Yaizu Suisankagaku Industry Co.

Shizuoka-shi, Japan

Yaizu Suisankagaku Industry Co.

Shizuoka-shi, Japan

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Kubomura D.,Yaizu Suisankagaku Industry Co. | Ueno T.,Yaizu Suisankagaku Industry Co. | Yamada M.,Yaizu Suisankagaku Industry Co. | Tomonaga A.,Tana Orthopedic Surgery | Nagaoka I.,Juntendo University
Experimental and Therapeutic Medicine | Year: 2017

N-acetylglucosamine (GlcNAc) is a widely accepted treatment for osteoarthritis (OA); however, its effect on healthy individuals is poorly understood. To evaluate the effect of GlcNAc administration on healthy subjects that do not exhibit symptoms of arthritis, the present randomized, double-blind, placebo-controlled study was performed. In the present study, 68 male and female Japanese participants, without symptomatic and radiographic evidence of OA, were enrolled and randomly allocated to receive placebo or GlcNAc (500 or 1,000 mg/day) for 16 weeks. Effects were evaluated using biomarkers for type II collagen degradation and synthesis, collagen type II cleavage (C2C), procollagen type II carboxy-terminal propeptide (PIICP) and their ratio (C2C/PIICP). Furthermore, safety assessments were performed via physical parameters, hematology, blood biochemistry and urinalysis. The results indicated that there was no significant change in the biomarkers for type II collagen degeneration and synthesis during and after the intervention with the placebo and two GlcNAc groups. However, subgroup analysis using subjects with impaired cartilage metabolism (who exhibited enhanced type II collagen degradation and reduced type II collagen synthesis) indicated that the C2C levels were significantly decreased at 8 (P<0.05) and 16 (P<0.01) weeks during the intervention in the two GlcNAc (500 mg and 1,000 mg/day) groups, compared with the placebo group. In contrast, PIICP levels were not notably different in the placebo and two GlcNAc groups. The C2C/PIICP ratio was markedly decreased at 12 and 16 weeks during the intervention in the two GlcNAc groups, compared with the placebo group. Moreover, no supplement-related adverse events were observed during and after the intervention. In conclusion, these observations indicate that oral administration of GlcNAc at doses of 500 and 1,000 mg/day improves cartilage metabolism in healthy subjects without apparent adverse effects. © 2017, Spandidos Publications. All rights reserved.


Patent
University of Tokyo and Yaizu Suisankagaku Industry Co. | Date: 2017-06-21

To provide an adiponectin secretion regulator whereby the effect of adiponectin can be efficiently expressed while the adverse effect of appetite increase associated with adiponectin is avoided, and to provide a food/drink product, a functional food product, a cosmetic, a pharmaceutical, and an animal feed having such adiponectin secretion regulating effects. In the present invention, fucose or a precursor thereof is used as an active ingredient of the adiponectin secretion regulator. A food/drink product, a functional food product, a cosmetic, a pharmaceutical, or an animal feed having adiponectin secretion regulating effects is obtained by compounding a specific amount of fucose or a precursor thereof.


Patent
University of Tokyo and Yaizu Suisankagaku Industry Co. | Date: 2015-07-31

To provide an adiponectin secretion regulator whereby the effect of adiponectin can be efficiently expressed while the adverse effect of appetite increase associated with adiponectin is avoided, and to provide a food/drink product, a functional food product, a cosmetic, a pharmaceutical, and an animal feed having such adiponectin secretion regulating effects. In the present invention, fucose or a precursor thereof is used as an active ingredient of the adiponectin secretion regulator. A food/drink product, a functional food product, a cosmetic, a pharmaceutical, or an animal feed having adiponectin secretion regulating effects is obtained by compounding a specific amount of fucose or a precursor thereof.


Nakagawa Y.S.,Ichinoseki National College of Technology | Oyama Y.,Ichinoseki National College of Technology | Kon N.,Ichinoseki National College of Technology | Nikaido M.,Ichinoseki National College of Technology | And 8 more authors.
Carbohydrate Polymers | Year: 2011

The production of N-acetylglucosamine (GlcNAc, chitin monosaccharide) from crab or shrimp shells generally requires numerous steps and the use of deleterious substances. One goal for researchers is the direct production of GlcNAc and NN′-diacetylchitobiose [(GlcNAc)2, chitin structural dimeric unit] from both chitin and crab shells. The present study reports the development of an intensive ball "converge" mill for the rapid mechanochemical conversion of chitin or crab shells into amorphous, chitinase-sensitive microparticles. Optimal crab shell grinding parameters were determined, and close to 100% direct degradation of chitin from crab shell to GlcNAc was achieved. This is the first report of using a mechanochemical process with enzymatic degradation to decrease the environmental burdens associated with GlcNAc production from chitin. © 2010 Elsevier Ltd. All rights reserved.


