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Zhang Z.,Yangzhou University | Gu C.,Yangzhou Maternal and Child Health Care Hospital | Fang P.,Yangzhou University | Shi M.,Yangzhou University | And 4 more authors.
Peptides | Year: 2014

Although a significantly higher level of plasma galanin was found in patients with gestational diabetes mellitus (GDM) in our previous study, it is unknown whether plasma galanin is biomarker for the prediction of GDM. The present study aims to further evaluate the relationship between endogenous galanin and GDM in pregnant women and to find out the precise mechanism by which galanin plays role in the pathogenesis of GDM. The study registered thirty pregnant women with GDM and thirty pregnant women with normal glucose tolerance (NGT). Demographic and biochemical parameters and fasting venous blood samples of two groups were collected from all cases. Galanin was analyzed by an enzyme-linked immunosorbent assay. Gamma-glutamyl transferase (GGT) was measured by enzymatic methods. The plasma galanin and GGT levels were found higher in GDM compared with NGT (P < 0.001). In addition, a significant positive correlation was shown between galanin and fasting glucose (P = 0.049), 1-h glucose (P = 0.033), body mass index (BMI) (P < 0.001) and GGT (P = 0.048) in pregnant women with GDM, whereas there was significant positive correlation between galanin and BMI (P = 0.030) in NGT group. The plasma galanin and GGT levels are higher in patients with GDM. The plasma galanin levels appear to be related to the changes of blood glucose, BMI and GTT in GDM. The higher level of galanin observed in GDM may represent a adaptation to the rise of glucose, weight, GGT associated with GDM. The higher level of plasma galanin is a novel biomarker for the prediction of GDM. © 2014 Elsevier Inc. Source


Zhang Z.,Yangzhou University | Fang P.,Yangzhou University | Shi M.,Yangzhou University | Gu C.,Yangzhou Maternal and Child Health Care Hospital | And 3 more authors.
Eating Behaviors | Year: 2015

Galanin is an important neuropeptide which induces an increase in obesity and appetite, improving insulin sensitivity and glucose tolerance in experimental animals. Although significantly higher levels of plasma galanin are found in pregnant women with gestational diabetes mellitus (GDM), there is a limited understanding of its precise mechanism underlying this variation. In the present study, concentrations of circulating galanin were determined at baseline in pregnant women with GDM and pregnant women with normal glucose tolerance (NGT). Correlation analyses were performed between galanin and pre-gestational body weight, pre-gestational BMI, and hormone involved in various homeostatic processes. Results showed that plasma galanin level was significantly higher in the patients with GDM than in the NGT subjects (p < 0.001) = 0.037), pre-gestational BMI (r = 0.643, p = 0.001), and fasting blood glucose (r = 0.840, p < 0.001) in the GDM group. Moreover, a significant negative correlation was shown between galanin and sex hormone binding globulin (SHBG) (r = - 0.901, p < 0.001) in the GDM group. These data indicate that serum galanin concentration increases markedly in pregnant women with GDM, and this increase seems to be related to the increase of pre-gestational BMI and significantly lower SHBG in patients with GDM. Thus, circulating galanin is affected under conditions of altered pre-gestational BMI with highest levels in GDM patients. The increase of galanin under conditions of GDM may indicate a physiological function to improve glucose tolerance which is often impaired in GDM subjects. © 2015 Elsevier Ltd. Source


Ji Y.P.,Yangzhou Maternal and Child Health Care Hospital | Xu Y.,Yangzhou Maternal and Child Health Care Hospital | Xia S.Z.,Yangzhou Maternal and Child Health Care Hospital | Bian F.Y.,Yangzhou Maternal and Child Health Care Hospital | And 2 more authors.
Genetics and Molecular Research | Year: 2015

The purpose of this study was to investigate the clinical value of the fluid bolus contrast flow meter during hysterosalpingography. Hysterosalpingography information of 342 cases, which included a manual handset group of 213 cases and a bolus instrument group of 129 cases were reviewed. Comparative analysis was used to compare the two groups in order to assess the clinical adverse reactions, contrast agent reflux, and image quality. In the instrument bolus group compared with the manual handset group, the clinical adverse reactions decreased from 75.12 to 31.78% (P < 0.001); the backflow phenomenon of the contrast agent decreased from 13.62 to 3.10% (P < 0.01); and image quality significantly improved, with the A class film rate increasing from 54.46 to 68.99% (P < 0.01) and the C class film rate decreasing from 8.92 to 2.33% (P < 0.05). The use of a contrast bolus through the liquid inlet of the hysterosalpingography instrument can provide fully dynamic observation, reducing the contrast agent reflux and adverse reactions as well as improving the image quality and diagnostic accuracy. In addition, the medical staff is not subjected to radiographic radiation. Therefore, it is a safe and reliable imaging method. ©FUNPEC-RP. Source

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