron microscopy, X-ray diffractometry, FTIR spectroscopy, and ultraviolet and visible spectrophotometer. Using parathion-methyl as a model, after a simple hydrolyzation process, p-nitrophenol as the hydrolysate of parathion-methyl could be obtained, the fabricated derivative photoelectrochemical sensor showed good performances with a rapid response, instrument simple and portable, low detection limit (0.08nmolL-1) at a signal-to-noise ratio of 3, and good selectivity against other pesticides and possible interferences. It had been successfully applied to the detection of parathion-methyl in green vegetables and the results agreed well with that by GC-MS. This strategy not only extends the application of PTCA, but also presents a simple, economic and novel methodology for photoelectrochemical sensing. © 2013 Elsevier B.V.


Ma M.-Z.,Shanghai JiaoTong University | Ma M.-Z.,Yangzhou University | Chu B.-F.,Shanghai JiaoTong University | Zhang Y.,Wannan Medical College | And 4 more authors.
Cell Death and Disease | Year: 2015

Protein-coding genes account for only ∼ 2% of the human genome, whereas the vast majority of transcripts are non-coding RNAs (ncRNAs) including long ncRNAs (lncRNAs). A growing volume of literature has proposed that lncRNAs are important factors in cancer. Colon cancer-associated transcript-1 (CCAT1), an lncRNA, which was first identified in colon cancer, was previously shown to promote tumor development and be a negative prognostic factor in gastric cancer. However, the mechanism through which CCAT1 exerts its oncogenic activity remains largely unknown. Recently, a novel regulatory mechanism has been proposed in which RNAs can cross-talk with each other via competing shared for microRNAs (miRNAs). The proposed competitive endogenous RNAs could mediate the bioavailability of miRNAs on their targets, thus imposing another level of posttranscriptional regulation. In this study, we demonstrated that CCAT1 was upregulated in gallbladder cancer (GBC) tissues. CCAT1 silencing downregulated, whereas CCAT1 overexpression enhanced the expression of miRNA-218-5p target gene Bmi1 through competitively 'spongeing' miRNA-218-5p. Our data revealed that CCAT1 knockdown impaired the proliferation and invasiveness of GBC cells, at least in part through affecting miRNA-218-5p-mediated regulation of Bmi1. Moreover, CCAT1 transcript level was correlated with Bmi1 mRNA level in GBC tissues. Together, these results suggest that CCAT1 is a driver of malignancy, which acts in part through 'spongeing' miRNA-218-5p. © 2015 Macmillan Publishers Limited All rights reserved.


Jin H.,Nanjing Southeast University | Jiang Y.,Yangzhou University | Wei Q.,Nanjing Southeast University | Chen L.,Nanjing Southeast University | Ma G.,Nanjing Southeast University
NeuroRehabilitation | Year: 2013

Objective: Using heart rate recovery (HRR) after exercise as an index of autonomic function, we evaluate the effects of aerobic cycling training on HRR and cardiovascular fitness (peak VO2) in chronic stroke patients and investigate the relationship between changes in HRR and those in peak VO 2. Methods: 128 participants with chronic stroke were randomized to a 12-week (5×/week) progressive aerobic cycling training group (n = 65) or a control group (n = 63). Peak VO2, muscle strength, 6-minute walking distance (6MWD) and HRR were measured before and after the intervention. Results: Cycling training leads to significant increase in peak VO2, HRR, muscle strength and 6MWD. In the cycling group, percent changes in peak VO2 were positively associated with those in paretic and nonparetic muscle strength and HRR. Linear regression revealed that percent increases in peak VO2 were significantly correlated with percent changes in HRR when controlling for pre-peak VO2, age, gender, duration since stroke and improved muscle strength. Conclusion: Aerobic cycling training can favorably modify HRR in stroke survivors. Rapid HRR, as an indicator of enhanced autonomic function, is useful for predicting gains in cardiovascular fitness. These findings indicate the underlying importance of autonomic modulation on cardiovascular adaptations to stroke exercise rehabilitation. © 2013 - IOS Press and the authors. All rights reserved.


Li S.,Nanjing University of Aeronautics and Astronautics | Li S.,Yangzhou University | Qiu J.,Nanjing University of Aeronautics and Astronautics | Li J.,Nanjing Southeast University | And 2 more authors.
IET Control Theory and Applications | Year: 2012

Piezoelectric panel is a fundamental element in many structures characterised with multi-variables, coupling and uncertain external excitation. Many advanced active control schemes have been reported for the multi-modal of piezoelectric structure. However, these control schemes, including the multi-loop PID method usually cannot achieve satisfying performance in the presence of strong external disturbances and coupling effects. To this end, an amended disturbance observer (DOB) based on multi-loop PID scheme is developed to control a two-mode piezoelectric panel. The system considered here is with lumped disturbances including external disturbances, such as the variations of the output of the modal and the external excitation, and internal disturbances, such as coupling effects. The proposed control approach consists of two compound controllers, and each controller includes a PID feedback part and a feed-forward compensation part based on DOB for disturbances. In order to obtain a better vibration suppressing performance, a chaos optimisation method based on Logistic map and a new transient performance function is designed to tune the parameters of PID controller. A rigorous analysis is also given to show why the DOB can effectively suppress the variations. At last, in order to verify the proposed algorithm, the dSPACE real-time simulation platform is used and an experimental platform for the all-clamped stiffened panel structure active vibration control is set up. The simulation and experiment results demonstrate that the proposed method has a much better vibration suppressing property with almost the same input voltage than the multi-loop PID method in the piezoelectric panel. © 2011 The Institution of Engineering and Technology.


Huo Z.,China Agricultural University | Feng S.,China Agricultural University | Feng S.,Yangzhou University | Kang S.,China Agricultural University | Dai X.,CAS Beijing Institute of Geographic Sciences and Nature Resources Research
Journal of Arid Environments | Year: 2012

We trained and tested artificial neural network (ANN) models for reference evapotranspiration (ET 0) using 50 years' meteorological data from three stations in northwest China. Multiple linear regressions (MLRs), the Penman equation, and two empirical equations were used to compare the performance of the ANNs. A connection weight method was used to quantify the importance of climate factors in performance. In addition, the error changes of the ANNs with seasons were evaluated according to absolute error, variance, and coefficient of variance. Results showed that in arid and semi-arid areas, the ANNs in which the climate data were used successfully estimated ET 0, and the ANNs with five inputs were more accurate than those with four or three. Relative to the MLRs, the Penman equation, and empirical equations, the ANNs exhibited high precision. Maximum air temperature, minimum air temperature, and relative humidity were the most crucial input of ANN-based ET 0 estimation for arid and semi-arid areas. In the study area, the importance of these three climate factors accounted respectively for 39.82-46.64%, 28.48-33.46%, and 10.73-26.17% to estimation of ET 0. Generally, ANNs underestimated ET 0 from January to July and overestimated it from August to December. © 2012.


Kim K.I.,Pohang University of Science and Technology | Lin Z.,Yangzhou University | Zhang Q.,Yangzhou University
Nonlinear Analysis: Real World Applications | Year: 2013

An SIR epidemic model with free boundary is investigated. This model describes the transmission of diseases. The behavior of positive solutions to a reaction-diffusion system in a radially symmetric domain is investigated. The existence and uniqueness of the global solution are given by the contraction mapping theorem. Sufficient conditions for the disease vanishing or spreading are given. Our result shows that the disease will not spread to the whole area if the basic reproduction number R0<1 or the initial infected radius h0 is sufficiently small even that R0>1. Moreover, we prove that the disease will spread to the whole area if R 0>1 and the initial infected radius h0 is suitably large. © 2013 Elsevier Ltd. All rights reserved.


Xu X.,Yangzhou University | Xu X.,Nanjing Southeast University | Hu J.,Yangzhou University | Yin Z.,Nanyang Technological University | Xu C.,Nanjing Southeast University
ACS Applied Materials and Interfaces | Year: 2014

A large area of hydrothermally grown MoS2 ultrathin nanosheets (NSs) with a vertically mesh-shaped structure on indium tin oxide (ITO) substrate was directly used as the photoanode of a potoelectrochemical (PEC) cell. The photoelectrocatalytic capacity of ultrathin MoS2 NSs was demonstrated, which was attributed not only to the excellent electrocatalytic activity originating from the exposed preferentially active edge sites but also to the superior photoelectric response resulting from the large light absorption of ultrathin MoS2 NSs and from the efficient separation of electron-hole pairs at the ITO/MoS2 interfaces. The significantly enhanced photocurrent indicates that the MoS2 ultrathin NSs can be a promising photoelectrocatalyst for PEC cells, unveiling the potential of MoS2-based PEC cells for solar energy absorption and conversion. © 2014 American Chemical Society.


Lei Z.,Nanjing Southeast University | Jiang Y.,Yangzhou University | Li T.,Nanjing Southeast University | Zhu J.,Nanjing Southeast University | Zeng S.,Nanjing Southeast University
Journal of Neuropathology and Experimental Neurology | Year: 2011

Glial cell line-derived neurotrophic factor (GDNF) and its receptor GFRα1 have been implicated in the survival of ventral midbrain dopaminergic (DA) neurons, but the molecular mechanisms bywhich GDNF generates DA neurons in grafted midbrain-derived neural stem cells (mNSCs) are not understood. Midbrain-derived neural stem cells isolated from rat embryonic mesencephalon (embryonic day 12) were treated with GDNF or in combination with GFRα1 small interfering RNA. Reverse transcription-polymerase chain reaction, Western blot, and immunocytochemistry were used totest the expression of the orphan nuclear receptor Nurr1 and thetranscription factor Pitx3 and newborn tyrosine hydroxylase (TH)-positive cells. Treatment of mNSCs with GDNF increased mNSCs' sphere diameter, reduced expression of caspase 3, and increased expression of Bcl-2. Glial cell line-derived neurotrophic factor-treated mNSCs enhanced Nurr1 and Pitx3 expression and the fraction of TH-, TH/Pitx3-, and TH/Nurr1-positive cells in culture. Grafted GDNF-treated mNSCs significantly decreased apomorphine-induced rotation behavior in 6-hydroxydopamine-lesioned rats. Glialcell line-derived neurotrophic factor-treated mNSCs showed increased numbers of TH/Pitx3-and TH/Nurr1-postivie cells. The effect elicited by GDNF was inhibited by small interfering RNA-mediated knockdown of GFRα1. Our data demonstrate the contribution of GDNF to DA neuron development and may also elucidate pathogenetic mechanisms in Parkinson disease and contribute to the development of novel therapies for the disorder. © 2011 by the American Association of Neuropathologists, Inc.


Huo Z.,China Agricultural University | Dai X.,CAS Beijing Institute of Geographic Sciences and Nature Resources Research | Feng S.,Yangzhou University | Kang S.,China Agricultural University | Huang G.,China Agricultural University
Journal of Hydrology | Year: 2013

Temporal variations in reference evapotranspiration (ET0) and aridity index (AI) were comprehensively investigated for 23 meteorological stations during 1955-2008 in the northwest China. The quantitative contributions of the major meteorological variables to the ET0 and AI trends were evaluated and the possible causes were also investigated. The results showed that in the past 50years annual temperature, humidity and precipitation had significant increasing trends with time, and wind speed and radiation had decreasing trends. ET0 had a significant decreasing trend with an averagely value of about 3mm per year, and AI had also witnessed a decreasing trend; For ET0, wind speed was the most sensitive meteorological variable, followed by relative humidity, temperature and radiation and for AI, precipitation was the most sensitive meteorological variable. The contribution of wind speed to the decrease of ET0 is more than that of other meteorological variables. The increase of precipitation contributes more than the decrease of ET0 to decrease of AI in past 50years. This study provides an understanding of the effect of recent climate change on drought in arid northwest China. © 2013 Elsevier B.V.


Xu X.,Nanjing Southeast University | Xu X.,Yangzhou University | Xu C.,Nanjing Southeast University | Lin Y.,Nanjing Southeast University | And 2 more authors.
Journal of Physical Chemistry C | Year: 2013

We carried out a detailed comparison on the defect-related photoluminescence and magnetism in two kinds of undoped ZnO nanorods synthesized by low-temperature chemical bath deposition and high-temperature chemical vapor deposition methods to clarify further the nature of visible emission and d 0 ferromagnetism in ZnO based on the fact that these two kinds of ZnO nanorods have significantly different crystallinity and defect states. The results obtained by analyzing X-ray diffraction, electron paramagnetic resonance, and Raman scattering show that the intrinsic ferromagnetism in ZnO nanorods is originated from the single ionized oxygen defects (vacancies and interstitials). Particularly, it is demonstrated that the lattice disorder along the c-axis along with the introduced oxygen interstitials can boost ferromagnetism and induce the red-shift in visible emission. © 2013 American Chemical Society.


Yu C.-M.,Yuan Ze University | Chen C.-Y.,National Ilan University | Chao H.-C.,Yangzhou University
IEEE Network | Year: 2015

Cloud storage such as Dropbox and Bitcasa is one of the most popular cloud services. Currently, with the prevalence of mobile cloud computing, users can even collaboratively edit the newest version of documents and synchronize the newest files on their smart mobile devices. A remarkable feature of current cloud storage is its virtually infinite storage. To support unlimited storage, the cloud storage provider uses data deduplication techniques to reduce the data to be stored and therefore reduce the storage expense. Moreover, the use of data deduplication also helps significantly reduce the need for bandwidth and therefore improve the user experience. Nevertheless, in spite of the above benefits, data deduplication has its inherent security weaknesses. Among them, the most severe is that the adversary may have an unauthorized file downloading via the file hash only. In this article we first review the previous solutions and identify their performance weaknesses. Then we propose an alternative design that achieves cloud server efficiency and especially mobile device efficiency. © 1986-2012 IEEE.


Shen J.,Yangzhou University | Wang W.,Nanjing Southeast University
Tumu Gongcheng Xuebao/China Civil Engineering Journal | Year: 2011

In order to completely measure the complexity of the spatial layout and orderliness of urban intersections, a complexity degree model was developed from macro and micro perspectives. Conflict point and conflict probability were selected as the two key factors, one of which was analyzed using the diagram method and photogrammetry principle, and the other determined by using statistical analysis and curve fitting. The complexity degree values of intersections of different spatial layout under various traffic demands were calculated. The results indicate that the complexity degree values of intersections of the same type increase with volume and those of intersections of different types increase with the number of lanes. Complexity degree is a comprehensive quantitative index showing the working condition of intersections, and can be applied to planning urban road networks and safety appraisal of intersections.


Zhang X.,Nanjing Southeast University | Zhang X.,Yangzhou University | Tian Z.,Nanjing Southeast University | Yang S.-W.,Institute of High Performance Computing of Singapore | Wang J.,Nanjing Southeast University
Journal of Physical Chemistry C | Year: 2011

We systematically investigate the stability and electronic and magnetic properties of one-dimensional (1D) bimetallic organic sandwich molecular wires (BOSMWs), [CpTiCpTM]∞ (TM = Sc-Co, Cp = C5H 5), [CpCrCpTM]∞ (TM = V, Mn, Co), and [CpFeCpTM]∞ (TM = Cr, Co), using ab initio methods. All the BOSMWs are highly stable due to mixed ionic-covalent bonding. With the exceptions of [CpTiCpV]∞, [CpTiCpMn]∞, and [CpCrCpV]∞ exhibiting antiferromagnetic behavior, all the other BOSMWs are ferromagnetic with tunable magnetic moments. In particular, magnetic moments of [CpTiCpCo]∞ and [CpCrCpMn]∞ can be as high as 5 μB per unit cell. Our calculations further show that [CpTiCpTM]∞ (TM = Cr, Fe), [CpCrCpTM]∞ (TM = Fe, Co), and [CpFeCpCo]∞ are robust half-metals (HMs) with large HM gaps. Most importantly, we identify an empirical valence electron filling rule for these BOSMWs, and a BOSMW is found to be a half-metallic ferromagnet whenever N - 5(10) = 5(7) (N is the sum of the valence electrons of two metal atoms). This electron filling rule, together with the HM equations formulized in this study, can be extended to predict new HM BOSMWs. © 2011 American Chemical Society.


Liu Y.,Yangzhou University | Wang Z.,Brunel University | Liang J.,Nanjing Southeast University | Liu X.,Brunel University
IEEE Transactions on Cybernetics | Year: 2013

In this paper, the synchronization problem is studied for an array of N identical delayed neutral-type neural networks with Markovian jumping parameters. The coupled networks involve both the mode-dependent discrete-time delays and the mode-dependent unbounded distributed time delays. All the network parameters including the coupling matrix are also dependent on the Markovian jumping mode. By introducing novel Lyapunov-Krasovskii functionals and using some analytical techniques, sufficient conditions are derived to guarantee that the coupled networks are asymptotically synchronized in mean square. The derived sufficient conditions are closely related with the discrete-time delays, the distributed time delays, the mode transition probability, and the coupling structure of the networks. The obtained criteria are given in terms of matrix inequalities that can be efficiently solved by employing the semidefinite program method. Numerical simulations are presented to further demonstrate the effectiveness of the proposed approach. © 2012 IEEE.


Guo L.,Beihang University | Cao S.,Beihang University | Cao S.,Yangzhou University
ISA Transactions | Year: 2014

The problem of anti-disturbance control has been an eternal topic along with the development of the control theory. However, most methodologies can only deal with systems subject to a single equivalent disturbance which was merged by various types of uncertainties. In this paper, a review on anti-disturbance control is presented for systems with multiple disturbances. First, the classical control methods are briefly reviewed for disturbance attenuation or rejection problems. Then, recent advances in disturbance observer based control (DOBC) theory are introduced and especially, the composite hierarchical anti-disturbance control (CHADC) is firstly addressed. A comparison of different approaches is briefly carried out. Finally, focuses in the field on the current research are also addressed with emphasis on the practical application of the techniques. © 2013 ISA.


Wu X.,Anhui Polytechnic University | Tang Y.,Potsdam Institute for Climate Impact Research | Tang Y.,Humboldt University of Berlin | Zhang W.,Yangzhou University
Neural Networks | Year: 2014

This paper is concerned with the global exponential stability of switched stochastic neural networks with time-varying delays. Firstly, the stability of switched stochastic delayed neural networks with stable subsystems is investigated by utilizing the mathematical induction method, the piecewise Lyapunov function and the average dwell time approach. Secondly, by utilizing the extended comparison principle from impulsive systems, the stability of stochastic switched delayed neural networks with both stable and unstable subsystems is analyzed and several easy to verify conditions are derived to ensure the exponential mean square stability of switched delayed neural networks with stochastic disturbances. The effectiveness of the proposed results is illustrated by two simulation examples. © 2013 Elsevier Ltd.


Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University | Liu X.,Yangzhou University | Zhao Y.,Nanjing Southeast University
Applied Physics Letters | Year: 2015

We combine experimental observations with numerical simulations to explore the deformation dynamics of double emulsion droplet under shear. Two types of transient deformation topologies are identified via the respective underlying physical mechanisms. Especially, we demonstrate that the inner droplet can enhance the retracting of integral droplet, which leads to more intense transient deformation oscillations of double emulsion droplet than those of single-phase one. We further provide a regime diagram to quantitatively recognize the respective regime of these two transient deformation topologies, depending on the capillary number and radius ratio of inner droplet to the outer one. © 2015 AIP Publishing LLC.


Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University | Liu X.,Nanjing Southeast University | Shi M.,Nanjing Southeast University
Applied Physics Letters | Year: 2013

Hydrodynamic behaviors of double emulsion droplets in shear flow, both deformation and breakup, are investigated numerically. We find that the inner drop is deformed in a uniform vortical flow interior to the outer drop under steady state deformation conditions and provides an additional deformation resistance for the integral droplet especially when its volume fraction is large. In particular, we report four types of breakup modes via three mechanisms (i.e., necking, end pinching, and capillary instability), respectively, and present the corresponding phase diagrams to describe the breakup criteria (critical capillary numbers) and morphologies. © 2013 American Institute of Physics.


Yang W.,Yangzhou University | Chen Y.,Yangzhou University | Shi M.,Nanjing Southeast University | Spitler J.D.,Oklahoma State University
Applied Thermal Engineering | Year: 2013

Underground thermal imbalance is a common problem in ground-coupled heat pump (GCHP) system operated in cooling-dominated district, which will cause the average underground soil temperature to rise, and inevitably deteriorate the operation performance of GCHP system. In this paper, a two-dimensional heat transfer model with groundwater advection was developed for modeling the heat transfer of underground GHE array. The influences of underground thermal imbalance rate, soil type, borehole layout and groundwater advection on the underground soil temperature distribution were analyzed. The results indicate that the soil temperature increase with the increase of the ratio of annual heat released into the ground to that extracted from the ground, and thus the underground thermal imbalance becomes worse. The better the soil thermal conductivity and diffusivity are, the faster the soil heat diffusion is, and thus the underground heat buildup can be alleviated. At the same time, the underground thermal imbalance can be controlled or eliminated by decreasing the intensive degree of borehole layout through increasing the borehole spacing or using strip type and block layout. Additionally, the underground heat buildup can be efficiently removed by the groundwater advection. © 2013 Published by Elsevier Inc.


Zhu Q.,Yangzhou University | Zhang T.,Yangzhou University | Fei S.,Nanjing Southeast University
Neurocomputing | Year: 2010

An adaptive control scheme combined with backstepping, radial basis function (RBF) neural networks is proposed for the output tracking control problem of a class of MIMO nonlinear systems with input delay and disturbances. Neural networks are employed to estimate the unknown continuous functions. The control scheme ensures that the closed-loop system is semi-globally uniformly ultimately bounded (SGUUB). The tracking error is proved to be bounded and ultimately converges to an adequately small compact set. The feasibility is investigated by a simulation example. © 2010 Elsevier B.V.


Zhang X.-W.,Subei Peoples Hospital | Bu P.,Yangzhou University | Liu L.,Yangzhou University | Zhang X.-Z.,Subei Peoples Hospital | Li J.,Subei Peoples Hospital
Biochemical and Biophysical Research Communications | Year: 2015

Background: The development of multidrug resistance (MDR) is a crucial problem of therapy failure in gastric cancer, which results in disease recurrence and metastasis. Plasmacytoma variant translocation 1 (PVT-1), a long non-coding RNA (lncRNA), was previously found to be increased in gastric cancer patients and regulated the chemotherapy sensitivity in pancreatic cancer cells. However, the role of PVT1 in multidrug resistant Gastric cancer remains largely unexplored. Methods: In this study, the mRNA levels of PVT1 in gastric cancer tissues of cisplatin-resistant patients and two kinds of cisplatin-resistant cells BGC823/DDP and SGC7901/DDP were detected by qRT-PCR. The influence of PVT1 knockdown or overexpression on anticancer drug resistance was assessed by measuring the cytotoxicity of cisplatin and the rate of apoptosis detected by CCK-8 assay and flow cytometry, respectively. Further, we investigated the expression levels of MDR1, MRP, mTOR and HIF-1α by qRT-PCR and western blotting. Results: PVT-1 was highly expressed in gastric cancer tissues of cisplatin-resistant patients and cisplatin-resistant cells. In addition, BGC823/DDP and SGC7901/DDP cells transfected with PVT-1 siRNA and treated with cisplatin exhibited significant lower survival rate and high percentage of apoptotic tumor cells. While, PVT1 overexpression exhibit the anti-apoptotic property in BGC823 and SGC7901 cells transfected with LV-PVT1-GFP and treated with cisplatin. Moreover, qRT-PCR and western blotting revealed that PVT1 up-regulation increased the expression of MDR1, MRP, mTOR and HIF-1α. Conclusions: Overexpression of LncRNA PVT1 in gastric carcinoma promotes the development of MDR, suggesting an efficacious target for reversing MDR in gastric cancer therapy. © 2015 Elsevier Inc. All rights reserved.


