Yadhunath Mahavidyalya

Bhind, India

Yadhunath Mahavidyalya

Bhind, India
SEARCH FILTERS
Time filter
Source Type

Sharma S.,Yadhunath Mahavidyalya | Sharma M.C.,Devi Ahilya University
International Journal of PharmTech Research | Year: 2010

Various organic solvents like methanol, chloroform, alcohol, dimethyl formamide; acetonitrile, hexane, acetone and carbon tetrachloride have been employed for solubilization of poorly water-soluble drugs for spectrophotometric estimations. Drawbacks of organic solvents include higher cost, toxicity and error in analysis due to volatility. Attempting to minimize these drawbacks, three new, simple, accurate, environmental friendly, cost effective, safe, sensitive spectrophotometric methods have been developed for simultaneous estimation of Atorvastatin Calcium (ATV) and Pioglitazone (PIO) in tablet dosage form tablet dosage form using 8.0 M sodium benzoate aqueous solution, as a hydrotropic agent. Aqueous solubility of these model drugs were enhanced to a great extent 55 and 71 fold for Atorvastatin Calcium (ATV) and Pioglitazone (PIO) in 8.0M sodium benzoate solution respectively. Sodium benzoate solution and additives of tablet did not interfere in analysis, as sodium benzoate did not show any absorbance above 300nm. In 8.0M sodium benzoate solution, Atorvastatin Calcium (ATV) and Pioglitazone (PIO) in tablet dosage form shows maximum absorbance at wavelength 313.0 nm and 324 nm respectively and isobestic point was observed at 303 nm. Beer's law was obeyed in the concentration range 5-35 μg/ml for Atorvastatin Calcium and 5-40μg/ml for Pioglitazone. Method-I is based on simultaneous equation method Results of analysis for methods were tested and validated for various parameters according to ICH guidelines, hence can be adopted for the routine analysis of Atorvastatin Calcium (ATV) and Pioglitazone (PIO) in tablet dosage form.


Sharma S.,Yadhunath Mahavidyalya | Sharma M.C.,Dr Hari Singh Gour University | Kohli D.V.,Dr Hari Singh Gour University
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The plant Argemone mexicana Linn. known as Ghamoya (Family papaveraceae) is an indigenous herb. In the current study ethanolic extract of the leaves of Argemone mexicana was evaluated for its peripheral analgesic activity by Acetic-acid induced writhing response in mice, central analgesic by Tail flicking method in mice and Hot plate method in mice. It was found that the ethanolic extract has very good peripheral activity and significant analgesic activity in comparison to the Aspirin. For drug administration to the animals 10mg of drug (Argemone mexicana) is taken and dissolved in 100ml of water and 20 mg of drug is taken and dissolved in 100ml of water in this way drug extract (10mg/100gm and 20mg/100gm) injection is prepared and it is injected i.p. to the animals according to their weight. The lethal dose of the drug Argemone mexicana was found to be 48.84 mg/100 gm.The aim of the study was to investigate the possible effect of ethanolic extract of whole plant of Argemone mexicana on analgesic activity by i.p. The presence of flavanoids in the extract may be contributory to its analgesic activity.


Sharma M.C.,Yadhunath Mahavidyalya | Kohli D.V.,Dr Hari Singh Gour University | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Annona Squamosa and rhizome of Curcuma longa. The mature green leaves of Annona Squamosa and Curcuma longa were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 49.3% and 61.73% on oral administration at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl. Antidepressant activity comparable to the standard drug Fluoxetine HCl.


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya | Kohli D.V.,Dr Hari Singh Gour University
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Azadiracta indica and rhizome of Curcuma longa. The mature green leaves of Azadiracta indica and Curcuma longa were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 43.3% and 57.73% on oral administration at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl. Antidepressant activity and Anxiolytics comparable to the standard drug Fluoxetine HCl.


Sharma M.C.,Dr Hari Singh Gour University | Kohli D.V.,Dr Hari Singh Gour University | Sharma S.,Yadhunath Mahavidyalya
International Journal of ChemTech Research | Year: 2010

Synthesis of a series of novel substituted benzimidazole derivatives by the condensation of ophenylenediamine (OPDA,) with Mandlic acid and subsequent reactions of the benzimidazole with different amino substituted is reported with reaction biphenyl tetrazole. All the compounds synthesized were screened for their potential anti-hypertensive properties.


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya
Journal of Optoelectronics and Advanced Materials | Year: 2010

Cefadroxil - β-Cyclodextrin dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of Cefadroxil was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:4 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), Xray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate.


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya
International Journal of ChemTech Research | Year: 2010

A three dimensional quantitative structure-activity relationship study using the k-nearest neighbor analysis method was performed on a series of -polyfluoroalkyl and 2-Nitrobenzylsulphanyl benzimidazoles for their Antimycobacterial, activity. This study was performed using 28 compounds, for which k-nearest neighbor analysis models were developed using a training set of 22 compounds. Database alignment of all 28 compounds was carried out by root-mean-square fit of atoms and field fit of the steric and electrostatic molecular fields. The resulting database was analyzed by partial least squares analysis with cross-validation; leave one out and no validation to extract optimum number of components. Further comparison of the coefficient contour maps with the steric and electrostatic properties of the receptor has shown a high level of compatibility and good predictive capability.


Sharma S.,Yadhunath Mahavidyalya | Sharma M.C.,Devi Ahilya University | Kohli D.V.,A And G Pharmaceutical, Inc. | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

This paper described validated high performance liquid chromatographic (HPLC) method for estimation of Rosuvastatin Calcium (ROS) and Ezetimibe (EZE) in tablet dosage form. HPLC separation was achieved on Licrosphere C18 column (250 × 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 3.5(60:20:20 v/v) at flow rate of 1.0ml/min at 25°C temperature. Quantitation was achieved by UV detection at 279 nm over the concentration range 5-10 mg/ml for both the drugs with mean recoveries of 99.01% + 0.12 and 100.64% + 0.20 for ROS and EZE respectively. This method is simple, precise and sensitive and it is applicable for the simultaneous estimation of ROS and EZE in tablet dosage form.


Smita S.,Yadhunath Mahavidyalya | Sharma M.C.,Devi Ahilya University | Kohli D.V.,A And G Pharmaceutical, Inc. | Chaturvedi S.C.,Shri Arvindo Institute of Pharmacy
Optoelectronics and Advanced Materials, Rapid Communications | Year: 2010

Validated high performance liquid chromatographic (HPLC) method for estimation of Torsemide (TOR) and Spironolactone (SPI) in tablet dosage form. Isocratic RP-HPLC separation was achieved on Licrosphere C18 column (250 × 4.6mm) using Methanol: Acetonitrile: Phosphate buffer, pH 6.5 (60:20:20 v/v) at flow rate of 1.5 ml/min at 30 °C temperature. Quantitation was achieved by UV detection at 252 nm over the conc. range 0-25 μg/ml for both the drugs with mean recoveries of 100.01% + 0.12 and 100.64% + 0.20 for TOR and SPI respectively. This method is simple, precise and sensitive and applicable for the simultaneous estimation of TOR and SPI in tablet pharmaceutical combined dosage form.

Loading Yadhunath Mahavidyalya collaborators
Loading Yadhunath Mahavidyalya collaborators