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Bhind, India

Sharma S.,Yadhunath Mahavidyalya | Sharma M.C.,Dr Hari Singh Gour University | Kohli D.V.,Dr Hari Singh Gour University
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The plant Argemone mexicana Linn. known as Ghamoya (Family papaveraceae) is an indigenous herb. In the current study ethanolic extract of the leaves of Argemone mexicana was evaluated for its peripheral analgesic activity by Acetic-acid induced writhing response in mice, central analgesic by Tail flicking method in mice and Hot plate method in mice. It was found that the ethanolic extract has very good peripheral activity and significant analgesic activity in comparison to the Aspirin. For drug administration to the animals 10mg of drug (Argemone mexicana) is taken and dissolved in 100ml of water and 20 mg of drug is taken and dissolved in 100ml of water in this way drug extract (10mg/100gm and 20mg/100gm) injection is prepared and it is injected i.p. to the animals according to their weight. The lethal dose of the drug Argemone mexicana was found to be 48.84 mg/100 gm.The aim of the study was to investigate the possible effect of ethanolic extract of whole plant of Argemone mexicana on analgesic activity by i.p. The presence of flavanoids in the extract may be contributory to its analgesic activity. Source


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya | Kohli D.V.,Dr Hari Singh Gour University
Digest Journal of Nanomaterials and Biostructures | Year: 2010

The aim of present study was to assess the anti-inflammatory activity of polyherbal formulation of leaves of Azadiracta indica and rhizome of Curcuma longa. The mature green leaves of Azadiracta indica and Curcuma longa were collected and authenticated. Extractions of dried leaves and rhizome were carried out with ethanol in soxhlet apparatus. The polyherbal formulation showed the significant anti-inflammatory activity comparable to the standard drug Indomethacin against carrageenan induced rat paw edema method. The polyherbal formulation reduced the inflammation induced by carrageenan by 43.3% and 57.73% on oral administration at 100 mg/ kg and 200 mg/kg respectively as compared to the control treated group an analgesic activity comparable to the standard drug tramadol HCl. Antidepressant activity and Anxiolytics comparable to the standard drug Fluoxetine HCl. Source


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya
Journal of Optoelectronics and Advanced Materials | Year: 2010

Cefadroxil - β-Cyclodextrin dispersions were prepared with a view to study the influence of β-CD on the solubility and dissolution rate of this poorly soluble drug. Phase-solubility profile indicated that the solubility of Cefadroxil was significantly increased in the presence of β-cyclodextrin and was classified as AL-type, indicating the 1:4 stoichiometric inclusion complexes. Physical characterization of the prepared systems was carried out by differential scanning calorimetry (DSC), Xray diffraction studies (XRD) and IR studies. Solid state characterization of the drug β-CD binary system using XRD, FTIR and DSC revealed distinct loss of drug crystallinity in the formulation, ostensibly accounting for enhancement of dissolution rate. Source


Sharma M.C.,Devi Ahilya University | Sharma S.,Yadhunath Mahavidyalya
International Journal of ChemTech Research | Year: 2010

A three dimensional quantitative structure-activity relationship study using the k-nearest neighbor analysis method was performed on a series of -polyfluoroalkyl and 2-Nitrobenzylsulphanyl benzimidazoles for their Antimycobacterial, activity. This study was performed using 28 compounds, for which k-nearest neighbor analysis models were developed using a training set of 22 compounds. Database alignment of all 28 compounds was carried out by root-mean-square fit of atoms and field fit of the steric and electrostatic molecular fields. The resulting database was analyzed by partial least squares analysis with cross-validation; leave one out and no validation to extract optimum number of components. Further comparison of the coefficient contour maps with the steric and electrostatic properties of the receptor has shown a high level of compatibility and good predictive capability. Source


Sharma M.C.,Dr Hari Singh Gour University | Kohli D.V.,Dr Hari Singh Gour University | Sharma S.,Yadhunath Mahavidyalya
International Journal of ChemTech Research | Year: 2010

Synthesis of a series of novel substituted benzimidazole derivatives by the condensation of ophenylenediamine (OPDA,) with Mandlic acid and subsequent reactions of the benzimidazole with different amino substituted is reported with reaction biphenyl tetrazole. All the compounds synthesized were screened for their potential anti-hypertensive properties. Source

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