Su D.,The Clean Tech Center | Wang C.,Yangzhou University | Ahn H.,Gyeongsang National University | Wang G.,The Clean Tech Center
Physical Chemistry Chemical Physics | Year: 2013

Single crystalline SnO2 nanocrystals (∼60 nm in size) with a uniform octahedral shape were synthesised using a hydrothermal method. Their phase and morphology were characterized by XRD and FESEM observation. TEM and HRTEM analyses identified that SnO2 octahedral nanocrystals grow along the [001] direction, consisting of dominantly exposed {221} high energy facets. When applied as anode materials for Na-ion batteries, SnO2 nanocrystals exhibited high reversible sodium storage capacity and excellent cyclability (432 mA h g-1 after 100 cycles). In particular, SnO 2 nanocrystals also demonstrated a good high rate performance. Ex situ TEM analysis revealed the reaction mechanism of SnO2 nanocrystals for reversible Na ion storage. It was found that Na ions first insert into SnO2 crystals at the high voltage plateau (from 3 V to ∼0.8 V), and that the exposed (1 × 1) tunnel-structure could facilitate the initial insertion of Na ions. Subsequently, Na ions react with SnO2 to form NaxSn alloys and Na2O in the low voltage range (from ∼0.8 V to 0.01 V). The superior cyclability of SnO 2 nanocrystals could be mainly ascribed to the reversible Na-Sn alloying and de-alloying reactions. Furthermore, the reduced Na2O "matrix" may help retard the aggregation of tin nanocrystals, leading to an enhanced electrochemical performance. This journal is © the Owner Societies 2013.


Fang Y.,Nanjing Southeast University | Fang Y.,Yangzhou University | Ma X.,Nanjing Southeast University
Dianli Xitong Zidonghua/Automation of Electric Power Systems | Year: 2011

A topology of coupled inductor double boost inverter (CIDBI) is proposed based on the photovoltaic micro-inverter module system. The operation principle and control strategy of CIDBI are analyzed in detail and the gain expression from DC side to AC side is deduced. It can generate an AC output voltage much larger than the DC input one, depending on the proper setup of instantaneous duty cycle and turn ratio of the coupled inductors. Firstly, based on a given driving signal series, the operational principle of CIDBI is discussed. Secondly, the voltage stress of switches in CIDBI and the relationship between input and output are analyzed. The gain is approximately proportional to the duty cycle when the duty cycle is around 0.5 and the sinusoidal pulse width modulation (SPWM) is applicable to this novel inverter. Finally, the proposed CIDBI serves as a grid-connected inverter in a photovoltaic generation system. Experimental results show that the CIDBI can competently implement the single-stage grid-connected generation of photovoltaic system with a low level total harmonic distortion of current and high efficiency, without traditional transformer and DC/DC converter. © 2011 State Grid Electric Power Research Institute Press.


Liang J.,Nanjing Southeast University | Wang Z.,Brunel University | Liu Y.,Yangzhou University | Liu X.,Brunel University
International Journal of Robust and Nonlinear Control | Year: 2014

This paper is concerned with the state estimation problem for two-dimensional (2D) complex networks with randomly occurring nonlinearities and randomly varying sensor delays. To describe the fact that measurement delays may occur in a probabilistic way, the randomly varying sensor delays are introduced in the delayed sensor measurements. The randomly occurring nonlinearity, on the other hand, is included to account for the phenomenon of nonlinear disturbances appearing in a random fashion that is governed by a Bernoulli distributed white sequence with known conditional probability. The stochastic Brownian motions are also considered, which enter into not only the coupling terms of the complex networks but also the measurements of the output systems. Through available actual network measurements, a state estimator is designed to estimate the true states of the considered 2D complex networks. By utilizing an energy-like function, the Kronecker product and some stochastic analysis techniques, several sufficient criteria are established in terms of matrix inequalities under which the 2D estimation error dynamics is globally asymptotically stable in the mean square. Furthermore, the explicit expression of the estimator gains is also characterized. Finally, a numerical example is provided to demonstrate the effectiveness of the design method proposed in this paper. Copyright © 2012 John Wiley & Sons, Ltd.


Jiang J.,Taiyuan University of Technology | Huo Z.,China Agricultural University | Feng S.,China Agricultural University | Feng S.,Yangzhou University | Zhang C.,Taiyuan University of Technology
Field Crops Research | Year: 2012

Sustainable development of agriculture is restricted by fresh water shortage and water quality deterioration in some arid and semi-arid areas. Therefore, deficit irrigation and saline water irrigation have to be applied for sustaining crop yield. In order to determine the rational irrigation management practice in an arid region of Northwest China, field experiments were conducted in 2008, 2009 and 2010 to study the effects of irrigation amount and water salinity on water consumption and water productivity of spring wheat. Altogether nine irrigation treatments including three levels of irrigation water amount with 375, 300, and 225mm (w1, w2 and w3) and three levels of irrigation water salinity with 0.65, 3.2, and 6.1dSm -1 (s1, s2 and s3) were arranged in a randomized split-plot design with three replications for each treatment. In 2008, yield increased with increasing irrigation amount under both fresh and saline water irrigation. However, in 2009 and 2010, the highest yield at the same salinity level under saline water irrigation was obtained by w2. Actual evapotranspiration (ET a) decreased with decreasing irrigation amount. Therefore, w2 got higher water use efficiency (WUE) (1.25-1.63kgm -3) and irrigation water use efficiency (IWUE) (2.11-2.36kgm -3) than w1, which indicated that irrigation amount 300mm is beneficial to yield and water use efficiency at water salinity 3.2 and 6.1dSm -1. Thus, for the purpose of highest yield and WUE, irrigation amount should be controlled at appropriate level under saline water irrigation. The effect of irrigation water salinity on ET a was significant in 2009 and 2010, while the effect on yield, WUE and IWUE was only significant in 2010. However, the differences of yield, ET a, WUE and IWUE between s2 and s1 were statistically insignificant in the 3 years. It can be concluded that irrigation water salinity 3.2dSm -1 has no significant effect on wheat yield and water productivity. The interaction effects of irrigation amount and water salinity on yield, ET a and WUE were statistically insignificant in the experiments. © 2012 Elsevier B.V.


Cao S.,Yangzhou University | Cao S.,Beihang University | Yi Y.,Yangzhou University | Guo L.,Beihang University
Neurocomputing | Year: 2014

In this paper, an anti-disturbance fault diagnosis scheme is proposed for non-Gaussian stochastic distribution systems (SDSs) with multiple disturbances. The available driven information for fault diagnosis is probability density functions (PDFs) of output rather than output value. Using B-spline expansion technique, the output PDFs can be approximated in terms of dynamic weights of B-spline neural network by which a nonlinear model can be established between input and weights. Therefore, the concerned problem is transformed into fault diagnosis problem of the weighting system presented by an uncertain nonlinear system with multiple disturbances and time-varying fault. Different from most of the existing results, the multiple disturbances are supposed to include unknown disturbance modeled by an exo-system and norm bounded uncertain disturbances. In the proposed approach, a disturbance observer is designed to estimate and compensate the modeled disturbance, and H∞ optimization technology is applied to attenuate the norm bounded disturbance. Finally, simulation results are given to show the efficiency of the proposed approach. © 2014 Elsevier B.V.


Xu X.,Nanjing Southeast University | Xu X.,Yangzhou University | Xu C.,Nanjing Southeast University | Dai J.,Nanjing Southeast University | And 3 more authors.
Journal of Physical Chemistry C | Year: 2012

We report the intrinsic room-temperature ferromagnetism in undoped ZnO nanoparticles with different sizes synthesized by a wet chemical method at different temperatures. Electron paramagnetic resonance, X-ray photoelectron spectroscopy, and photoluminescence measurements demonstrate clearly the singly charged oxygen vacancies are the main defects, and the relative occupancy of that decreases with increasing sizes and annealing temperatures. Importantly, a direct correlation between the ferromagnetism and the relative concentration of the singly charged oxygen vacancies is established, which suggests that the singly charged oxygen vacancies play a crucial role in modulating ferromagnetic behaviors. Moreover, the size-dependent ferromagnetism can be manipulated conveniently by changing of the surface-volume ratio, which is in favor of future electronic and spintronic application. © 2012 American Chemical Society.


Yuan X.,Nanjing Southeast University | Yuan X.,Yangzhou University | Liu N.,Nanjing Southeast University
Journal of Genetics and Genomics | Year: 2011

Advanced glycation end products (AGEs) play an important role in vascular complications of diabetes, including fibrinolytic abnormalities. Pioglitazone, a peroxisome proliferator-activated receptor gamma (PPARγ) agonist, has recently been shown to reduce circulating plasminogen activator inhibitor-1 (PAI-1) levels in diabetes mellitus. In the present study, we investigated the effects of pioglitazone on the expression of local PAI-1 in rat vascular smooth muscle cells (VSMCs) induced by AGEs and the underlying mechanism. The result showed that AGEs could enhance the PAI-1 expression by 5.1-fold in mRNA and 2.7-fold in protein level, as evaluated by real-time RT-PCR and Western blotting, respectively. Pioglitazone was found to down-regulate the AGE-stimulated PAI-1 expression in VSMCs. However, these inhibitory effects were partially attenuated by the PPARγ antagonist, GW9662. Furthermore, we found that AGEs induced a rapid increase in phosphorylation and activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2). The ERK kinase inhibitor, U0126, partially prevented the induction of PAI-1 by AGEs. Moreover, pioglitazone was also found to inhibit the phosphorylation of ERK1/2. Taken together, it was concluded that pioglitazone could inhibit AGE-induced PAI-1 expression, which was mediated by the ERK1/2 and PPARγ pathways. Our findings suggested pioglitazone had a therapeutic potential in improving fibrinolytic activity, and consequently preventing thromboembolic complications of diabetes and cardiovascular disease. © 2011.


Zhang X.,Yangzhou University | Han J.,Yangzhou University | Liu Y.,Yangzhou University | Wang J.,Nanjing Southeast University
Journal of Physical Chemistry C | Year: 2012

We systematically investigate the structural, electronic, and magnetic properties of one-dimensional bimetallic naphethalene sandwich nanowires, [Np 2V 2TM 2] ∞ (TM = Ti, Cr, Mn, Fe, Np = C 10H 8, naphethalene) by employing ab initio calculations. Three structures with different alignments of TM atoms (isomer-I, -II, -III) are considered, and they are all of high stability with exceptions of [Np 2V 2Mn 2] ∞ (isomer-II, -III) and [Np 2V 2Fe 2] ∞ (isomer-III). Furthermore, the electronic and magnetic properties of [Np 2V 2TM 2] ∞ show clear dependence on chemical component and geometries. Most sandwich wires favor ferromagnetic coupling, while [Np 2V 2Ti 2] ∞ (isomer-I, -III) shows antiferromagnetic ground states. Interestingly, [Np 2V 2Cr 2] ∞ (isomer-II, -III), [Np 2V 2Mn 2] ∞ (isomer-I), and [Np 2V 2Fe 2] ∞ (isomer-I) are found to be robust ferromagnetic half-metals, and [Np 2V 2Cr 2] ∞ (isomer-I) is a ferromagnetic quasi-half metal. © 2012 American Chemical Society.


Su D.,The Clean Tech Center | Wang C.,Yangzhou University | Ahn H.-J.,Gyeongsang National University | Wang G.,The Clean Tech Center
Chemistry - A European Journal | Year: 2013

Single crystalline rhombus-shaped Na0.7MnO2 nanoplates have been synthesized by a hydrothermal method. TEM and HRTEM analyses revealed that the Na0.7MnO2 single crystals predominantly exposed their (100) crystal plane, which is active for Na +-ion insertion and extraction. When applied as cathode materials for sodium-ion batteries, Na0.7MnO2 nanoplates exhibited a high reversible capacity of 163 mA h g-1, a satisfactory cyclability, and a high rate performance. The enhanced electrochemical performance could be ascribed to the predominantly exposed active (100) facet, which could facilitate fast Na+-ion insertion/extraction during the discharge and charge process. © 2013 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.


Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University | Wu L.,Nanjing Southeast University | Zhang C.,Nanjing Southeast University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2013

We investigate emulsion droplet formation in coflowing liquid streams based on a computational fluid dynamics simulation using the volume-of-fluid method to track the interface motion with a focus on the dynamics of the dripping and jetting regimes. The simulations reproduce dripping, widening jetting and narrowing jetting simultaneously in a coflowing microchannel in agreement with the experimental observations in this work. The result indicates that the dripping regime, rather than the jetting regime, is a favorable way to producing monodisperse emulsions. We find that, in dripping and widening jetting regimes, the breakup of a drop is induced by higher pressure in the neck which squeezes liquid into the lower-pressure region in subsequent and primary droplets, while the breakup in the narrowing jetting regime is due to slow velocity at the back end of the trough with respect to the leading end of the trough. In addition, the capillary number of the outer fluid and the Weber number of the inner fluid not only determine the drop diameter and generation rate but also the regime of emulsification. © 2013 American Physical Society.


Li M.,Yangzhou University | Quan H.,Yangzhou University | Xu G.,Henan Institute of Science and Technology | Kim D.-P.,Pohang University of Science and Technology
Microchemical Journal | Year: 2013

In this paper, reactive polyvinylsilazane (PVSZ) is employed as silicate source for poly(dimethylsiloxane) (PDMS) channel surface modification. The PVSZ submicron layer is simply constructed by flushing 1wt.% PVSZ-anhydrous DMF solution into PDMS channel for 1min. After UV and thermal curing, the reactive coating is subjected to hydrolysis reaction in an alkali solution for 1h to convert the consolidated polymer surface to silicate phase. The surface is characterized by SEM, AFM and contact angle measurement. The PVSZ silicate channel is of optical transparence and solvent resistance, and provides a long-term stable electroosmotic flow (EOF) with 4.3±0.1×10-4cm2V-1s-1 at pH9.00, and a reliable capillary electrophoresis (CE) performance. Theoretical plate numbers of five FITC-labeled amino acids were all over 14,000 (2.8μm height), and EOF repeatability is much superior to that of PDMS channel. © 2013 Elsevier B.V.


Wong W.K.,Hong Kong Polytechnic University | Zhang W.,Yangzhou University | Tang Y.,Humboldt University of Berlin | Tang Y.,Potsdam Institute for Climate Impact Research | Wu X.,Anhui Polytechnic University
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2013

In this paper, stochastic synchronization is studied for complex networks with delayed coupling and mixed impulses. Mixed impulses are composed of desynchronizing and synchronizing impulses. The delayed coupling term involves transmission delay and self-feedback delay. By using the average impulsive interval approach and the comparison principle, several conditions are derived to guarantee thatexponential synchronization of complex networks is achieved in the mean square. The derived conditions are closely related to the impulsive strengths, the frequency of impulse occurrence, and the coupling structure of complex networks. Numerical simulations are presented to further demonstrate the effectiveness of the proposed approach. © 2013 IEEE.


Zhan X.,Yangzhou University | Li Z.,Nanjing Southeast University
2010 2nd International Conference on Industrial and Information Systems, IIS 2010 | Year: 2010

Cognitive radion attracted more attention as it access and use spectrum opportunity in communication. Energy detection is given more reseach as advantage of simple algorithm and without prior knowledge compared to other spectrum sensing. This paper study energy detection in keyhole channel when others do it in Rayleigh and other channels, and contrast to it's performance in AGWN. What's more, this paper persent cooperative sensing to offset deficiency of single secondary user detection in Keyhole channel. © 2010 IEEE.


Chen Y.,Nanjing Southeast University | Chen Y.,Yangzhou University | Wang C.,Nanjing Southeast University
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics | Year: 2014

We investigate hydrodynamic interaction between two neutrally buoyant circular drops in a confined shear flow based on a computational fluid dynamics simulation using the volume-of-fluid method. The rheological behaviors of interactive drops and the flow regimes are explored with a focus on elucidation of underlying physical mechanisms. We find that two types of drop behaviors during interaction occur, including passing-over motion and reversing motion, which are governed by the competition between the drag of passing flow and the entrainment of reversing flow in matrix fluid. With the increasing confinement, the drop behavior transits from the passing-over motion to reversing motion, because the entrainment of the reversing-flow matrix fluid turns to play the dominant role. The drag of the ambient passing flow is increased by enlarging the initial lateral separation due to the departure of the drop from the reversing flow in matrix fluid, resulting in the emergence of passing-over motion. In particular, a corresponding phase diagram is plotted to quantitatively illustrate the dependence of drop morphologies during interaction on confinement and initial lateral separation. © 2014 American Physical Society.


Liu S.Z.,Kaifeng University | Zhang Y.C.,Yangzhou University | Wang T.X.,Henan Institute of Science and Technology | Yang F.X.,Henan Institute of Science and Technology
Materials Letters | Year: 2012

ZnO 2 hollow nanospheres and nanotubes were synthesized via hydrothermal treatment of ZnO submicron-sized powder in 20 vol.% H 2O 2 aqueous solution at 120 °C for 6 h, and ZnO with similar hollow nanostructures could be obtained by thermal decomposition of the hydrothermally-synthesized ZnO 2 hollow nanospheres and nanotubes in air at 200 °C for 6 h. The possible formation mechanisms of the ZnO 2 and ZnO hollow nanostructures were proposed. The present work pointed out a simple, cost-effective and green way of converting bulk ZnO powder into hollow-nanostructured ZnO 2 and ZnO powders. The as-synthesized hollow-nanostructured ZnO 2 and ZnO powders have promising uses as catalysts, adsorbents and light weight fillers, etc. © 2011 Elsevier B.V. All rights reserved.


Chen X.,China Agricultural University | Cui Z.,China Agricultural University | Fan M.,Stanford University | Vitousek P.,Chinese Academy of Agricultural Sciences | And 28 more authors.
Nature | Year: 2014

Agriculture faces great challenges to ensure global food security by increasing yields while reducing environmental costs1,2. Here we address this challenge by conducting a total of 153 site-year field experiments covering the main agro-ecological areas for rice, wheat and maize production in China. As et of integrated soil-crop systemmanagement practices based ona modern understanding of crop ecophysiology and soil biogeochemistry increases average yields for rice, wheat and maize from 7.2 million grams per hectare (Mg ha-1), 7.2Mg ha-1 and 10.5Mgha-1 to 8.5Mgha-1, 8.9Mgha-1 and 14.2Mgha-1, respectively, without any increase in nitrogen fertilizer. Model simulation and life-cycle assessment3 show that reactive nitrogen losses and greenhouse gasemissions are reduced substantially by integrated soil-crop system management. If farmers in China could achieve average grain yields equivalent to 80%of this treatment by 2030, over the sameplanting area as in 2012, total production of rice, wheat and maize in China would be more than enough to meet the demand for direct human consumption and a substantially increased demand for animal feed, while decreasing the environmental costs of intensive agriculture. © 2014 Macmillan Publishers Limited. All rights reserved.


Ding S.-N.,Nanjing Southeast University | Cosnier S.,CNRS Molecular Chemistry Department | Shan D.,Yangzhou University | Sun Y.-M.,Nanjing Southeast University | Wang Y.,Nanjing Southeast University
Electrochemistry Communications | Year: 2010

Elelctrogenerated chemiluminescence (ECL) of electropolymerized films based on [(2,2′-bipyridyl)(4-(2-pyrrol-1-ylethyl)-4′-methyl-2,2′- bipyridyl)2]ruthenium (II) was firstly investigated in both organic and aqueous solution. The ECL behaviors have been explained by two typical mechanisms, namely, redox-cycling type and oxidative-reduction type. For the former, no co-reactant was required and for the latter, tripropylamine (TPA) and (NH4)2C2O4 were selected as co-reactants in the organic and aqueous system, respectively. © 2010 Elsevier B.V. All rights reserved.


Shan D.,Yangzhou University | Qian B.,Yangzhou University | Ding S.-N.,Nanjing Southeast University | Zhu W.,Nanjing Southeast University | And 2 more authors.
Analytical Chemistry | Year: 2010

An electrospun poly(acrylonitrile-co-acrylic acid) nanofiber mat (PAN-co-PAA nfm) was successfully collected on the surface of a glassy carbon electrode (GCE). Scanning electron microscope (SEM) images showed that the porous electrospun mat was composed of ∼160 nm diameter of uniform knitted nanofibers. The cationic luminescence probe, tris(2,2′-bipyridyl) ruthenium(II) complex ([Ru(bpy) 3] 2+), was innovatively and first incorporated into the negatively charged PAN-co-PAA nfm- modified GCE via electrostatic interaction. Compared with the [Ru(bpy) 3] 2+ immobilized on normal PAN-co-PAA deposited coating, [Ru(bpy) 3] 2+/PAN-co-PAA nfm exhibited dramatically enhanced electrochemical and electrochemiluminescence (ECL) performances, namely, more than 100 times higher ECL intensity could be feasibly obtained via the electrospinning technique. © 2010 American Chemical Society.


Guo L.,Beihang University | Cao S.,Yangzhou University
2011 International Symposium on Advanced Control of Industrial Processes, ADCONIP 2011 | Year: 2011

In this paper, the robust initial alignment problem for inertial navigation systems (INSs) is investigated. Different from most previous works only focusing on Gaussian noises (or other single disturbance), the INS error equation with multiple types of disturbances is constructed. We consider two types of disturbances, where the first type is the sensor drifts described by an exosystem, and the second one includes the nonlinear modeling uncertainties and other measurement noises. A robust filter is constructed for the concerned INS with disturbance rejection and attenuation performance. In the proposed approach, the drift estimations are applied to reject the inertial sensor drifts, H∞ performance is applied to attenuate the norm bounded uncertain disturbances. The proposed multi-objective filter is with both disturbance rejection and attenuation performance. Finally, simulation for stationary base alignment of an INS is given to show the efficiency of the proposed approach. © 2011 Zhejiang University.


Jin H.,Nanjing Southeast University | Jiang Y.,Yangzhou University | Wei Q.,Nanjing Southeast University | Wang B.,Nanjing Southeast University | Ma G.,Nanjing Southeast University
Disability and Rehabilitation | Year: 2012

Purpose: To evaluate the effect of aerobic cycling training with lower limb weights on cardiovascular fitness (peak VO 2) and walking ability in chronic stroke survivors, and to investigate the relationship between changes in these parameters. Methods: 133 Chinese patients with chronic hemiparetic stroke (mean age 58 years) were randomized to either 8-week (5×/week) aerobic cycling training with lower limb weights group (n = 68) or a low-intensity overground walking group (n = 65). Peak VO 2, 6-minute walk distance (6MWD), knee muscle strength, balance and spasticity were measured before and after intervention. Results: Cycling training increased peak VO 2 (24% vs. 3%, p < 0.001), 6MWD (2.7% vs. 0.5%, p < 0.001), paretic (11% vs. 1.6%, p < 0.001) and nonparetic knee strength (16% vs. 1.0%, p < 0.001). In the cycling group, percent changes in peak VO 2 were positively associated with those in paretic (r = 0.491, p < 0.001) and nonparetic knee strength (r = 0.432, p < 0.001). Increased 6MWD correlated significantly with improved balance, spasticity and paretic knee strength by the stepwise regression analysis (r = 0.342, p = 0.004), but not fitness gains. Conclusions: The enhanced cardiovascular fitness after aerobic cycling training in Chinese patients with chronic stroke is not associated with the increased walking ability. Unparallel improvements in these parameters related different determinants may have implications for intervention strategy. © 2012 Informa UK, Ltd.


Cao S.,Yangzhou University | Zhao Y.,Yangzhou University | Qiao J.,Beihang University
Transactions of the Institute of Measurement and Control | Year: 2016

The attitude control problem is much more complicated due to the existence of faults and multiple disturbances simultaneously in satellites. In this paper, an adaptive fault tolerant attitude control method is presented for satellites with both time-varying actuator faults and multiple disturbances. Differing from previous results, the first part of the multiple disturbance is the uncertain modelled disturbance and the second part represents an uncertain variable bounded by a given function. A composite observer is designed to estimate the uncertain modelled disturbance and the time-varying fault simultaneously. Then, a new fault tolerant control strategy consisting of disturbance observer based control, fault accommodation and an adaptive controller is constructed to reconfigure the concerned systems and so as to achieve the anti-disturbance performance. In the proposed method, the modelled disturbance can be rejected by its estimation and the uncertain bounded disturbance can be compensated by the adaptive compensation term. The simulation results are given to show the efficiency of the proposed approach. © 2016 SAGE Publications.


