Xuanwu Hospital

Beijing, China

Xuanwu Hospital

Beijing, China

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News Article | November 7, 2016
Site: en.prnasia.com

BEIJING, Nov 7, 2016 /PRNewswire/ -- An HTC VIVE™-empowered neuroimaging solution made its China debut at the Sino-US Neuroimaging Virtual Reality Solution Seminar in Beijing on November 5th. Hosted by HTC Healthcare department, this seminar brought together 30 of the country's most distinguished neurosurgeons for an interactive VR showcase by Dr. Neil Martin, a world-renowned neurosurgeon from the University of California Los Angeles. As part of the HTC Healthcare strategy, this co-developed VR solution with Surgical Theater in neuroimaging aims to assist neurosurgeons in better analyzing and planning surgeries, training medical professionals, and more importantly, engaging with their patients. Healthcare constitutes one of the most important and exciting industries for VR, as the technology has the potential to dramatically transform the medical arena for both doctors and patients. Applications include using VR to train surgeons, sharpening and discovering new techniques, and aiding patient recovery through more in-depth and effective means. With VR's influence extending far beyond gaming, developers are spreading their focus to developing VR apps and 360 videos for vertical industries. A recent survey of China's VR/AR developers found that 40.3% of all developers are developing non-game content for vertical industries, with 23.8% of them dedicated to driving innovation in healthcare. Many industry reports also backed that VR/AR combining healthcare will represent a multi-billion-dollar market in the coming years. Dr. Neil Martin, Chairman of the University of California Los Angeles' Department of Neurosurgery, has long been a major proponent of VR in healthcare. As he put on the Vive HMD (head-mounted display), he was able to zoom in and out, rotate, measure and navigate inside of a visualized brain model, thanks to Vive's room-scale tracking, high-definition display and two precision controllers. "Virtual Reality is among the few modern technologies that we medical practitioners have to embrace for our mission to cure," Dr. Neil Martin said, "I'm simply amazed at the unprecedented experience and unlimited possibilities enabled by a fully immersive VR system like the HTC Vive." "I was extremely impressed by the technology on display today, which marks a great advance in analyzing and mapping complex pathological changes and surgical cases," said Dr. Zhang Hongqi, Chairman and Professor of Neurosurgery Department, Xuanwu Hospital Capital Medical University, "I hope to see even further improvements in areas like tissue displacement and hemodynamics." HTC is committed to cultivating a healthy and robust VR ecosystem that cuts across all industries and sectors of society. By focusing on vertical industries in addition to gaming, the company is dedicated to unleashing the possibilities of VR so that more people can benefit from technological innovation in their everyday life. Vive is a first-of-its-kind virtual reality system developed in partnership by HTC and Valve. Designed from the ground up for room-scale VR, Vive allows true-to-life interactions and experiences thanks to an adjustable headset displaying stunning graphics, two wireless controllers with HD haptic feedback and 360?? absolute motion tracking. For a convenient and safe experience, Vive incorporates essential functionality from your phone and features a front facing camera that blends physical elements into the virtual world. Working in concert, this system immerses you visually, physically and emotionally in the virtual world. For more information on Vive, please visit www.vive.com. HTC Corporation aims to bring brilliance to life. As a global innovator in smart mobile and virtual reality devices and technology, HTC has produced award-winning products and industry firsts since its inception in 1997, including the critically acclaimed HTC One and HTC Desire lines of smartphones, and is now leading the VR industry with the Vive line of products. The pursuit of brilliance is at the heart of everything we do, inspiring best-in-class design and game-changing mobile and virtual reality experiences for consumers around the world. HTC is listed on the Taiwan Stock Exchange (TWSE: 2498). www.htc.com. To view the original version on PR Newswire, visit:http://www.prnewswire.com/news-releases/neuroimaging-virtual-reality-solution-empowered-by-htc-vivetm-debuts-in-china-300358302.html

Cheng F.,Xuanwu Hospital | Li X.,Xuanwu Hospital | Li Y.,Xuanwu Hospital | Wang C.,Xuanwu Hospital | And 7 more authors.
Journal of Neurochemistry | Year: 2011

