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Kofu-shi, Japan

Yamanashi Prefectural University is a public university in Kofu, Yamanashi, Japan. The university was established in 2005 as a result of merger of Yamanashi College of Nursing and Yamanashi Women's Junior College. Wikipedia.

Yamakita M.,Yamanashi Prefectural University | Sato M.,Yamanashi University | Ando D.,Japan National Defense Academy | Suzuki K.,Health Science University | Yamagata Z.,Health Science University
Sleep and Biological Rhythms

Self-report questionnaires about sleep habits are useful for population-based studies because of their low cost. However, there is no valid and reliable self-report sleep questionnaire for elementary school-aged children. The aim of this study was to examine the availability of a simple self-report sleep questionnaire for 9- to 12-year-old children. Participants were 58 children aged 9-12 years from one elementary school in a rural area of Japan. Participants wore an accelerometer for 10 consecutive days and completed the sleep questionnaire twice. Sleep measures included bedtime, wake time, and assumed and actual sleep duration on weekdays and weekends. The data obtained from the accelerometer and sleep/wake scoring software were used to assess criterion validity. Pearson correlation coefficients and Bland-Altman plots were used to evaluate the relationships between objective and self-reported sleep measures. Test-retest reliability was evaluated using intraclass correlation coefficients. The correlations between the objective and questionnaire measures were moderate to high (r = 0.45 to 0.90) and significant, except girls' wake time, assumed sleep duration, and actual sleep duration on weekends. The Bland-Altman plots indicated that bedtime and wake time obtained from the questionnaire were underestimated for both weekdays and weekends. Test-retest reliability of the questionnaire was high, with intraclass coefficients ranging from 0.71 to 0.99. Although caution should be exercised when evaluating sleep duration on weekends, this simple self-reported sleep questionnaire is a useful tool for assessing sleep habits in 9- to 12-year-old children, particularly in school-based and large-scale epidemiological studies. © 2014 Japanese Society of Sleep Research. Source

Misawa F.,Yamanashi Prefectural Kita Hospital | Shimizu K.,Yamanashi Prefectural University | Fujii Y.,Yamanashi Prefectural Kita Hospital | Miyata R.,Yamanashi Prefectural Kita Hospital | And 8 more authors.
BMC Psychiatry

Background: Although the validity and safety of antipsychotic polypharmacy remains unclear, it is commonplace in the treatment of schizophrenia. This study aimed to investigate the degree that antipsychotic polypharmacy contributed to metabolic syndrome in outpatients with schizophrenia, after adjustment for the effects of lifestyle.Methods: A cross-sectional survey was carried out between April 2007 and October 2007 at Yamanashi Prefectural KITA hospital in Japan. 334 patients consented to this cross-sectional study. We measured the components consisting metabolic syndrome, and interviewed the participants about their lifestyle. We classified metabolic syndrome into four groups according to the severity of metabolic disturbance: the metabolic syndrome; the pre-metabolic syndrome; the visceral fat obesity; and the normal group. We used multinomial logistic regression models to assess the association of metabolic syndrome with antipsychotic polypharmacy, adjusting for lifestyle.Results: Seventy-four (22.2%) patients were in the metabolic syndrome group, 61 (18.3%) patients were in the pre-metabolic syndrome group, and 41 (12.3%) patients were in visceral fat obesity group. Antipsychotic polypharmacy was present in 167 (50.0%) patients. In multinomial logistic regression analyses, antipsychotic polypharmacy was significantly associated with the pre-metabolic syndrome group (adjusted odds ratio [AOR], 2.348; 95% confidence interval [CI], 1.181-4.668), but not with the metabolic syndrome group (AOR, 1.269; 95%CI, 0.679-2.371).Conclusions: These results suggest that antipsychotic polypharmacy, compared with monotherapy, may be independently associated with an increased risk of having pre-metabolic syndrome, even after adjusting for patients' lifestyle characteristics. As metabolic syndrome is associated with an increased risk of cardiovascular mortality, further studies are needed to clarify the validity and safety of antipsychotic polypharmacy. © 2011 Misawa et al; licensee BioMed Central Ltd. Source

Odagiri Y.,Yamanashi Prefectural University
[Nihon kōshū eisei zasshi] Japanese journal of public health

The increase in the overweight or underweight student population in Japanese schools is an important health issue. To assess the independent effects of age, period, and birth cohorts, we analyzed trends in the rates of overweight and underweight students from 1977 to 2006 using a Bayesian age-period-cohort (APC) analysis. Additionally, we predicted the rates overweight and underweight students in 2007-2016. We created a data set of the rates of overweight and underweight students aged 6-14 years using the annual school health survey report data. We then analyzed a cohort table that plotted age against calendar time using a Bayesian APC model. We also made a prediction of the rates of overweight and underweight students in 2007-2016. For overweight students, the age effect increased from 6 to 11 years of age for male students and from 6 to 12 years of age for female students; thereafter, the effects decreased. The period effects consistently increased until late 1990, and decreased thereafter for both male and female students. The cohort effects increased for male students born between 1963 and 1969, and later decreased for those born in 1981. However, this trend for male students later increased. For female students, the cohort effects decreased for those born between 1963 and 1975, and later increased for those born in 1990, indicating a plateau or slight increase in the trend. For underweight students, the age effect in male students increased from 7 to 10 years of age, and then plateaued; whereas, the age effect increased from 7 to 12 years of age for female students before reaching a plateau. The period effects increased consistently by 2000 and decreased slightly in both male and female students. The birth cohort effect in male students increased for those born after the mid-1980s, and then plateaued in the early 1990s. The cohort effect increased for female students born after 1984, and then plateaued in 1993. The projections for the rates of overweight and underweight student population indicated a steady trend until 2016. The rate of overweight and underweight students was strongly influenced by age; however, period and birth cohort also played a role. The projections for the rates of overweight and underweight students indicated a steady trend until 2016. These results suggest that strategies based on age-, period-, and cohort-specific measures may be required for future interventions for preventing overweight and underweight among students. Source