Xu J.,University of Strasbourg | Xu J.,Yangzhou University | Houssin R.,University of Strasbourg | Bernard A.,École Centrale Nantes | Caillaud E.,University of Strasbourg
CIRP Journal of Manufacturing Science and Technology | Year: 2013

Manufacturing companies are compelled to innovate through design that is a knowledge-intensive process. However, there lacks a comprehensive knowledge model while considering the specific requirements of innovation in design. In this paper, we propose a systemic model of knowledge for innovation based on our analyses and argumentations, which is characterized by the knowledge content and context from the perspective of systems thinking. By using Unified Modeling Language (UML), the model is implemented and developed into a prototype system of knowledge management for innovation. Then, a simple industrial use case is presented for demonstrating the applicability of our model. Finally, our major contributions and future work about the performance evaluation of knowledge development are discussed. © 2012 CIRP.


Xu X.,Nanjing Southeast University | Xu X.,Yangzhou University | Xu C.,Nanjing Southeast University | Wang X.,Nanjing Southeast University | And 3 more authors.
CrystEngComm | Year: 2013

ZnO quantum dots with tunable size in the range of 2.0-7.8 nm were synthesized through a facile sol-gel route. Photoluminescence and photoluminescence excitation spectral examinations revealed that two types of transition mechanisms might occur under control during excitation regulation corresponding to the coexistence of deep and shallow levels in energy band structure. The broad-color emission from violet to orange could be tuned by adjusting the excitation energy and quantum dot size. Moreover, ZnO quantum dots with tunable and broad luminescence were demonstrated to be promising in the anti-fake labeling applications. © 2013 The Royal Society of Chemistry.


Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University | Liu X.,Yangzhou University | Zhang C.,Nanjing Southeast University | Zhao Y.,Nanjing Southeast University
Lab on a Chip - Miniaturisation for Chemistry and Biology | Year: 2015

We combine experimental investigation with numerical simulation to explore fundamental hydrodynamic effects of an inner droplet on deformation of a double emulsion droplet under shear. The transient deformation oscillation is found to be intensified by the inner droplet. Especially, we demonstrate that the double emulsion droplet can exhibit both larger and smaller steady deformation than the single-phase droplet, which arises from the competition between the coexisting enhancing and suppressing effects by the inner droplet on the deformation. We further provide a regime diagram to quantitatively recognize the respective dominant regime of these two effects, depending on the capillary number and radius ratio of the inner droplet to the outer one. This journal is © The Royal Society of Chemistry 2015.


Yang W.,Yangzhou University | Kong L.,Yangzhou University | Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University
Applied Thermal Engineering | Year: 2015

Freezing of soil around ground heat exchangers (GHE) is a common problem for a ground coupled heat pump (GCHP) operated in the cold district, which will affect the underground soil temperature variation and its heat transfer performance. In this paper, a two-dimensional model for heat transfer with freezing-thawing phase change in soil around GHE is developed and numerically analyzed by apparent heat capacity method. The influences of soil freezing, soil water content, and soil type on soil temperature variations and long term underground thermal imbalance of GCHP with GHE array are investigated. The results indicate that the soil freezing can lessen the soil temperature drop and thus increase the temperature difference between the fluid inside GHE and far-field soil. This helps to shorten the GHE design length and cut down the initial system cost. The soil freezing characteristics are mostly affected by the soil thermal diffusivity. From the view of the ability in delaying soil temperature drop, the sandstone is preferable to sand, and sand is better than clay. Additionally, increasing water content can reduce the drop degree and speed of the soil temperature, as well as, accordingly alleviate the underground thermal imbalance of GCHP. © 2014 Elsevier Ltd. All rights reserved.


Li B.,Nanjing Southeast University | Li B.,CAS Institute of Software | Sun X.,Nanjing Southeast University | Sun X.,Yangzhou University | Keung J.,City University of Hong Kong
Information and Software Technology | Year: 2013

Background: Software Change Impact Analysis (CIA) is an essential technique in software engineering to identifying the potential influences of a change, or determining change entities to accomplish such a change. The results derived, in many cases, ambiguous for the software maintainers, introduces the problem of unclear starting point of these impacted entities. Objective In an attempt to address this issue, this work proposes a novel approach for cross-level CIA, producing a ranked list of potentially impacted methods derived from class-level changes. Moreover, the approach of ranking the impact results is expected to be effective for maintainers to distinguish the probability of the impacted methods to be false-positives. Such results provide an eclectic approach for CIA. Method The approach, FCA-CIA, uses formal concept analysis (FCA) to produce an intermediate representation of the program based on the static analysis of the source code. The representation is called Lattice of Class and Method Dependence (LoCMD). FCA-CIA takes the changed classes in the change set as a whole, and determines the reachable set from the changed classes on the LoCMD. Based on the hierarchical property of the LoCMD, the impacted methods are ranked according to the impact factor metric which corresponds to the priority of these methods to be inspected. Result Empirical evaluations on four real-world software projects demonstrate the effectiveness of the impact factor metric and the FCA-CIA technique. The result shows the predicted impacted methods with higher impact factor values are more likely to be affected by the changes. Our study also shows that the FCA-CIA technique generates more accurate impact set than the JRipples and ICP coupling based CIA technique. © 2013 Elsevier B.V. All rights reserved.


Kim K.I.,Pohang University of Science and Technology | Lin Z.,Yangzhou University | Zhang L.,Yangzhou University
Nonlinear Analysis: Real World Applications | Year: 2010

A diffusive epidemic model is investigated. This model describes the transmission of avian influenza among birds and humans. The behavior of positive solutions to a reaction-diffusion system with homogeneous Neumann boundary conditions are investigated. Sufficient conditions for the local and global asymptotical stability are given by spectral analysis and by using Lyapunov functional. Our result shows that the disease-free equilibrium is globally asymptotically stable, if the contact rate for the susceptible birds and the contact rate for the susceptible humans are small. It suggests that the best policy to prevent the occurrence of a pandemic is not only to exterminate the infected birds with avian influenza but also to reduce the contact rate for susceptible humans with the individuals infected with mutant avian influenza. Numerical simulations are presented to illustrate the main results. © 2008 Elsevier Ltd. All rights reserved.


Gu J.,Wageningen University | Gu J.,Yangzhou University | Yin X.,Wageningen University | Zhang C.,China Agricultural University | And 2 more authors.
Annals of Botany | Year: 2014

Background and Aims Genetic markers can be used in combination with ecophysiological crop models to predict the performance of genotypes. Crop models can estimate the contribution of individual markers to crop performance in given environments. The objectives of this study were to explore the use of crop models to design markers and virtual ideotypes for improving yields of rice (Oryza sativa) under drought stress. Methods Using the model GECROS, crop yield was dissected into seven easily measured parameters. Loci for these parameters were identified for a rice population of 94 introgression lines (ILs) derived from two parents differing in drought tolerance. Marker-based values of ILs for each of these parameters were estimated from additive allele effects of the loci, and were fed to the model in order to simulate yields of the ILs grown under well-watered and drought conditions and in order to design virtual ideotypes for those conditions. Key Results To account for genotypic yield differences, it was necessary to parameterize the model for differences in an additional trait 'total crop nitrogen uptake' (Nmax) among the ILs. Genetic variation in Nmax had the most significant effect on yield; five other parameters also significantly influenced yield, but seed weight and leaf photosynthesis did not. Using the marker-based parameter values, GECROS also simulated yield variation among 251 recombinant inbred lines of the same parents. The model-based dissection approach detected more markers than the analysis using only yield per se. Model-based sensitivity analysis ranked all markers for their importance in determining yield differences among the ILs. Virtual ideotypes based on markers identified by modelling had 10-36% more yield than those based on markers for yield per se. Conclusions This study outlines a genotype-to-phenotype approach that exploits the potential value of marker based crop modelling in developing new plant types with high yields. The approach can provide more markers for selection programmes for specific environments whilst also allowing for prioritization. Crop modelling is thus a powerful tool for marker design for improved rice yields and for ideotyping under contrasting conditions. © 2014 The Author.


Shan D.,Yangzhou University | Li Q.-B.,Yangzhou University | Ding S.-N.,Nanjing Southeast University | Xu J.-Q.,Yangzhou University | And 2 more authors.
Biosensors and Bioelectronics | Year: 2010

Horseradish peroxidase (HRP) was successfully incorporated into the laponite/chitosan (Chit)-modified glassy carbon electrode (GCE) using step-by-step self-assembly. The self-assembly processes were monitored by X-ray photoelectron spectroscopy (XPS) and electrochemical impedance spectra (EIS). Direct electrochemistry and electrocatalysis of the self-assembled HRP were investigated. Cyclic voltammetry of HRP/laponite/Chit/GCE, in anaerobic phosphate buffer solution (0.025M PBS, pH 7.0), displayed a pair of stable and quasi-reversible peaks at potentials Epa=0.024V and Epc=-0.132V vs. SCE, attributed to the HRP-Fe(III)/HRP-Fe(II) redox couple. The electrochemical reaction of the HRP/laponite/Chit/GCE exhibited a surface-controlled electrode process. The electron transfer rate constant was estimated to be 1.82s-1. The self-assembled HRP maintained its biological activity and exhibited an excellent electrocatalytic performance for the reduction of H2O2 with fast amperometric response (10s), broad linear range (2.9×10-5 to 1.4×10-3M), good sensitivity (19.7±0.5mAM-1cm-2) and low detection limit (5×10-6M) at a signal-to-noise ratio of 3. Moreover, the inhibitory of sulfide to the self-assembled HRP was also investigated. © 2010 Elsevier B.V.


Chen Q.-H.,Nanjing Southeast University | Yang Y.,Nanjing Southeast University | He H.-L.,Nanjing Southeast University | Xie J.-F.,Nanjing Southeast University | And 4 more authors.
Critical Care | Year: 2014

Introduction: Glutamine supplementation is supposed to reduce mortality and nosocomial infections in critically ill patients. However, the recently published reducing deaths due to oxidative stress (REDOX) trials did not provide evidence supporting this. This study investigated the impact of glutamine-supplemented nutrition on the outcomes of critically ill patients using a meta-analysis.Methods: We searched for and gathered data from the Cochrane Central Register of Controlled Trials, MEDLINE, Elsevier, Web of Science and ClinicalTrials.gov databases reporting the effects of glutamine supplementation on outcomes in critically ill patients. We produced subgroup analyses of the trials according to specific patient populations, modes of nutrition and glutamine dosages.Results: Among 823 related articles, eighteen Randomized Controlled Trials (RCTs) met all inclusion criteria. Mortality events among 3,383 patients were reported in 17 RCTs. Mortality showed no significant difference between glutamine group and control group. In the high dosage subgroup (above 0.5 g/kg/d), the mortality rate in the glutamine group was significantly higher than that of the control group (relative risk (RR) 1.18; 95% confidence interval (CI), 1.02 to 1.38; P = 0.03). In 15 trials, which included a total of 2,862 patients, glutamine supplementation reportedly affected the incidence of nosocomial infections in the critically ill patients observed. The incidence of nosocomial infections in the glutamine group was significantly lower than that of the control group (RR 0.85; 95% CI, 0.74 to 0.97; P = 0.02). In the surgical ICU subgroup, glutamine supplementation statistically reduced the rate of nosocomial infections (RR 0.70; 95% CI, 0.52 to 0.94; P = 0.04). In the parental nutrition subgroup, glutamine supplementation statistically reduced the rate of nosocomial infections (RR 0.83; 95% CI, 0.70 to 0.98; P = 0.03). The length of hospital stay was reported in 14 trials, in which a total of 2,777 patients were enrolled; however, the patient length of stay was not affected by glutamine supplementation.Conclusions: Glutamine supplementation conferred no overall mortality and length of hospital stay benefit in critically ill patients. However, this therapy reduced nosocomial infections among critically ill patients, which differed according to patient populations, modes of nutrition and glutamine dosages. © 2014 Chen et al.; licensee BioMed Central Ltd.


Shen J.-J.,Yangzhou University | Wang W.,Nanjing Southeast University
Journal of Central South University | Year: 2015

The primary objective of this work is to explore how drivers react to flashing green at signalized intersections. Through video taping and data procession based on photogrammetry, the operating speeds of vehicles before and after the moment when flashing green started was compared using paired-samples T-test. The critical distances between go and stop decisions was defined through cumulative percentage curve. The boundary of dilemma zone was determined by comparing stop distance and travel distance. Amber-running violation was analyzed on the basis of the travel time to the stop line. And finally, a logistic model for stop and go decisions was constructed. The results shows that the stopping ratios of the first vehicles of west-bound and east-bound approaches are 41.3% and 39.8%, respectively; the amber-light running violation ratios of two approaches are 31.6% and 25.4%, respectively; the operating speed growth ratios of first vehicles selecting to cross intersection after the moment when flashing green started are 26.7% and 17.7%, respectively; and the critical distances are 48 m and 46 m, respectively, which are close to 44 m, the boundary of dilemma zone. The developed decision models demonstrate that the probability of go decision is higher when the distance from the stop line is shorter or operating speed is higher. This indicates that flashing green is an effective way to enhance intersection safety, but it should work together with a strict enforcement. In addition, traffic signs near critical distance and reasonable speed limitation are also beneficial to the safety of intersections. © 2015, Central South University Press and Springer-Verlag Berlin Heidelberg.


Frei M.,Japan International Research Center for Agricultural science | Wang Y.,Yangzhou University | Ismail A.M.,International Rice Research Institute | Wissuwa M.,Japan International Research Center for Agricultural science
Functional Plant Biology | Year: 2010

Zinc deficiency reduces rice growth and yield, and this is, in part, due to leaf damage caused by reactive oxygen species (ROS). The aim of this study was to identify biochemical mechanisms conferring tolerance to Zn deficiency-induced oxidative stress. A field experiment and three nutrient solution experiments were conducted with the intolerant genotype IR74 and recombinant inbred lines (RILs) derived from a cross between IR74 and the tolerant landrace Jalmagna. After 2 weeks of growth in low Zn soil, stress symptoms developed in leaves of IR74, but not in the tolerant RIL46. Activity of antioxidant enzymes showed clear treatment effects, but did not explain tolerance of RIL46. On the contrary, the intolerant IR74 showed higher activities of superoxide dismutase (SOD), guaiacol peroxidase (POX), ascorbate peroxidase (APX), dehydroascorbate reductase (DHAR) and glutathione reductase (GR) under Zn deficiency. This contrasted with a constitutively higher level of total and reduced ascorbic acid (AsA) in RIL46. Three further nutrient solution experiments focussed on enzymes and reducing substrates of the ascorbateglutathione cycle. The first experiment included the highly sensitive RIL76 in addition to the genotypes used in the field trial, to test whether the patterns of antioxidant response observed in the field were specific to the genotypes used. This genotype had similarly low AsA level as IR74, but did not respond to Zn deficiency with an increase in enzyme activity, leading to even more pronounced leaf symptoms. In a second experiment, co-segregation of AsA concentration and Zn deficiency tolerance was confirmed in five genotypes from the IR74/Jalmagna quantitative trait loci (QTL) mapping population. A third experiment was conducted to determine whether the observed patterns of antioxidant response were specific to Zn deficiency or would also apply to oxidative stress caused by iron deficiency. Although high AsA level apparently conferred tolerance under both types of stress, the enzymatic response to iron deficiency differed from that to Zn deficiency. In particular, APX activity showed a decrease instead of an increase under low iron stress. In conclusion, we suggest that a high AsA level is a promising target for developing rice genotypes with tolerance to oxidative stress. © 2010 CSIRO.


Yang W.,Yangzhou University | Sun L.,Yangzhou University | Chen Y.,Yangzhou University | Chen Y.,Nanjing Southeast University
Energy and Buildings | Year: 2015

Solar-ground source heat pump system (SGSHPS) is a new type of high efficiency, energy saving and environmental protection air-conditioning technology. In this paper, experimental studies and numerical simulation on the performance of a SGSHPS operated in different heating modes were carried out. The experimental system was installed in Nanjing of China and solar collectors were coupled with ground heat exchangers (GHE) through an insulated water tank. Four operation modes including ground source heat pump (GSHP), combined operation mode, day and night alternate operation mode and solar U-tube feeding heat alternate operation mode were investigated during winter season. The heat pump performance, solar collecting performance and borehole wall temperature variations were analyzed and compared for various modes. The experimental results indicate that for the combined operation mode, the system operation efficiency during day can be improved by the assistance of solar energy, and the excess solar energy collected during day can be stored in ground by the GHE to improve the operation performance of GSHP during night. The proportions of heat source burdened by solar and geothermal energy are 43.3% and 50.2% respectively. For the alternate operation modes, the temperature resumption of ground surrounding the GHE can be well achieved due to the intermittent heat extraction of GHE or feeding solar heat into ground and thus the overall utilization efficiency of solar and geothermal energy can be improved greatly. During the whole experimental period, the average COPs are 2.37 and 2.72 for GSHP and SAHP operation mode respectively, and the corresponding parameters are 2.69, 2.65 and 2.56 for the combined operation mode, day and night alternate operation mode and solar U-tube feeding heat alternate operation mode, respectively. The average solar collecting efficiency are 43.6%, 47.3% and 38.8% for the combined operation mode, SAHP operation mode and solar U-tube feeding heat operation mode, respectively. Based on the unit modeling, a dynamic simulation program was constructed to investigate the seasonal performance of the SGSHPS operated in different heating modes, the simulation results show that the seasonal average COP are 3.67, 3.64, 3.52 and 3.48 for the combined operation, day and night alternate operation, solar U-tube feeding heat and GSHP mode, respectively. From the view of improving the overall efficiency and increasing heat source fraction of solar energy, the combined operation mode is the best. © 2014 Elsevier B.V. All rights reserved.


Wei Q.,Nanjing Southeast University | Ren X.,Nanjing Southeast University | Jiang Y.,Yangzhou University | Jin H.,Nanjing Southeast University | And 2 more authors.
BMC Cardiovascular Disorders | Year: 2013

Background: Arterial media calcification (AMC) is highly prevalent and is a major cause of morbidity, mortality, stroke and amputation in patients with diabetes mellitus (DM). Previous research suggests that advanced glycation end products (AGEs) are responsible for vascular calcification in diabetic patients. The potential link between oxidative stress and AGEs-induced vascular calcification, however, has not been examined.Methods: Male Wistar rats received a high fat diet for 8 weeks followed by a single dose of streptozotocin to induce DM (DM). Calcification was induced with Vitamin D3 and nicotine (VDN). We started VDN treatment at 1 week after the initial streptozotocin injection (DM+VDN). Age-matched rats were used as controls (CON). Metabolic parameters, aortic calcium content, alkaline phosphatase (ALP) protein, malondialdehyde (MDA) content, Cu/Zn superoxide dismutase (SOD) activity, aorta receptor for advanced glycation end products (RAGE) and aorta AGEs levels were measured. In vitro, vascular smooth muscle cells (VSMCs) were cultured with AGEs in DMEM containing 10 mmol·L-1 ß -glycerophosphate (ß-GP). Calcium content and ALP activity were used to identify osteoblastic differentiation and mineralization. Western blots were used to examine protein expression of Cu/Zn SOD, NADPH oxidase Nox1 and RAGE. In addition, the intracellular reactive oxygen species (ROS) generation was evaluated using fluorescent techniques with dihydroethidine (DHE) method.Results: The DM+VDN group showed a significant increase in aortic calcium content, levels of aorta AGEs, MDA content, ALP protein levels and RAGE expression, although Cu/Zn SOD activity decreased significantly. In vitro, enhanced Nox1, RAGE expression as well as the production of intracellular superoxide anions, and reduced expression of Cu/Zn SOD induced by AGEs were attenuated by the anti-RAGE antibody or a ROS inhibitor. Furthermore, the AGEs-stimulated ROS increase was also significantly inhibited by a SOD mimetic. Increased ALP activity and calcium deposition were also inhibited markedly by the ROS inhibitor and the anti-RAGE antibody.Conclusions: These results suggest that AGEs enhance vascular calcification partly through a RAGE/oxidative stress pathway. © 2013 Wei et al.; licensee BioMed Central Ltd.


Lu X.,Nanjing Southeast University | Li B.,Nanjing Southeast University | Zhu P.,Yangzhou University | Xue G.,Nanjing University | Li D.,Nanjing University
Soft Matter | Year: 2014

In this paper, we demonstrate our ability to directly probe the molecular structures of the buried polymer/metal interface using sum frequency generation (SFG) vibrational spectroscopy. Spectroscopic data from different experimental approaches were compared and analyzed to deduce the molecular ordering information at a buried polymer/metal interface, i.e. the poly(n-butyl methylacrylate) (PBMA)/silver (Ag) interface. Solid spectroscopic evidence suggested that we successfully detected the molecular vibrational signals generated from the buried PBMA/Ag interface. It was found that the side butyl methyl groups at the PBMA/Ag interface are polar-ordered and have different orientational ordering from those at the PBMA surface in air. We believe that this study will provide a useful experimental and analytical framework for the SFG spectroscopy to probe the buried polymer/metal interfaces in the future. This journal is © the Partner Organisations 2014.


Shen J.-J.,Yangzhou University | Wang W.,Nanjing Southeast University
Jiaotong Yunshu Xitong Gongcheng Yu Xinxi/Journal of Transportation Systems Engineering and Information Technology | Year: 2011

In order to quantify the traffic conflict between motor vehicles and pedestrians at urban intersections, conditions under which traffic conflict may occur are presented at first, then three critical parameters which influenced traffic conflict probability are selected including distribution law of motor traffic headways, critical gap of pedestrians crossing motor vehicles and occupying duration of pedestrians, afterwards the function relation between amount and occupying duration of pedestrians is constructed with photogrammetry and the critical gap with occupying duration of a certain amount of pedestrians is compared, finally the condition that several rows of pedestrians occupied conflict zone is analyzed and the conflict probability model between difference configurations of pedestrians and motor vehicles is developed. The values of conflict probability is calculated through an actual example. The results indicate that the conflict probability increases with the volume of pedestrians growing, which accords with traffic actual working condition.


Xu X.,Nanjing Southeast University | Xu X.,Yangzhou University | Xu C.,Nanjing Southeast University | Lin Y.,Nanjing Southeast University | And 5 more authors.
Applied Physics Letters | Year: 2012

ZnO nanorod arrays were synthesized by a hydrothermal method on the Si substrate with ZnO thin film as seed layer prepared by magnetron sputtering. The presence of -OH ligands on the surface of the as-grown sample was confirmed, and its dominant role in both suppressing the visible emission and boosting the room-temperature ferromagnetism (FM) was revealed. Through alternative H 2 and O 2 annealing to remove the -OH ligands, reconstruct surface-states and tune the oxygen occupancy in ZnO nanorods, the clear correlation between the characteristic green emission and ferromagnetism was established. © 2012 American Institute of Physics.


Zhuang X.,Yangzhou University | Zhuang X.,University of Louisville | Xiang X.,University of Louisville | Grizzle W.,University of Alabama at Birmingham | And 10 more authors.
Molecular Therapy | Year: 2011

In this study, exosomes used to encapsulate curcumin (Exo-cur) or a signal transducer and activator of transcription 3 (Stat3) inhibitor, i.e., JSI124 (Exo-JSI124) were delivered noninvasively to microglia cells via an intranasal route. The results generated from three inflammation-mediated disease models, i.e., a lipopolysaccharide (LPS)-induced brain inflammation model, experimental autoimmune encephalitis and a GL26 brain tumor model, showed that mice treated intranasally with Exo-cur or Exo-JSI124 are protected from LPS-induced brain inflammation, the progression of myelin oligodendrocyte glycoprotein (MOG) peptide induced experimental autoimmune encephalomyelitis (EAE), and had significantly delayed brain tumor growth in the GL26 tumor model. Intranasal administration of Exo-cur or Exo-JSI124 led to rapid delivery of exosome encapsulated drug to the brain that was selectively taken up by microglial cells, and subsequently induced apoptosis of microglial cells. Our results demonstrate that this strategy may provide a noninvasive and novel therapeutic approach for treating brain inflammatory-related diseases. © 2011 The American Society of Gene & Cell Therapy.


