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Yonezawa, Japan

Yamagata University is a national university located in the Japanese cities of Yamagata, Yonezawa, and Tsuruoka in Yamagata Prefecture.The university was established in 1949, but its origin can be traced back to the Yamagata Normal School , a public teacher-training institution, founded in 1878 in Yamagata City. The university also has other roots: the Yonezawa Higher Technical School founded in 1910 in Yonezawa City, the Yamagata Higher School founded in 1920 in Yamagata City, the Yamagata Youth Normal School founded in 1922 in Yamagata City, and the Yamagata Prefectural Agricultural College founded in 1947 in Tsuruoka City.Yamagata University is the second-largest university in the Tohoku Region. The university has six faculties and about 10,000 students in four campuses. It also has an additional subcampus in which University K-9 schools are administered. Wikipedia.

Objective To investigate the prognosis and prognostic factors of patients with metastatic renal cell carcinoma who underwent metastasectomy. Methods We sent questionnaires to Japanese hospitals. The questionnaires included data of patients with metastatic renal cell carcinoma who had their metastatic lesions removed between January 1988 and December 2009. We collected them and retrospectively analyzed these data and calculated the overall survival from the first metastasectomy until death or last follow-up. We also analyzed the relationship between survival and clinico-pathologic features and determined adverse prognostic factors. Furthermore, we identified a poor prognostic group by counting the number of prognostic factors. Results A sample size of 556 patients from 48 institutions was studied. The median overall survival was 80 months. Four adverse prognostic factors were detected: incomplete resection by metastasectomy (hazard ratio [HR], 2.15), brain metastasis (HR, 3.73), >1.0 mg/dL C-reactive protein (HR, 2.45), and the highest histologic grade in Japanese classification (nuclei of tumor cells are larger than nuclei of normal tubular cells; HR, 1.88). The median overall survivals of patients with 3 or 4 prognostic factors, 2 factors, and 0 and 1 factors were 10 months, 42 months, and 105 months, respectively. Conclusion Four adverse prognostic factors for predicting the survival of patients with removed metastases were identified. Patients with 3 or 4 of these adverse prognostic factors had a worse prognosis. © 2013 Elsevier Inc. All Rights Reserved.

Tanaka M.,Yamagata University
Biochimica et Biophysica Acta - General Subjects | Year: 2011

Background: The design of biocompatible 2D surfaces and 3D nano/micro topographies based on self-organization has a variety of potential applications in medical devices and tissue engineering. We have reported that biocompatible 2D surface using poly(2-methoxyethyl acrylate) (PMEA) and honeycomb-patterned 3D films with regular interconnected pores that is formed by self-organization. Scope of Review: We highlight that 1) the reasons for this compatibility by comparing the structure of water in hydrated PMEA to the water structure of other polymers and 2) the reasons that 3D films exerted a strong influence on normal, cancer and stem cell morphology, proliferation, differentiation, cytoskeleton, focal adhesion, and functions including matrix production profiles. Major Conclusions: 1) We hypothesized that intermediate water, which prevents the biocomponents from directly contacting the polymer surface or non-freezing water on the polymer surface, plays an important role in the excellent biocompatibility. 2) The cellular response to 3D films originates from the regularly aligned adsorbed proteins determined by the pore structure of the film. General Significance: It is expected that combining the biocompatible 2D surfaces and 3D nano/micro topographies will provide an effective strategy for medical devices and tissue engineering scaffolds. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine. © 2010 Elsevier B.V.

Kuroda M.,Yamagata University
Acta Materialia | Year: 2013

Deformation behavior in single-slip oriented micropillars subjected to compressive loading is analyzed using a three-dimensional finite element method incorporating a higher-order gradient crystal plasticity theory in which the spatial gradients of the geometrically necessary dislocation densities are assumed to give rise to backstress that impedes or promotes dislocation motion, depending on its sign. In experimental studies, it has been frequently observed that the gauge portion of micropillar samples is split into a shear zone and two nearly unstrained dead zones under compressive loading. Here it is shown that effects of a higher-order gradient are essential for the formation of this particular deformation mode.

Yokoyama D.,Yamagata University
Journal of Materials Chemistry | Year: 2011

In research on small-molecule organic light-emitting diodes (OLEDs), the molecular orientation in vacuum-deposited amorphous films has been disregarded for around 20 years, and its effects on device performance have not been sufficiently discussed at the microscopic level. Only recently have the intermolecular interaction and subsequent horizontal molecular orientation in OLEDs been investigated and reported. In this article, an overview of the recent studies on molecular orientation in OLEDs is presented. The general properties of molecular orientation of OLED materials are shown, and its significant effects on the electrical and optical properties of devices are discussed to understand device physics and improve the future performance and reliability of OLEDs. © 2011 The Royal Society of Chemistry.

Ichinose A.,Yamagata University
Seminars in Thrombosis and Hemostasis | Year: 2011

Coagulation factor XIII (F13) circulates in blood as a heterotetramer composed of an A subunit dimer and a B subunit dimer. It is activated by thrombin and crosslinks fibrin monomers. Congenital F13 deficiency demonstrates a lifelong bleeding tendency, abnormal wound healing, and recurrent miscarriages, and it first manifests as umbilical bleeding after birth. In contrast, secondary F13 deficiencies due to its overconsumption and/or hypobiosynthesis by disseminated intravascular coagulation, major surgery, liver diseases, and other disorders are rather common but rarely complicated with bleeding symptoms. Recently, consultations with physicians who have patients with hemorrhagic-acquired F13 deficiency with anti-F13 inhibitors (acquired hemorrhaphilia 13) have indicated an increase in this disease in Japan. We performed a nationwide survey, supported by the Japanese Ministry of Health, Welfare and Labor and confirmed 21 Japanese cases of this disease with anti-F13 inhibitors. Because neither prolonged clotting times nor reduced platelet counts are observed in patients with this disease, many more cases may have been overlooked. Physicians must be mindful of acquired hemorrhaphilia 13 when seeing such patients and should measure F13 activity. Products containing F13 are effective for hemostasis generally, and immunosuppressive therapy must be started immediately to eradicate anti-F13 antibodies. © 2011 by Thieme Medical Publishers, Inc.

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