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Kofu, Japan

The University of Yamanashi is a university that has campuses in Kofu and Tamaho, Japan.The University of Yamanashi has its origin in “Kitenkan” which was founded in 1795 as a branch school of “Shoheizaka-School” of Tokugawa Government and was developed to the Normal School of Yamanashi after the Meiji Restauration. In 1921 the Normal School of Yamanashi for Junior and in 1924 the Yamanashi High School of Engineering were established. After the World War II these three schools were integrated to the University of Yamanashi according to the new school system of Japan. In 1978 the Yamanashi Medical University was opened which was only a Medical University in Prefecture of Yamanashi. Today’s University of Yamanashi was founded in 2002 by a merger between University of Yamanashi and Yamanashi Medical University. It is formally referred to as the National university corporation, University of Yamanashi. In 2012 the Faculty of Education and Human science and the Faculty of Engineering were reorganized and the Faculty of Life and Environmental Science was newly established.The university has therefore four faculties: the Faculty of Education Human science, the Faculty of Medicine, the Faculty of Engineering and the Faculty of Life and Environmental Science. It should not be confused with the similarly named Yamanashi Prefectural University.The University of Yamanashi is located in Kofu, which is the prefectural capital of Yamanashi and is distant about 120 kilometers west from Tokyo. For the University stands in the Center of the Kofu Basin surrounded by many mountains, many students are often engaged in leisure and sports in holidays.The project of the Faculty of Engineering "Research and Education of Integrated Water Resources Management for the Asian Monsoon Region" was adopted as the 21st Century COE Program of 2002-2006. It has been followed by the Global COE Program "Evolution of Research and Education of integrated River Basin Management in Asian Region" since 2007. Kofu Eastern CampusOnly this university has the institution for wine in Japan. The produced wine is available in the shop in this campus.Cooperative Research and Development CenterCenter for Instrumental AnalysisUniversal Information CenterFuel Cell Nanomaterials CenterAdvanced Biotechnology CenterCenter for Higher EducationCenter for Crystal Science and TechnologyThe Institute of Enology and ViticultureCenter for International Education& Office of International Affairs Kofu Western CampusThe Open University of Japan University LibraryHealth Service CenterStudent Hall Campus of the Faculty of MedicineUniversity HospitalUniversal Center for Medical Analysis and ExperimentGround of the Faculty of Medicine↑ ↑ ↑ Wikipedia.

Kondo N.,Yamanashi University
Journal of Epidemiology | Year: 2012

Growing socioeconomic disparity is a global concern, as it could affect population health. The author and colleagues have investigated the health impacts of socioeconomic disparities as well as the pathways that underlie those disparities. Our meta-analysis found that a large population has risks of mortality and poor self-rated health that are attributable to income inequality. The study results also suggested the existence of threshold effects (ie, a threshold of income inequality over which the adverse impacts on health increase), period effects (ie, the potential for larger impacts in later years, specifically after the 1990s), and lag effects between income inequality and health outcomes. Our other studies using Japanese national representative survey data and a large-scale cohort study of Japanese older adults (AGES cohort) support the relative deprivation hypothesis, namely, that invidious social comparisons arising from relative deprivation in an unequal society adversely affect health. A study with a natural experiment design found that the socioeconomic gradient in self-rated health might actually have become shallower after the 1997-98 economic crisis in Japan, due to smaller health improvements among middle-class white-collar workers and middle/ upper-income workers. In conclusion, income inequality might have adverse impacts on individual health, and psychosocial stress due to relative deprivation may partially explain those impacts. Any study of the effects of macroeconomic fluctuations on health disparities should also consider multiple potential pathways, including expanding income inequality, changes in the labor market, and erosion of social capital. Further studies are needed to attain a better understanding of the social determinants of health in a rapidly changing society. © 2011 by the Japan Epidemiological Association. Source

Tsuneda T.,Yamanashi University | Hirao K.,RIKEN
Wiley Interdisciplinary Reviews: Computational Molecular Science | Year: 2014

