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Cao C.,Xuzhou Municipal Central Hospital | Cheng L.,Xuzhou Municipal Central Hospital | Li G.-J.,Xuzhou Municipal Central Hospital | Cui N.,Xuzhou Municipal Central Hospital | Wu H.-J.,Xuzhou Municipal Central Hospital
Journal of Interventional Radiology | Year: 2011

Objective: To assess the clinical efficacy and safety of biliary stent implantation combined with high intensity-focused ultrasound ablation for the treatment of malignant biliary obstruction. Methods: A total of 122 patients with malignant biliary obstruction were randomly divided into study group (n = 63) and control group (n = 59). A total of 146 biliary stents were implanted in 122 patients. High intensity-focused ultrasound ablation was carried out in patients of study group 5-7 days after stent implantation. Anti-tumor therapy was not used in patients of control group. The clinical results and survival time were analyzed. Results: One month after the stent implantation the remission rate of the study group and the control group was 98.4% (62/63) and 96.6% (57/59), respectively, but no significant difference in the remission rate existed between the two groups (P > 0.05). A follow-up lasting for 2-26 months was conducted in 91 patients, including 46 cases of study group and 45 cases of control group, with a follow-up rate of 74.6% (91/122). In the study group the recurrence of obstructive jaundice appeared 4-13 months (median of 8.2 months) after the treatment, and the survival time was 2-26 months with a median survival time of 8.7 months. In the control group the recurrence of obstructive jaundice appeared 2-6 months (median of 4.8 months) after the treatment, and the survival time was 2-10 months with a median survival time of 6.4 months. The differences between the two groups were statistically significant (P = 0.001). Conclusion: For the treatment of malignant biliary obstruction biliary stent implantation combined with high intensity-focused ultrasound ablation is safe and effective, this technique can markedly prolong the patient's survival time. Source

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