Abnormalities of α-synuclein (α-syn) and NMDA receptors (NMDARs) are implicated in the pathogenesis of Parkinson's disease. However, how these proteins interact with each other has not been elucidated. Here, the effect of α-syn on NMDARs was investigated by examining the alterations of surface NMDAR NR1 subunits in MES23.5 dopaminergic cells transfected with the human α-syn gene as well as in cells treated with extracellularly added human α-syn. As demonstrated previously that α-syn can enter cells in a non-endocytic manner without being degraded by the cellular proteolytic systems, the extracellularly added α-syn entered the cytoplasm of MES23.5 cells in a concentration-dependent manner. Both the α-syn-transfected cells and α-syn-treated cells exhibited increased intracellular α-syn levels and reduced surface NR1 without altering the total NR1. The α-syn-induced surface NR1 reduction was accompanied by suppression of NMDA-elicited intracellular Ca 2+ elevation and reductions of NMDA-induced caspase 3 activation and cell death, which was abolished by hypotonic shock and K + depletion, a procedure that blocks clathrin-mediated endocytosis, and by suppression of RAB5B expression with anti-RAB5B oligonucleotides. The data obtained provide evidence for the first time that α-syn may promote clathrin-mediated NMDAR endocytosis. © 2011 International Society for Neurochemistry.

Yan H.,Xuanwu Hospital | Ou T.-W.,Xuanwu Hospital | Chen L.,Xuanwu Hospital | Wang Q.,Xuanwu Hospital | And 4 more authors.
International Journal of Urology | Year: 2013

Objectives: To characterize the hemodynamics comparing thulium laser vaporesection of the prostate with traditional transurethral resection of the prostate. Methods: A total of 80 consecutive patients with benign prostatic hyperplasia were randomly assigned into the thulium laser vaporesection of the prostate group or transurethral resection of the prostate group. Transpulmonary thermodilution hemodynamic monitoring was used before and 1h after surgery to assess patient hemodynamics. Acute complications and treatment efficiency were evaluated after surgery. Results: There were no statistical differences in age, prostate volume, anticoagulants and International Prostate Symptom Score between the two groups. The postoperative Stroke Volume Index was significantly higher in the thulium laser vaporesection of the prostate group (P=0.007). The extravascular lung water and intrathoracic blood volume indices differed significantly pre- and postoperatively, and were similar in both groups. Decreases in serum sodium and hemoglobin concentrations after surgery were lower in the thulium laser vaporesection of the prostate group (P<0.01). Acute complications, and improvements in International Prostate Symptom Score and maximum urinary flow rates, were similar in both groups. Conclusions: Transpulmonary thermodilution hemodynamic monitoring provides additional safety measures during surgical procedures. Thulium laser vaporesection of the prostate is associated with fewer hemodynamic changes and provides similar efficacy to transurethral resection of the prostate. Thus, it can be considered a safe and effective procedure. © 2013 The Japanese Urological Association.

Zhang L.-Q.,Northwestern University | Zhang L.-Q.,Rehabilitation Institute of Chicago | Chung S.G.,Rehabilitation Institute of Chicago | Chung S.G.,Seoul National University | And 7 more authors.
Journal of Neurophysiology | Year: 2013

