Liao C.,Chongqing Medical University |
Feng Z.,Chongqing Medical University |
Zhou D.,Chongqing Medical University |
Dai Q.,Chongqing Medical University |
And 4 more authors.
Neuroscience | Year: 2012
Background: depression is characterized by a stable negative bias toward emotional stimuli. This bias is associated with abnormal activities in emotion-processing regions (such as the amygdala) and cognitive-control regions (such as the dorsolateral prefrontal cortex [DLPFC]). However, it remains unclear whether the emotion-processing and cognitive-control regions affect negative cognitive bias independently or reciprocally. Experimental procedure: a functional magnetic resonance imaging (fMRI) study of 16 depressed patients and 16 matched control subjects was conducted during an emotion-interference task. Results: the accuracies were significantly lower in the depressed group than in the control group when subjects attended to the happy and the neutral faces. Compared with control participants, depressed patients showed abnormal activity in bilateral amygdala and the right DLPFC. In addition, a significant correlation was found between the right amygdala and the right DLPFC when subjects observed the happy faces. Conclusions: the results suggest that the dysfunction in positive emotion-processing and cognitive-control regions may reciprocally affect negative cognitive bias. Additionally, altered positive emotional interference processing in the fronto-limbic brain circuitry might be another cause of negative cognitive bias that finally leads to depression. © 2011 IBRO.
Cao F.,Northwestern University |
Lee R.,Northwestern University |
Shu H.,Beijing Normal University |
Yang Y.,Xuanwu Hospital |
And 3 more authors.
Cerebral Cortex | Year: 2010
Developmental differences in phonological and orthographic processing in Chinese were examined in 9 year olds, 11 year olds, and adults using functional magnetic resonance imaging. Rhyming and spelling judgments were made to 2-character words presented sequentially in the visual modality. The spelling task showed greater activation than the rhyming task in right superior parietal lobule and right inferior temporal gyrus, and there were developmental increases across tasks bilaterally in these regions in addition to bilateral occipital cortex, suggesting increased involvement over age on visuo-orthographic analysis. The rhyming task showed greater activation than the spelling task in left superior temporal gyrus and there were developmental decreases across tasks in this region, suggesting reduced involvement over age on phonological representations. The rhyming and spelling tasks included words with conflicting orthographic and phonological information (i.e., rhyming words spelled differently or nonrhyming words spelled similarly) or nonconflicting information. There was a developmental increase in the difference between conflicting and nonconflicting words in left inferior parietal lobule, suggesting greater engagement of systems for mapping between orthographic and phonological representations. Finally, there were developmental increases across tasks in an anterior (Broadman area [BA] 45, 46) and posterior (BA 9) left inferior frontal gyrus, suggesting greater reliance on controlled retrieval and selection of posterior lexical representations. © 2009 The Author.
Cao F.,Northwestern University |
Cao F.,University of Pittsburgh |
Khalid K.,Northwestern University |
Lee R.,Northwestern University |
And 5 more authors.
NeuroImage | Year: 2011
Developmental differences in phonological and orthographic processing of Chinese spoken words were examined in 9-year-olds, 11-year-olds and adults using functional magnetic resonance imaging (fMRI). Rhyming and spelling judgments were made to two-character words presented sequentially in the auditory modality. Developmental comparisons between adults and both groups of children combined showed that age-related changes in activation in visuo-orthographic regions depended on a task. There were developmental increases in the left inferior temporal gyrus and the right inferior occipital gyrus in the spelling task, suggesting more extensive visuo-orthographic processing in a task that required access to these representations. Conversely, there were developmental decreases in activation in the left fusiform gyrus and left middle occipital gyrus in the rhyming task, suggesting that the development of reading is marked by reduced involvement of orthography in a spoken language task that does not require access to these orthographic representations. Developmental decreases may arise from the existence of extensive homophony (auditory words that have multiple spellings) in Chinese. In addition, we found that 11-year-olds and adults showed similar activation in the left superior temporal gyrus across tasks, with both groups showing greater activation than 9-year-olds. This pattern suggests early development of perceptual representations of phonology. In contrast, 11-year-olds and 9-year-olds showed similar activation in the left inferior frontal gyrus across tasks, with both groups showing weaker activation than adults. This pattern suggests late development of controlled retrieval and selection of lexical representations. Altogether, this study suggests differential effects of character acquisition on development of components of the language network in Chinese as compared to previous reports on alphabetic languages. © 2010.