Fei K.,Hohai University | Fei K.,Yangzhou University | Wang J.-J.,Yangzhou University | Chen Y.,Yangzhou University
Yantu Lixue/Rock and Soil Mechanics | Year: 2011

In order to improve the understanding of soil arching effect in the piled embankment, a series of three-dimensional model tests were carried out. The stress reduction ratio and the vertical stress distribution in the embankment fill were studied in detail. Based on the measured and the computed results, the applicability of Terzaghi method and Hewlett & Randolph method were verified. Three-dimensional finite element analysis was also performed in this research; the computed orientation of maximum principal stresses, the stress level and the settlement pattern were analyzed in detail. Based on the test and numerical results, it is found that the value of stress reduction ratio computed by Terzaghi method is closed to that of Hewlett & Randolph method; but the vertical stress distributions of the two methods are different considerably. If the failure surface observed from the numerical result is used, the prediction of vertical stresses using Terzaghi's method is found to be coincident with the measured value.


Xing D.,University of Alabama at Birmingham | Li P.,University of Alabama at Birmingham | Gong K.,Yangzhou University | Yang Z.,University of Alabama at Birmingham | And 5 more authors.
Circulation | Year: 2012

Background-Interleukin-8 (IL8) receptors IL8RA and IL8RB on neutrophil membranes bind to IL8 and direct neutrophil recruitment to sites of inflammation, including acutely injured arteries. This study tested whether administration of IL8RA-and/or IL8RB-transduced rat aortic endothelial cells (ECs) accelerates adhesion of ECs to the injured surface, thus suppressing inflammation and neointima formation in balloon-injured rat carotid arteries. We tested the hypothesis that targeted delivery of ECs by overexpressing IL8RA and IL8RB receptors prevents inflammatory responses and promotes structural recovery of arteries after endoluminal injury. Methods and Results-Young adult male rats received balloon injury of the right carotid artery and were transfused intravenously with ECs (total, 1.5×10 6 cells at 1, 3, and 5 hours after injury) transduced with adenoviral vectors carrying IL8RA, IL8RB, and IL8RA/RB (dual transduction) genes, AdNull (empty vector), or vehicle (no EC transfusion). ECs overexpressing IL8Rs inhibited proinflammatory mediators expression significantly (by 60% to 85%) and reduced infiltration of neutrophils and monocytes/macrophages into injured arteries at 1 day after injury, as well as stimulating a 2-fold increase in reendothelialization at 14 days after injury. IL8RA-EC, IL8RB-EC, and IL8RA/RB-EC treatment reduced neointima formation dramatically (by 80%, 74%, and 95%) at 28 days after injury. Conclusions-ECs with overexpression of IL8RA and/or IL8RB mimic the behavior of neutrophils that target and adhere to injured tissues, preventing inflammation and neointima formation. Targeted delivery of ECs to arteries with endoluminal injury provides a novel strategy for the prevention and treatment of cardiovascular disease. © 2012 American Heart Association, Inc.


Wang J.-C.,CAS Shanghai Institutes for Biological Sciences | Xu H.,Zhejiang Academy of Agricultural Sciences | Zhu Y.,Zhejiang Academy of Agricultural Sciences | Liu Q.-Q.,Yangzhou University | Cai X.-L.,CAS Shanghai Institutes for Biological Sciences
Journal of Experimental Botany | Year: 2013

Starch composition and the amount in endosperm, both of which contribute dramatically to seed yield, cooking quality, and taste in cereals, are determined by a series of complex biochemical reactions. However, the mechanism regulating starch biosynthesis in cereal seeds is not well understood. This study showed that OsbZIP58, a bZIP transcription factor, is a key transcriptional regulator controlling starch synthesis in rice endosperm. OsbZIP58 was expressed mainly in endosperm during active starch synthesis. osbzip58 null mutants displayed abnormal seed morphology with altered starch accumulation in the white belly region and decreased amounts of total starch and amylose. Moreover, osbzip58 had a higher proportion of short chains and a lower proportion of intermediate chains of amylopectin. Furthermore, OsbZIP58 was shown to bind directly to the promoters of six starch-synthesizing genes, OsAGPL3, Wx, OsSSIIa, SBE1, OsBEIIb, and ISA2, and to regulate their expression. These findings indicate that OsbZIP58 functions as a key regulator of starch synthesis in rice seeds and provide new insights into seed quality control. © The Author [2013].


Zhang W.,Yangzhou University | Tang Y.,Humboldt University of Berlin | Wu X.,Anhui Polytechnic University | Fang J.-A.,Donghua University
IEEE Transactions on Circuits and Systems I: Regular Papers | Year: 2014

In this paper, the synchronization problem is investigated for a class of nonlinear delayed dynamical networks with heterogeneous impulsive effects. The intrinsic properties of heterogeneous impulses are that impulsive strengths are inhomogeneous in both time and space domains, i.e., the impulsive effect in each node is not only nonidentical from each other, but also time-varying at different impulsive instants. The purpose of the addressed problem is to derive synchronization criteria such that, the nonlinear delayed dynamical networks with heterogeneous impulses can be synchronized to a desired state. By means of a time-dependent Lyapunov function and the comparison principle, several sufficient conditions are established under which nonlinear dynamical networks with heterogeneous impulsive effects are exponentially synchronized to a desired state. An example is given to show the effectiveness of the proposed results. © 2004-2012 IEEE.


Tang B.,Yangzhou University | Lu X.,Tsinghua University | Ye L.,Tsinghua University | Shi W.,Tsinghua University
Earthquake Engineering and Engineering Vibration | Year: 2011

According to the Code for Seismic Design of Buildings (GB50011-2001), ten typical reinforced concrete (RC) frame structures, used as school classroom buildings, are designed with different seismic fortification intensities (SFIs) (SFI=6 to 8. 5) and different seismic design categories (SDCs) (SDC=B and C). The collapse resistance of the frames with SDC=B and C in terms of collapse fragility curves are quantitatively evaluated and compared via incremental dynamic analysis (IDA). The results show that the collapse resistance of structures should be evaluated based on both the absolute seismic resistance and the corresponding design seismic intensity. For the frames with SFI from 6 to 7. 5, because they have relatively low absolute seismic resistance, their collapse resistance is insufficient even when their corresponding SDCs are upgraded from B to C. Thus, further measures are needed to enhance these structures, and some suggestions are proposed. © 2011 Institute of Engineering Mechanics, China Earthquake Administration and Springer-Verlag Berlin Heidelberg.


Wang M.,Yangzhou University | Zhang H.,Yangzhou University | Wang C.,Yangzhou University | Hu X.,Yangzhou University | Wang G.,University of Technology, Sydney
Electrochimica Acta | Year: 2013

For the first time, poly-o-phenylenediamine (PoPD) bulk material was electrochemically synthesized using an electrochemical method. Sodium dodecyl sulfate (SDS) was added to o-phenylenediamine (oPD) solution and PoPD with different morphologies were obtained. The as-prepared materials were applied as the electrode materials in supercapacitors. The specific capacitance (SC) of the resultant PoPD was determined to be 106.4 F g-1 in 1 mol L -1 KNO3 electrolyte from CV test. The electrochemical stability of PoPD electrode was investigated by charging and discharging the electrode for 1000 times in the potential range of -0.2 to 0.6 V versus SCE at the current density of 500 mA g-1. The electrode exhibits a good cycling stability, retaining up to 82% of its initial specific capacitance at 1000th cycle. This novel technique enables PoPD non-film material for supercapacitor application. © 2013 Elsevier Ltd. All rights reserved.


Wan Q.,Jiangsu Key Laboratory of Integrated Traditional Chinese | Wan Q.,Jiangsu Electric Power Company | Wan Q.,Yangzhou University | Bennett B.C.,University of Virginia | And 5 more authors.
Proceedings of the National Academy of Sciences of the United States of America | Year: 2014

Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate (DHF) to tetrahydrofolate (THF). An important step in the mechanism involves proton donation to the N5 atom of DHF. The inability to determine the protonation states of active site residues and substrate has led to a lack of consensus regarding the catalytic mechanism involved. To resolve this ambiguity, we conducted neutron and ultrahigh-resolution X-ray crystallographic studies of the pseudo-Michaelis ternary complex of Escherichia coli DHFR with folate and NADP+. The neutron data were collected to 2.0-A˚ resolution using a 3.6-mm3 crystal with the quasi-Laue technique. The structure reveals that the N3 atom of folate is protonated, whereas Asp27 is negatively charged. Previous mechanisms have proposed a keto-to-enol tautomerization of the substrate to facilitate protonation of the N5 atom. The structure supports the existence of the keto tautomer owing to protonation of the N3 atom, suggesting that tautomerization is unnecessary for catalysis. In the 1.05-A˚ resolution X-ray structure of the ternary complex, conformational disorder of the Met20 side chain is coupled to electron density for a partially occupied water within hydrogen-bonding distance of the N5 atom of folate; this suggests direct protonation of substrate by solvent. We propose a catalytic mechanism for DHFR that involves stabilization of the keto tautomer of the substrate, elevation of the pKa value of the N5 atom of DHF by Asp27, and protonation of N5 by water that gains access to the active site through fluctuation of the Met20 side chain even though the Met20 loop is closed. © 2014, National Academy of Sciences. All rights reserved.


Wang M.,Yangzhou University | Zhang H.,Yangzhou University | Wang C.,Yangzhou University | Wang G.,University of Technology, Sydney
Electrochimica Acta | Year: 2013

A composite of MnO2 and poly-o-phenylenediamine (PoPD) was one-step synthesized by co-precipitation with the reaction of KMnO4 and o-phenylenediamine in acidic solution at room temperature. The influence of the addition of cetyl trimethyl ammonium bromide (CTAB) and sodium dodecyl sulfate (SDS) on the morphology and electrochemical performance was investigated. FT-IR, XRD and SEM were adopted to examine the obtained materials, and the electrochemical properties of the products were characterized by cyclic voltammetry and galvanostatic charge-discharge. The material synthesized in the presence of 2.5 g L-1 had a specific capacitance of 262.2 F g -1 determined with cyclic voltammetry in a potential window of 0-0.9 V vs. saturated calomel electrode in 1.0 mol L-1 KNO3 solution. © 2013 Elsevier Ltd. All rights reserved.


Xu W.,Chinese University of Hong Kong | Xu W.,CAS Nanjing Institute of Soil Science | Jia L.,Chinese University of Hong Kong | Jia L.,Inner Mongolia Agricultural University | And 5 more authors.
New Phytologist | Year: 2013

Maintenance of root growth is essential for plant adaptation to soil drying. Here, we tested the hypothesis that auxin transport is involved in mediating ABA's modulation by activating proton secretion in the root tip to maintain root growth under moderate water stress. Rice and Arabidopsis plants were raised under a hydroponic system and subjected to moderate water stress (-0.47 MPa) with polyethylene glycol (PEG). ABA accumulation, auxin transport and plasma membrane H+-ATPase activity at the root tip were monitored in addition to the primary root elongation and root hair density. We found that moderate water stress increases ABA accumulation and auxin transport in the root apex. Additionally, ABA modulation is involved in the regulation of auxin transport in the root tip. The transported auxin activates the plasma membrane H+-ATPase to release more protons along the root tip in its adaption to moderate water stress. The proton secretion in the root tip is essential in maintaining or promoting primary root elongation and root hair development under moderate water stress. These results suggest that ABA accumulation modulates auxin transport in the root tip, which enhances proton secretion for maintaining root growth under moderate water stress. © 2012 New Phytologist Trust.


Wang H.,CAS Shanghai Institute of Materia Medica | Jiang Y.,CAS Shanghai Institute of Materia Medica | Peng H.,CAS Shanghai Institute of Materia Medica | Chen Y.,CAS Shanghai Institute of Materia Medica | And 2 more authors.
Advanced Drug Delivery Reviews | Year: 2015

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Because of significant changes in their expression in cancer, miRNAs are believed to be key factors in cancer genetics and to have potential as anticancer drugs. However, the delivery of miRNAs is limited by many barriers, such as low cellular uptake, immunogenicity, renal clearance, degradation by nucleases, elimination by phagocytic immune cells, poor endosomal release, and untoward side effects. Nonviral delivery systems have been developed to overcome these obstacles. In this review, we provide insights into the development of non-viral synthetic miRNA vectors and the promise of miRNA-based anticancer therapies, including therapeutic applications of miRNAs, challenges of vector design to overcome the delivery obstacles, and the development of miRNA delivery systems for cancer therapy. Additionally, we highlight some representative examples that give a glimpse into the current trends into the design and application of efficient synthetic systems for miRNA delivery. Overall, a better understanding of the rational design of miRNA delivery systems will promote their translation into effective clinical treatments. © 2014 Elsevier B.V.


Wang B.,University of Technology, Sydney | Park J.,Gyeongsang National University | Su D.,University of Technology, Sydney | Wang C.,Yangzhou University | And 3 more authors.
Journal of Materials Chemistry | Year: 2012

A CoS 2-graphene nanocomposite was prepared by a facile solvothermal method. FESEM and TEM analyses have confirmed that CoS 2 nanoparticles with sizes of 5-15 nm are densely anchored on graphene nanosheets. The as-prepared nanocomposite was electrochemically tested as an electrode material for supercapacitors. The CoS 2-graphene nanocomposite exhibited specific capacitances of 314 F g -1 in the aqueous electrolyte and 141 F g -1 in the organic electrolyte at a current rate of 0.5 A g -1 with excellent cycling stability. The electrochemical performance of the nanocomposite has been significantly improved, compared to bare graphene nanosheets and CoS 2 nanoparticles. This could be credited to the 3D nanoarchitecture, in which CoS 2 nanoparticles were sandwiched between graphene nanosheets, and the additional electrochemical contribution of the decorated CoS 2 nanoparticles. © 2012 The Royal Society of Chemistry.


Liu L.,Yangzhou University | Wang C.,Yangzhou University | Wang G.,University of Technology, Sydney
Analytical Methods | Year: 2013

Novel cysteic acid/reduced graphene oxide composite film on a glassy carbon electrode has been prepared through the electrochemical oxidation of l-cysteine for silver sensing. Differential pulse anodic stripping voltammetry (DPASV) was employed for the detection of trace Ag(i) in aqueous solutions with the composite film modified electrode, which is referred to as an efficient method for the detection of trace heavy metals. We found the linear relationship between the peak current of the stripping voltammetry of Ag(i) and the concentration of Ag(i) in the range of 1.0 × 10-8 ∼ 2.0 × 10-4 M with a correlation coefficient R2 = 0.996, and the detection limit can be down to 1.0 × 10-9 M (S/N = 3). The as-developed cysteic acid/reduced graphene oxide composite film modified electrode demonstrated ultrahigh sensitivity, reproducibility and recovery for the selective detection of trace Ag(i) without any interference from other metal ions. © 2013 The Royal Society of Chemistry.


Zhang Y.,Yangzhou University | Qu Q.,Yangzhou University | Wang G.,University of Technology, Sydney | Wang C.,Yangzhou University
Analytical Methods | Year: 2013

A highly sensitive pre-column derivatization HPLC method for simultaneous determination of glyphosate (GLYP) and its major metabolite aminomethylphosphonic acid (AMPA) in soybean samples was developed. The analytes were labeled with a novel fluorescent labeling reagent 3,6-dimethoxy-9-phenyl- 9H-carbazole-1-sulfonyl chloride (DPCS-Cl) at 70 °C for 25 min. The optimized concentration of DPCS-Cl was 25 μg mL-1 and the molar ratio of analytes to DPCS-Cl was 1:4.2. The derivatives were separated on a reversed-phase column by gradient elution and were monitored with fluorescence detection at 318 nm (excitation) and 440 nm (emission). The method linearity, calculated for GLYP and AMPA, had a correlation coefficient greater than 0.999. The detection limits for GLYP and AMPA were 0.02 ng mL-1 and 0.01 ng mL-1 (S/N = 3), respectively. In addition, a simple sample pretreatment for the soybean samples was developed to extract GLYP and AMPA. The recovery of extraction was more than 95%. Then, this method gave the detection limits of 0.002 mg kg-1 for GLYP and 0.001 mg kg-1 for AMPA in soybean samples. This HPLC method was applied to the determination of glyphosate and AMPA in soybean samples with its merits of simplicity in pretreatment, rapidity in derivatization, stability of the derivatives and high sensitivity. © 2013 The Royal Society of Chemistry.


Xing D.,University of Alabama at Birmingham | Gong K.,University of Alabama at Birmingham | Gong K.,Yangzhou University | Feng W.,University of Alabama at Birmingham | And 4 more authors.
PLoS ONE | Year: 2011

Background: We have shown that glucosamine (GlcN) or O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) treatment augments O-linked-N-acetylglucosamine (O-GlcNAc) protein modification and attenuates inflammatory mediator expression, leukocyte infiltration and neointima formation in balloon injured rat carotid arteries and have identified the arterial smooth muscle cell (SMC) as the target cell in the injury response. NFκB signaling has been shown to mediate the expression of inflammatory genes and neointima formation in injured arteries. Phosphorylation of the p65 subunit of NFκB is required for the transcriptional activation of NFκB. This study tested the hypothesis that GlcN or PUGNAc treatment protects vascular SMCs against tumor necrosis factor (TNF)-α induced inflammatory stress by enhancing O-GlcNAcylation and inhibiting TNF-α induced phosphorylation of NFκB p65, thus inhibiting NFκB signaling. Methodology/Principal Findings: Quiescent rat aortic SMCs were pretreated with GlcN (5 mM), PUGNAc (10 -4 M) or vehicle and then stimulated with TNF-α (10 ng/ml). Both treatments inhibited TNF-α-induced expression of chemokines [cytokine-induced neutrophil chemoattractant (CINC)-2β and monocyte chemotactic protein (MCP)-1] and adhesion molecules [vascular cell adhesion molecule (VCAM)-1 and P-Selectin]. Both treatments inhibited TNF-α induced NFκB p65 activation and promoter activity, increased NFκB p65 O-GlcNAcylation and inhibited NFκB p65 phosphorylation at Serine 536, thus promoting IκBα binding to NFκB p65. Conclusions: There is a reciprocal relationship between O-GlcNAcylation and phosphorylation of NFκB p65, such that increased NFκB p65 O-GlcNAc modification inhibits TNF-α-Induced expression of inflammatory mediators through inhibition of NFκB p65 signaling. These findings provide a mechanistic basis for our previous observations that GlcN and PUGNAc treatments inhibit inflammation and remodeling induced by acute endoluminal arterial injury. © 2011 Xing et al.


Hilgers R.H.P.,University of Alabama at Birmingham | Xing D.,University of Alabama at Birmingham | Gong K.,University of Alabama at Birmingham | Gong K.,Yangzhou University | And 3 more authors.
American Journal of Physiology - Heart and Circulatory Physiology | Year: 2012

Acute increases in cellular protein O-linked N-acetyl-glucosamine (OGlcNAc) modification (O-GlcNAcylation) have been shown to have protective effects in the heart and vasculature. We hypothesized that D-glucosamine (D-GlcN) and Thiamet-G, two agents that increase protein O-GlcNAcylation via different mechanisms, inhibit TNF-α-induced oxidative stress and vascular dysfunction by suppressing inducible nitric oxide (NO) synthase (iNOS) expression. Rat aortic rings were incubated for 3h at 37°C with D-GlcN or its osmotic control L-glucose (L-Glc) or with Thiamet-G or its vehicle control (H 2O) followed by the addition of TNF-α or vehicle (H 2O) for 21 h. After incubation, rings were mounted in a myograph to assess arterial reactivity. Twenty-four hours of incubation of aortic rings with TNF-α resulted in 1) a hypocontractility to 60 mM K + solution and phenylephrine, 2) blunted endothelium-dependent relaxation responses to ACh and substance P, and 3) unaltered relaxing response to the Ca 2+ ionophore A-23187 and the NO donor sodium nitroprusside compared with aortic rings cultured in the absence of TNF-α. D-GlcN and Thiamet-G pretreatment suppressed the TNF-α-induced hypocontractility and endothelial dysfunction. Total protein OGlcNAc levels were significantly higher in aortic segments treated with D-GlcN or Thiamet-G compared with controls. Expression of iNOS protein was increased in TNF-α-treated rings, and this was attenuated by pretreatment with either D-GlcN or Thiamet-G. Dense immunostaining for nitrotyrosylated proteins was detected in the endothelium and media of the aortic wall, suggesting enhanced peroxynitrite production by iNOS. These findings demonstrate that acute increases in protein O-GlcNAcylation prevent TNF-α-induced vascular dysfunction, at least in part, via suppression of iNOS expression. © 2012 the American Physiological Society.


Zhou Y.-X.,Anhui University of Science and Technology | Zhou Y.-X.,Yangzhou University | Yao H.-B.,Anhui University of Science and Technology | Wang Y.,Sun Yat Sen University | And 4 more authors.
Chemistry - A European Journal | Year: 2010

A simple solvothermal route in a binary solution of triethylenetetramine (TETA) and deionized water (DIW) has been used to synthesize hierarchical hollow Co9S8 microspheres with high surface area (80.38 m 2g-1). An appropriate volume ratio of TETA:DIW has been found to be essential for the formation of hollow Co9S8 microspheres. The magnetic study indicated that the Co9S8 hollow microspheres are paramagnetic at high temperature and antiferromagnetic at low temperature. The oxygen reduction reaction experiments demonstrated that the onset potential of the Co9S8 sample is 0.88 V, which is comparable to the value predicted for Co9S8 (0.74 V) from the theoretical simulation. The discharge capability of Co 9S8 hollow microspheres as cathode materials for lithium ion batteries and their electrocatalytic activity for the oxygen reduction reaction (ORR) have been studied. Cathode materials: Hierarchical hollow Co 9S8 microspheres (shown here) can be synthesized by a simple solvothermal route in a binary solution of triethylenetetramine and deionized water. The onset potential of Co9S8 hollow spheres is 0.88 V for the oxygen reduction reaction. The magnetic properties of Co9S8 hollow microspheres and their use as cathode materials for lithium ion cells have been studied. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Fei K.,Yangzhou University | Liu H.-L.,Hohai University
Yantu Lixue/Rock and Soil Mechanics | Year: 2010

On the basis of subroutine UMAT provided by ABAQUS, the Duncan nonlinear elastic model for static analysis and the equivalent linear model for dynamic analysis are implemented; so the database of constitutive model in ABAQUS is enlarged. The methods to model layered construction of dam, correct the displacement of new fill layer, consider the effect of wetting effect, evaluate liquefaction resistance of dam material and compute the permanent displacement induced by earthquake are described in detail. The results of examples are found to be reasonable and reliable, it verifies that ABAQUS can be used in static and dynamic analyses of earth-rockfill dam after the secondary development. The present method can make use of the advantages of ABAQUS, such as convenient preprocessor and postprocessor, high solution precision and high ability to handle complex problems; so an alternative method for static and dynamic analyses of earth-rockfill dam is provided.


Wang Y.,University of Technology, Sydney | Su D.,University of Technology, Sydney | Wang C.,Yangzhou University | Wang G.,University of Technology, Sydney
Electrochemistry Communications | Year: 2013

We report the synthesis and characterization of SnO2@multiwalled carbon nanotubes (MWCNTs) nanocomposite as a high capacity anode material for sodium-ion battery. SnO2@MWCNT nanocomposite was synthesized by a solvothermal method. SEM and TEM analyses show the uniform distribution of SnO2 nanoparticles on carbon nanotubes. When applied as anode materials in Na-ion batteries, SnO2@MWCNT nanocomposite exhibited a high sodium storage capacity of 839 mAh g- 1 in the first cycle. SnO2@MWCNT nanocomposite also demonstrated much better cycling performance than that of bare SnO2 nanoparticles and bare MWCNTs. Furthermore, the nanocomposite electrode also showed a good cyclability and an enhanced Coulombic efficiency on cycling. © 2013 Elsevier B.V.


