Yabang Medical Research Institute

Changzhou, China

Yabang Medical Research Institute

Changzhou, China
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Zhang M.,Yabang Medical Research Institute | Zhang M.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | Zhang M.,Nanjing Forestry University | Qiu L.,Changzhou University | And 5 more authors.
Journal of Chemical Research | Year: 2017

3,5-Dimethoxy-2,4-difluorobenzoic acid, as a key intermediate for preparing an impurity of moxifloxacin, was synthesised from 2,3,4,5-tetrafluorobenzoic acid in moderate yield by nitration, methoxyl substitution, reduction of NO2, diazotisation and reduction. The structures of the intermediates and the target compound were identified and determined with IR, NMR and HRMS (ESI). © 2017, Science Reviews 2000 Ltd. All rights reserved.


Yu S.,Yabang Medical Research Institute | Yu S.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | Zhou W.,Yabang Medical Research Institute | Zhou W.,Changzhou University | And 6 more authors.
Journal of Chemical Research | Year: 2015

5-Chloro-2, 3, 4-trifluorobenzoic acid, a key intermediate for preparing quinolone-3-carboxylic acid derivatives, was synthesised from the commercially available 2, 3, 4, 5-trifluorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination. © 2015, Science Reviews 2000 Ltd. All rights reserved.


Zhoua W.,Yabang Medical Research Institute | Zhoua W.,Changzhou University | Fenga X.,Yabang Medical Research Institute | Fenga X.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | And 8 more authors.
Journal of Chemical Research | Year: 2015

2,4-Dichloro-3,5-difluorobenzoic acid was synthesised from the commercially available 4-chloro-3,5-difluorobenzonitrile in good yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.


Zhou W.,Yabang Medical Research Institute | Zhou W.,Changzhou University | Yu S.,Yabang Medical Research Institute | Yu S.,Jiangsu Novel Quinolone Antibacterial Drugs Engineering Research Center | And 8 more authors.
Journal of Chemical Research | Year: 2015

2,4-Difluoro-3,5-dichlorobenzoic acid, as a key intermediate for preparing quinolone-3-carboxylic acids, was synthesised from the commercially available 2,4-difluoro-3-chlorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.

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