Yabashi Industries Co.

Ōgaki, Japan

Yabashi Industries Co.

Ōgaki, Japan
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Nakamura J.,Japan National Institute of Materials Science | Ota Y.,Yabashi Industries Co. | Sakka Y.,Japan National Institute of Materials Science | Kasuga T.,Nagoya Institute of Technology
Advanced Powder Technology | Year: 2017

Siloxane-containing vaterite (SiV) microparticles were prepared with controlling the degree of aminopropyl-functionalization in the siloxane; they are aiming for applications as bone regenerative devices. The aim of this work was to evaluate the structure at siloxane/vaterite interphase and to control the solubility of particles by the structural tuning of siloxane. The particles were spherical with average diameters of 1.1-1.4μm. Differential infrared spectrometry revealed the transformation of aminopropyl terminals in the siloxane into carbamate (NH-COO-) groups. Moreover, the vaterite crystallites in the particles were slightly oriented towards the (001) plane. These results describe the interphase structure, with the carbamate groups coordinating on the Ca2+ ion face in the (001) plane of neighbouring vaterite. Upon soaking in buffer solution, the particles exhibited a rapid initial release of Ca2+ ions within 30min and of soluble silica within 2h. The vaterite in this particle survived for more than 6h. The chemical stability of the siloxane was enhanced by incorporating tetraethoxysilane-derived siloxane with fractions of 24mol% or 50mol%. This enhancement controlled the initial release of not only soluble silica but also Ca2+ ions. © 2017.


Obata A.,Nagoya Institute of Technology | Hotta T.,Nagoya Institute of Technology | Wakita T.,Nagoya Institute of Technology | Wakita T.,Yamahachi Dental Manufacturing Co. | And 2 more authors.
Acta Biomaterialia | Year: 2010

Silicon-releasable microfiber meshes consisting of silicon-doped vaterite (SiV) particles and poly(lactic acid) (PLA) hybrids were prepared by electrospinning. Due to their flexibility and porosity they formed ideal membranes or scaffolds for guided bone regeneration. In addition, a trace amount of silicon species has been reported to stimulate osteogenic cells to mineralize and enhance bone formation. We propose a new method of preparation of silicon-releasing microfiber meshes by electrospinning. Their structure and hydroxyapatite (HA)-forming abilities in simulated body fluid were examined. In addition, we studied their stimulatory effects on osteoblast-like cells in vitro and bone-forming ability in vivo, with a special emphasis on their ability to release silicon. The meshes consisted of a hybrid of carboxy groups in PLA and amino groups in siloxane, derived from aminopropyltriethoxysilane or calcium ions on the SiV surface. This hybrid exhibited an enhanced ability to form HA. The meshes coated with HA released 0.2-0.7 mg l-1 silicon species into the culture medium over 7 days. Enhanced proliferation of osteoblast-like cells was observed using the meshes and new bone formed on the meshes when implanted into the calvaria of rabbits. These meshes, therefore, provide an excellent substrate for bone regeneration and exhibit enhanced bone-forming ability under both in vitro and in vivo conditions. © 2009 Acta Materialia Inc.


Patent
Nagoya Institute of Technology, YAMAHACHI DENTAL Manufacturing CO. and Yabashi Industries Co. | Date: 2012-08-22

A guided bone regeneration material is disclosed. The guided bone regeneration material includes biodegradable fibers produced by an electro spinning method. The biodegradable fibers produced by the method include a silicon-releasing calcium carbonate and a biodegradable polymer. The silicon-releasing calcium carbonate is a composite of siloxane and calcium carbonate of vaterite phase. The biodegradable fibers may be coated with apatite. When the guided bone regeneration material is immersed in a neutral aqueous solution, silicon species ions are eluted from the calcium carbonate. The guided bone regeneration material excels in bone reconstruction ability.


Inoue M.,Rigaku Corporation | Yamada Y.,Rigaku Corporation | Kitamura M.,Yabashi Industries Co. | Gotoh N.,Yabashi Industries Co. | And 2 more authors.
Powder Diffraction | Year: 2015

The authors present and discuss a method for simultaneous quantitative analysis of total loss on ignition (LOI) (CO2 + H2O) and CO2 content separate from the LOI, in an industrial environment of quicklime production. Total LOI is determined by the Compton scattered RhKα tube radiation which is used directly in the calibration equation. The resulting calibration curve for LOI, including matrix correction shows an accuracy of 0.15 mass%. The carbon content (CO2) is distinguished from total LOI by measuring CKα radiation, which is possible with the required accuracy by employing a new multilayer analyzer with greatly improved background characteristics. The method aims at high reliability and sample throughput and at becoming a less time-consuming alternative to the conventional method of LOI determination by weighing sequences before and after ignition at 1050 °C. © International Centre for Diffraction Data 2015.