Wang J.,Tangshan College | Hua I.,Yangzhou University
Neural Processing Letters | Year: 2011

In the past few decades, many face recognition methods have been developed. Among thesemethods, subspace analysis is an effective approach for face recognition. Unsuperviseddiscriminant projection (UDP) finds an embedding subspace that preserves local structure information, and uncovers and separates embedding corresponding to different manifolds. Though UDP has been applied in many fields, it has limits to solve the classification tasks, such as the ignorance of the class information. Thus, a novel subspace method, called supervised discriminant projection (SDP), is proposed for face recognition in this paper.In our method, the class information was utilized in the procedure of feature extraction.In SDP, the local structure of the original data is constructed according to a certain kind of similarity between data points, which takes special consideration of both the localinformation and class information. We test the performance of the proposed method SDP on three popular face image databases (i.e. AR database, Yale database, and a subset of FERET database). Experimental results show that the proposed method is effective. © Springer Science+Business Media, LLC. 2011.


Yang J.S.,Jiangnan University | Yang J.S.,Yangzhou University | Jiang B.,Yangzhou University | He W.,Yangzhou University | Xia Y.M.,Jiangnan University
Carbohydrate Polymers | Year: 2012

Dodecanol was covalently coupled to sodium alginate (NaAlg) via ester functions using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC-HCl) as a coupling reagent to provide an amphiphilic dodecanol alginate (DA) for subsequent use in oil-in-water (O/W) emulsion application. The structure of DA was confirmed by FT-IR spectrometry. The stability of the emulsions prepared with different concentrations (0.3-1.2 wt%) of DA or 1.0 wt% NaAlg was evaluated by measuring droplet size, microstructure, viscosity and creaming. The results showed that the emulsions containing 1.0 wt% NaAlg, 0.3 and 0.5 wt% DA were unstable and the emulsions containing 0.8-1.2 wt% DA presented better stability during storage. © 2011 Elsevier Ltd. All rights reserved.


Wu S.,Yangzhou University | Wan L.,Wenzhou University
Journal of Applied Physics | Year: 2012

The electronic structures of a CdSe spherical quantum dot in a magnetic field are obtained by using an exact diagonalization method and a variational method within the effective-mass approximation. The dependences of the energies and wave functions of electron states, exciton binding energy, exciton transition energy, and exciton diamagnetic shift on the applied magnetic field are investigated theoretically in detail. It is observed that the degeneracy of magnetic quantum number m is removed due to the Zeeman effect when the magnetic field is present. For the states with m 0, the electron energies increase as the magnetic field increases. However, for the states with m 0, the electron energies decrease to a minimum, and then increase with increasing the magnetic field. The energies and wave functions of electron states obtained from the variational method based on the variational functions we proposed are in excellent agreement with the results obtained from the exact diagonalization method we presented. A comparison between the results obtained from the variational functions proposed by us and Xiao is also verified. © 2012 American Institute of Physics.


Chen Q.,CAS National Center for Nanoscience and Technology | Wang J.-X.,CAS National Center for Nanoscience and Technology | Wang J.-X.,Yangzhou University | Wang Q.,CAS National Center for Nanoscience and Technology | And 5 more authors.
Macromolecules | Year: 2011

Preparation and sorption properties of spiro(fluorene-9,9′-xanthene)- based porous organic polymers (SPOPs) are reported for the first time. Using a same linker monomer, the micropore size and specific surface area in SPOPs are tunable by variation of the structure of core building blocks. According to the obtained nitrogen physisorption isotherms, the Brunauer-Emmett-Teller specific surface area for these polymers varies between 750 and 1020 m2 g -1. Copolymer SPOP-3 containing spiro(fluorene-9,9′-xanthene) and spirobifluorene with 1:1 ratio, prepared through Suzuki coupling polymerization, possesses 2.22 wt % hydrogen adsorption capacity at 1.0 bar and 77 K, which not only is the exceptional uptake capacity for hydrogen at low pressure among the best reported results for organic polymers but also can be competitive with other kinds of porous materials such as activated carbons and metal-organic frameworks. © 2011 American Chemical Society.


Fei M.,Soochow University of China | Hang Q.,Nantong University | Hang Q.,Tohoku Pharmaceutical University | Hou S.,Yangzhou University | Ruan C.,Soochow University of China
International Journal of Hematology | Year: 2013

Spy1 is a member of the Speedy/Ringo family, which regulates cell proliferation and survival. Spy1 has been demonstrated to promote the cell-cycle progress through p27Kip1 degradation. Previous investigations have suggested cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM) is a primary factor for minimal residual disease (MRD) leading to relapse after chemotherapy. However, the precise mechanism remains elusive. In this study, we used MM cell lines to determine whether Spy1 plays a role in CAM-DR. We demonstrated that adhesion of MM cells to fibronectin (FN) decreased Spy1 expression. Overexpression of Spy1 did not affect MM cells adhesion to FN, but did reverse the doxorubicin- or mitoxantrone-induced CAM-DR phenotype. Spy1 protein level was also correlated with reciprocal up-regulation of p27 Kip1 when RPMI 8226 cells bound FN. Spy1 overexpression promoted p27Kip1 phosphorylation at T187, then induced the p27Kip1 degradation in the adhesion model. In addition, increasing p27Kip1 level or disturbing p27Kip1 phosphorylation at T187 abolished the CAM-DR reversion when Spy1 was overexpressed. Collectively, our data suggest that Spy1 plays an important role in CAM-DR, which depends on the function of p27Kip1. Our findings provide a rational framework for further development of Spy1 as a novel target for MM therapy. © 2013 The Japanese Society of Hematology.


Liu Y.,Jiangnan University | Sun J.,Jiangsu University | Rao S.,Yangzhou University | Su Y.,Jiangnan University | Yang Y.,Jiangnan University
Food and Chemical Toxicology | Year: 2013

It is the first time to extract polysaccharides (CVPs) from Catathelasma ventricosum. The antihyperglycemic and antioxidant activity of CVPs in streptozotocin-induced diabetic mice were examined. Compared with untreated diabetic mice, the administration of CVPs for 30days caused a significant decrease in the concentrations of blood glucose, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C) and maleic dialdehyde (MDA), and a significant increase in the concentrations of high density lipoprotein-cholesterol (HDL-C) and the activities of antioxidant enzymes. Specially, when normal mice were treated with CVPs, all detection indexes and pathologic morphologies of liver, kidney and pancreas are similar to untreated normal mice, which indicated CVPs are safe for normal mice. In addition, the average molecular weight of CVPs was estimated to be from 3.7×103 to 1.7×107Da and they were mainly composed of glucose (93.5%) with the conformation of α-d-Glucopyranose. © 2013 Elsevier Ltd.


Wu S.,Yangzhou University | Wan L.,Wenzhou University
Journal of Applied Physics | Year: 2011

The thermal dependence of the optical gain and threshold current density of GaInNAs/GaAs/AlGaAs quantum well (QW) lasers with the emission wavelength of 1.3 m have been theoretically investigated. The optical gain is found to decrease with the increase of the temperature due to the hole leakage in the separate confinement heterostructure (SCH) region. The distribution of unconfined electrons in the SCH region is negligible while the distribution of unconfined holes in the SCH region plays an important role in the leakage process, reflecting the smaller bandgap discontinuity in the valence band than in the conduction band. The threshold current density increases with the increase of temperature, which is dominated by the monomolecular recombination process. Our calculated threshold current densities with temperatures are in agreement with the available experimental results. © 2011 American Institute of Physics.


Chen W.,Anhui Normal University | Luo J.,Central China Normal University | Tang Y.,Yangzhou University
IEEE Transactions on Information Theory | Year: 2015

In this paper, we consider a class of exponential sums from some half quadratic binomials. The exponential sums are proven to be eleven-valued with maximal magnitude (1}/2(q-q) except for the trivial value q. As applications, first, we investigate the autocorrelation and cross-correlation distribution among the sequences in a sequence family. Second, we determine the weight distributions of several classes of linear codes. Some of the dual codes have minimum distance four, which are optimal with respect to the Hamming bound. Our results extend the result by Choi et al. and show that some correlation values in it do not occur. © 2014 IEEE.


Gao P.,Nanjing University | Gao P.,Yangzhou University | Guo W.,Wenzhou University | Xue J.,Nanjing University | And 4 more authors.
Journal of the American Chemical Society | Year: 2015

By developing a new Ir(III)-catalyzed C-C cross-coupling, a versatile method for direct arylation of sp2 and sp3 C-H bonds in ketoximes, nitrogen-containing heterocycles, various arenes, and olefins has been established. The key to this arylation depends on the appropriate choice of catalyst and the use of diaryliodonium triflate salts as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C-H arylation of complex compounds. Mechanistic studies by density functional theory calculations suggested that the sp3 C-H activation was realized by a triflate-involved concerted metalation-deprotonation process, and the following oxidation of Ir(III) to Ir(V) is the most favorable when a bistriflimide is contained in the diaryliodonium salt. Calculations indicated that both steps are enabled by initial anion exchange between the reactant complexes. © 2015 American Chemical Society.


Yu L.,Wenzhou University | Yu L.,Yangzhou University | Yu L.,University of Toronto | Li H.,Yangzhou University | And 7 more authors.
Organic Letters | Year: 2014

Areneselenenic acids (ArSeOH), readily generated from diaryl diselenides and H2O2 by in situ oxidation, were found to be effective and reusable catalysts for dehydration of aldoximes, leading to a practical and scalable preparation of useful organonitriles under mild conditions. © 2014 American Chemical Society.


Sun L.,Yangzhou University | Kong D.,Hydrochina Guiyang Engineering Corporation
Advances in Science and Technology of Water Resources | Year: 2014

In practical construction of arch dams, the actual values of some design parameters, such as the deformation modulus of a foundation rock mass, are often different from their design values. In order to adapt the arch dam to the change of design parameters, considering the uncertainty of the design parameters, the robust feasibility constraint condition was formulated with the maximal variation analysis method, and a robust feasibility optimization model for shape design of arch dams was established with consideration of uncertainty of the deformation modulus of the foundation rock mass. The optimization of a planned elliptic arch dam indicates that the optimized dam volume is 3.31% smaller than the initially designed dam volume, the optimized arch dam can adapt to the uncertainty of the deformation modulus of the foundation rock mass, and the dam stress can always meet the design requirements when the foundation deformation modulus changes within its range of variation. © 2014, Editorial Board of Advances in Science and Technology of Water Resources, Hohai University. All right reserved.


Yu L.,Yangzhou University | Yu L.,Wenzhou University | Yu L.,Nanjing University | Wu Y.,Yangzhou University | And 3 more authors.
Organic Letters | Year: 2013

Direct [3 + 2] radical cycloaddition of methylenecyclopropanes and elemental chalcogens (S, Se, Te) can readily occur under simple thermal conditions, providing an efficient, practical method for preparation of useful but not easily accessed methylene-1,2-dichalcogenolanes. © 2012 American Chemical Society.


Wang Z.W.,Hong Kong Baptist University | Wang Z.W.,Yangzhou University | Liang J.S.,Yangzhou University | Liang Y.,Hong Kong Baptist University | Liang Y.,Chinese Academy of Sciences
International Biodeterioration and Biodegradation | Year: 2013

A bacterial strain, YZU1, with remarkable ability to decolorize Reactive Black 5 (RB-5), was isolated from soil samples collected around a textile factory. Phenotypic and phylogenetic analyses of the 16S rDNA sequence indicated that YZU1 belonged to Bacillus sp. Bacillus sp. YZU1 showed great capability to decolorize various reactive textile dyes, including azo dye. Static conditions with pH 7.0 and 40 °C were considered to be optimum for decolorizing RB-5. Bacillus sp. YZU1 grew well in medium containing high concentration of dye (100. mg/l), resulting in approximately 95% decolorization in 120. h, and could tolerate up to 500. mg/1 of RB-5. Enzyme assays demonstrated that Bacillus sp. YZU1 possessed azoreductase and played the most important role in decolorization, while a small percentage of decolorization occurred via passive surface adsorption. High biodegradation extent under a mild condition suggested that Bacillus sp. YZU1 had great potential to be applied in dye effluent treatment. © 2012 Elsevier Ltd.


Fu J.,Yangzhou University | Huang Z.,Yangzhou University | Wang Z.,Yangzhou University | Yang J.,Yangzhou University | Zhang J.,Hong Kong Baptist University
Field Crops Research | Year: 2011

Sink strength plays an important role in grain filling of cereals but how it is related to the pre-anthesis non-structural carbohydrate (NSC) reserves is not clear. This study investigated if and how an increase in NSC reserves could enhance sink strength, and consequently improve grain filling of later-flowering inferior spikelets (in contrast to the earlier flowering superior spikelets) for rice varieties with large panicles. Two "super" rice varieties (the recently bred high-yielding rice) and two New Plant Type (NPT, named in IRRI for the extra-large panicle) rice lines were compared with two elite inbred varieties under field-grown conditions. Three nitrogen (N) treatments, applied at the stages of panicle initiation, spikelet differentiation or both, were adopted with no N application during the mid-season as control. Both super rice and NPT rice showed a greater yield capacity as a result of a larger panicle than the elite inbred rice. However, a lower percentage of filled grains limited the realization of higher yield potential in super rice and especially in NPT rice, due to their lower grain filling rate and the smaller grain weight of their inferior spikelets. The low grain filling rate and small grain weight of inferior spikelets are mainly attributed to a poor sink strength as a result of small sink size (small number of endosperm cells) and low sink activity, e.g. low activities of sucrose synthase (SuSase) and adenosine diphosphoglucose pyrophosphorylase (AGPase). The amounts of NSC in the stem and NSC per spikelet at the heading time are significantly and positively correlated with sink strength (number of endosperm cells and activities of SuSase and AGPase), grain filling rate, and grain weight of inferior spikelets. Nitrogen application at the spikelet differentiation stage significantly increased, whereas N application at the panicle initiation or at both panicle initiation and spikelet differentiation stages, significantly reduced, NSC per spikelet at the heading time, sink strength, grain filling rate, and grain weight of inferior spikelets in super rice. The results suggest that pre-anthesis NSC reserves in the stem are closely associated with the sink strength during grain filling of rice, and N application at the spikelet differentiation stage would be a good practice to increase pre-anthesis NSC reserves, and consequently to enhance sink strength for rice varieties with large panicles, such as super rice varieties. © 2011 Elsevier B.V.


Zhang H.,Yangzhou University | Chen T.,Yangzhou University | Wang Z.,Yangzhou University | Yang J.,Yangzhou University | Zhang J.,Hong Kong Baptist University
Journal of Experimental Botany | Year: 2010

Cytokinins may reflect soil water status and regulate rice (Oryza sativa L.) grain filling. This study investigated the changes in cytokinin levels in rice plants and their relations with grain filling under alternate wetting and drying irrigation. Two 'super' rice cultivars were field grown. Three irrigation regimes, alternate wetting and moderate soil drying (WMD), alternate wetting and severe soil drying (WSD), and conventional irrigation (CI, continuously flooded), were imposed after flowering. No significant differences in grain-filling rate, grain weight, and cytokinin content were observed for the earlier-flowering superior spikelets among the three irrigation regimes. For the later-flowering inferior spikelets, however, their grain-filling rate and grain weight were significantly increased in the WMD and significantly reduced in the WSD when compared with those in the CI. Cytokinin contents in shoots (inferior spikelets and the flag leaves) in the WMD at the soil drying time were comparable with those in the CI, but they were significantly increased when plants were rewatered. The WSD significantly reduced cytokinin contents in the shoot either during soil drying or during the rewatering period. Cytokinin contents in roots showed no significant difference between the WMD and CI regimes. The WSD increased trans-zeatin-type cytokinins, whereas it reduced isopentenyladenine-type cytokinins, in roots. Grain-filling rate and grain weight of inferior spikelets were very significantly correlated with cytokinin contents in these spikelets. The results suggest that a post-anthesis WMD holds great promise to improve grain filling of inferior spikelets through elevating cytokinin levels in the rice shoot. © 2010 The Author.


Zhang H.,Yangzhou University | Li H.,Yangzhou University | Yuan L.,Yangzhou University | Wang Z.,Yangzhou University | And 2 more authors.
Journal of Experimental Botany | Year: 2012

This study tested the hypothesis that a post-anthesis moderate soil drying can improve grain filling through regulating the key enzymes in the sucrose-to-starch pathway in the grains of rice (Oryza sativa L.). Two rice cultivars were field grown and two irrigation regimes, alternate wetting and moderate soil drying (WMD) and conventional irrigation (CI, continuously flooded), were imposed during the grain-filling period. The grain-filling rate and activities of four key enzymes in sucrose-to-starch conversion, sucrose synthase (SuSase), adenosine diphosphate-glucose pyrophosphorylase (AGPase), starch synthase (StSase), and starch branching enzyme (SBE), showed no significant difference between WMD and CI regimes for the earlier flowering superior spikelets. However, they were significantly enhanced by the WMD for the later flowering inferior spikelets. The activities of both soluble and insoluble acid invertase in the grains were little affected by the WMD. The two cultivars showed the same tendencies. The activities of SuSase, AGPase, StSase, and SBE in grains were very significantly correlated with the grain-filling rate. The abscisic acid (ABA) concentration in inferior spikelets was remarkably increased in the WMD and very significantly correlated with activities of SuSase, AGPase, StSase, and SBE. Application of ABA on plants under CI produced similar results to those seen in plants receiving WMD. Applying fluridone, an indirect inhibitor of ABA synthesis, produced the opposite effect. The results suggest that post-anthesis WMD could enhance sink strength by regulating the key enzymes involved, and consequently, increase the grain-filling rate and grain weight of inferior spikelets. ABA plays an important role in this process. © 2011 The Author(s).


Yang J.,Yangzhou University | Zhang J.,Hong Kong Baptist University
Journal of Experimental Botany | Year: 2010

Modern rice (Oryza sativa L.) cultivars, especially the newly bred 'super' rice, have numerous spikelets on a panicle with a large yield capacity. However, these cultivars often fail to achieve their high yield potential due to poor grain-filling of later-flowering inferior spikelets (in contrast to the earlier-flowering superior spikelets). Conventional thinking to explain the poor grain-filling is the consequence of carbon limitation. Recent studies, however, have shown that carbohydrate supply should not be the major problem because they have adequate sucrose at their initial grain-filling stage. The low activities of key enzymes in carbon metabolism may contribute to the poor grain-filling. Proper field practices, such as moderate soil drying during mid-and late grain-filling stages, could solve some problems in poor grain-filling. Further studies are needed by molecular approaches to investigate the signal transport, the hormonal action, the gene expressions, and the biochemical processes in inferior spikelets.


Zhang Y.C.,Yangzhou University | Zhang Y.C.,University of Cincinnati | Yao L.,Yangzhou University | Zhang G.,University of Cincinnati | And 4 more authors.
Applied Catalysis B: Environmental | Year: 2013

A simple and cost-effective one-step hydrothermal method, which was based on the reactions of tin(IV) chloride pentahydrate and different dosages of thioacetamide in water at 190°C for 6h, was employed for the synthesis of composition-tunable SnS2/SnO2 nanoheterojunctions (e.g., SnS2/SnO2-A, SnS2/SnO2-B and SnS2/SnO2-C). The photocatalytic properties of the as-synthesized SnS2/SnO2 nanoheterojunctions were tested by the reduction of aqueous Cr(VI) under visible-light (λ>420nm) irradiation. Furthermore, the photocatalytic efficiency of SnS2/SnO2-B was compared with those of PM-SnS2/SnO2 (which denotes the physically mixed SnS2/SnO2 nanocomposite with the same composition as SnS2/SnO2-B) and SnS2 nanoflakes at different dosages of photocatalysts. It was observed that (i) the photocatalytic activities of the as-synthesized SnS2/SnO2 nanoheterojunctions depended on their compositions, and SnS2/SnO2-B with 70mol% SnS2 displayed the highest photocatalytic activity; (ii) SnS2/SnO2-B invariably exhibited higher photocatalytic efficiencies than PM-SnS2/SnO2 and SnS2 nanoflakes at different dosages of photocatalysts; (iii) the washing with 1mol/L HNO3 can effectively regenerate the used photocatalyst; (iv) SnS2/SnO2-B exhibited good photocatalytic stability in reuses, with regeneration by 1mol/L HNO3-washing after each cycle of photocatalytic use; and (v) Cr(VI) was reduced to Cr(III). The possible formation mechanism of SnS2/SnO2 nanoheterojunctions and the reasons accounting for the photocatalytic results were also discussed. © 2013 Elsevier B.V.


Xu W.,CAS Nanjing Institute of Soil Science | Xu W.,Chinese University of Hong Kong | Xu W.,Hong Kong Baptist University | Shi W.,CAS Nanjing Institute of Soil Science | And 3 more authors.
Plant, Cell and Environment | Year: 2012

14-3-3 proteins are a large family of proteins but exact roles of their members in plant response to abiotic stresses are not clear, especially under nutrient deficiency. We investigated the expressions of all the tomato 14-3-3 gene family members (TFT1-TFT12) under low phosphorus stress (LP) and found that TFT6 belongs to the later responsive gene while TFT7 belongs to the early responsive gene. When the two genes were separately introduced into Arabidopsis and overexpressed, their plant growth under LP was much enhanced compared with wild-type plant. TFT6 overexpressing plants showed reduced starch synthase activity, reduced starch content but enhanced sucrose loading into phloem in the shoot under LP. TFT7 overexpressing plants had much enhanced H + flux along their root tip and activity of plasma membrane H +-ATPase in the roots under LP. Our results suggest that TFT6 and TFT7 play different roles in plant adaption to LP. TFT6 acts mainly in leaves and is involved in the systemic response to LP by regulating leaf carbon allocation and increasing phloem sucrose transport to promote root growth, while TFT7 directly functions in root by activating root plasma membrane H +-ATPase to release more protons under LP. © 2012 Blackwell Publishing Ltd.


Zhang Y.C.,Yangzhou University | Zhang Y.C.,University of Cincinnati | Yang M.,Yangzhou University | Zhang G.,University of Cincinnati | And 2 more authors.
Applied Catalysis B: Environmental | Year: 2013

A one-step low temperature (180°C) solvothermal route, which utilized HNO3 as the nitrogen source, was proposed for the synthesis of nanocrystalline N-doped TiO2 (denoted as TiO2-HNO3). The structure, composition, BET specific surface area and optical properties of TiO2-HNO3 were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, N2 adsorption-desorption isotherms and UV-vis diffuse reflectance spectroscopy. The photocatalytic properties of TiO2-HNO3 were tested for the reduction of Cr(VI) in water under both UV and visible light (λ>420nm) irradiation, and compared with those of TiO2-NH3·H2O (which was solvothermally synthesized using NH3·H2O as the nitrogen source) and TiO2 P25. The photocatalytic results demonstrated that TiO2-HNO3 possessed much higher photocatalytic activity than TiO2-NH3·H2O and TiO2 P25 in the reduction of aqueous Cr(VI) under both UV and visible light (λ>420nm) irradiation, and the dosage of TiO2-HNO3 and the initial concentration of Cr(VI) aqueous solution had significant effects on the efficiency of Cr(VI) reduction. Besides, Cr(VI) was reduced to Cr(III) after the TiO2-HNO3-mediated photocatalytic reactions. The present work suggests that HNO3 is a promising nitrogen source for low temperature solvothermal synthesis of nanocrystalline N-doped TiO2, which can be applied as a visible light-activated photocatalyst in efficient utilization of solar energy for treating Cr(VI) wastewater. © 2013 Elsevier B.V.


Ye J.,University of Maryland University College | Shao H.,University of Maryland University College | Shao H.,Yangzhou University | Perez D.R.,University of Maryland University College
Immunotherapy | Year: 2012

Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses. © 2012 Future Medicine Ltd.


