Yabang Medical Research Institute

Changzhou, China

Yabang Medical Research Institute

Changzhou, China

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Yu S.,Yabang Medical Research Institute | Yu S.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | Zhou W.,Yabang Medical Research Institute | Zhou W.,Changzhou University | And 6 more authors.
Journal of Chemical Research | Year: 2015

5-Chloro-2, 3, 4-trifluorobenzoic acid, a key intermediate for preparing quinolone-3-carboxylic acid derivatives, was synthesised from the commercially available 2, 3, 4, 5-trifluorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination. © 2015, Science Reviews 2000 Ltd. All rights reserved.


Zhoua W.,Yabang Medical Research Institute | Zhoua W.,Changzhou University | Fenga X.,Yabang Medical Research Institute | Fenga X.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | And 8 more authors.
Journal of Chemical Research | Year: 2015

2,4-Dichloro-3,5-difluorobenzoic acid was synthesised from the commercially available 4-chloro-3,5-difluorobenzonitrile in good yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.


Zhou W.,Yabang Medical Research Institute | Zhou W.,Changzhou University | Yu S.,Yabang Medical Research Institute | Yu S.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | And 8 more authors.
Journal of Chemical Research | Year: 2015

2,4-Difluoro-3,5-dichlorobenzoic acid, as a key intermediate for preparing quinolone-3-carboxylic acids, was synthesised from the commercially available 2,4-difluoro-3-chlorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.

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