Fujita R.,Osaka University | Tanaka Y.,Panasonic | Saihara Y.,Panasonic | Yamakita M.,Yamanashi Prefectural University | And 2 more authors.
Journal of Physiological Anthropology

The objectives of this paper were to determine the level of oxidative stress in atrophied gastrocnemius, and to verify the effect of molecular hydrogen (H 2) saturated alkaline electrolyzed water (HSW) on gastrocnemius atrophy by modifying the redox status, indicated by 8-hydroxy-2'- deoxyguanosine (8-OHdG), malondialdehyde (MDA), and superoxide dismutase (SOD)-like activity. Female Wistar rats were divided into four groups: (1) the control (CONT); (2) the Hindlimb unloading (HU, for 3 weeks) given purified normal water (HU-NW); (3) the HU given alkaline electrolyzed reduced water (HU-AEW); and (4) the HU given HSW (HUHSW). We showed that 8-OHdG, but not MDA, significantly increased by 149% and 145% in HU-NW and HU-AEW, respectively, when compared with CONT. In contrast, there was a trend toward suppression in 8-OHdG levels (increased by 95% compared with CONT) by treatment of HSW, though this effect was not prominent. Additionally, SOD-like activity significantly increased in both HU-NW (184%) and HU-AEW (199%) when compared with CONT. This result suggests the elevation of O - 2in the atrophied gastrocnemius. However, upregulation of SOD-like activity in the HU-HSW was increased by only 169% compared with CONT, though this difference is too small to detect statistical significance. HU led to 13% and 15% reduction of gastrocnemius wet weights in HU-NW and HU-AEW, respectively, compared with CONT. And the reduction of gastrocnemius wet weights in HU-HSW was attenuated by 7% compared with CONT. The gastrocnemius wet weights in the HU-HSW group were significantly greater than those in the HU-AEW, but not statistically significant with HU-NW. These results indicate that HU causes an increase in oxidative stress, but, in this experimental protocol, continuous consumption of HSW during HU does not demonstrate successful attenuation of oxidative stress and HU-mediated gastrocnemius atrophy. Source

Hirao Y.,Kitasato University | Hirao Y.,Yamanashi Prefectural University | Ikeda-Dantsuji Y.,Kitasato University | Matsui H.,Kitasato University | And 5 more authors.
BMC Microbiology

Background: A class of methicillin-resistant Staphylococcus aureus (MRSA) shows resistance to vancomycin only in the presence of β-lactam antibiotics (BIVR). This type of vancomycin resistance is mainly attributable to the rapid depletion of free vancomycin in the presence of β-lactam antibiotics. This means that β-lactam antibiotics remain active or intact in BIVR culture, although most MRSA cells are assumed to produce β-lactamase. We hypothesised that the BIVR cells either did not harbour the β-lactamase gene, blaZ, or the gene was quiescent. We tested this hypothesis by determining β-lactamase activity and conducting PCR amplification of blaZ. Results: Five randomly selected laboratory stock BIVR strains showed an undetectable level of β-lactamase activity and were blaZ-negative. Five non-BIVR stock strains showed an average β-lactamase activity of 2.59 ± 0.35 U. To test freshly isolated MRSA, 353 clinical isolates were collected from 11 regionally distant hospitals. Among 25 BIVR strains, only 16% and 8% were blaZ positive and β-lactamase-positive, respectively. In contrast, 95% and 61% of 328 non-BIVR strains had the blaZ gene and produced active β-lactamase, respectively. To know the mechanism of low β-lactamase activity in the BIVR cells, they were transformed with the plasmid carrying the blaZ gene. The transformants still showed a low level of β-lactamase activity that was several orders of magnitude lower than that of blaZ-positive non-BIVR cells. Presence of the β-lactamase gene in the transformants was tested by PCR amplification of blaZ using 11 pairs of primers covering the entire blaZ sequence. Yield of the PCR products was consistently low compared with that using blaZ-positive non-BIVR cells. Nucleotide sequencing of blaZ in one of the BIVR transformants revealed 10 amino acid substitutions. Thus, it is likely that the β-lactamase gene was modified in the BIVR cells to downregulate active β-lactamase production. Conclusions: We concluded that BIVR cells gain vancomycin resistance by the elimination or inactivation of βlactamase production, thereby preserving β-lactam antibiotics in milieu, stimulating peptidoglycan metabolism, and depleting free vancomycin to a level below the minimum inhibitory concentration of vancomycin. Source

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