Wakita T.,Nagoya Institute of Technology | Nakamura J.,Nagoya Institute of Technology | Ota Y.,Yabashi Industries Co. | Obata A.,Nagoya Institute of Technology | And 2 more authors.
Dental Materials Journal | Year: 2011

Two types of nonwoven fabric, consisting of siloxane-doped vaterite (SiV) and poly(lactic acid) (PLA), for guided bone regeneration (GBR) were prepared by an electrospinning. One of the fabrics, SiV-PLA(M), was derived from PLA mixed with the solution of SiV dispersed in chloroform. Another one, SiV-PLA(K), was derived from a composite prepared by kneading SiV and PLA while heating at 200°C. The SiV-PLA(K) fabric shows higher degradability in dilute NaOH aq. than the SiV-PLA(M) fabric. To improve the cellular compatibility of the fabric, the fibers were coated with hydroxyapatite (HA) by soaking in simulated body fuid. The HA-coated SiV-PLA(K) fabric showed the release of silicate ions; the amount was reduced by 1/5 to 1/8 compared with that of the HA-coated SiV-PLA(M) fabric, and the excessive release was controlled. The preparation route of kneading at 200°C led to formation of a fabric with degradation behavior and ion releasability effective for bone regeneration.


Patent
Orthorebirth Co., Nagoya Institute of Technology, Yabashi Industries Co. and Showa Ika Kohgyo Co. | Date: 2012-08-08

A fiber wadding formed from a biodegradable polymer fiber containing calcium carbonate fine particles including silicon that is characterized in that hydroxyapatite is precipitated and scattered nearly uniformly on the surface of the biodegradable polymer fiber is disclosed. Further, a method for production of fiber wadding that includes the steps of heating and kneading silicon-containing calcium carbonate fine particles and a biodegradable polymer to produce a composite, dissolving the composite by mixing the composite with a solvent to obtain a spinning solution, processing the spinning solution into fiber wadding by using electrospinning method, and alternatingly immersing the fiber wadding in a calcium aqueous solution and a phosphate aqueous solution to cause precipitation of hydroxyapatite in an approximately uniformly scattered manner on the surface of the fibers is disclosed.


Yamada S.,Nagoya Institute of Technology | Ota Y.,Yabashi Industries Co. | Nakamura J.,Japan National Institute of Materials Science | Sakka Y.,Japan National Institute of Materials Science | Kasuga T.,Nagoya Institute of Technology
Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan | Year: 2014

Siloxane-containing vaterite doped with magnesium (MgSiV) was prepared by a carbonation process for application in bone regeneration. Ca(OH)2, aminopropyltriethoxysilane (APTES) and Mg(OH)2 were mixed with a solvent consisting of methanol and distilled water under CO2 gas. After the mixture was aged, the translucent precursor gel was dried, resulting in the formation of MgSiV particles containing 2.0 wt % magnesium and 2.8 wt % silicon. The MgSiV consists of distorted spherical particles with diameters of approximately 1.3 μm and a thickness of approximately 0.6 μm while the siloxane-containing vaterite without magnesium (SiV) was spherical with a diameter of approximately 1.5 μm. X-ray diffraction (XRD) analysis suggests the incorporation of magnesium into the vaterite structure. Fourier transform infrared spectroscopy (FTIR) indicated the presence of amorphous calcium carbonate (ACC) while the magnesium and the siloxane formed Si-O-Mg bonds. After heating the MgSiV at 500°C, the magnesium removed from the vaterite structure formed Si-O-Mg bonds with the siloxane. The MgSiV released Ca2+, Mg2+ and Si4+ ions into a Tris buffer solution. The amount of Ca2+ ion dissolved in the Tris buffer solution increased within the initial 12 h and subsequently decreased with time because of the formation of precipitates. ©2014 The Ceramic Society of Japan. All rights reserved.


Gotoh Y.,Yabashi Industries Co. | Iwata G.,Nagoya University | Choh K.,Yabashi Industries Co. | Kubota M.,Nagoya University | Matsuda H.,Nagoya University
Chemosphere | Year: 2011