Zhu G.,South China Agricultural University | Ye N.,Hong Kong Baptist University | Yang J.,Yangzhou University | Peng X.,South China Agricultural University | Zhang J.,Hong Kong Baptist University
Journal of Experimental Botany | Year: 2011

Later-flowering spikelets in a rice panicle, referred to as the inferior spikelets, are usually poorly filled and often limit the yield potential of some rice cultivars. The physiological and molecular mechanism for such poor grain filling remains unclear. In this study the differentially expressed genes in starch synthesis and hormone signalling between inferior and superior spikelets were comprehensively analysed and their relationships with grain filling was investigated. DNA microarray and real-time PCR analysis revealed that a group of starch metabolism-related genes showed enhanced expression profiles and had higher transcript levels in superior spikelets than in inferior ones at the early and middle grain-filling stages. Expression of the abscisic acid (ABA) synthesis genes, 9-cis-epoxycarotenoid dioxygenase 1 (NCED1) and NCED5, and the ethylene synthesis genes, 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1) and ACO3, declined with development of the caryopses. Meanwhile, if compared with inferior spikelets, expression of these genes in superior spikelets decreased faster and had lower transcript profiles, especially for ethylene. ABA concentration and ethylene evolution rate showed similar trends to their gene expression. Exogenous supply of ABA reduced the sucrose synthase (SUS) mRNA level and its enzyme activity in detached rice grains, while exogenously supplied ethephon (an ethylene-releasing reagent) suppressed the expression of most starch synthesis genes; that is, SUS, ADP-glucose pyrophosphorylase (AGPase), and soluble starch synthase (SSS), and down-regulated their enzyme activities. In summary, it is concluded that the relatively high concentrations of ethylene and ABA in inferior spikelets suppress the expression of starch synthesis genes and their enzyme activities and consequently lead to a low grain-filling rate. © 2011 The Author(s).


Yang J.,Yangzhou University | Zhang J.,Hong Kong Baptist University
Journal of Experimental Botany | Year: 2010

A major challenge in rice (Oryza sativa L.) production is to enhance water use efficiency (WUE) and maintain or even increase grain yield. WUE, if defined as the biomass accumulation over water consumed, may be fairly constant for a given species in given climate. WUE can be enhanced by less irrigation. However, such enhancement is largely a trade-off against lower biomass production. If WUE is defined as the grain production per unit amount of water irrigated, it would be possible to increase WUE without compromising grain yield through the manipulation of harvest index. Harvest index has been shown to be a variable factor in crop production, and in many situations, it is closely associated with WUE and grain yield in cereals. Taking rice as an example, this paper discussed crop management techniques that can enhance harvest index. Several practices such as post-anthesis controlled soil drying, alternate wetting and moderate soil drying regimes during the whole growing season, and non-flooded straw mulching cultivation, could substantially enhance WUE and maintain or even increase grain yield of rice, mainly via improved canopy structure, source activity, sink strength, and enhanced remobilization of pre-stored carbon reserves from vegetative tissues to grains. All the work has proved that a proper crop management holds great promise to enhance harvest index and, consequently, achieve the dual goal of increasing grain production and saving water. © 2010 The Author(s).


Zhu L.-J.,Yangzhou University | Zhu L.-J.,Kansas State University | Liu Q.-Q.,Yangzhou University | Wilson J.D.,U.S. Department of Agriculture | And 2 more authors.
Carbohydrate Polymers | Year: 2011

Digestibility of starches in four rice samples with amylose content (AC) from 1.7 to 55.4%, including a newly developed high-amylose rice, was investigated. An in vitro enzymatic starch digestion method and an AOAC method were applied to correlate rapidly digestible starch (RDS), slowly digestible starch (SDS), resistant starch (RS), and total dietary fiber (TDF) content with the AC in the samples. SDS content decreased and RS and TDF content increased with the increase in AC. The low-amylose rice (AC = 16.1%) had starch granules with weak crystalline structure and was lower in RS and TDF content even though it had a higher AC compared to waxy rice. The digestibility of the starches was not correlated with granule size or degree of crystallinity. The newly developed high-amylose rice starch exhibited a predominant B-type X-ray diffraction pattern, a great proportion of long chains in amylopectin, high gelatinization temperature, and semi-compound starch granules which are attributed to its increased resistance to enzyme digestion. © 2011 Elsevier Ltd. All rights reserved..


Gu X.,The University of Oklahoma Health Sciences Center | Gu X.,Yangzhou University | Vricella G.J.,Case Western Reserve University | Spaliviero M.,Yangzhou University | Wong C.,SouthWest Urology Inc.
Journal of Endourology | Year: 2012

Purpose: To evaluate the efficacy and safety of GreenLight HPS™ laser photoselective vaporization of the prostate (PVP) for the treatment of benign prostatic hyperplasia (BPH) in patients with different prostate volumes. Patients and Methods: Between July 2006 and February 2011, 207 consecutive patients were identified from a prospectively maintained urologic database. Based on preoperative prostate volume measured by transrectal ultrasonography, patients were stratified into two groups: ≥80 cc (group 1, n=57) and <80 cc (group 2, n=150). Transurethral PVP was performed using a 120W GreenLight HPS side-firing laser system. American Urological Association Symptom Score (AUASS), quality-of-life (QoL) score, maximum flow rate (Qmax), and postvoid residual (PVR) volume were measured preoperatively and at 1 and 4 weeks and 3, 6, 12, 18, 24, and 36 months postoperatively. Results: Among the preoperative parameters evaluated, there were significant differences (P<0.05) in the incidence of preoperative urinary retention (1: 24.6%; 2: 7.3%), serum prostate-specific antigen level (1: 4.5±2.7; 2: 1.8±1.9 ng/mL), QoL (1: 4.2±1.1; 2: 4.7±0.9), and mean prostate volume (1: 118.1±37.9; 2: 48.5±15.5 cc), while AUASS, Qmax, and PVR were similar (P>0.05) between groups. Significant differences (P<0.05) in laser use (1: 22.8±13.3; 2: 10.4±6.4 minutes) and energy usage (1: 152.7±90.6; 2: 70.9±44.8 kJ) were also noted. Clinical outcomes (AUASS, QoL, Qmax, and PVR) showed immediate and stable improvement from baseline (P<0.05) within each group, but no significant differences between the two groups were observed during the follow-up period (P>0.05). The incidence of adverse events was low and similar in both cohorts. Conclusions: These results suggest that prostate volume has little effect on the efficacy and safety of GreenLight HPS laser PVP, and that this technique remains a viable surgical option for BPH, irrespective of preoperative prostate volume. © Copyright 2012, Mary Ann Liebert, Inc.


Hasinovic H.,Ashland Consumer Markets | Friberg S.E.,Yangzhou University | Rong G.,Yangzhou University
Journal of Colloid and Interface Science | Year: 2011

Aqueous high internal phase volume ratio (O/W 90/10) Janus emulsions of a vegetable oil and a silicone fluid were prepared in a single step emulsification by the common vibrator equipment. The basis for the unique structure is discussed in relation to pair-wise interactions between the components with especial emphasis on the surfactant concentration in the aqueous phase. © 2010 Elsevier Inc.


Qiao S.,Lanzhou University | Feng G.,Yangzhou University | Feng G.,National Climate Center
Journal of Geophysical Research: Atmospheres | Year: 2016

During winter, the December North Atlantic Oscillation (NAO) has an impact on the following February East Asian trough (EAT), and a significant positive correlation exists between them. It is shown that the circulation anomalies affected by the December NAO for December and for the following January are primarily confined to the Euro-Atlantic sector while they extend to East Asia during the following February, and this is related to anomalous wave trains originating from the southwestern Atlantic and spreading to the northeastern Atlantic, northern Europe, western Siberia, and East Asia. When the NAO is positive phase in December, the sea surface temperature (SST) tripole pattern is forced by persistence positive NAO from December to the following January, contributing to pronounced positive SST anomalies in midlatitude areas of the North Atlantic during the following February. The pronounced positive SST anomalies found during this period can generate feedback for atmospheric anomalies, and the westerly winds are enhanced (reduced) to the north (south) side of the positive SST anomalies, which result from strengthened (weakened) baroclinicity there. In addition, the Rossby wave source over the northeastern Atlantic shows a positive anomaly, establishing a link between the positive SST anomalies in midlatitude areas of the North Atlantic and the deepened EAT downstream. ©2016. American Geophysical Union. All Rights Reserved.


Li T.,Yangzhou University | Li T.,Kansas State University | Bai G.,U.S. Department of Agriculture | Wu S.,Kansas State University | Gu S.,Yangzhou University
Theoretical and Applied Genetics | Year: 2011

Fusarium head blight (FHB) of wheat causes not only significant reduction in grain yield and end-use quality, but also the contamination of the grain with mycotoxins that are detrimental to human and animal health after consumption of infected grain. Growing resistant varieties is an effective approach to minimize the FHB damage. The Chinese wheat landrace Haiyanzhong (HYZ) shows a high level of resistance to FHB. To identify quantitative trait loci (QTL) that contribute to FHB resistance in HYZ, 136 recombinant inbred lines (RIL) were developed from a cross of HYZ and Wheaton, a hard spring wheat cultivar from the USA. The RIL and their parents were evaluated for percentage of scabbed spikelets (PSS) in both greenhouse and field environments. Five QTL were detected for FHB resistance in HYZ with one major QTL on 7DL. The 7DL QTL peaked at SSR marker Xwmc121, which is flanked by the SSR markers Xcfd46 and Xwmc702. This QTL explained 20.4-22.6% of the phenotypic variance in individual greenhouse experiments and 15.9% in a field experiment. Four other minor QTL on 6BS (two QTL), 5AS and 1AS each explained less than 10% of the phenotypic variance in individual experiments. HYZ carried the favorable alleles associated with FHB resistance at the QTL on 7DL, 6BS and 5AS, and the unfavorable allele at the QTL on 1AS. The major QTL on 7D can be used to improve the FHB resistance in wheat breeding programs and add diversity to the FHB resistance gene pool. © 2011 Springer-Verlag.


Hao D.,Nanjing Agricultural University | Hao D.,Jiangsu Yanjiang Institute of Agricultural science | Cheng H.,Nanjing Agricultural University | Yin Z.,Yangzhou University | And 4 more authors.
Theoretical and Applied Genetics | Year: 2012

Genome-wide association analysis is a powerful approach to identify the causal genetic polymorphisms underlying complex traits. In this study, we evaluated a population of 191 soybean landraces in five environments to detect molecular markers associated with soybean yield and its components using 1,536 single-nucleotide polymorphisms (SNPs) and 209 haplotypes. The analysis revealed that abundant phenotypic and genetic diversity existed in the studied population. This soybean population could be divided into two subpopulations and no or weak relatedness was detected between pair-wise landraces. The level of intra-chromosomal linkage disequilibrium was about 500 kb. Genome-wide association analysis based on the unified mixed model identified 19 SNPs and 5 haplotypes associated with soybean yield and yield components in three or more environments. Nine markers were found co-associated with two or more traits. Many markers were located in or close to previously reported quantitative trait loci mapped by linkage analysis. The SNPs and haplotypes identified in this study will help to further understand the genetic basis of soybean yield and its components, and may facilitate future high-yield breeding by marker-assisted selection in soybean. © 2011 Springer-Verlag.


Li S.,Yangzhou University | Fan L.,Xi'an Jiaotong University
Science China: Physics, Mechanics and Astronomy | Year: 2014

Free vibration of functionally graded beams with a through-width delamination is investigated. It is assumed that the material property is varied in the thickness direction as power law functions and a single through-width delamination is located parallel to the beam axis. The beam is subdivided into three regions and four elements. Governing equations of the beam segments are derived based on the Timoshenko beam theory and the assumption of 'constrained mode'. By using the differential quadrature element method to solve the eigenvalue problem of ordinary differential equations governing the free vibration, numerical results for the natural frequencies of the beam are obtained. Natural frequencies of delaminated FGM beam with clamped ends are presented. Effects of parameters of the material gradients, the size and location of delamination on the natural frequency are examined in detail. © 2014 Science China Press and Springer-Verlag Berlin Heidelberg.


Xu Y.,Suqian College | Frasin B.A.,Al al-Bayt University | Liu J.,Yangzhou University
Acta Mathematica Scientia | Year: 2013

In this paper we derive certain sufficient conditions for starlikeness and convexity of order α of meromorphically multivalent functions in the punctured unit disk. © 2013 Wuhan Institute of Physics and Mathematics.


Fan Y.,University of Tasmania | Shabala S.,University of Tasmania | Ma Y.,University of Tasmania | Xu R.,Yangzhou University | Zhou M.,University of Tasmania
BMC Genomics | Year: 2015

Background: Drought and salinity are two major abiotic stresses that severely limit barley production worldwide. Physiological and genetic complexity of these tolerance traits has significantly slowed the progress of developing stress-tolerant cultivars. Marker-assisted selection (MAS) may potentially overcome this problem. In the current research, seventy two double haploid (DH) lines from a cross between TX9425 (a Chinese landrace variety with superior drought and salinity tolerance) and a sensitive variety, Franklin were used to identify quantitative trait loci (QTL) for drought and salinity tolerance, based on a range of developmental and physiological traits. Results: Two QTL for drought tolerance (leaf wilting under drought stress) and one QTL for salinity tolerance (plant survival under salt stress) were identified from this population. The QTL on 2H for drought tolerance determined 42% of phenotypic variation, based on three independent experiments. This QTL was closely linked with a gene controlling ear emergency. The QTL on 5H for drought tolerance was less affected by agronomic traits and can be effectively used in breeding programs. A candidate gene for this QTL on 5H was identified based on the draft barley genome sequence. The QTL for proline accumulation, under both drought and salinity stresses, were located on different positions to those for drought and salinity tolerance, indicating no relationship with plant tolerance to either of these stresses. Conclusions: Using QTL mapping, the relationships between QTL for agronomic and physiological traits and plant drought and salinity tolerance were studied. A new QTL for drought tolerance which was not linked to any of the studied traits was identified. This QTL can be effectively used in breeding programs. It was also shown that proline accumulation under stresses was not necessarily linked with drought or salinity tolerance based on methods of phenotyping used in this experiment. The use of proline content in breeding programs can also be limited by the accuracy of phenotyping. © 2015 Fan et al.


Yang X.,Chongqing Jiaotong University | Song Q.,Chongqing Jiaotong University | Liu Y.,Yangzhou University | Liu Y.,King Abdulaziz University | Zhao Z.,Huzhou Teachers College
Neurocomputing | Year: 2015

Stability analysis of fractional-order neural networks with delay is addressed in this paper. By using the contracting mapping principle, method of iteration and inequality techniques, a sufficient condition is established to ensure the existence, uniqueness and finite-time stability of the equilibrium point of the proposed networks. Finally, based on the Predictor-Corrector Approach, two numerical examples are presented to illustrate the validity and feasibility of the obtained result. © 2014 Elsevier B.V.


Chang Y.-K.,National Taiwan Sport University | Nien Y.-H.,University of Taipei | Chen A.-G.,Yangzhou University | Yan J.,Yangzhou University
Journal of Sport and Health Science | Year: 2014

The relationship between physical activity (PA) and cognition has received much attention recently. While evidence of improved cognition following PA has consistently been observed, the majority of studies have spotlighted aerobic exercise and the effects of other modes of PA, such as Tai Ji Quan, on cognition have received limited attention. This article provides a brief review of the literature concerning the influence of Tai Ji Quan on cognition in older adults, including those with intact cognition and those with cognitive impairment. In addition, this review proposes potential mechanisms (cardiovascular fitness, motor fitness, movement coordination, social interaction, and meditation statuses as well brain structure and function) evaluated from a neuroimaging perspective that may explain the Tai Ji Quan-cognition relationship. Finally, we present suggestions for future research. In conclusion, Tai Ji Quan, with its multi-faceted characteristics, shows promise as a mode of PA for enhancing cognition, as well as brain health, in older adults. Based on the findings in this review, further exploration of the effects of Tai Ji Quan on cognition in older adults is warranted. © 2014 Shanghai University of Sport.


Gu C.,Appalachian State University | Bai Y.,Yangzhou University | Tao T.,Yangzhou University | Chen G.,Yangzhou University | Shan Y.,Yangzhou University
Journal of Environmental Quality | Year: 2013

Mudflat soil amendment by sewage sludge is a potential way to dispose of solid wastes and increase fertility of mudflat soils for crop growth. the present study aimed to assess the impact of sewage sludge amendment (SSA) on heavy metal accumulation and growth of ryegrass (Lolium perenne L.) in a seedling stage. We investigated the metal availability, plant uptake, and plant yield in response to SSA at rates of 0, 30, 75, 150, and 300 t ha-1. the SSA increased the metal availability in a mudflat soil and subsequently metal accumulation in ryegrass. the SSA increased the bioavailable fraction of the metals by 4550, 58.8, 898, 189, 35.8, and 84.8% for Zn, Mn, Cu, Ni, Cr, and Cd, respectively, at an SSA rate of 300 t ha-1 as compared to unamended soil. Consequently, the metal concentrations in ryegrass increased by 1130, 12.9, 355, 108, 2230, and 497% in roots and by 431, -4.3, 92.6, 58.3, 890, and 211% in aboveground parts, for Zn, Mn, Cu, Ni, Cr, and Cd, respectively, at the 300 t ha-1 rate as compared to unamended soil. the enhanced metal accumulation, however, did not induce growth inhibition of ryegrass. Fresh weight of aboveground parts and roots of ryegrass at 300 t ha-1 SSA rate increased by 555 and 128%, respectively, as compared to those grown in unamended soil. the study suggests that SSA can promote yield of ryegrass seedlings grown in mudflat soils. None of metal concentrations at all SSA rates was above the Chinese permissible limits. Despite the data at only the seedling stage, our results indicate that SSA in mudflat soils might be a potential way for mudflat soil fertility improvement and sewage sludge disposal. Further study at plants' maturity stage is warranted to fully assess the suitability of sewage sludge amendment on mudflat soils. © American Society of Agronomy, Crop Science Society of America, and Soil Science Society of America.


Qian L.,Second Military Medical University | Qian L.,Yangzhou University | Qian C.,Second Military Medical University | Chen Y.,Second Military Medical University | And 5 more authors.
Blood | Year: 2012

Regulatory dendritic cells (DCs) play important roles in the induction of peripheral tolerance and control of adaptive immune response. Our previous studies demonstrate that splenic stroma can drive mature DCs to proliferate and further differentiate into a unique subset of CD11b hiIa low regulatory DCs, which could inhibit T-cell response, program generation of immunosuppressive memory CD4 T cells. However, the effect of regulatory DCs on B-cell function remains unclear. Here, we report that regulatory DCs can induce splenic B cells to differentiate into a distinct subtype of IL-10-producing regulatory B cells with unique phenotype CD19 hiFcγIIb hi. CD19 hiFcγIIb hi B cells inhibit CD4 T-cell response via IL-10. CD19 hiFcγIIb hi B cells have enhanced phagocytic capacity compared with conventional CD19 + B cells, and FcγRIIb mediates the uptake of immune complex by CD19 hiFcγIIb hi B cells. We found that regulatory DC-derived IFN-β and CD40 ligand are responsible for the differentiation of CD19 hiFcγIIb hi B cells. Furthermore, an in vivo counterpart of CD19 hiFcγIIb hi B cells in the spleen and lymph nodes with similar phenotype and regulatory function has been identified. Our results demonstrate a new manner for regulatory DCs to down-regulate immune response by, at least partially, programming B cells into regulatory B cells. © 2012 by The American Society of Hematology.


Luo J.,Yangzhou University | Luo J.,University of Bergen | Helleseth T.,University of Bergen
IEEE Transactions on Information Theory | Year: 2011

Constant composition codes are codes where the frequency distribution of the elements in a codeword is the same for all codewords. In this paper, three classes of constant composition codes are constructed. These codes are subcodes of cyclic codes which have few weights occurring among the codewords. The new codes are excellent asymptotically compared to the previously best known constant composition codes. © 2011 IEEE.


Yao G.,Yangzhou University | Zhang B.,East China University of Science and Technology | Zhang B.,Beijing Institute of Technology | Xiu G.,East China University of Science and Technology | And 2 more authors.
Fuel | Year: 2013

Although the detonation phenomenon in liquid hydrocarbon fuel/air mixtures is a significant issue for chemical processing and development of propulsion materials, very limited amount of critical energy of direct initiation and detonation cell size - which provide a measure of detonability or sensitivity of an explosive mixture - are available in literature. In this study, the critical energies for direct initiation of planar detonations and detonation cell sizes in propylene oxide (PO), petroleum ether, isopropyl nitrate (IPN), n-hexane, n-heptane, n-decane and air mixtures are carried out in a vertical detonation tube with an inner diameter of 200 mm and a length of 6.5 m. In the experiment, direct initiation is achieved via #8 industrial electronic detonator associate with different amount of high explosive (i.e., Hexogen), the initiation energy is estimated accordingly to the amount of the explosive. Characteristic detonation cell sizes of those liquid hydrocarbon fuel/air mixtures are measured and obtained simultaneously. The experimental results show that the relationship between critical energy of direct detonation initiation and equivalence ratio is a 'U' shape behavior. For the alkane fuels, i.e., n-hexane, n-heptane, n-decane, the critical energy rises gradually with the increase of the carbon atom number of the liquid hydrocarbon fuel/air mixtures. By measuring the detonation cell size, it is found detonation cell sizes in the liquid hydrocarbon/air mixtures are very irregular, the behavior between cell size and equivalence is also a 'U' shaped curve. By the comparison of the critical energy and detonation cell size, it is shown PO/air and IPN/air are very sensitive to from a detonation, which followed by n-hexane/air and petroleum ether/air, the detonation sensitivity is relatively weak for n-heptane/air and n-decane/air. © 2013 Elsevier Ltd. All rights reserved.


Meng S.,Dalian Medical University | Xu J.,Yangzhou University | Wu Y.,Yangzhou University | Ding C.,Chinese Academy of Agricultural Sciences
Expert Opinion on Biological Therapy | Year: 2013

Introduction: Autophagy is a conserved catabolic process crucial in maintaining cellular homeostasis. On infection, oncolytic viruses (OVs) perturb the cellular autophagy machinery in infected tumor cells both in vitro and in vivo. Currently, pharmacological modulation of autophagy in OV-infected tumor cells has been shown to augment OV-mediated antitumor effects in preclinical studies. Combination of OVs with autophagy modulators can, therefore, have many potential applications in the future research on targeting autophagy and novel anticancer therapies. Areas covered: This review provides a detailed description of known interactions between OVs and autophagy and summarizes the roles of autophagy in OV replication and cell lysis. The recent literature on targeting autophagy with either the autophagy inducers, such as rapamycin, or autophagy inhibitors, such as chloroquine, to increase OV-induced cytotoxicity is reviewed to help researchers in further investigations. The major challenge for investigators is to understand the molecular mechanism underlying the interplay between OV and the autophagy machinery and its effect on oncolysis. Expert opinion: Targeting the cellular autophagy machinery could be explored as a new therapeutic strategy to enhance OV-mediated antitumor effects in the future. © 2013 Informa UK, Ltd.


Zhang K.-L.,Yangzhou University | Hou C.-T.,Yangzhou University | Song J.-J.,Yangzhou University | Deng Y.,Yangzhou University | And 3 more authors.
CrystEngComm | Year: 2012

Two temperature-dependent structures of 2D and 3D Zn(ii)-organic frameworks (ZOFs) with a new 5-substituted benzene-1, 3-dicarboxylic ligand, 5-iodoisophthalic acid (H2IIP), and an auxiliary flexible ligand, 1,4-bis(1,2,4-triazol-1-yl)butane (btb), with different motifs, have been investigated. Results show that when the reaction was carried out at room temperature, a undulating 2D (4,4)-network, {[Zn(IIP)(btb)]·4H 2O}n (1), which further extends into a novel "soft" 3D supramolecular microporous framework with two kinds of 1D nanochannels supported by face to face π⋯π stacking interactions and C-I⋯I halogen bonds, was generated. Under hydrothermal condition at 170 °C, however, a two-fold interpenetrated 3D framework with α-Po network topology, [Zn(IIP)(btb)]n (2), would be obtained. Interestingly, both the right- and left-handed 21 helical water chains lie in one kind of the nanochannels in 1. When the auxiliary ligand was replaced by a less flexible one with a shorter spacer length, 1,3-bis(1,2,4-triazol-1-yl)propane (btp), a novel temperature-independent single-walled discrete coordination tube, {[Zn(IIP)(btp)]·2H 2O}n (3), was obtained at the same two temperatures. Inside the tube is found the 21 helical water chain. Interestingly, the reversible desorption/adsorption behavior to water is significantly observed in the frameworks 1 and 3. The framework 1 falls within the category of "recoverable collapsing" and "guest-induced re-formation" frameworks. The result shows their potential application as late-model water absorbents in the field of adsorption materials. Remarkably, the first discrete single-walled Zn(ii) coordination tube 3 shows high framework stability and exhibits reversible desorption/adsorption to some small guest organic molecules (methanol, ethanol and isopropanol). Furthermore, these compounds exhibit blue fluorescence in the solid state.


