Wang J.-K.,Yanan Peoples Hospital Yanan City |
Zhang F.-L.,Yanan Peoples Hospital Yanan City
World Chinese Journal of Digestology | Year: 2014
AIM: To investigate the relationship between Helicobacter pylori (H. pylori) infection and chemotherapy sensitivity in gastric cancer to provide a theoretical basis for H. pylori eradication therapy in gastric cancer patients undergoing chemotherapy. METHODS: Two hundred and forty H. pylori positive patients with gastric cancer who did not undergo surgery for various reasons but received chemotherapy in recent five years at our hospital were included in this study. Based on whether to receive H. pylori eradication therapy, they were divided into an observation group and a control group. After two cycles of chemotherapy, they were evaluated to analyze the relationship between H. pylori infection and chemotherapy sensitivity. RESULTS: The curative effect was significantly better in the observation group than in the control group. In the observation group, the curative effect was significantly better in the eradicated group than in the non-eradicated group. The curative effect was better in the non-eradicated group than in the control group, but the difference was not statistically significant. CONCLUSION: The eradication of H. pylori can improve chemotherapy sensitivity in patients with gastric cancer. © 2014 Baishideng Publishing Group Co., Limited. All rights reserved.