Yamagata-shi, Japan
Yamagata-shi, Japan

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Pal B.,University of Cincinnati | Schwartz A.J.,University of Cincinnati | Abdesselam A.,University of Tabuk | Adachi I.,Graduate University for Advanced Studies | And 187 more authors.
Physical Review D - Particles, Fields, Gravitation and Cosmology | Year: 2015

We report a search for the charmless hadronic decay B0→ηπ0 with a data sample corresponding to an integrated luminosity of 694 fb-1 containing 753×106 BB¯ pairs. The data were collected by the Belle experiment running on the Y(4S) resonance at the KEKB e+e- collider. We measure a branching fraction B(B0→ηπ0)=(4.1-1.5-0.7+1.7+0.5)×10-7, where the first uncertainty is statistical and the second is systematic. Our measurement gives an upper limit of B(B0→ηπ0)<6.5×10-7 at 90% confidence level. The signal has a significance of 3.0 standard deviations and constitutes the first evidence for this decay mode. © 2015 American Physical Society. © 2015 American Physical Society.


Sasaki M.,Royal Melbourne Hospital | Sasaki M.,Tachikawa Hospital | Sasaki M.,Sensory Medical | Sasaki M.,Keio University | And 15 more authors.
Investigative Ophthalmology and Visual Science | Year: 2015

PURPOSE. To assess the associations between dietary intake of polyunsaturated fatty acids (PUFAs) and diabetic retinopathy (DR). METHODS. This was a cross-sectional study of 379 patients (median age: 66.0 years) with diabetes attending a diabetes eye clinic. Daily fatty acid intake was assessed by using a validated Food Frequency Questionnaire and adjusted for energy intake. Diabetic retinopathy was graded from fundus photographs as no DR, nonproliferative DR, or proliferative DR. Patients were categorized as ‘‘well-controlled diabetes’’ (n = 123) and ‘‘poorly controlled diabetes’’ (n = 256), defined as glycated hemoglobin (HbA1c) level < 7.0% or ≥ 7.0%, respectively. RESULTS. There were no associations between any fatty acid intake and DR. However, among patients with well-controlled diabetes, increasing daily intake of PUFAs was associated with a reduced likelihood of the presence (odds ratio [OR]: 0.18; 95% confidence interval [CI]: 0.06– 0.59) and severity of DR after adjusting for age, sex, HbA1c, mean arterial blood pressure, and duration of diabetes. Moreover, an increased saturated fatty acid (SFA) intake was associated with increased likelihood of the presence (OR: 2.37; 95% CI: 1.15–4.88) and severity of DR. No association was found among those with poorly controlled diabetes. CONCLUSIONS. Increasing PUFA intake was associated with a reduced likelihood of the presence and severity of DR in well-controlled diabetes, whereas increasing SFA intake was associated with an increased likelihood of the presence and severity of DR. Further studies to confirm this observation are warranted to elucidate the underlying mechanisms and potential role of dietary PUFA and SFA intake in the management of DR. © 2015 The Association for Research in Vision and Ophthalmology, Inc.


Sato S.,Nihon University | Kabeya H.,Nihon University | Yoshino A.,Nihon University | Sekine W.,Nihon University | And 5 more authors.
Emerging Infectious Diseases | Year: 2015

Bartonella quintana bacteremia was detected in 6 (13.3%) of 45 wild-caught Japanese macaques (Macaca fuscata). Multilocus sequence typing of the isolates revealed that Japanese macaques were infected with a new and specific B. quintana sequence type. Free-ranging Japanese macaques thus represent another natural reservoir of B. quintana. © 2015, Centers for Disease Control and Prevention (CDC). All rights reserved.


Hirata T.,Kyushu University | Matsuno H.,Kyushu University | Kawaguchi D.,Kyushu University | Yamada N.L.,Research Accelerator | And 3 more authors.
Polymer (United Kingdom) | Year: 2015

The technique of surface segregation was applied to prepare a bio-inert polymer interface. A small amount, 10 wt%, of poly(2-methoxyethyl acrylate) (PMEA), which exhibits excellent bio-inertness properties, fed into a matrix polymer was able to suppress platelet adhesion sufficiently to be of practical use. PMEA was effective because it was preferentially segregated at the outermost region of the polymer blend. Combining interfacial-sensitive analyses such as the air bubble contact angle and neutron reflectivity measurements and sum-frequency generation spectroscopy with the platelet adhesion test gives a better understanding of how the bio-inert property is expressed at the water interface. © 2015 Published by Elsevier Ltd.