Yang L.,Xuzhou Normal University | Xu L.,Yangzhou University
Information Sciences | Year: 2011

Rough set theory is a powerful mathematical tool for dealing with inexact, uncertain or vague information. The core concepts of rough set theory are information systems and approximation operators of approximation spaces. Approximation operators draw close links between rough set theory and topology. This paper concerns generalized approximation spaces via topological methods and studies topological properties of rough sets. Classical separation axioms, compactness and connectedness for topological spaces are extended to generalized approximation spaces. Relationships among separation axioms for generalized approximation spaces and relationships between topological spaces and their induced generalized approximation spaces are investigated. An example is given to illustrate a new approach to recover missing values for incomplete information systems by regularity of generalized approximation spaces. © 2011 Elsevier Inc. All rights reserved.


Wu X.,Shanghai Institute of Technology | He J.,Yangzhou University | Chen J.,Shanghai Institute of Technology | Yang S.,Shanghai Institute of Technology | Zha D.,Shanghai Institute of Technology
Protoplasma | Year: 2014

Cytokinins were recently shown to control plant adaptation to environmental stresses. To characterize the roles of cytokinins in the tolerance of eggplant (Solanum melongena Mill.) to salt stress, the protective effects of 6-benzyladenine (6-BA) on the growth, photosynthesis, and antioxidant capacity in the leaves of two eggplant cultivars Huqie12 (salt-sensitive) and Huqie4 (salt-tolerant) were investigated. Under 90 mM NaCl stress, Huqie4 showed higher biomass accumulation and less oxidative damage compared to the Huqie12. Application of exogenous 10 μM 6-BA significantly alleviated the growth suppression caused by salt stress in two eggplant genotypes. In parallel with the growth, 6-BA application in salt-stressed plants resulted in enhanced chlorophyll contents, as well as photosynthetic parameters such as net CO2 assimilation rate (P n), stomatal conductance (g s), transpiration rate (E), and intercellular CO2 concentration (C i). Furthermore, exogenous 6-BA also significantly reduced the O2 - production rate and malondialdehyde content and markedly increased the antioxidant enzymes superoxide dismutase and peroxidase, the antioxidant metabolites ascorbate and reduced glutathione (GSH), and proline in both genotypes under salt stress. The results indicate that exogenous 6-BA is useful to improve the salt resistance of eggplant, which is most likely related to the increase in photosynthesis and antioxidant capacity. © 2013 Springer-Verlag Wien.


Deng S.,Yangzhou University | Ye X.,Ningbo University
Procedia Engineering | Year: 2016

In this paper, we takes the parking vehicle out of the off-street parking access in the city as the research object, analyzes the main influence factors of the vehicle in the process of entering in the parking lot, and the crossing time is defined as the cross through the waiting time and travel time. By the way of theoretical analysis and field investigation, we present one calculation model through the waiting time while another through the travel time, and verify the analysis. Based on the measured data about parking entering rate, we conducted a sensitivity analysis the combination conditions of different non-motorized vehicle lane width and flow, the main conclusions are as follow: First of all, compared with the non-motorized vehicle lane width, the impact of non-motorized vehicle flow on crossing time is more obvious; Secondly, in the same flow conditions, changes of crossing time and non-motorized vehicle lane width is inversely proportional to the width of non-motorized vehicle lane; Thirdly, when less than 5 meters, crossing time changed significantly affected by it; finally, when the non-motorized vehicle lane width is greater than 6 meters, crossing time had small changes affected by it. © 2016 The Authors. Published by Elsevier Ltd.


Chai H.-N.,Yangzhou University | Du Y.-Z.,Yangzhou University | Zhai B.-P.,Nanjing Agricultural University
International Journal of Biological Sciences | Year: 2012

The complete mitochondrial genomes (mitogenomes) of Cnaphalocrocis medinalis and Chilo suppressalis (Lepidoptera: Pyralidae) were determined and analyzed. The circular genomes were 15,388 bp long for C. medinalis and 15,395 bp long for C. suppressalis. Both mitogenomes contained 37 genes, with gene order similar to that of other lepidopterans. Notably, 12 protein-coding genes (PCGs) utilized the standard ATN, but the cox1 gene used CGA as the initiation codon; the cox1, cox2, and nad4 genes in the two mitogenomes had the truncated termination codons T, T, and TA, respectively, but the nad5 gene was found to use T as the termination codon only in the C. medinalis mitogenome. Additionally, the codon distribution and Relative Synonymous Codon Usage of the 13 PCGs in the C. medinalis mitogenome were very different from those in other pyralid moth mitogenomes. Most of the tRNA genes had typical cloverleaf secondary structures. However, the dihydrouridine (DHU) arm of the trnS1(AGN) gene did not form a stable stem-loop structure. Forty-nine helices in six domains, and 33 helices in three domains were present in the secondary structures of the rrnL and rrnS genes of the two mitogenomes, respectively. There were four major intergenic spacers, except for the A+T-rich region, spanning at least 12 bp in the two mitogenomes. The A+T-rich region contained an ′ATAGT(A)′-like motif followed by a poly-T stretch in the two mitogenomes. In addition, there were a potential stem-loop structure, a duplicated 25-bp repeat element, and a microsatellite ′(TA)13′ observed in the A+T-rich region of the C. me-dinalis mitogenome. A poly-T motif, a duplicated 31-bp repeat element, and a 19-bp triplica-tion were found in the C. suppressalis mitogenome. However, there are many differences in the A+T-rich regions between the C. suppressalis mitogenome sequence in the present study and previous reports. Finally, the phylogenetic relationships of these insects were recon-structed based on amino acid sequences of mitochondrial 13 PCGs using Bayesian inference and maximum likelihood methods. These molecular-based phylogenies support the traditional morphologically based view of relationships within the Pyralidae. © Ivyspring International Publisher.


Guo P.,CAS Shanghai Institute of Applied Physics | Guo P.,University of Chinese Academy of Sciences | Tu Y.,Yangzhou University | Yang J.,CAS Shanghai Institute of Applied Physics | And 4 more authors.
Physical Review Letters | Year: 2015

By combining molecular dynamics simulations and quantum mechanics calculations, we show the formation of a composite structure composed of embedded water molecules and the COOH matrix on carboxyl-terminated self-assembled monolayers (COOH SAMs) with appropriate packing densities. This composite structure with an integrated hydrogen bond network inside reduces the hydrogen bonds with the water above. This explains the seeming contradiction on the stability of the surface water on COOH SAMs observed in experiments. The existence of the composite structure at appropriate packing densities results in the two-step distribution of contact angles of water droplets on COOH SAMs, around 0° and 35°, which compares favorably to the experimental measurements of contact angles collected from forty research articles over the past 25 years. These findings provide a molecular-level understanding of water on surfaces (including surfaces on biomolecules) with hydrophilic functional groups. © 2015 American Physical Society. © 2015 American Physical Society.


Wei Z.,Nanjing Agricultural University | Yang X.,Nanjing Agricultural University | Yin S.,Yangzhou University | Shen Q.,Nanjing Agricultural University | And 2 more authors.
Applied Soil Ecology | Year: 2011

Ralstonia solanacearum (Smith) has been a severe pathogen on tomato worldwide and no effective control measure is available yet. To develop a new bio-product for controlling this disease, antagonistic Bacillus amyloliquefaciens strains QL-5 and QL-18 were isolated from rhizosphere soil of tomato and used separately or together to fortify organic fertilisers to control bacterial wilt of tomato (BWT), both in the greenhouse and in the field. The bio-organic fertiliser (BOF) fortified with a mixed inoculation of QL-5 and QL-18 effectively decreased R. solanacearum disease incidence in both greenhouse and field conditions. However, the suppressive efficacy in the field depended on the season. Disease incidence in the spring crop season in 2009 and 2010 was significantly reduced, while a low suppressive effect was observed in the autumn crop season in 2008 and 2009. The initial R. solanacearum population in the soil was nearly three times lower in the spring before transplanting seedlings than in the autumn crop season. The pathogen population in the field was positively and significantly correlated with air temperature but was not correlated with relative humidity. The interaction between BOF and other soil and climatic factors that affect pathogen density in the field should be clarified. © 2011 Elsevier B.V.


Song H.,Nanjing Agricultural University | Yin Z.,Yangzhou University | Chao M.,Nanjing Agricultural University | Ning L.,Nanjing Agricultural University | And 2 more authors.
Plant, Cell and Environment | Year: 2014

In this paper, we analyzed the function and modulation of the soybean phosphate transporter gene GmPT1. Overexpression of GmPT1 in tobacco showed that this gene played a role in Pi remobilization. In a soybean RIL population, the expression level of GmPT1 showed significantly positive correlations with seed yield, phosphorus-use efficiency, photosynthetic rate (PN) and the quantum yield of PSII primary photochemistry (ΦPSII). Expression quantitative trait loci (eQTL) mapping for GmPT1 revealed one cis-eQTL and one trans-eQTL. These results suggest the possibility to improve soybean seed yields under Pi-limiting conditions by modulating GmPT1 expression. Phosphate (Pi) remobilization within a plant is critical for plant survival under Pi-limiting conditions. In this paper, a soybean Pi transporter gene, GmPT1, was characterized. A marked induction of GmPT1 transcript was observed in young leaves, mature leaves and lateral roots during long-term Pi starvation. Transgenic tobacco plants containing the GmPT1 gene were obtained using an Agrobacterium-mediated transformation system. Compared with wild-type plants, transgenic plants showed significant increases in phosphorus-use efficiency (PUE), photosystem II (PSII) function, total dry weight and seed weight under Pi-deficient conditions. GmPT1 expression levels and PUE were determined in a soybean recombinant inbred line population during a pot experiment that was conducted to measure chlorophyll fluorescence parameters, photosynthetic rate (PN) and seed yield. Correlation analysis revealed that GmPT1 expression levels had significantly positive correlations with seed yield, PUE, PN and the quantum yield of PSII primary photochemistry (ΦPSII). Expression quantitative trait loci (eQTL) mapping for GmPT1 revealed two eQTLs, one of which coincided with both the physical location of GmPT1 and a QTL associated with seed yield. These results suggest that GmPT1 plays a role in Pi remobilization, and it may be possible to improve soybean seed yields under Pi-limiting conditions by modulating GmPT1 expression levels. © 2013 John Wiley & Sons Ltd.


Lu L.,Yangzhou University | Yin S.,Yangzhou University | Liu X.,Gansu Agricultural University | Zhang W.,Gansu Agricultural University | And 3 more authors.
Soil Biology and Biochemistry | Year: 2013

Most previous studies on soil microbial communities have been focused on species abundance and diversity, but not the interactions among species. In present study, the Molecular Ecological Network Analysis tool was used to study the interactions and network organizations of fungal communities in yield-invigorating (healthy) and -debilitating (diseased) soils induced by prolonged potato monoculture, based on the relative abundances of internal transcribed spacer sequences derived using pyrosequencing. An emphasis was placed on the differences between the healthy and diseased networks. The constructed healthy and diseased networks both showed scale-free, small world and modular properties. The key topological properties and phylogenetic composition of the two networks were similar. However, major differences included: a) the healthy network had more number of functionally interrelated operational taxonomic units (OTUs) than the diseased one; b) healthy network contained 6 (4%) generalist OTUs whereas the diseased contained only 1 (0.6%) marginal generalist OTU; and c) majority (55%) of OTUs in healthy soils were stimulated by a certain set of soil variables but the majorities (63%) in diseased soils were inhibited. Based on these data, a conceptual picture was synthesized: a healthy community was a better organized or a better operated community than the diseased one; a healthy soil was a soil with variables that encouraged majority of fungi whereas a diseased soil discouraged. By comparing the topological roles of different sets of shared OTUs between healthy and diseased networks, it was found that role-shifts prevailed among the network members such as generalists/specialists, significant module memberships and the OTU sets irresponsive to soil variables in one network but responsive in the counterpart network. Soil organic matter was the key variable associated with healthy community, whereas ammonium nitrogen (NH4 +-N) and Electrical conductivity (EC) were the key variables associated with diseased community. Major affected phylogenetic groups were Sordariales and Hypocreales. © 2013 The Authors.


Wang J.,Yangzhou University | Li Y.,Yangzhou University | Han Z.,Nanjing Agricultural University | Zhu Y.,Yangzhou University | And 3 more authors.
PLoS ONE | Year: 2012

Ryanodine receptors (RyRs) are the targets of two novel classes of synthetic insecticidal chemicals, phthalic acid diamides and anthranilic diamides. Isolation of full-length RyR cDNAs is a critical step towards the structural and functional characterization of insect RyRs and an understanding of the molecular mechanisms underlying the species selective toxicity of diamide insecticides. However, there has been little research on the insect RyR genes due to the high molecular weight of the RyR proteins. In this study, we isolated a full-length RyR cDNA (named as CmRyR) from Cnaphalocrocis medinalis, an important rice pest throughout Southeast Asia. The composite CmRyR gene contains an ORF of 15264 bp encoding a protein of 5087 amino acid residues, which shares 79% overall identity with its Drosophila melanogaster homologue. All hallmarks of the RyR proteins are conserved in the CmRyR protein, suggesting that CmRyR is a structural and functional analogue of known RyRs. A multiple sequence alignment illustrates that the insect RyRs share high levels of amino acid sequence identity at the the COOH-terminal region. However, the amino acid residues analogous to the CmRyR residues N4922, N4924, N4935, L4950, L4981, N5013 and T5064 are unique to lepidopteran RyRs compared with non-lepidopteran insect RyRs. This finding suggests that these residues may be involved in the differences in channel properties between lepidopteran and non-lepidopteran insect RyRs and in the species selective toxicity of diamide insecticides. Furthermore, two alternative splicing sites were identified in the CmRyR gene, one of which was located in the central part of the predicted second SPRY domain. Diagnostic PCR showed that the inclusion frequencies of two mutually exclusive exons (a/b) and one optional exon (c) differed between developmental stages or adult anatomical regions. Our results imply that alternative splicing may be a major means of generating functional diversity in C. medinalis RyR channel. © 2012 Wang et al.


Yang J.,CAS Shanghai Institute of Applied Physics | Shi G.,CAS Shanghai Institute of Applied Physics | Tu Y.,Yangzhou University | Fang H.,CAS Shanghai Institute of Applied Physics
Angewandte Chemie - International Edition | Year: 2014

Recent experiments have shown the coexistence of both large unoxidized and oxidized regions on graphene oxide (GO), but the underlying mechanism for the formation of the GO atomic structure remains unknown. Now, using density functional calculations, 52 oxidation pathways for local pyrene structures on GO were identified, and a kinetic profile for graphene oxidation with a high correlation between oxidation loci was proposed, which is different from the conventional view, which entails a random distribution of oxidation loci. The high correlation is an essential nature of graphene oxidation processes and can be attributed to three crucial effects: 1) breaking of delocalized π bonds, 2) steric hindrance, and 3) hydrogen-bond formation. This high correlation leads to the coexistence of both large unoxidized and oxidized regions on GO. Interestingly, even in oxidized regions on GO, some small areas of sp2-hybridized domains, similar to "islands", can persist because of steric effects. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Wu A.,CAS Institute of Biophysics | Su C.,Yangzhou University | Wang D.,Chinese National Institute for Viral Disease Control and Prevention | Peng Y.,Hunan University | And 15 more authors.
Cell Host and Microbe | Year: 2013

Initial genetic characterizations have suggested that the influenza A (H7N9) viruses responsible for the current outbreak in China are novel reassortants. However, little is known about the pathways of their evolution and, in particular, the generation of diverse viral genotypes. Here we report an in-depth evolutionary analysis of whole-genome sequence data of 45 H7N9 and 42 H9N2 viruses isolated from humans, poultry, and wild birds during recent influenza surveillance efforts in China. Our analysis shows that the H7N9 viruses were generated by at least two steps of sequential reassortments involving distinct H9N2 donor viruses in different hosts. The first reassortment likely occurred in wild birds and the second in domestic birds in east China in early 2012. Our study identifies the pathways for the generation of diverse H7N9 genotypes in China and highlights the importance of monitoring multiple sources for effective surveillance of potential influenza outbreaks. © 2013 Elsevier Inc.


Ma Y.C.,Nanjing Agricultural University | Kong X.W.,Nanjing Agricultural University | Yang B.,Nanjing Agricultural University | Zhang X.L.,Nanjing Agricultural University | And 3 more authors.
Agriculture, Ecosystems and Environment | Year: 2013

The impact of management practices on the net global warming potential (GWP) and greenhouse gas intensity (GHGI) of rice cropping systems is not well documented. A field experiment was established in 2009 to gain insight into the net ecosystem carbon budget and the net GWP and GHGI on the crop seasonal scale over two cycles of rice-wheat rotations. With the local farmer's practices (FP) as the control, three integrated soil-crop system management (ISSM) practices at different nitrogen (N) application rates were established - ISSM-N1, ISSM-N2 and ISSM-N3 - for improvement of rice yield and agronomic nitrogen use efficiency (NUE). Compared with the FP, the rice yields significantly increased by 8.2%, 18% and 31%, while the agronomic NUE increased by 68%, 74% and 99% for ISSM-N1, ISSM-N2 and ISSM-N3, respectively. Within the three ISSM practices averaged over the two cycles, the soil organic carbon sequestration potentials, CH4 and N2O emissions were estimated to be 0.089-0.67tCha-1yr-1, 166-288kgCH4Cha-1yr-1 and 4.27-5.47kgN2ONha-1yr-1, respectively. Compared to the net GWPs (8.36tCO2eqha-1yr-1) and GHGI (0.58kgCO2eqkg-1 grain) from the FP, the ISSM-N1 and ISSM-N2 reduced both the net GWPs and GHGIs to some extent, indicating that GHG mitigation can be simultaneously achieved with improved food production and NUE. Although it produced similar GHGIs, the ISSM-N3 increased the net GWPs by 16% compared to the FP, indicating that more research is required on ISSMs for mitigating GHGs to further increase the grain yield and NUE in rice agriculture. © 2012 Elsevier B.V.


Zhou B.,Nanjing Agricultural University | Liu H.L.,Nanjing Agricultural University | Shi F.X.,Nanjing Agricultural University | Wang J.Y.,Yangzhou University
Animal Genetics | Year: 2010

MicroRNAs (miRNAs) are endogenous non-coding RNAs of ∼22 nucleotides in length that play important roles in multiple biological processes by degrading targeted mRNAs or repressing mRNA translation. To evaluate the roles of miRNA in porcine skeletal muscle, miRNA expression profiles were investigated using longissimus muscle tissue from pigs at embryonic day 90 (E90) and postpartum day 120 (PD120). First, we used previously known miRNA sequences from humans and mice to perform blast searches against the porcine expressed sequence tag (EST) database; 98 new miRNA candidates were identified according to a range of filtering criteria. These miRNA candidates and 73 known miRNAs (miRBase 13.0) from pigs were chosen for porcine miRNA microarray analysis. A total of 16 newly identified miRNAs and 31 previously known miRNAs were detected in porcine skeletal muscle tissues. During later foetal development at E90, miR-1826, miR-26a, miR-199b and let-7 were highly expressed, whilst miR-1a, miR-133a, miR-26a and miR-1826 showed highest abundance during the fast growing stage at PD120. Using the 47 miRNAs detected by the microarray assay, we performed further investigations using the publicly available porcine mRNA database from NCBI and computed potential target hits using the software rnahybrid. This study identified 16 new miRNA candidates, computed potential target hits for 18 miRNA families and determined the miRNA expression profiles in porcine skeletal muscle tissues at different developmental stages. These results provide a valuable resource for investigators interested in post-transcriptional gene regulation in pigs and related animals. © 2010 Stichting International Foundation for Animal Genetics.


Li W.,Yangzhou University | Li W.,Jiangsu Key Laboratory Of Intgd Traditional Chinese And W Med For Prev And Treatm Of Senile Diseases | Xing Y.,Dalian University of Technology | Liu Y.,Dalian University of Technology
Cancer Chemotherapy and Pharmacology | Year: 2015

Drug combinations including irinotecan and gefitinib have been evaluated in clinical trials. SN-38 is the active metabolite of irinotecan, and the increase in its concentration due to drug interactions will result in increased clinical toxicity. We aimed to investigate the effects of gefitinib and its predominant metabolite observed in human plasma, O-desmethyl-gefitinib (DMG), on SN-38 glucuronidation. Our data indicated that both gefitinib and DMG are potent inhibitors of SN-38 glucuronidation via UGT1A1 inhibition. It is predicted from in vitro data that gefitinib administered at 700 mg/day may result in about 149 % increase in SN-38 AUC, but there is no significant effects on SN-38 AUC at lower concentrations. Our prediction study provides a basis for design of clinical studies for the development and optimization of this combination. © 2015 Springer-Verlag Berlin Heidelberg.


Liu J.,Yangzhou University | Liu J.,Nanjing Agricultural University | Luo J.,Nanjing Agricultural University | Ye H.,Nanjing Agricultural University | Zeng X.,Nanjing Agricultural University
Food and Chemical Toxicology | Year: 2012

A levan-type exopolysaccharide (EPS) from Paenibacillus polymyxa EJS-3 was successfully acetylated, phosphorylated and benzylated, respectively, affording its derivatives of acetylated levan (AL), phosphorylated levan (PL) and benzylated levan (BL). Then, the antioxidant and antitumor activities in vitro of the natural polysaccharide and its derivatives were determined. As results, AL, BL and PL all exhibited higher reducing power, scavenging activity against superoxide radical and scavenging activity on hydroxyl radical than the natural polysaccharide, EPS-1. In addition, AL, BL and PL also exhibited higher antiproliferative activity against human gastric cancer BGC-823 cells in vitro than EPS-1. The enhanced activities of the derivatives were probably due to the introduction of acetyl, benzyl, or phosphoryl groups into EPS-1 molecules that increased electron-donating ability and affinity with the receptors on immune cells. The results suggested that the derivatives could be explored as promising antioxidant and antitumor agents. © 2011 Elsevier Ltd.


Li Z.,Yangzhou University | Li Z.,Jiangsu University | Han J.,Yangzhou University | Fan L.,Yangzhou University | And 3 more authors.
Chemical Communications | Year: 2015

By exploiting a facile and controllable anion exchange strategy, mesoporous α-Ni(OH)2 nanowires with multinanocavities in surfaces have been successfully developed. The novel nanoscale morphology has been proven to be responsible for their excellent capacitive performances. This journal is © The Royal Society of Chemistry 2015.


Guo X.,Yangzhou University | Gao J.,Yangzhou University | Li F.,Nanjing Agricultural University | Wang J.,Yangzhou University
Scientific Reports | Year: 2014

Horizontal transfer (HT) of transposable elements has been recognized to be a major force driving genomic variation and biological innovation of eukaryotic organisms. However, the mechanisms of HT in eukaryotes remain poorly appreciated. The non-autonomous Helitron family, Lep1, has been found to be widespread in lepidopteran species, and showed little interspecific sequence similarity of acquired sequences at 3-2 end, which makes Lep1 a good candidate for the study of HT. In this study, we describe the Lep1-like elements in multiple non-lepidopteran species, including two aphids, Acyrthosiphon pisum and Aphis gossypii, two parasitoid wasps, Cotesia vestalis, and Copidosoma floridanum, one beetle, Anoplophora glabripennis, as well as two bracoviruses in parasitoid wasps, and one intracellular microsporidia parasite, Nosema bombycis. The patchy distribution and high sequence similarity of Lep1-like elements among distantly related lineages as well as incongruence of Lep1-like elements and host phylogeny suggest the occurrence of HT. Remarkably, the acquired sequences of both NbLep1 from N. bombycis and CfLep1 from C. floridanum showed over 90% identity with their lepidopteran host Lep1. Thus, our study provides evidence of HT facilitated by host-parasite interactions. Furthermore, in the context of these data, we discuss the putative directions and vectors of HT of Lep1 Helitrons.