Shigemura Y.,Tokyo Kasei University | Kubomura D.,Yaizu Suisankagaku Industry Co. | Sato Y.,Tokyo Kasei University | Sato K.,Kyoto Prefectural University
Food Chemistry | Year: 2014

The presence of hydroxyproline (Hyp)-containing peptides in human blood after collagen hydrolysate ingestion is believed to exert beneficial effects on human health. To estimate the effective beneficial dose of these peptides, we examined the relationship between ingested dose and food-derived Hyp levels in human plasma. Healthy volunteers (n = 4) ingested 30.8, 153.8 and 384.6 mg per kg body weight of collagen hydrolysate. The average plasma concentration of Hyp-containing peptides was dose-dependent, reaching maximum levels of 6.43, 20.17 and 32.84 nmol/ml following ingestion of 30.8, 153.8 and 384.6-mg doses of collagen hydrolysate, respectively. Ingesting over 153.8 mg of collagen hydrolysate significantly increased the average concentrations of the free and peptide forms of Hyp in plasma. The Hyp absorption limit was not reached with ingestion of as much as 384.6 mg of collagen hydrolysate. These finding suggest that ingestion of less than 30.8 mg of collagen hydrolysate is not effective for health benefits. © 2014 Elsevier Ltd. All rights reserved.


PubMed | Yaizu Suisankagaku Industry Co., Kyoto Prefectural University and Tokyo Kasei University
Type: | Journal: Food chemistry | Year: 2014

The presence of hydroxyproline (Hyp)-containing peptides in human blood after collagen hydrolysate ingestion is believed to exert beneficial effects on human health. To estimate the effective beneficial dose of these peptides, we examined the relationship between ingested dose and food-derived Hyp levels in human plasma. Healthy volunteers (n=4) ingested 30.8, 153.8 and 384.6 mg per kg body weight of collagen hydrolysate. The average plasma concentration of Hyp-containing peptides was dose-dependent, reaching maximum levels of 6.43, 20.17 and 32.84 nmol/ml following ingestion of 30.8, 153.8 and 384.6-mg doses of collagen hydrolysate, respectively. Ingesting over 153.8 mg of collagen hydrolysate significantly increased the average concentrations of the free and peptide forms of Hyp in plasma. The Hyp absorption limit was not reached with ingestion of as much as 384.6 mg of collagen hydrolysate. These finding suggest that ingestion of less than 30.8 mg of collagen hydrolysate is not effective for health benefits.


Shintani T.,Kyoto University | Yamazaki F.,Kyoto University | Katoh T.,Kyoto University | Umekawa M.,Kyoto University | And 6 more authors.
Biochemical and Biophysical Research Communications | Year: 2010

Autophagy is a cellular process that nonspecifically degrades cytosolic components and is involved in many cellular responses. We found that amino sugars with a free amino group such as glucosamine, galactosamine and mannosamine induced autophagy via an mTOR-independent pathway. Glucosamine-induced autophagy at concentrations of at least 500 μM to over 40 mM. In the presence of 40 mM glucosamine, autophagy induction was initiated at 6 h and reached a plateau at 36 h. Glucosamine-induced autophagy could remove accumulated ubiquitin-conjugated proteins as well as 79-glutamine repeats. Therefore, orally administered glucosamine could contribute to the prevention of neurodegenerative diseases and promotion of antiaging effects. © 2010 Elsevier Inc. All rights reserved.


Kubomura D.,Yaizu Suisankagaku Industry Co. | Matahira Y.,Yaizu Suisankagaku Industry Co. | Nagai K.,Osaka University | Nagai K.,ANBAS Corporation | Niijima A.,Niigata University
Nutritional Neuroscience | Year: 2010

Anserine and L-carnosine are similar dipeptides synthesized by muscles of vertebrates. The functional role of anserine is unknown, although previous studies showed hypoglycemic effects of carnosine through autonomic nerves. Thus, we evaluated the effects of anserine on blood glucose levels and the neural activities. Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for the blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine. © 2010 W. S. Maney & Son Ltd.


PubMed | Yaizu Suisankagaku Industry Co.
Type: Journal Article | Journal: Bioscience, biotechnology, and biochemistry | Year: 2016

Theaflavins are reddish-colored polyphenols in black tea. To test the efficacy of theaflavin administration on body fat and muscle, we performed a randomized, double-blind, placebo-controlled study and investigated the effect of theaflavins administration on the body composition using of healthy subjects. In this study, 30 male and female Japanese were enrolled and participants were randomly allocated to receive placebo, theaflavin (50 or 100mg/day), or catechin (400mg/ml) for 10weeks. The effects were evaluated using body weight, body fat percentage, subcutaneous fat percentage, and skeletal muscle percentage. Theaflavin administration significantly improved body fat percentage, subcutaneous fat percentage, and skeletal muscle percentage when compared to with the placebo. In contrast, there was no significant difference in all measured outcomes between the catechin and the placebo groups. The results indicate that oral administration of theaflavin had a beneficial effect on body fat and muscle in healthy individuals.


PubMed | Yaizu Suisankagaku Industry Co.
Type: Journal Article | Journal: Nutritional neuroscience | Year: 2010

Anserine and L-carnosine are similar dipeptides synthesized by muscles of vertebrates. The functional role of anserine is unknown, although previous studies showed hypoglycemic effects of carnosine through autonomic nerves. Thus, we evaluated the effects of anserine on blood glucose levels and the neural activities. Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for the blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine.

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