Luo Y.,Yangtze University
Behavioural Pharmacology | Year: 2017
Emotional memory deficit is a well-known complication in early Parkinson’s disease. However, its molecular mechanism is still not well known. To address this issue, we examined the cue-related fear-conditioning task and long-term potentiation (LTP) of the thalamus to the lateral amygdala in rats treated with low doses of reserpine (Res). We found that low-dose Res treatment impaired emotional memory and LTP. We also found that exogenous upregulation of norepinephrine (NE) ameliorated the impairment of LTP by facilitating β-adrenergic receptors. Finally, acute treatment with NE or desipramine rescued the impaired emotional memory induced by a low-dose of Res. These results imply a pivotal role for NE in synaptic plasticity and associative fear memory in rats treated with low doses of Res and suggest that desipramine is a potential candidate for treating Parkinson’s disease-related emotional memory deficit. Copyright © 2017 YEAR Wolters Kluwer Health, Inc. All rights reserved.
Li G.,Yangtze University
Journal of Chemical and Engineering Data | Year: 2017
The production of phosphoric acid by wet processes is quite energy consuming. The adoption of azeotropic distillation in the evaporation process, using cyclohexane as an entrainer, may be potentially economical. The vapor-liquid equilibria (VLE) data were determined by ebulliometric method for the following systems at 20, 40, 60, 80, and 101.3 kPa: (1) phosphoric acid + water + ethanol; (2) phosphoric acid + water + cyclohexane + ethanol; (3) phosphoric acid + water + cyclohexane. The electrolyte NRTL parameters for the following pairs were correlated from the VLE data by using Aspen Plus as a tool: H3PO4-H2O, H+[H2PO4]--H2O, H3PO4-C2H6O, H3PO4-C6H12, and H+[H2PO4]--C6H12. The VLE data and the obtained parameters may provide basic data for the enhancement of phosphoric acid by azeotropic distillation. © 2017 American Chemical Society.
Xu Y.,Yangtze University |
Lu M.,Jingdezhen Ceramic Institute
Journal of Hazardous Materials | Year: 2010
Biostimulation with inorganic fertilizer and bioaugmentation with hydrocarbon utilizing indigenous bacteria were employed as remedial options for 12 weeks in a crude oil-contaminated soil. To promote oil removal, biocarrier for immobilization of indigenous hydrocarbon-degrading bacteria was developed using peanut hull powder. Biodegradation was enhanced with free-living bacterial culture and biocarrier with a total petroleum hydrocarbon removal ranging from 26% to 61% after a 12-week treatment. Oil removal was also enhanced when peanut hull powder was only used as a bulking agent, which accelerated the mass transfer rate of water, oxygen, nutrients and hydrocarbons, and provided nutrition for the microflora. Dehydrogenase activity in soil was remarkably enhanced by the application of carrier material. Metabolites of polycyclic aromatic hydrocarbons were identified by Fourier transform ion cyclotron resonance mass spectrometry. © 2010 Elsevier B.V.
Chen H.,Yangtze University
Measurement: Journal of the International Measurement Confederation | Year: 2010
In this paper, we propose and experimentally demonstrate a pressure sensor based on birefringent single-mode fiber F-P cavity using optical heterodyne. The proof of concept device consists of a light source, a polarizer controller, a modulator, a RF generator, a single-mode fiber Fabry-Perot cavity, a strain inspector, an erbium doped fiber amplifier, a filter, a polarizer, an optical spectrum analyzer, and a digital communication analyzer. The dynamic range of the proposed sensor is explored. The results demonstrate the new concept of fiber pressure sensors and the technical feasibility for pressure measurements. © 2009 Elsevier Ltd. All rights reserved.
Yang B.,Yangtze University
Iranian Polymer Journal (English Edition) | Year: 2014
The first example of N-tetradecyl-N-methyl-2-pyrrolidonium was synthesized by using bromide as both an ionic liquid and a surfactant in ionic liquid-based microemulsion polymerization of methyl methacrylate under atom transfer radical polymerization at activator generated electron transfer conditions. The polymerization was carried out at room temperature using copper (II) chloride (CuCl2)/hexamethylene tetramine (HMTA) as a catalyst and CCl 4 as an initiator in the absence of surfactant. Ascorbic acid was used as reducing agent. A pseudoternary phase diagram was constructed at 25 C using the water titration method in the presence and absence of hexadecyltrimethylammonium bromide (CTAB). Kinetics experimental results showed that the polymerization proceeded in a controlled/'living' process as evidenced by a linear increase of molecular weights of polymers with monomer conversion with a relatively narrow polydispersity (<1.35) in all cases and M n,GPC values of the resulting polymer were in excellent agreement with the theoretical values M n,th. The polymerization rate increased with the amount of surfactant. However, the polydispersity became broader. The polymerization rate increased with the amount of ligand and decreased with the amount of monomer. In this system, particles of nanoscale (33-51 nm) were prepared. The average particle diameter was found to be affected by the amount of surfactant. The AGET-ATRP of MMA retained the characteristic of living polymerization when the ionic liquid C14MPnBr and catalyst complex were recovered and reused. Living nature of the polymerization was confirmed by the successful homo chain extension experiment. The resultant PMMA was characterized by 1H NMR spectroscopy and gel permeation chromatography techniques. © 2013 Iran Polymer and Petrochemical Institute.
