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Berkeley, CA, United States

Patent
Novartis and Xoma | Date: 2015-06-03

M-CSF-specific RX1-based or RX-1 derived antibodies are provided, along with pharmaceutical compositions containing such antibody, kits containing a pharmaceutical composition, and methods of preventing and treating bone loss in a subject afflicted with an osteolytic disease.


Patent
Xoma | Date: 2015-07-24

The present disclosure relates, in general, to materials and methods for antibodies specific for transforming growth factor beta (TGF), including TGF1, TGF2 and TGF3, and uses of these antibodies in the treatment of subjects having cancer, an eye disease, condition or disorder, fibrosis, including ophthalmic fibrosis or fibrosis of the eye, and other conditions or disorders related to TGF expression.


Patent
Xoma | Date: 2014-11-26

Antibodies that modulate insulin receptor signaling are provided.


Patent
Xoma and Novartis | Date: 2014-12-18

Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.


Patent
Xoma | Date: 2015-07-14

This invention relates to stable formulations of multiple antibodies comprising a plurality of antibodies and an effective amount of a succinate buffer wherein the pH of the formulation is between about 4.5 and about 7.0.

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