This study characterizes tonic and phasic stretch reflex and stiffness and viscosity changes associated with spastic hemiparesis. Perturbations were applied to the ankle of 27 hemiparetic and 36 healthy subjects under relaxed or active contracting conditions. A nonlinear delay differential equation model characterized phasic and tonic stretch reflex gains, elastic stiffness, and viscous damping. Tendon reflex was characterized with reflex gain and threshold. Reflexively, tonic reflex gain was increased in spastic ankles at rest (P < 0.038) and was not regulated with muscle contraction, indicating impaired tonic stretch reflex. Phasic-reflex gain in spastic plantar flexors was higher and increased faster with plantar flexor contraction (P < 0.012) than controls (P < 0.023) and higher in dorsi-flexors at lower torques (P < 0.038), primarily because of its increase at rest (P = 0.045), indicating exaggerated phasic stretch reflex especially in more spastic plantar flexors, which showed higher phasic stretch reflex gain than dorsi-flexors (P < 0.032). Spasticity was associated with increased tendon reflex gain (P = 0.002) and decreased threshold (P < 0.001). Mechanically, stiffness in spastic ankles was higher than that in controls across plantar flexion/dorsi-flexion torque levels (P < 0.032), and the more spastic plantar flexors were stiffer than dorsi-flexors at comparable torques (P < 0.031). Increased stiffness in spastic ankles was mainly due to passive stiffness increase (P < 0.001), indicating increased connective tissues/shortened fascicles. Viscous damping in spastic ankles was increased across the plantar flexion torque levels and at lower dorsi-flexion torques, reflecting increased passive viscous damping (P = 0.033). The more spastic plantar flexors showed higher viscous damping than dorsi-flexors at comparable torque levels (P < 0.047). Simultaneous characterizations of reflex and nonreflex changes in spastic hemiparesis may help to evaluate and treat them more effectively. © 2013 the American Physiological Society.

Wang F.,Capital Medical University | Liu Y.,Capital Medical University | Duan Y.,Capital Medical University | Li K.,Capital Medical University | Li K.,Xuanwu Hospital
European Journal of Radiology | Year: 2011

Objective: The purpose of this study was to explore brain MRI findings in neuromyelitis optica (NMO) and to investigate specific brain lesions with respect to the localization of aquaporin-4 (AQP-4). Materials and methods: Forty admitted patients (36 women) who satisfied the 2006 criteria of Wingerchuk et al. for NMO were included in this study. All patients received a neurological examination and MRI scanning including brain and spinal cord. MRIs were classified as normal, nonspecific, multiple sclerosis-like, typical abnormalities. MS-like lesions were too few to satisfy the Barkhof et al. criteria for MS. Confluent lesions involving high AQP-4 regions were considered typical. Non-enhancing deep white matter lesions other than MS-like lesions or typical lesions were classified as nonspecific. Results: Brain MRI lesions were delineated in 12 patients (25%). Four patients (10%) had hypothalamus, brainstem or periventricle lesions. Six (15%) patients were nonspecific, and 2 (5%) patients had multiple sclerosis-like lesions. Conclusion: Brain MRIs are negative in most NMO, and brain lesions do not exclude the diagnosis of NMO. Hypothalamus, brainstem or periventricle lesions, corresponding to high sites of AQP-4 in the brain, are indicative of lesions of NMO. © 2010 Elsevier Ireland Ltd.

Zhu Y.,Capital Medical University | Duan C.,Capital Medical University | Lu L.,Capital Medical University | Gao H.,Capital Medical University | And 7 more authors.
International Journal of Biochemistry and Cell Biology | Year: 2011

α-Synuclein (α-syn), a protein involved in the pathogenesis of Parkinson's disease (PD), is known to accumulate in mitochondria, disrupt mitochondrial function. However, the molecular mechanisms that link these pathological responses have not been investigated. In rats overexpressing α-syn in the substantia nigra (SN) through adeno-associated virus (AAV) transduction, about 50% of tyrosine hydroxylase positive neurons were lost after 24 weeks. Overexpression of α-syn was also associated with morphological deformation of mitochondria and depolarization of the mitochondrial membrane potential (ΔΨm). Both co-immunoprecipitation and confocal microscopy demonstrated that mitochondrial α-syn associated with adenylate translocator (ANT), a component of the mitochondrial permeability transition pore (mPTP). The depolarization of ΔΨm was partially reversed in vitro by bongkrekic acid (BKA), an inhibitor of ANT, suggesting that the molecular association between α-syn and ANT facilitated ΔΨm depolarization. Concomitant with α-syn accumulation in mitochondria, abnormal mitochondrial morphology, ΔΨm depolarization, and loss of TH-positive neurons, there was a decrease in apoptosis-inducing factor (AIF) within the mitochondrial matrix, suggesting possible translocation to the cytosol. Our findings suggest that overexpression of α-syn may cause mitochondrial defects in dopaminergic neurons of the substantia nigra through an association with adenylate translocator and activation of mitochondria- dependent cell death pathways. Disruption of normal mitochondrial function may contribute to the loss of dopaminergic neurons in Parkinson's disease. © 2011 Elsevier Ltd.