Li F.,Yangtze University
Advanced Materials Research | Year: 2011
Set pair analysis (SPA) is emerging as a new system theory method for analyzing vagueness and uncertainty of facts. Many problems of uncertainty of fuzziness can be solved with the application of identity-discrepancy-contrary expression, and five-element connection number (FECN) is an extension of SPA. Aiming at the problem being too complex for the present evaluation methods on lake eutrophication, an assessment of lake eutrophication based on situation of five-element connection number was suggested. The results of the assessment are basically in concordance with other evaluation methods. So, the evaluation model provides realistic support for remediation-related decisions for water resource management. © (2011) Trans Tech Publications.
Yang J.,Yangtze University
Photodermatology, photoimmunology & photomedicine | Year: 2010
BACKGROUND/PURPOSE: Based on the observation that increasing skin temperature could improve 5-aminolevulinic acid (ALA) penetration and accumulation of protoporphyrin IX (PpIX) in the ALA-based photodynamic therapy (PDT), this study was designed to investigate how temperature change varied the therapeutic effect of ALA-based PDT in vitro. METHODS: HaCat cells were cultured with or without ALA at various temperatures. ALA uptake and PpIX accumulation were analyzed before laser irradiation as the baseline. After irradiation, cell death and cytokine secretions in the media, including interleukin (IL)-1alpha, tumor necrosis factor (TNF)-alpha and basic fibroblast growth factor (bFGF) were assayed, and the morphological changes were recorded. RESULTS: With increasing temperature, the amount of ALA uptake, intracellular PpIX concentration and cell death increased in both the PDT and the non-PDT groups. Secretions of IL-1alpha, TNF-alpha and bFGF also increased and reached a peak around 44-47 degrees C and then declined at a higher temperature. This biphasic response might be due to protein thermolysis that occurs when cells reach beyond thermal tolerance. CONCLUSIONS: Elevating temperature could augment photodynamic reactions to a certain extent, but adverse effects occurred when cells were overheated.
Cai L.,Yangtze University |
Cai X.,Yangtze University
Diagnostic Pathology | Year: 2014
Background: MicroRNAs (miRNAs) are endogenous small (19-24 nt long) noncoding RNAs that regulate gene expression in a sequence specific manner. An increasing association between miRNA and cancer has been recently reported. Hepatocellular carcinoma (HCC), as the fifth most common cancer and the most common cause of death in men, has become the third leading cause of cancer-related deaths globally. In this study, we investigated the miR-9 expression in HCC to evaluate their value in prognosis of this tumor. Methods: The expression of miR-9 in matched normal and tumor tissues of HCC was evaluated using a quantitative real-time RT-PCR. A Kaplan-Meier survival curve was generated following a log-rank test. Results: It was observed that miR-9 expression was upregulated in HCC tissues compared with noncancerous liver tissues (7.26 ± 1.30 vs. 3.14 ± 1.08, P < 0.001). The up-regulation of miR-9 in HCC cancer tissues was also significantly correlated with aggressive clinicopathological features. We found that the patients with high miR-9 expression have a higher tumor staging (P = 0.0389) and are in higher risk of venous infiltration (P < 0.0001). Moreover, the results of Kaplan-Meier analyses showed that HCC patients with the high miR-9 expression tend to have shorter overall survival (P < 0.0001). The multivariate analysis clearly indicated that the high miR-9 expression in biopsy samples may be considered as an independent prognostic factor in HCC for decreased survival (4.28; 95%CI, 2.77-7.23, P < 0.001). Conclusion: Our data indicate the potential of miR-9 as a novel prognostic biomarker for HCC. Large well-designed studies with diverse populations and functional evaluations are warranted to confirm and extend our findings. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_228. © 2014 Cai and Cai.
Yangtze University | Date: 2013-07-03
A downhole high power electromagnetic pulse transmitting device including a ground instrument and a downhole instrument. The ground instrument, with an industrial control computer as the core, includes a depth/magnetic mark/GPS signal recording module, a Manchester coding and decoding module, and a cable drive module, wherein the depth/magnetic mark recording and the Manchester coding and decoding modules communicate respectively through two serial ports with the industrial control computer, and the cable drive module communication for the downhole instrument through four cables by means of phantom power supply. The downhole instrument includes, in turn from front to rear, an AC voltage boosting module, a rectifier, an energy storage capacitor, a transmitting coil, and a data acquisition module, and further comprises a high-voltage discharge switch and a computer-manipulated controller. Power supply of the downhole instrument is provided by the ground instrument through cables.
Yangtze University | Date: 2012-10-24
A method for detecting formation resistivity outside of metal casing using borehole time-domain electromagnetic pulse including steps of a) providing a borehole large power pulse transmitting source, recording an induced electromotive force , and full time digital recording a transmitted waveform and a received signal; b) conducting transmission-reception and superimposing received signals to improve signal to noise ratio; c) calculating corresponding casing response according to known casing parameters and recorded current waveform of the transmitting source to obtain a relative induced electromotive force ; d) correcting relative induced electromotive force value; e) carrying out one-dimensional inversion and converting the observation signal into radial variation information of the formation resistivity; f) obtaining a two dimensional image of the longitudinal and radial resistivity distribution of outer cased formation resistivity for measured well sections; and g) determining residual oil distribution in a reservoir from outer cased reservoir resistivity distribution.