Tanaka A.,Teikyo University | Miura K.,Teikyo University | Yagi M.,Teikyo University | Kikuchi K.,Teikyo University | And 4 more authors.
Acta Hepatologica Japonica | Year: 2016

Patients with primary biliary cholangitis (PBC) occasionally complain of subjective symptoms including pruritus, fatigue and sicca syndrome. The aims of the study employing 180 Japanese PBC patients were1) to validate the Japanese versions of PBC-40, a disease-specific questionnaire for the quality of life, and 2) to assess subjective symptoms in Japanese patients with PBC. Statistical analyses confirmed validity of the Japanese version of PBC-40. Among all Japanese PBC patients, 26%, 31% and 54% reported fatigue, pruritus and sicca, respectively as more than “moderate” and 32% of patients assessed “absent” or “mild” in all three symptoms. The association was observed between pruritus and presence of cirrhosis, and between sicca and age. Regarding general health-related QOL assessment with SF-36, QOL was impaired in “general health perceptions”, “physical role functioning”, “vitality”, and “mental health”. © 2016 The Japan Society of Hepatology.


Daimon M.,Hirosaki University | Oizumi T.,Hematology | Kameda W.,Hematology | Matsui J.,Hirosaki University | And 7 more authors.
Journal of Atherosclerosis and Thrombosis | Year: 2015

Aim: To evaluate the effects of treatment for hyperlipidemia on total mortality, we examined the association with adjustments for multiple factors, including those related to general health, such as blood hemoglobin and serum levels of albumin, adiponectin, brain natriuretic peptide, and lipids, using a prospective cohort study of a general Japanese population. Methods: The population-based, longitudinal Takahata study enrolled 3,291 Japanese individuals (1515 male, 1776 female; age: 62.5±10.3 years) between 2004 and 2006. The incidence and causes of death were annually monitored until January 10, 2012 (median follow-up period: 2,655 days). Results: During the follow-up period, there were 169 deaths. The Cox proportional hazard regression model analysis used to adjust for factors related to general health condition, cardiovascular disease risks, and serum lipid levels showed a significant association between treatment for hyperlipidemia and decreased total mortality compared with no treatment for hyperlipidemia [hazard ratio (HR): 0.24; 95% confidence interval (CI): 0.08–0.69) and subjects without hyperlipidemia (HR: 0.34; 95%CI: 0.12– 0.96). The Cox proportional hazard regression model analysis with adjustments for factors related to general health conditions showed a significantly lower total mortality in subjects without hyperlipidemia than that in subjects with untreated hyperlipidemia (HR: 0.70; 95%CI: 0.50 – 0.99). Conclusions: Not only antihyperlipidemic drugs used but also selection bias and non-evaluated factors, such as socio-economic status, educational level, health literacy, and daily nutrition, affected the results. Subjects taking treatment for hyperlipidemia were found to have reduced total mortality, which was independent of serum lipid levels. © 2015, Japan Atherosclerosis Society. All rights reserved.


Jiromaru T.,Yamagata UniversityYamagata | Kosaka T.,Yamagata UniversityYamagata | Matsuo T.,Japan Advanced Institute of Industrial Technology
Studies in Computational Intelligence | Year: 2015

It is important for each leader to know relationship of the reason why each learner mistakes the problem of Mathematics. But, it does not exist about previous research. Therefore, in this research, we collected answers of each learner for knowing element of difficulty level in Mathematics. And we identified 10 types. 10 types are “lack of understand(problem statement, Number & Symbol, Formula, Concept)”, “circumstances of learner (inside)”, “circumstances of learner (outside)”, “Miscalculation”, “Copy miss”, “Lack of logical thinking (Deduction)” and “Lack of logical thinking (Induction)”. © Springer International Publishing Switzerland 2015.

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