Yu S.,Xuanwu Hospital | Chan P.,Xuanwu Hospital
Essays in Biochemistry | Year: 2014

α-Syn (α-synuclein) is a small soluble acidic protein that is extensively expressed in the nervous system. Genetic, clinical and experimental studies demonstrate that α-syn is strongly implicated in the pathogenesis of PD (Parkinson's disease). However, the pathogenic mechanism remains elusive. In the present chapter, we fi rst describe the normal expression and potential physiological functions of α-syn. Then, we introduce recent research progress related to the pathogenic role of α-syn in PD, with special emphasis on how α-syn oligomers cause the preferential degeneration of dopaminergic neurons in the substantia nigra and the spreading of α-syn pathology in the brain of PD patients. © 2014 Biochemical Society.

Chen T.-Z.,Shandong University | Chen T.-Z.,Taishan Medical University | Xu G.-J.,Taishan Medical University | Zhou G.-A.,Central Hospital of Taian | And 3 more authors.
Brain Research | Year: 2014

There is compelling evidence that postural instability occurs at very early clinical stages of Parkinsons disease (PD), making it tempting to speculate that changes in postural sway may even occur at a prodromal phase. Studies estimate that approximately half of patients with idiopathic rapid eye movement (REM) sleep behavior disorder (RBD) will eventually develop PD, so RBD may be an indicator of prodromal PD. This study was undertaken to investigate postural sway and its relation to stereopsis function in patients with RBD. We examined 24 patients with polysomnography-confirmed RBD and 23 healthy, sex-and age-matched control subjects. Postural sway was measured with an accelerometer at the center of mass at the lower spine. Subjects were asked to stand quietly for 30 s under two usual conditions (eyes open and eyes closed) and three challenging conditions (eyes open with dual task, eyes closed with dual task, and tandem standing). Stereopsis was assessed using the Titmus fly test. RBD patients showed an increased variability of trunk acceleration and a decrease of smoothness of sway, compared to control subjects. These differences reached significance in the challenging conditions. RBD patients demonstrated significant impairment in stereopsis. There were statistically significant correlations between log seconds of arc of the Titmus test and some sway parameters within the RBD group. RBD patients with abnormal stereopsis showed a significant increase of JERK values compared to patients with normal stereopsis in the challenging conditions. Our results indicate that idiopathic RBD patients, especially with abnormal stereopsis, have subtle signs of postural instability under challenging conditions. Postural sway performance may serve as a biological marker for prodromal PD. © 2014 Elsevier B.V.

Dong S.,Xuanwu Hospital | Zhang X.,Xuanwu Hospital | Li J.,Xuanwu Hospital | Li Y.,Xuanwu Hospital
Acta Neurochirurgica | Year: 2014

A 30-year-old man underwent bilateral GPi DBS for refractory TS. His tics and obsessive-compulsive symptoms were significantly improved after chronic stimulation. At 22 months postoperatively, the implantable pulse generator had to be removed because of an infection in the infraclavicular pouch. However, we observed an unexpected effectiveness at follow-up more than 4 years after stopping the stimulation. This is the first case report of TS that showed a favorable long-term outcome after cessation of chronic GPi DBS. © 2014 Springer-Verlag.

Li K.-C.,Xuanwu Hospital
Chinese Journal of Contemporary Neurology and Neurosurgery | Year: 2014

Alzheimer's disease is the most common neurodegenerative disease which gives rise to senile dementia. High morbidity and poor efficacy of Alzheimer's disease have brought about much pressure to the aging society. However, based on early diagnosis, early clinical intervention may slow down the progression of disease and improve its prognosis. In this review, we attempt to introduce the progress of early neuroimaging diagnosis of Alzheimer's disease.

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