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Yamagata-shi, Japan

Wakabayashi I.,Hyogo College of Medicine | Sotoda Y.,Yamagata Saisei Hospital | Hirooka S.,Yamagata Saisei Hospital | Orita H.,Yamagata Saisei Hospital
Clinica Chimica Acta | Year: 2015

Background: Cardiometabolic index (CMI), calculated as a product of waist-to-height ratio and triglycerides-to-HDL cholesterol ratio, is a new index for discriminating diabetes mellitus. Patients with peripheral arterial disease (PAD) are prone to have other atherosclerotic diseases such as coronary artery disease and stroke. The purpose of this study was to clarify the relationships between CMI and indicators of atherosclerotic progression in patients with PAD. Methods: The subjects were 63 outpatients with PAD. Relationships of CMI with variables related to atherosclerotic progression were investigated using multivariate linear regression analysis and analysis of covariance with adjustment for age, sex and histories of smoking and alcohol drinking. Results: Log-transformed CMI was significantly correlated with mean intima-media thickness of the common carotid artery (IMT) (standardized regression coefficient: 0.350, p<. 0.01) and % decrease in ankle-brachial systolic pressure index (ABI) after treadmill exercise (standardized regression coefficient: 0.365, p<. 0.01). Mean IMT and % decrease in ABI by treadmill exercise were significantly higher (. p<. 0.01) in the group of the 3rd tertile for CMI than in the group of its 1st tertile (mean. ±. SE: mean IMT (mm), 0.94. ±. 0.06 (1st tertile) vs. 0.94. ±. 0.06 (2nd tertile) vs. 1.19. ±. 0.06 (3rd tertile); % decrease in ABI, 14.1. ±. 3.4 [1st tertile] vs. 26.0. ±. 3.5 [2nd tertile] vs. 30.0. ±. 3.5 [3rd tertile]). Conclusion: CMI was shown to be associated with the degrees of atherosclerosis in the common carotid artery and ischemia in leg arteries and is therefore a useful discriminator of atherosclerotic progression in patients with PAD. © 2015 Elsevier B.V. Source


Kantake M.,Juntendo University | Yoshitake H.,Juntendo University | Ishikawa H.,Yamagata Saisei Hospital | Araki Y.,Juntendo University | Shimizu T.,Juntendo University
BMJ Open | Year: 2014

Objective: To examine the environmental effects on cytosine methylation of preterm infant's DNA, because early life experiences are considered to influence the physiological and mental health of an individual through epigenetic modification of DNA. Design: A prospective cohort study, comparison of epigenetic differences in the glucocorticoid receptor (GR) gene between healthy term and preterm infants. Setting: Neonatal Intensive Care Unit in a Japanese University Hospital. Participants: A cohort of 40 (20 term and 20 preterm) infants was recruited on the day of birth, and peripheral blood was obtained from each infant at birth and on postnatal day 4. Main outcome measures: The methylation rates in the 1-F promoter region of the GR gene using the Mquant method. Results: The methylation rate increased significantly between postnatal days 0 and 4 in preterm infants but remained stable in term infants. Thus, the methylation rate was significantly higher in preterm than in term infants at postnatal day 4. Several perinatal parameters were significantly correlated with this change in the methylation rate. Logistic regression analysis revealed that methylation rates at postnatal day 4 predicted the occurrence of later complications that required glucocorticoid administration during the neonatal period. No gene polymorphism was detected within the GR promoter region analysed. Conclusions: Although further large-scale studies are needed to detect the environmental factors that explain the difference in epigenetic modification among infants after birth, our data show that the postnatal environment influences epigenetic programming of GR expression through methylation of the GR gene promoter in premature infants, which may result in relative glucocorticoid insufficiency during the postnatal period. Source


Hirooka S.,Yamagata Saisei Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2012

True left ventricular aneurysms are thought to arise from the expansion and thinning of the transmural infarct area, whereas false aneurysms result from containment of ventricular rupture by pericardial adhesions. We reported a case of true left ventricular aneurysm with pseudoaneurysm( mixed type aneurysm) which was treated surgically. Source


Hirooka S.,Yamagata Saisei Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2013

This case report describes a 77-year-old man who developed infective endocarditis resulting in perforated aneurysm of the non-coronary cusp with aortic regurgitation. Diagnosis was made by transesophageal echocardiogram and successful surgical valve replacement was performed. Source


Hirooka S.,Yamagata Saisei Hospital
Kyobu geka. The Japanese journal of thoracic surgery | Year: 2012

We reported a case of peripheral embolization arising from diffuse thoracoabdominal aortic thrombi with minimal evidence for atherosclerosis or other aortic pathology. After the patient was treated with anticoagulation therapy, surgical removal of peripheral embolus was performed. Source

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