News Article | November 7, 2016
BEIJING, Nov 7, 2016 /PRNewswire/ -- An HTC VIVE™-empowered neuroimaging solution made its China debut at the Sino-US Neuroimaging Virtual Reality Solution Seminar in Beijing on November 5th. Hosted by HTC Healthcare department, this seminar brought together 30 of the country's most distinguished neurosurgeons for an interactive VR showcase by Dr. Neil Martin, a world-renowned neurosurgeon from the University of California Los Angeles. As part of the HTC Healthcare strategy, this co-developed VR solution with Surgical Theater in neuroimaging aims to assist neurosurgeons in better analyzing and planning surgeries, training medical professionals, and more importantly, engaging with their patients. Healthcare constitutes one of the most important and exciting industries for VR, as the technology has the potential to dramatically transform the medical arena for both doctors and patients. Applications include using VR to train surgeons, sharpening and discovering new techniques, and aiding patient recovery through more in-depth and effective means. With VR's influence extending far beyond gaming, developers are spreading their focus to developing VR apps and 360 videos for vertical industries. A recent survey of China's VR/AR developers found that 40.3% of all developers are developing non-game content for vertical industries, with 23.8% of them dedicated to driving innovation in healthcare. Many industry reports also backed that VR/AR combining healthcare will represent a multi-billion-dollar market in the coming years. Dr. Neil Martin, Chairman of the University of California Los Angeles' Department of Neurosurgery, has long been a major proponent of VR in healthcare. As he put on the Vive HMD (head-mounted display), he was able to zoom in and out, rotate, measure and navigate inside of a visualized brain model, thanks to Vive's room-scale tracking, high-definition display and two precision controllers. "Virtual Reality is among the few modern technologies that we medical practitioners have to embrace for our mission to cure," Dr. Neil Martin said, "I'm simply amazed at the unprecedented experience and unlimited possibilities enabled by a fully immersive VR system like the HTC Vive." "I was extremely impressed by the technology on display today, which marks a great advance in analyzing and mapping complex pathological changes and surgical cases," said Dr. Zhang Hongqi, Chairman and Professor of Neurosurgery Department, Xuanwu Hospital Capital Medical University, "I hope to see even further improvements in areas like tissue displacement and hemodynamics." HTC is committed to cultivating a healthy and robust VR ecosystem that cuts across all industries and sectors of society. By focusing on vertical industries in addition to gaming, the company is dedicated to unleashing the possibilities of VR so that more people can benefit from technological innovation in their everyday life. Vive is a first-of-its-kind virtual reality system developed in partnership by HTC and Valve. Designed from the ground up for room-scale VR, Vive allows true-to-life interactions and experiences thanks to an adjustable headset displaying stunning graphics, two wireless controllers with HD haptic feedback and 360？？ absolute motion tracking. For a convenient and safe experience, Vive incorporates essential functionality from your phone and features a front facing camera that blends physical elements into the virtual world. Working in concert, this system immerses you visually, physically and emotionally in the virtual world. For more information on Vive, please visit www.vive.com. HTC Corporation aims to bring brilliance to life. As a global innovator in smart mobile and virtual reality devices and technology, HTC has produced award-winning products and industry firsts since its inception in 1997, including the critically acclaimed HTC One and HTC Desire lines of smartphones, and is now leading the VR industry with the Vive line of products. The pursuit of brilliance is at the heart of everything we do, inspiring best-in-class design and game-changing mobile and virtual reality experiences for consumers around the world. HTC is listed on the Taiwan Stock Exchange (TWSE: 2498). www.htc.com. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/neuroimaging-virtual-reality-solution-empowered-by-htc-vivetm-debuts-in-china-300358302.html
Yan H.,Xuanwu Hospital |
Ou T.-W.,Xuanwu Hospital |
Chen L.,Xuanwu Hospital |
Wang Q.,Xuanwu Hospital |
And 4 more authors.
International Journal of Urology | Year: 2013
Objectives: To characterize the hemodynamics comparing thulium laser vaporesection of the prostate with traditional transurethral resection of the prostate. Methods: A total of 80 consecutive patients with benign prostatic hyperplasia were randomly assigned into the thulium laser vaporesection of the prostate group or transurethral resection of the prostate group. Transpulmonary thermodilution hemodynamic monitoring was used before and 1h after surgery to assess patient hemodynamics. Acute complications and treatment efficiency were evaluated after surgery. Results: There were no statistical differences in age, prostate volume, anticoagulants and International Prostate Symptom Score between the two groups. The postoperative Stroke Volume Index was significantly higher in the thulium laser vaporesection of the prostate group (P=0.007). The extravascular lung water and intrathoracic blood volume indices differed significantly pre- and postoperatively, and were similar in both groups. Decreases in serum sodium and hemoglobin concentrations after surgery were lower in the thulium laser vaporesection of the prostate group (P<0.01). Acute complications, and improvements in International Prostate Symptom Score and maximum urinary flow rates, were similar in both groups. Conclusions: Transpulmonary thermodilution hemodynamic monitoring provides additional safety measures during surgical procedures. Thulium laser vaporesection of the prostate is associated with fewer hemodynamic changes and provides similar efficacy to transurethral resection of the prostate. Thus, it can be considered a safe and effective procedure. © 2013 The Japanese Urological Association.
