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Zamami Y.,Okayama University | Fujiwara H.,Okayama University | Hosoda M.,Okayama University | Hino H.,Okayama University | And 6 more authors.
Yakugaku Zasshi | Year: 2010

Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. © 2010 The Pharmaceutical Society of Japan. Source

Takeuchi H.,Tottori University | Morizane R.,Tottori University | Sakoda T.,Tottori University | Hashimoto K.,Yamada Apiculture Center Inc. | And 4 more authors.
Japanese Pharmacology and Therapeutics | Year: 2010

Background: The current management of Japanese cedar pollinosis (JCP) with antiallergic drugs has a substantial limitation in efficacy and safety, generating the need of some complementary treatment. As extracts of propolis, bee pollen and/or several herbs have been considered promisingly applicable to such treatment, we used a tablet-form supplementary diet containing Brazilian propolis (P) -, bee pollen (BP) - and mixed herbal (MH) -extracts, together with group-B vitamins, as the active diet and examined its potential usefulness in subjects with JCP. Methods: A randomized, double-blind, placebo-controlled clinical study was conducted on 30 male and female adult subjects with JCP, who were randomly assigned to receive either active diet or placebo once daily for 12 weeks over the pre-pollen season through the on-pollen season in 2005. The active diet contained (in a daily dose) : 120 mg of P-extract, 120 mg of BP-extract, 335.4 mg of MH-extracts, and 24.6 mg of group-B vitamins. The efficacy was primarily evaluated on the basis of daily symptom scores, medication scores and symptommedication scores. Results: Compared with placebo-intake group, a significant improvement in both medication scores and symptom-medication scores were observed in active diet-intake group. The active diet significantly reduced the need for rescue medication, and was well tolerated without any untoward side-effect nor laboratory abnormalities. Conclusions: Ingestion of the active diet throughout the pre-and on-pollen seasons of the year is useful for JCP patients to save the conventional drug medication for the disease. Source

Paerhati Y.,Iwate University | Paerhati Y.,ARKRAY Inc. | Ishiguro S.,Iwate University | Ueda-Matsuo R.,Iwate University | And 7 more authors.
PLoS ONE | Year: 2015

We investigated the association between the expression of a gene encoding gustatory receptor (G10) and division of labor in the honey bee, Apis mellifera. Among 10 GR genes encoding proteins 15% ∼ 99% amino acid identity in the honey bee, we found that AmGR10 with 99% identity is involved in nursing or brood care. Expression of AmGR10 was restricted to organs of the hypopharyngeal gland, brain, and ovary in the nurse bee phase. Members of an extended nursing caste under natural conditions continued to express this gene. RNAi knockdown of AmGR10 accelerated the transition to foraging. Our findings demonstrate that this one gene has profound effects on the division of labor associated with the development and physiology of honeybee society. © 2015 Paerhati et al.This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Source

Tani H.,Yamada Apiculture Center Inc. | Hasumi K.,Yamada Apiculture Center Inc. | Hasumi K.,RIKEN | Tatefuji T.,Yamada Apiculture Center Inc. | And 3 more authors.
Bioorganic and Medicinal Chemistry | Year: 2010

The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors. Crown Copyright © 2009. Source

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