Long-range correction for exchange functionals in Kohn-Sham density functional theory and its applicability are reviewed. Long-range correction simply supplements the long-range exchange effect in exchange functionals by replacing the Hartree-Fock exchange integral with the long-range part of exchange functionals. Nevertheless, this correction has solved many problems in Kohn-Sham calculations. Using this correction, valence occupied and unoccupied orbital energies are quantitatively reproduced in a comprehensive manner for the first time. Long-range correction has also solved the underestimations of charge transfer excitation energies and oscillator strengths in time-dependent Kohn-Sham calculations and has clearly improved poor optical response properties such as hyperpolarizability in coupled-perturbed Kohn-Sham and finite-field calculations. Moreover, this correction has drastically improved the reproducibility of van der Waals bonds by simply combining with conventional van der Waals calculation methods. We, therefore, believe that the long-range correction clearly extends the applicability of the Kohn-Sham method in future quantum chemistry calculations. © 2013 John Wiley & Sons, Ltd. Source

Saitoh M.,Yamanashi University
Oncogene | Year: 2015

The epithelial–mesenchymal transition (EMT) is a crucial morphological event that occurs during the progression of epithelial tumors. EMT can be induced by transforming growth factor β (TGF-β) in certain kinds of cancer cells through the induction of Snail, a key regulator of EMT. We have previously found that TGF-β remarkably induces Snail expression in cooperation with Ras signals; however, the underlying mechanism of this synergism has not yet been determined. Here, we demonstrate that signal transducer and activator of transcription 3 (STAT3) acts as a mediator that synergizes TGF-β and Ras signals. The overexpression of STAT3 enhanced Snail induction, whereas siRNA-mediated knockdown of STAT3 inhibited it. The STAT3-YF mutant, which has Tyr 705 substituted with Phe, did not enhance Snail induction. Several STAT3 mutants lacking transcriptional activity also failed to enhance it; however, the putative STAT3-binding elements in the Snail promoter regions were not required for STAT3-mediated Snail induction. Protein inhibitor of activated STAT3 (PIAS3) inhibited the enhanced Snail promoter activity induced by TGF-β and Ras. The interaction between PIAS3 and STAT3 was reduced by TGF-β in cells harboring oncogenic Ras, whereas TGF-β promoted the binding of PIAS3 to Smad3, a crucial mediator of TGF-β signaling. Therefore, these findings suggest that STAT3 enhances Snail induction when it is dissociated from PIAS3 by TGF-β in cooperation with Ras signals.Oncogene advance online publication, 11 May 2015; doi:10.1038/onc.2015.161. © 2015 Macmillan Publishers Limited Source

Kitamura M.,Yamanashi University
Seminars in Immunopathology | Year: 2013

Endoplasmic reticulum (ER) stress and consequent unfolded protein response (UPR) are involved in a diverse range of pathologies including ischemic diseases, neurodegenerative disorders, and metabolic diseases, such as diabetes mellitus. The UPR is also triggered by various environmental factors; e.g., pollutants, infectious pathogens, therapeutic drugs, alcohol, physical stress, and malnutrition. This review summarizes current knowledge on environmental factors that induce ER stress and describes how the UPR is linked to particular pathological states after exposure to environmental triggers. © 2013 Springer-Verlag Berlin Heidelberg. Source

We have recently identified C-type lectin-like receptor 2 (CLEC-2) as a receptor for the platelet activating snake venom rhodocytin. CLEC-2 elicits powerful platelet activation signals in conjunction with single YxxL motif in its cytoplasmic tail, Src, Syk kinases, and phospholipase Cγ2. An endogenous ligand of CLEC-2 has been identified as podoplanin, which is a membrane protein of tumour cells and facilitates tumour metastasis by inducing platelet activation. Studies of CLEC-2-deficient mice have revealed several physiological roles of CLEC-2. Podoplanin is also expressed in lymphatic endothelial cells. In the developmental stages, when the primary lymph sac is derived from the cardinal vein, podoplanin activates platelets in lymphatic endothelial cells, which facilitates blood/lymphatic vessel separation. Moreover, CLEC-2 is involved in thrombus stabilization under flow conditions in part through homophilic interactions. The absence of CLEC-2 does not significantly increase bleeding tendency, implying that CLEC-2 may be a good target protein for anti-platelet drugs in addition to anti-metastatic drugs. © The Authors 2011. Source

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