Wang F.,Capital Medical University |
Liu Y.,Capital Medical University |
Duan Y.,Capital Medical University |
Li K.,Capital Medical University |
Li K.,Xuanwu Hospital
European Journal of Radiology | Year: 2011
Objective: The purpose of this study was to explore brain MRI findings in neuromyelitis optica (NMO) and to investigate specific brain lesions with respect to the localization of aquaporin-4 (AQP-4). Materials and methods: Forty admitted patients (36 women) who satisfied the 2006 criteria of Wingerchuk et al. for NMO were included in this study. All patients received a neurological examination and MRI scanning including brain and spinal cord. MRIs were classified as normal, nonspecific, multiple sclerosis-like, typical abnormalities. MS-like lesions were too few to satisfy the Barkhof et al. criteria for MS. Confluent lesions involving high AQP-4 regions were considered typical. Non-enhancing deep white matter lesions other than MS-like lesions or typical lesions were classified as nonspecific. Results: Brain MRI lesions were delineated in 12 patients (25%). Four patients (10%) had hypothalamus, brainstem or periventricle lesions. Six (15%) patients were nonspecific, and 2 (5%) patients had multiple sclerosis-like lesions. Conclusion: Brain MRIs are negative in most NMO, and brain lesions do not exclude the diagnosis of NMO. Hypothalamus, brainstem or periventricle lesions, corresponding to high sites of AQP-4 in the brain, are indicative of lesions of NMO. © 2010 Elsevier Ireland Ltd.
Yu S.,Xuanwu Hospital |
Chan P.,Xuanwu Hospital
Essays in Biochemistry | Year: 2014
α-Syn (α-synuclein) is a small soluble acidic protein that is extensively expressed in the nervous system. Genetic, clinical and experimental studies demonstrate that α-syn is strongly implicated in the pathogenesis of PD (Parkinson's disease). However, the pathogenic mechanism remains elusive. In the present chapter, we fi rst describe the normal expression and potential physiological functions of α-syn. Then, we introduce recent research progress related to the pathogenic role of α-syn in PD, with special emphasis on how α-syn oligomers cause the preferential degeneration of dopaminergic neurons in the substantia nigra and the spreading of α-syn pathology in the brain of PD patients. © 2014 Biochemical Society.
Chen T.-Z.,Shandong University |
Chen T.-Z.,Taishan Medical University |
Xu G.-J.,Taishan Medical University |
Zhou G.-A.,Central Hospital of Taian |
And 3 more authors.
Brain Research | Year: 2014
There is compelling evidence that postural instability occurs at very early clinical stages of Parkinsons disease (PD), making it tempting to speculate that changes in postural sway may even occur at a prodromal phase. Studies estimate that approximately half of patients with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) will eventually develop PD, so RBD may be an indicator of prodromal PD. This study was undertaken to investigate postural sway and its relation to stereopsis function in patients with RBD. We examined 24 patients with polysomnography-confirmed RBD and 23 healthy, sex-and age-matched control subjects. Postural sway was measured with an accelerometer at the center of mass at the lower spine. Subjects were asked to stand quietly for 30 s under two usual conditions (eyes open and eyes closed) and three challenging conditions (eyes open with dual task, eyes closed with dual task, and tandem standing). Stereopsis was assessed using the Titmus fly test. RBD patients showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to control subjects. These differences reached significance in the challenging conditions. RBD patients demonstrated significant impairment in stereopsis. There were statistically significant correlations between log seconds of arc of the Titmus test and some sway parameters within the RBD group. RBD patients with abnormal stereopsis showed a significant increase of JERK values compared to patients with normal stereopsis in the challenging conditions. Our results indicate that idiopathic RBD patients, especially with abnormal stereopsis, have subtle signs of postural instability under challenging conditions. Postural sway performance may serve as a biological marker for prodromal PD. © 2014 Elsevier B.V.
Dong S.,Xuanwu Hospital |
Zhang X.,Xuanwu Hospital |
Li J.,Xuanwu Hospital |
Li Y.,Xuanwu Hospital
Acta Neurochirurgica | Year: 2014
A 30-year-old man underwent bilateral GPi DBS for refractory TS. His tics and obsessive-compulsive symptoms were significantly improved after chronic stimulation. At 22 months postoperatively, the implantable pulse generator had to be removed because of an infection in the infraclavicular pouch. However, we observed an unexpected effectiveness at follow-up more than 4 years after stopping the stimulation. This is the first case report of TS that showed a favorable long-term outcome after cessation of chronic GPi DBS. © 2014 Springer-Verlag.
Li K.-C.,Xuanwu Hospital
Chinese Journal of Contemporary Neurology and Neurosurgery | Year: 2014
Alzheimer's disease is the most common neurodegenerative disease which gives rise to senile dementia. High morbidity and poor efficacy of Alzheimer's disease have brought about much pressure to the aging society. However, based on early diagnosis, early clinical intervention may slow down the progression of disease and improve its prognosis. In this review, we attempt to introduce the progress of early neuroimaging diagnosis of Alzheimer's disease.