A comparison of CaOs produced by calcining two types of hydrated lime and calcium carbonate was made for decomposition of trichloroethylene and in-situ dry sorption of the decomposed Cl-products using a lab-scale gas flow type tubular packed bed reactor. About 20mg of CaO sample was mixed with about 2g of Al 2O 3 particles and packed in the reactor and allowed to react with a flowing standard gas containing 500ppm of C 2HCl 3 (N 2 balance) at 673 and 873K, under the condition that the reaction of CaO with C 2HCl 3 might be completed within a few hours.It was found that no thermal decomposition of C 2HCl 3 at or below 673K was observed in a reactor packed only with Al 2O 3 particles. However, a considerable amount of decomposition of C 2HCl 3 was obtained in a reactor packed with CaO and Al 2O 3, even at 673K. For 1mol of CaO prepared by calcining highly reactive Ca(OH) 2 at 673K, decomposition of 0.42mol of C 2HCl 3 and in-situ absorption product of 0.53mol of CaCl 2 were obtained. At 873K, about 46% of C 2HCl 3 was thermally decomposed. The total amount of C 2HCl 3 decomposed in CaO-Al 2O 3 particle bed at 873K became nearly twice larger than that at 673K. For 1mol of CaO prepared by calcining highly reactive Ca(OH) 2 at 873K, decomposition of 0.59mol of C 2HCl 3 and in-situ absorption product of 0.67mol of CaCl 2 were obtained. Small amounts of C 2Cl 2, C 2Cl 4, CCl 4, etc. were detected during decomposition of C 2HCl 3 at 673 and 873K.It was recognized that the data on decomposition of C 2HCl 3 as well as in-situ dry sorption of Cl-products in CaO particle bed were correlated with specific surface area of the CaO employed. © 2011 Elsevier Ltd.


PubMed | Yabashi Industries Co.
Type: Journal Article | Journal: Chemosphere | Year: 2011

A comparison of CaOs produced by calcining two types of hydrated lime and calcium carbonate was made for decomposition of trichloroethylene and in-situ dry sorption of the decomposed Cl-products using a lab-scale gas flow type tubular packed bed reactor. About 20 mg of CaO sample was mixed with about 2 g of Al2O3 particles and packed in the reactor and allowed to react with a flowing standard gas containing 500 ppm of C2HCl3 (N2 balance) at 673 and 873 K, under the condition that the reaction of CaO with C2HCl3 might be completed within a few hours. It was found that no thermal decomposition of C2HCl3 at or below 673 K was observed in a reactor packed only with Al2O3 particles. However, a considerable amount of decomposition of C2HCl3 was obtained in a reactor packed with CaO and Al2O3, even at 673 K. For 1 mol of CaO prepared by calcining highly reactive Ca(OH)2 at 673 K, decomposition of 0.42 mol of C2HCl3 and in-situ absorption product of 0.53 mol of CaCl2 were obtained. At 873 K, about 46% of C2HCl3 was thermally decomposed. The total amount of C2HCl3 decomposed in CaO-Al2O3 particle bed at 873 K became nearly twice larger than that at 673 K. For 1 mol of CaO prepared by calcining highly reactive Ca(OH)2 at 873 K, decomposition of 0.59 mol of C2HCl3 and in-situ absorption product of 0.67 mol of CaCl2 were obtained. Small amounts of C2Cl2, C2Cl4, CCl4, etc. were detected during decomposition of C2HCl3 at 673 and 873 K. It was recognized that the data on decomposition of C2HCl3 as well as in-situ dry sorption of Cl-products in CaO particle bed were correlated with specific surface area of the CaO employed.


PubMed | Nagoya Institute of Technology and Yabashi Industries Co.
Type: | Journal: Frontiers in bioengineering and biotechnology | Year: 2015

Development of novel biomaterials with Mg(2+), Ca(2+), and silicate ions releasability for bone regeneration is now in progress. Several inorganic ions have been reported to stimulate bone-forming cells. We featured Ca(2+), silicate, and especially, Mg(2+) ions as growth factors for osteoblasts. Various biomaterials, such as ceramic powders and organic-inorganic composites, that release the ions, have been developed and investigated for their cytocompatibilities in our previous work. Through the investigation, providing the three ions was found to be effective to activate osteogenic cells. Magnesium and siloxane--containing vaterite was prepared by a carbonation process as an inorganic particle that can has the ability to simultaneously release Ca(2+), silicate, and Mg(2+) ions to biodegradable polymers. Poly (l-lactic acid) (PLLA)- and bioactive PLLA-based composites containing vaterite coatings were discussed regarding their degradability and cytocompatibility using a metallic Mg substrate as Mg(2+) ion source. PLLA/SiV composite film, which has a releasability of silicate ions besides Ca(2+) ion, was coated on a pure Mg substrate to be compared with the PLLA/V coating. The degradability and releasability of inorganic ions were morphologically and quantitatively monitored in a cell culture medium. The bonding strength between the coatings and Mg substrates was one of the key factors to control Mg(2+) ion release from the substrates. The cell culture tests were conducted using mouse osteoblast-like cells (MC3T3-E1 cells); cellular morphology, proliferation, and differentiation on the materials were evaluated. The PLLA/V and PLLA/SiV coatings on Mg substrates were found to enhance the proliferation, especially the PLLA/SiV coating possessed a higher ability to induce the osteogenic differentiation of the cells.

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