Van Esch B.,TU Eindhoven | Cheng L.,Yangzhou University
ASME-JSME-KSME 2011 Joint Fluids Engineering Conference, AJK 2011 | Year: 2011

Many mixed-flow and axial flow pumps exhibit a so-called unstable head curve. Due to the risk of instabilities this flow region is usually avoided during pump operation. This paper presents experimental and numerical research on the relation between the instability in the head curve and the magnitude of unsteady hydraulic forces. It is found that there is a strong influence of the extend of the clearance gap between impeller blades and casing. The spectral content of the forces shows evidence of rotating instabilities. It indicates that not only instability of the head curve and unsteady forces are interrelated, but also rotating instabilities play a role in this phenomenon. Results of CFD calculations are presented as well, showing the difficulties in simulating the flow under such conditions. Copyright © 2011 by ASME.


Grant
Agency: GTR | Branch: BBSRC | Program: | Phase: Research Grant | Award Amount: 22.79K | Year: 2011

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.


Zhang J.,Yangzhou University | Peng A.,Huaihai Institute of Technology
Transactions of Nanjing University of Aeronautics and Astronautics | Year: 2010

Based on analyzing the influences of a slicing scheme on stair-stepping effect, supporting structure, efficiency and deformation, etc., analytical hierarchical process (AHP) combining with fuzzy synthetic evaluation is introduced to make decision in slicing schemes for a processing part. The application in determining the slicing scheme for a computer mouse during prototyping shows that the method increases the rationality during decision-making and improves quality and efficiency for the prototyping part.


Wang Z.,Donghua University | Wang Z.,Brunel University | Liu Y.,Yangzhou University | Liu X.,Brunel University | Shi Y.,Chinese Academy of Sciences
Neurocomputing | Year: 2010

In this paper, the robust H state estimation problem is investigated for a general class of uncertain discrete-time stochastic neural networks with probabilistic measurement delays. The measurement delays of the neural networks are described by a binary switching sequence satisfying a conditional probability distribution. The neural network under study involves parameter uncertainties, stochastic disturbances and time-varying delays, and the activation functions are characterized by sector-like nonlinearities. The problem addressed is the design of a full-order state estimator, for all admissible uncertainties, nonlinearities and time-delays, the dynamics of the estimation error is constrained to be robustly exponentially stable in the mean square and, at the same time, a prescribed H disturbance rejection attenuation level is guaranteed. By using the Lyapunov stability theory and stochastic analysis techniques, sufficient conditions are first established to ensure the existence of the desired estimators. These conditions are dependent on the lower and upper bounds of the time-varying delays. Then, the explicit expression of the desired estimator gains is described in terms of the solution to a linear matrix inequality (LMI). Finally, a numerical example is exploited to show the usefulness of the results derived. © 2010 Elsevier B.V.


Liu L.,Yangzhou University | Chen T.,Yangzhou University | Wang Z.,Yangzhou University | Zhang H.,Yangzhou University | And 2 more authors.
Field Crops Research | Year: 2013

Site-specific nitrogen management (SSNM) and alternate wetting and drying (AWD) irrigation are two applied technologies developed in recent years in rice production. Little is known, however, how synergistic these two technologies can be in terms of grain yield, nitrogen and water use efficiencies. We investigated this issue using super rice under SSNM, AWD, or both. Two super rice varieties subjected to four N and irrigation treatments, i.e., continuously flooded (CF) and farmer's N practice (FNP) (CF-FNP), CF-SSNM, AWD-FNP, and AWD-SSNM, were field-grown in 2011 and 2012. SSNM or AWD significantly increased the percentage of productive tillers, leaf area duration, leaf photosynthetic rate, root oxidation activity and dry matter accumulation during grain filling compared with FNP or CF. Such increases were more evident when both AWD and SSNM were adopted together. The AWD-SSNM treatment increased not only the number of spikelets per panicle, but also the percentage of filled grains and grain weight. Root biomass at heading time and the harvest index were significantly higher under the AWD-SSNM treatment than those under any other treatments. When compared to those under the CF-FNP treatment, grain yield, N partial factor productivity (grain yield over the N rate) and WUE (grain yield over the amount of irrigation water and rainfall) under the SSNM-AWD treatment were increased by 12.4-14.5%, 26.5-30.7% and 22.8-26.7%, respectively, and also significantly higher than those under SSNM or AWD alone. The results suggest that synergistic interaction between SSNM and AWD occurs in the yield formation, and such an interaction could increase not only grain yield, but also resource-use efficiency in super rice. © 2013 Elsevier B.V.


Wang T.,Henan Institute of Science and Technology | Zhang Y.,Yangzhou University | Ding T.,Yongcheng Vocational College
Materials Letters | Year: 2014

A one-step in situ solvothermal method was proposed for the synthesis of SnIn4S8/TiO2 nanocomposite with 6.5 mol% SnIn4S8, using SnCl4·5H2O, InCl3·4H2O, thiourea, tetrabutyl titanate and absolute ethanol as the source materials. The structure, composition, BET specific surface area and optical property of the as-synthesized SnIn 4S8/TiO2 nanocomposite were characterized by powder X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, N2 adsorption and UV-vis diffuse reflectance spectra. The photocatalytic activity of the as-synthesized SnIn 4S8/TiO2 nanocomposite was tested in the reduction of aqueous Cr(VI) under visible-light (λ>420 nm) irradiation, and compared with those of nanostructured SnIn4S 8 and TiO2. The photocatalytic results demonstrated that the as-synthesized SnIn4S8/TiO2 nanocomposite exhibited much higher visible-light-activated photocatalytic activity than SnIn4S8 and TiO2 nanoparticles. The reasons accounting for the photocatalytic results were also discussed. © 2014 Elsevier B.V.


Chen N.,Chinese University of Hong Kong | Liu X.,Yangzhou University | Yao D.D.,Columbia University
Operations Research | Year: 2016

Financial institutions are interconnected directly by holding debt claims against each other (the network channel), and they are also bound by the market when selling assets to raise cash in distressful circumstances (the liquidity channel). The goal of our study is to investigate how these two channels of risk interact to propagate individual defaults to a systemwide catastrophe. We formulate a constrained optimization problem that incorporates both channels of risk, and exploit the problem structure to generate the solution (to the clearing payment vector) via a partition algorithm. Through sensitivity analysis, we are able to identify two key contributors to financial systemic risk, the network multiplier and the liquidity amplifier, and to discern the qualitative difference between the two, confirming that the market liquidity effect has a great potential to cause systemwide contagion. We illustrate the network and market liquidity effects-in particular, the significance of the latter-in the formation of systemic risk with data from the European banking system. Our results contribute to a better understanding of the effectiveness of certain policy interventions. In addition, our algorithm can be used to pin down the changes of the net worth (marked to market) of each bank in the system as the spillover effect spreads, so as to estimate the extent of contagion, and to provide a metric of financial resilience as well. Our framework can also be easily extended to incorporate the effect of bankruptcy costs. © 2016 INFORMS.


Li J.,Yangzhou University | Zhang Y.C.,Yangzhou University | Wang T.X.,Henan Institute of Science and Technology | Zhang M.,Yangzhou University
Materials Letters | Year: 2011

Choosing low-melting-point Ca(NO3)2•4H 2O and high-reactive-activity TiO2 nanocrystals as the raw materials, a simple and cost-effective route was developed for the synthesis of CaTiO3 nanoparticles at 600 °C, which is much lower than that (about 1350 °C) used in the conventional solid state reaction methods. X-ray diffraction, energy dispersive X-ray spectroscopy and field emission scanning electron microscopy revealed the formation of orthorhombic phase CaTiO 3 nanoparticles with oxygen-deficiency at the surface. UV-vis absorption spectrum of the as-obtained CaTiO3 nanoparticles displayed an absorption peak centered at around 325 nm (3.8 eV), together with a tail at lower energy side. Room temperature photoluminescence spectrum of the as-obtained CaTiO3 nanoparticles upon laser excitation at 325 nm demonstrated a strong and broad visible light emission ranging from about 527 to 568 nm, which may be originated from the surface states and defect levels. © 2011 Elsevier B.V.


Zong L.,Peoples Hospital of Jiangsu Province | Zong L.,University of Tokyo | Chen P.,Peoples Hospital of Jiangsu Province | Wang D.-X.,Yangzhou University
World Journal of Gastroenterology | Year: 2014

Aim: To evaluate human epidermal growth factor receptor 2 (HER2) and death decoy receptor (DcR3) as colorectal cancer prognostic indicators. Methods: Colorectal carcinoma specimens from 300 patients were analyzed by immunohistochemistry to detect the staining patterns of HER2 and DcR3. Classification of HER2 staining was carried out using the United States Food and Drug Administration semi-quantitative scoring system, with scores of 0 or 1+ indicating a tumor-negative (normal expression) status and scores of 2+ and 3+ indicating a tumor-positive (overexpression) status. Classification of DcR3 was carried out by quantitating the percentage of positive cells within the stained section, with < 10% indicating a tumor-negative status and ≥ 10% indicating a tumor-positive status. Correlation of the HER2 and DcR3 staining status with clinicopathological parameters [age, sex, tumor size, differentiation, and the tumor, node, metastasis (pTNM) classification] and survival was statistically assessed. Results: Tumor-positive status for HER2 and DcR3 was found in 18.33% and 58.33% of the 300 colorectal carcinoma specimens, respectively. HER2 tumorpositive status showed a significant correlation with tumor size (P = 0.003) but not with other clinicopathological parameters. DcR3 tumor-positive status showed a significant correlation with tumor differentiation (P < 0.001), pTNM stage (P < 0.001), and lymph node metastasis (P < 0.001). However, correlation coefficient analysis did not indicate that a statistically significant correlation exists between tumor-positive status for the HER2 and DcR3 overexpression (P = 0.236). Patients with specimens classified as DcR3-overexpressing had a significantly worse overall survival (OS) rate than those without DcR3 overexpression (median OS: 42.11 vs 61.21 mo; HR = 50.27, 95%CI: 44.90-55.64, P < 0.001). HER2 overexpression had no significant impact on median OS (35.10 mo vs 45.25 mo; HR = 44.40, 95%CI: 39.32-49.48, P = 0.344). However, patients with specimens classified as both HER2- and DcR3- overexpressing had a significantly poorer median OS than those with only HER2 overexpression (31.80 mo vs 52.20 mo; HR = 35.10, 95%CI: 22.04-48.16, P = 0.006). Conclusion: HER2 overexpression is not an independent prognostic marker of colorectal cancer, but DcR3 overexpression is highly correlated with lymph node metastasis and poor OS. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.


Wang Z.,Donghua University | Wang Z.,Brunel University | Wang Y.,Donghua University | Liu Y.,Yangzhou University
IEEE Transactions on Neural Networks | Year: 2010

In this paper, the problem of stochastic synchronization analysis is investigated for a new array of coupled discretetime stochastic complex networks with randomly occurred nonlinearities (RONs) and time delays. The discrete-time complex networks under consideration are subject to: 1) stochastic nonlinearities that occur according to the Bernoulli distributed white noise sequences; 2) stochastic disturbances that enter the coupling term, the delayed coupling term as well as the overall network; and 3) time delays that include both the discrete and distributed ones. Note that the newly introduced RONs and the multiple stochastic disturbances can better reflect the dynamical behaviors of coupled complex networks whose information transmission process is affected by a noisy environment (e.g., internet-based control systems). By constructing a novel Lyapunov-like matrix functional, the idea of delay fractioning is applied to deal with the addressed synchronization analysis problem. By employing a combination of the linear matrix inequality (LMI) techniques, the free-weighting matrix method and stochastic analysis theories, several delay-dependent sufficient conditions are obtained which ensure the asymptotic synchronization in the mean square sense for the discrete-time stochastic complex networks with time delays. The criteria derived are characterized in terms of LMIs whose solution can be solved by utilizing the standard numerical software. A simulation example is presented to show the effectiveness and applicability of the proposed results. © 2009 IEEE.


Liu Y.,Yangzhou University | Ho D.W.C.,City University of Hong Kong | Wang Z.,Brunel University
International Journal of Control | Year: 2012

In this article, the distributed consensus problem is considered for discrete-time delayed networks of dynamic agents with fixed topologies, where the networks under investigation are directed and the time delays involved are distributed time delays including a single or multiple time delay(s) as special cases. By using the invariance principle of delay difference systems, a new unified framework is established to deal with the consensus for the discrete-time delayed multi-agent system. It is shown that the addressed discrete-time network with arbitrary distributed time delays reaches consensus provided that it is strongly connected. A numerical example is presented to illustrate the proposed methods. © 2012 Taylor & Francis Group, LLC.


Sha O.,Yangzhou University | Sha O.,Huaihai Institute of Technology | Zhu X.,Yangzhou University
Analytical Letters | Year: 2014

A new simplified extraction of gold(III) using a room-temperature ionic liquid prior to determination by flame atomic absorption spectrometry has been developed. The extraction method uses 1-butyl-3-methylimidazolium hexafluorophosphate without a chelating agent. The parameters of the extraction system were investigated in detail. Under the optimized conditions, a linear range of 0.19 to 38.20 μg · mL-1, a limit of detection of 0.072 μg · mL-1, an enrichment factor of 10.0, and an extraction capacity of 6.6 mg · g-1 were obtained. The extraction mechanism and the selectivity of 1-butyl-3-methylimidazolium hexafluorophosphate for gold(III) were also investigated. The method was applied for the determination of gold(III) in water samples with satisfactory results. © 2014 Copyright Taylor & Francis Group, LLC.


Wang Z.,Brunel University | Wang Z.,Donghua University | Liu Y.,Yangzhou University | Wei G.,Donghua University | Liu X.,Brunel University
Automatica | Year: 2010

This paper is concerned with the state feedback control problem for a class of discrete-time stochastic systems involving sector nonlinearities and mixed time-delays. The mixed time-delays comprise both discrete and distributed delays, and the sector nonlinearities appear in the system states and all delayed states. The distributed time-delays in the discrete-time domain are first defined and then a special matrix inequality is developed to handle the distributed time-delays within an algebraic framework. An effective linear matrix inequality (LMI) approach is proposed to design the state feedback controllers such that, for all admissible nonlinearities and time-delays, the overall closed-loop system is asymptotically stable in the mean square sense. Sufficient conditions are established for the nonlinear stochastic time-delay systems to be asymptotically stable in the mean square sense, and then the explicit expression of the desired controller gains is derived. A numerical example is provided to show the usefulness and effectiveness of the proposed design method. © 2009 Elsevier Ltd. All rights reserved.


Lu B.,Yangzhou University | Wang J.,Yangzhou University | Zhang Y.,Yangzhou University | Wang H.,Yangzhou University | And 2 more authors.
Journal of Experimental Botany | Year: 2012

AT14A has a small domain that has sequence similarities to integrins from animals. Integrins serve as a transmembrane linker between the extracellular matrix and the cytoskeleton, which play critical roles in a variety of biological processes. Because the function of AT14A is unknown, Arabidopsis thaliana AT14A, which is a transmembrane receptor for cell adhesion molecules and a middle member of the cell wall-plasma membrane- cytoskeleton continuum in plants, has been described. AT14A, co-expressed with green fluorescent protein (GFP), was found to localize mainly to the plasma membrane. The mutant Arabidopsis at14a-1 cells exhibit various phenotypes with cell shape, cell cluster size, thickness, and cellulose content of cell wall, the adhesion between cells, and the adhesion of plasma membrane to cell wall varied by plasmolysis. Using direct staining of filamentous actin and indirect immunofluorescence staining of microtubules, cortical actin filaments and microtubules arrays were significantly altered in cells, either where AT14A was absent or over-expressed. It is concluded that AT14A may be a substantial middle member of the cell wall-plasma membrane-cytoskeleton continuum and play an important role in the continuum by regulating cell wall and cortical cytoskeleton organization. © The Author 2012.


Chu G.,Yangzhou University | Chen T.,Yangzhou University | Wang Z.,Yangzhou University | Yang J.,Yangzhou University | Zhang J.,Chinese University of Hong Kong
Field Crops Research | Year: 2014

Water-saving and drought-resistant rice (WDR) could substantially reduce irrigation water and meanwhile produce higher grain yield compared with paddy rice under water-saving irrigation. The mechanism underlain, however, is yet to be understood. We investigated if improved root traits would contribute to an increase in water productivity in WDR. Two rice varieties, each for WDR and paddy rice, were field-grown with two irrigation methods, continuous flooding (CF) and alternate wetting and drying (AWD) irrigation, which were imposed during the whole growing season. Under CF, grain yield, water productivity (grain yield over amount irrigation water and precipitation) and root morpho-physiological traits, such as root biomass and root oxidation activity (ROA), showed no significant difference between WDR and paddy rice. Under AWD, however, WDR exhibited greater root dry weight, root length density, ROA, total absorbing surface area and active absorbing surface area of roots, greater zeatin (Z). +. zeatin riboside (ZR) contents in both roots and leaves, and higher activities of enzymes involved in sucrose-to-starch conversion in grains during grain filing, in relative to paddy rice. Grain yield under AWD was significantly decreased for paddy rice compared with that under CF, but showed no significant difference for WDR between the two irrigation treatments. The WDR variety increased grain yield by 9.2-13.4% and water productivity by 9.0-13.7% over the paddy rice variety under AWD. The root dry weight was significantly correlated with shoot dry weight, and ROA and root Z. +. ZR content were significantly correlated with leaf photosynthetic rate, Z. +. ZR content in leaves and activities of key enzymes involved in sucrose-to-starch conversion in grains. Collectively, the data suggest that improved morpho-physiological traits, as showing a greater root biomass, root length density, ROA and root Z. +. ZR content, contributes to higher grain yield and water productivity for WDR under water-saving irrigation. © 2013 Elsevier B.V.


Li H.,Yangzhou University | Liu L.,Yangzhou University | Wang Z.,Yangzhou University | Yang J.,Yangzhou University | Zhang J.,Chinese University of Hong Kong
Field Crops Research | Year: 2012

Understanding agronomic and physiological performance of crop high yield is essential to make strategies for breeding and crop management. This study aimed to identify major agronomic and physiological traits associated with high grain yields of rice and wheat in the wheat-rice rotation system in the lower reaches of Yangtze River of China. Two high-yielding cultivars, each for winter wheat and rice, were field-grown from 2008 to 2010 for 3 years. Two crop management treatments, the local farmer's practice (LFP) and improved high-yielding cultivation (IHC), were used. The IHC adopted two new techniques, i.e., site-specific nitrogen management in both rice and wheat and alternate wetting and moderate drying irrigation in rice and controlled soil drying irrigation in wheat. Across the 3 years, the IHC yielded an average 9.67tha -1 of wheat and 12.55tha -1 of rice with an annual total of 22.2tha -1, an increase of 26.8% when compared with that (17.5tha -1) under the LFP. The increased grain yield under the IHC was mainly attributed to expanded sink size as a result of more kernels per spike or more spikelets per panicle, increased kernel weight of wheat and increased percentage of filled grains of rice. When compared with LFP, IHC showed a greater percentage of productive tillers, more pre-anthesis nonstructural carbohydrate (NSC) storage in the stem, greater leaf photosynthetic rate and concentration of cytokinins in root exudates, higher activities of sucrose synthase and adenosine diphosphoglucose pyrophosphorylase in grains, more dry mater production during the grain filling period, and higher harvest index. We conclude that (1) expanding sink capacity through an increase in kernels per spike or spikelets per panicle, (2) enhancing grain filling efficiency by an increase in pre-anthesis NSC in the stem, and (3) increasing post-anthesis dry mater production by an enhancement in root activity during grain filling should be considered as three major strategies for further increases in grain yields of wheat and rice in the lower reaches of Yangtze River of China. © 2012 Elsevier B.V..


Li Q.-F.,Chinese University of Hong Kong | Li Q.-F.,Yangzhou University | He J.-X.,Chinese University of Hong Kong
Molecular Plant | Year: 2016

Light and brassinosteroid (BR) are two central stimuli that regulate plant photomorphogenesis. Although previous phenotypic and physiological studies have implied possible interactions between BR and light in regulating photomorphogenesis, the underlying molecular mechanism(s) remain largely unknown. In the present study, we identified a physical connection between the BR and light signaling pathways, which was mediated by the BR-regulated transcription factor BZR1 and light-regulated transcription factor HY5 in Arabidopsis thaliana. Genetic evidence showed that the gain-of-function bzr1-1D mutant in the BR signaling pathway and loss-of-function hy5-215 mutant in the light signaling pathway exhibited closed cotyledons under BR-deficient and dark-grown conditions and both bzr1-1D and hy5-215 mutants were able to suppress the cotyledon opening phenotype of the BR-insensitive mutants bri1-5 and bin2-1. Biochemical studies demonstrated that BZR1 interacts with HY5 both in vitro and in vivo and ectopic expression of HY5 considerably reduces the accumulation of BZR1 protein. In addition, HY5 specifically interacts with the dephosphorylated form of BZR1 and attenuates BZR1's transcriptional activity in regulating its target genes related to cotyledon opening. Our study provides a molecular framework for coordination of BR and light signals in regulating cotyledon opening, an important process in photomorphogenesis in plants. © 2016 The Author.


Zhang Y.,Yangzhou University | Shi Q.,CAS Dalian Institute of Chemical Physics | Schliesser J.,Brigham Young University | Woodfield B.F.,Brigham Young University | Nan Z.,Yangzhou University
Inorganic Chemistry | Year: 2014

Normal spinel zinc ferrite (ZnFe2O4) nanoparticles (NPs) with zero net magnetization were synthesized by a facile coprecipitation method in which two kinds of organic alkali, namely, 1-amino-2-propanol (MIPA) and bis(2-hydroxypropyl)-amine (DIPA), were used. The diameters of the ZnFe2O4 NPs were determined to be about 7 and 9 nm for samples prepared with MIPA and DIPA, respectively, and the normal spinel structure was confirmed by the magnetic property measurement at room temperature and the temperature dependence of the direct current magnetization. These results are different from those reported in the literature, where ZnFe2O4 NPs show a nonzero net magnetization. The heat capacity of the ZnFe2O4 NPs synthesized using DIPA was measured using a physical property measurement system in the temperature range from 2 to 300 K, and the thermodynamic functions were calculated based on the curve fitting of the experimental heat capacity data. The heat capacity of the ZnFe2O4 NPs was compared with that of a nanosized (Zn0.795Fe0.205)[Zn0.205Fe1.795]O4 material studied in the literature, indicating that the Debye temperature of the present sample is more comparable with that of the bulk ZnFe2O4 reported by Westrum et al. © 2014 American Chemical Society.


Tang D.,Peoples Hospital of Jiangsu Province | Zhang J.-Q.,Yangzhou University | Wang D.-R.,Peoples Hospital of Jiangsu Province
Hepato-Gastroenterology | Year: 2011

Background/Aims: Clinical benefit from pancreatectomy combined with portal vein/superior mesenteric resection in the pancreatic carcinoma with local venous invasion still remains controversial. The aim of this study was to review the overall outcome of the pancreatectomy combined with portal vein/superior mesenteric resection for pancreatic carcinoma with local venous invasion. Methodology: A systematic literature search (Medline, Embase, Cochrane Library, Biosis, Science Citation Index, Ovid Journals) was performed to identify all eligible articles from January 2000 to December 2009. The methodological quality of included studies on portal vein/superior mesenteric resection during pancreatectomy for pancreatic carcinoma was evaluated independently by 2 authors and 47 non-duplicated studies providing relevant data was found. Quantitative data on operation, perioperative results (blood loss, operative time, and length of hospital stay), mortality, morbidity, hi